{"id":"https://openalex.org/W2734845306","doi":null,"title":"Developing Photo-responsive Metal-Organic Frameworks towards Controlled Drug Delivery","display_name":"Developing Photo-responsive Metal-Organic Frameworks towards Controlled Drug Delivery","publication_year":2017,"publication_date":"2017-07-14","ids":{"openalex":"https://openalex.org/W2734845306","mag":"2734845306"},"language":"en","primary_location":{"id":"pmh:oai:vtechworks.lib.vt.edu:10919/78346","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10919/78346","pdf_url":"https://vtechworks.lib.vt.edu/bitstreams/e188a121-e2f6-41be-9596-72094dba07ed/download","source":{"id":"https://openalex.org/S4306400248","display_name":"VTechWorks (Virginia Tech)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I859038795","host_organization_name":"Virginia Tech","host_organization_lineage":["https://openalex.org/I859038795"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://vtechworks.lib.vt.edu/bitstreams/e188a121-e2f6-41be-9596-72094dba07ed/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008427848","display_name":"Charity C. Epley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Charity C. Epley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5008427848"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10096","display_name":"Metal-Organic Frameworks: Synthesis and Applications","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10096","display_name":"Metal-Organic Frameworks: Synthesis and Applications","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metal-organic-frameworks","display_name":"metal-organic frameworks","score":0.9750000238418579},{"id":"https://openalex.org/keywords/light-triggered-drug-release","display_name":"light-triggered drug release","score":0.8080000281333923},{"id":"https://openalex.org/keywords/zirconium-based-mofs","display_name":"zirconium MOF","score":0.7639999985694885},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.8640000224113464},{"id":"https://openalex.org/keywords/cancer-nanocarriers","display_name":"cancer nanocarriers","score":0.7680000066757202},{"id":"https://openalex.org/keywords/breast-cancer-cells","display_name":"breast cancer cells","score":0.7710000276565552},{"id":"https://openalex.org/keywords/mri-contrast-agents","display_name":"MRI contrast agents","score":0.875},{"id":"https://openalex.org/keywords/manganese-mof","display_name":"manganese MOF","score":0.7080000042915344},{"id":"https://openalex.org/keywords/gadolinium-toxicity","display_name":"gadolinium toxicity","score":0.8220000267028809},{"id":"https://openalex.org/keywords/photothermal-therapy","display_name":"photothermal therapy","score":0.39100000262260437},{"id":"https://openalex.org/keywords/photothermal-ablation","display_name":"photothermal ablation","score":0.4490000009536743}],"concepts":[{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.6328679919242859},{"id":"https://openalex.org/C179366358","wikidata":"https://www.wikidata.org/wiki/Q909212","display_name":"Metal-organic framework","level":3,"score":0.45820876955986023},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.39886027574539185},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.39650899171829224},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.34508007764816284},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.29085299372673035},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2890651226043701},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.25287920236587524},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.09568607807159424},{"id":"https://openalex.org/C150394285","wikidata":"https://www.wikidata.org/wiki/Q180254","display_name":"Adsorption","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:vtechworks.lib.vt.edu:10919/78346","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10919/78346","pdf_url":"https://vtechworks.lib.vt.edu/bitstreams/e188a121-e2f6-41be-9596-72094dba07ed/download","source":{"id":"https://openalex.org/S4306400248","display_name":"VTechWorks (Virginia Tech)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I859038795","host_organization_name":"Virginia