{"id":"https://openalex.org/W2734864482","doi":"https://doi.org/10.1007/s10067-017-3742-2","title":"Impact of rituximab on patient-reported outcomes in patients with rheumatoid arthritis from the US Corrona Registry","display_name":"Impact of rituximab on patient-reported outcomes in patients with rheumatoid arthritis from the US Corrona Registry","publication_year":2017,"publication_date":"2017-07-17","ids":{"openalex":"https://openalex.org/W2734864482","doi":"https://doi.org/10.1007/s10067-017-3742-2","mag":"2734864482","pmid":"https://pubmed.ncbi.nlm.nih.gov/28718043","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5554472"},"language":"en","primary_location":{"id":"doi:10.1007/s10067-017-3742-2","doi":"https://doi.org/10.1007/s10067-017-3742-2","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10067-017-3742-2","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs10067-017-3742-2.pdf","source":{"id":"https://openalex.org/S44888363","display_name":"Clinical Rheumatology","issn_l":"0770-3198","issn":["0770-3198","1434-9949"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Rheumatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007%2Fs10067-017-3742-2.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079841694","display_name":"Leslie R. Harrold","orcid":"https://orcid.org/0000-0002-0170-2747","observed_orcids":["https://orcid.org/0000-0002-0170-2747"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Leslie R. Harrold","raw_affiliation_strings":["Corrona, LLC, Southborough, MA, USA. leslie.harrold@umassmed.edu","University of Massachusetts Medical School, Worcester, MA, USA. leslie.harrold@umassmed.edu","University of Massachusetts Medical School, Worcester, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Corrona, LLC, Southborough, MA, USA. leslie.harrold@umassmed.edu","institution_ids":[]},{"raw_affiliation_string":"University of Massachusetts Medical School, Worcester, MA, USA. leslie.harrold@umassmed.edu","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"University of Massachusetts Medical School, Worcester, MA, USA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050789092","display_name":"Ani K. John","orcid":"https://orcid.org/0000-0001-9309-7128","observed_orcids":["https://orcid.org/0000-0001-9309-7128"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ani John","raw_affiliation_strings":["Genentech, Inc., South San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., South San Francisco, CA, USA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108098563","display_name":"Jennie H. Best","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennie Best","raw_affiliation_strings":["Genentech, Inc., South San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., South San Francisco, CA, USA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067238693","display_name":"Steve Zlotnick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steve Zlotnick","raw_affiliation_strings":["Genentech, Inc., South San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., South San Francisco, CA, USA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000045044","display_name":"Chitra K. Karki","orcid":"https://orcid.org/0000-0001-9336-7589","observed_orcids":["https://orcid.org/0000-0001-9336-7589"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chitra Karki","raw_affiliation_strings":["Corrona, LLC, Southborough, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Corrona, LLC, Southborough, MA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"YouFu Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"YouFu Li","raw_affiliation_strings":["University of Massachusetts Medical School, Worcester, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Massachusetts Medical School, Worcester, MA, USA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030768494","display_name":"Jeffrey D. Greenberg","orcid":"https://orcid.org/0000-0001-9711-0457","observed_orcids":["https://orcid.org/0000-0001-9711-0457"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey D. Greenberg","raw_affiliation_strings":["New York University School of Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York University School of Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014147030","display_name":"Joel M. Kremer","orcid":"https://orcid.org/0000-0001-6674-9901","observed_orcids":["https://orcid.org/0000-0001-6674-9901"]},"institutions":[{"id":"https://openalex.org/I4210159453","display_name":"Center for Rheumatology","ror":"https://ror.org/04rtaxr13","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210159453"]},{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel M. Kremer","raw_affiliation_strings":["Albany Medical College and the Center for Rheumatology, Albany, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albany Medical College and the Center for Rheumatology, Albany, NY, USA","institution_ids":["https://openalex.org/I4210159453","https://openalex.org/I4405260259"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5079841694"],"corresponding_institution_ids":["https://openalex.org/I166722992"],"apc_list":{"value":4890,"currency":"USD","value_usd":4890},"apc_paid":{"value":4890,"currency":"USD","value_usd":4890},"fwci":1.912,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.84512817,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"36","issue":"9","first_page":"2135","last_page":"2140"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rituximab","display_name":"rituximab","score":1.0},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":1.0},{"id":"https://openalex.org/keywords/patient-reported-outcomes","display_name":"patient-reported outcomes","score":1.0},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.8920000195503235},{"id":"https://openalex.org/keywords/disease-activity","display_name":"disease activity","score":0.7139999866485596},{"id":"https://openalex.org/keywords/fatigue","display_name":"fatigue","score":0.6179999709129333},{"id":"https://openalex.org/keywords/pain","display_name":"pain","score":0.9449999928474426},{"id":"https://openalex.org/keywords/morning-stiffness","display_name":"morning stiffness","score":0.9079999923706055},{"id":"https://openalex.org/keywords/health-assessment-questionnaire","display_name":"Health Assessment Questionnaire","score":0.8579999804496765},{"id":"https://openalex.org/keywords/eq-5d","display_name":"EQ-5D","score":0.7839999794960022},{"id":"https://openalex.org/keywords/refractory-rheumatoid-arthritis","display_name":"refractory