Tech","host_organization_lineage":["https://openalex.org/I859038795"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"mag:2734845306","doi":null,"is_oa":false,"landing_page_url":"https://vtechworks.lib.vt.edu/handle/10919/78346","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:vtechworks.lib.vt.edu:10919/78346","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10919/78346","pdf_url":"https://vtechworks.lib.vt.edu/bitstreams/e188a121-e2f6-41be-9596-72094dba07ed/download","source":{"id":"https://openalex.org/S4306400248","display_name":"VTechWorks (Virginia Tech)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I859038795","host_organization_name":"Virginia Tech","host_organization_lineage":["https://openalex.org/I859038795"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320333655","display_name":"Institute for Critical Technology and Applied Science","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2734845306.pdf","grobid_xml":"https://content.openalex.org/works/W2734845306.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W1533474754","https://openalex.org/W1964991943","https://openalex.org/W1966745120","https://openalex.org/W1967551950","https://openalex.org/W1968095762","https://openalex.org/W1975746685","https://openalex.org/W1976062460","https://openalex.org/W1982974605","https://openalex.org/W1984943802","https://openalex.org/W1986518135","https://openalex.org/W1988257941","https://openalex.org/W1995465669","https://openalex.org/W1996234823","https://openalex.org/W1996998905","https://openalex.org/W1998280182","https://openalex.org/W1998358059","https://openalex.org/W2002449355","https://openalex.org/W2002516695","https://openalex.org/W2013470095","https://openalex.org/W2018307798","https://openalex.org/W2018478612","https://openalex.org/W2020237905","https://openalex.org/W2029351008","https://openalex.org/W2029432014","https://openalex.org/W2029749273","https://openalex.org/W2037191338","https://openalex.org/W2044422343","https://openalex.org/W2050901558","https://openalex.org/W2052087590","https://openalex.org/W2057610600","https://openalex.org/W2059513213","https://openalex.org/W2060381305","https://openalex.org/W2061948232","https://openalex.org/W2062804521","https://openalex.org/W2063994814","https://openalex.org/W2066991705","https://openalex.org/W2069537362","https://openalex.org/W2070609818","https://openalex.org/W2078107514","https://openalex.org/W2082587127","https://openalex.org/W2082902103","https://openalex.org/W2086587366","https://openalex.org/W2096676732","https://openalex.org/W2096964444","https://openalex.org/W2099360420","https://openalex.org/W2107991409","https://openalex.org/W2115060917","https://openalex.org/W2116927089","https://openalex.org/W2120007914","https://openalex.org/W2124640343","https://openalex.org/W2128319320","https://openalex.org/W2130360607","https://openalex.org/W2131762032","https://openalex.org/W2139702993","https://openalex.org/W2140313942","https://openalex.org/W2144843667","https://openalex.org/W2148895371","https://openalex.org/W2148936002","https://openalex.org/W2160641185","https://openalex.org/W2170811673","https://openalex.org/W2171757680","https://openalex.org/W2314231766","https://openalex.org/W2322174213","https://openalex.org/W2322744662","https://openalex.org/W2325667030","https://openalex.org/W2326596580","https://openalex.org/W2333019810","https://openalex.org/W3023255929"],"related_works":["https://openalex.org/W4324368141","https://openalex.org/W2807536517","https://openalex.org/W7135300813","https://openalex.org/W7221429203","https://openalex.org/W4323923034","https://openalex.org/W4396812350","https://openalex.org/W4385969315","https://openalex.org/W2962550153","https://openalex.org/W7138877772","https://openalex.org/W3198394488"],"abstract_inverted_index":{"The":[0,242],"development":[1,447],"of":[2,14,29,70,86,155,167,179,190,211,279,293,304,335,374,436,448,465,476,510],"therapeutic":[3],"drugs":[4,73,94,354],"or":[5,398],"drug":[6,52,104,126,144,150,288,489],"systems":[7,145],"that":[8,40,74,93,102,139,146,172,193,203,233,258,300,347,371,393,468],"enhance":[9],"a":[10,19,26,137,141,156,163,219,239,284,294,336,342,369,481],"cancer":[11,72,313,321,492,498,512],"patient's":[12,363],"quality":[13],"life":[15],"during":[16],"treatment":[17],"is":[18,91,106,111,245,323,372],"primary":[20],"goal":[21],"for":[22,143,176,445,462,483],"many":[23],"researchers":[24],"across":[25],"wide":[27],"range":[28],"disciplines.":[30],"Many":[31],"investigators":[32],"turn":[33],"to":[34,42,49,54,113,123,199,252,266,318,351,360,385,395,420,442,486,495,506],"nanoparticles":[35,98],"(~50-200":[36],"nm":[37