rheumatoid arthritis","score":0.8529999852180481},{"id":"https://openalex.org/keywords/corrona-registry","display_name":"Corrona registry","score":0.6830000281333923}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9588314294815063},{"id":"https://openalex.org/C2780653079","wikidata":"https://www.wikidata.org/wiki/Q412323","display_name":"Rituximab","level":3,"score":0.9528824090957642},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.8104454874992371},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6902636885643005},{"id":"https://openalex.org/C198451711","wikidata":"https://www.wikidata.org/wiki/Q327657","display_name":"Rheumatology","level":2,"score":0.5864298343658447},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.5279892086982727},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.49513331055641174},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.4644280672073364},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.4346274435520172},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.12244373559951782},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069283","descriptor_name":"Rituximab","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000071066","descriptor_name":"Patient Reported Outcome Measures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012042","descriptor_name":"Registries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1007/s10067-017-3742-2","doi":"https://doi.org/10.1007/s10067-017-3742-2","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10067-017-3742-2","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs10067-017-3742-2.pdf","source":{"id":"https://openalex.org/S44888363","display_name":"Clinical Rheumatology","issn_l":"0770-3198","issn":["0770-3198","1434-9949"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Rheumatology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5554472","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5554472","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Rheumatol","raw_type":"Text"},{"id":"pmid:28718043","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28718043","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical rheumatology","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.umassmed.edu:oapubs-4220","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.umassmed.edu/oapubs/3212","pdf_url":null,"source":{"id":"https://openalex.org/S7407064370","display_name":"eScholarship@UMassChan","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Publications by UMass Chan Authors","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1007/s10067-017-3742-2","doi":"https://doi.org/10.1007/s10067-017-3742-2","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10067-017-3742-2","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs10067-017-3742-2.pdf","source":{"id":"https://openalex.org/S44888363","display_name":"Clinical Rheumatology","issn_l":"0770-3198","issn":["0770-3198","1434-9949"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Rheumatology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307105","display_name":"Amgen","ror":"https://ror.org/03g03ge92"},{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320313778","display_name":"Horizon Pharma","ror":"https://ror.org/00kyj9h67"},{"id":"https://openalex.org/F4320315082","display_name":"Momenta Pharmaceuticals","ror":"https://ror.org/01xdkk717"},{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2734864482.pdf","grobid_xml":"https://content.openalex.org/works/W2734864482.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W848515071","https://openalex.org/W1969093054","https://openalex.org/W1990707361","https://openalex.org/W2002166646","https://openalex.org/W2094232837","https://openalex.org/W2105422073","https://openalex.org/W2109667143","https://openalex.org/W2146157868","https://openalex.org/W2157399320","https://openalex.org/W2164024605","https://openalex.org/W2169012266","https://openalex.org/W2413265834","https://openalex.org/W2538832497"],"related_works":["https://openalex.org/W3022111851","https://openalex.org/W848515071","https://openalex.org/W2757782014","https://openalex.org/W1410689690","https://openalex.org/W1968684024","https://openalex.org/W1969093054","https://openalex.org/W2756375013","https://openalex.org/W4409951565","https://openalex.org/W2333155706","https://openalex.org/W2169012266"],"abstract_inverted_index":{"To":[0],"evaluate":[1],"the":[2,83],"impact":[3],"of":[4,15,107,110,126,151],"rituximab":[5,38,49,119],"on":[6],"patient-reported":[7],"outcomes":[8],"(PROs)":[9],"in":[10,42,132,147,167],"a":[11],"US-based":[12],"observational":[13],"cohort":[14],"patients":[16,85,97,111,127,160],"with":[17,22,161],"rheumatoid":[18],"arthritis":[19],"(RA).":[20],"Patients":[21],"active":[23],"RA,":[24],"prior":[25],"exposure":[26],"to":[27],"\u22651":[28],"tumor":[29],"necrosis":[30],"factor":[31],"inhibitor":[32],"(TNFi)":[33],"and":[34,64,79,92,105,124,137,142,149],"who":[35,86],"newly":[36,87],"initiated":[37,88],"were":[39,44,98],"identified.":[40],"Changes":[41],"PROs":[43,168],"assessed":[45],"1":[46,169],"year":[47,117,170],"after":[48,118,171],"initiation.":[50],"PRO":[51,91],"measures":[52,94],"included":[53],"Clinical":[54],"Disease":[55],"Activity":[56],"Index":[57],"(CDAI);":[58],"patient":[59,133],"global":[60],"disease":[61,104,114],"activity,":[62],"pain":[63],"fatigue":[65],"(visual":[66],"analog":[67],"score;":[68],"0-100);":[69],"morning":[70],"stiffness":[71,141],"(hours);":[72],"modified":[73],"Health":[74],"Assessment":[75],"Questionnaire":[76],"(mHAQ;":[77],"0-3);":[78],"EuroQoL":[80],"EQ-5D.":[81],"Of":[82],"667":[84],"rituximab,":[89],"baseline":[90],"clinical":[93],"indicated":[95],"that":[96,159],"substantially":[99],"impacted":[100],"by":[101],"their":[102],"RA":[103,164],"quality":[106],"life;":[108],"54%":[109],"had":[112],"high":[113],"activity.":[115],"One":[116],"initiation,":[120],"49.0,":[121],"47.1,":[122],"49.8,":[123],"23.2%":[125],"reported":[128],"clinically":[129],"meaningful":[130],"improvements":[131,166],"global,":[134],"pain,":[135],"fatigue,":[136],"mHAQ,":[138],"respectively.":[139,153],"Morning":[140],"EuroQol":[143],"EQ-5D":[144],"domains":[145],"improved":[146],"48":[148],"19-32%":[150],"patients,":[152],"These":[154],"real-world":[155],"registry":[156],"data":[157],"demonstrated":[158],"long-standing,":[162],"refractory":[163],"experienced":[165],"initiating":[172],"rituximab.":[173]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-07-21T00:00:00"}