],"in":[38,44,47,57,76,276,301,325,332,412,452,471,491,497,503],"size)":[39],"tend":[41],"accumulate":[43],"tumor":[45],"tissues":[46],"order":[48],"deliver":[50],"active":[51],"compounds":[53,198,392],"specific":[55],"sites":[56],"the":[58,66,87,97,118,125,153,177,209,253,260,277,280,291,302,305,326,333,358,383,405,427,434,446,463,472,508],"body.":[59],"This":[60,455],"targeted":[61],"delivery":[62,490],"approach":[63],"would":[64],"reduce":[65],"total":[67],"body":[68],"effects":[69],"current":[71],"result":[75],"unwanted":[77],"(sometimes":[78],"painful":[79],"and":[80,213,263,355,408,494],"even":[81],"fatal)":[82],"side":[83],"effects.":[84],"One":[85],"main":[88],"obstacles":[89],"however,":[90,328,433],"ensuring":[92],"incorporated":[95],"into":[96],"are":[99,162,184,194,204,391,426],"anchored":[100],"such":[101],"premature":[103],"release":[105,124,151,278,289],"prohibited.":[107],"Also,":[108],"while":[109],"it":[110,128,265],"important":[112],"ensure":[114],"strong":[115],"drug-nanocarrier":[116],"interactions,":[117],"nanocarrier":[119,138,221,307,345],"must":[120],"be":[121,349,443],"able":[122],"when":[127,236],"has":[129,439,458],"reached":[130],"its":[131],"biological":[132],"target.":[133],"We":[134,216,297],"have":[135,217,298],"developed":[136,218,368],"provides":[140],"platform":[142],"could":[147,348],"achieve":[148],"this":[149,272],"via":[152],"use":[154,292],"light":[157,240,295,337],"\"trigger\".":[158],"Metal-Organic":[159],"Frameworks":[160],"(MOFs)":[161],"relatively":[164],"new":[165],"class":[166],"often":[168],"highly":[169],"porous":[170],"materials":[171],"act":[173],"as":[174],"\"sponges\"":[175],"absorption":[178],"various":[180,353],"small":[181],"molecules.":[182],"MOFs":[183],"so":[185],"named":[186],"because":[187],"they":[188,410],"consist":[189],"metal":[191,212,226,384],"clusters":[192,227],"linked":[195],"by":[196,229,381,415],"organic":[197,214,231,254],"form":[200],"networked":[201],"solids":[202],"easily":[205],"tuned":[206],"based":[207,403],"on":[208,286,404],"choice":[210],"\"linker\".":[215],"MOF":[220,261,306,344,501],"incorporating":[222,308],"benign":[223],"zirconium":[224],"(IV)":[225],"bridged":[228],"an":[230,361,400,504],"component":[232],"changes":[234],"shape":[235,256],"illuminated":[237],"with":[238,270,290],"source.":[241,338],"resulting":[243],"material":[244,370,457],"therefore":[246,356,409],"not":[247],"stable":[248],"upon":[249],"irradiation":[250],"due":[251],"linker":[255],"change":[257],"disturbs":[259],"structure":[262],"causes":[264],"degrade.":[267],"When":[268],"loaded":[269],"drugs,":[271],"photo-enhanced":[273],"degradation":[274],"results":[275],"cargo":[281],"thereby,":[282],"providing":[283,375],"handle":[285],"controlling":[287],"trigger.":[296],"demonstrated":[299],"presence":[303,334],"5-fluorouracil":[309],"(a":[310],"clinically":[311],"available":[312],"drug),":[314],"very":[315],"low":[316],"toxicity":[317,435],"human":[319],"breast":[320],"cells":[322],"observed":[324],"dark,":[327],"cell":[329],"death":[330],"occurs":[331],"These":[339,478],"reports":[340,479],"offer":[341,487],"model":[343],"system":[346,359],"used":[350,407,430],"incorporate":[352],"tune":[357],"individual":[362],"needs.":[364],"Furthermore,":[365],"we":[366],"also":[367,459],"capable":[373],"magnetic":[376],"resonance":[377],"imaging":[378],"(MRI)":[379],"contrast":[380,389,431],"changing":[382],"manganese":[386,456],"(II).":[387],"MRI":[388,401],"agents":[390],"serve":[394],"either":[396],"darken":[397],"brighten":[399],"image":[402],"agent":[406],"aid":[411,470,496],"clinical":[413],"diagnosis":[414,475,499],"making":[416],"internal":[417],"abnormalities":[418],"easier":[419],"spot.":[421],"Currently":[422],"gadolinium":[423,437],"(III)":[424,438],"complexes":[425],"most":[428],"widely":[429],"agents;":[432],"been":[440],"shown":[441,460],"responsible":[444],"nephrogenic":[449],"systemic":[450],"fibrosis":[451],"some":[453],"patients.":[454],"useful":[461],"attachment":[464],"fluorescent":[466],"dyes":[467],"can":[469],"benchtop":[473],"optical":[474],"biopsies.":[477],"provide":[480],"basis":[482],"developing":[484],"ways":[485],"controlled":[488],"patients":[493],"using":[500],"materials,":[502],"effort":[505],"reach":[507],"goals":[509],"comfortable":[511],"treatment.":[513]},"counts_by_year":[],"updated_date":"2026-08-19T15:00:24.278416","created_date":"2017-07-21T00:00:00"}