{"id":"https://openalex.org/W2734827181","doi":null,"title":"Cell therapy in brain neurodegenerative movement disorders :a clinical perspective","display_name":"Cell therapy in brain neurodegenerative movement disorders :a clinical perspective","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2734827181","mag":"2734827181"},"language":"en","primary_location":{"id":"pmh:oai:estudogeral.sib.uc.pt:10316/27934","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10316/27934","pdf_url":"http://hdl.handle.net/10316/27934","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"http://purl.org/coar/resource_type/c_bdcc"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10316/27934","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105988293","display_name":"A.C. Ribeiro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"A.C. Ribeiro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5105988293"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.4603999853134155,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.4603999853134155,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.3833000063896179,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.041099999099969864,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.9649999737739563},{"id":"https://openalex.org/keywords/neurodegenerative-movement-disorders","display_name":"neurodegenerative movement disorders","score":0.984000027179718},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9959999918937683},{"id":"https://openalex.org/keywords/huntington-s-disease","display_name":"Huntington's disease","score":1.0},{"id":"https://openalex.org/keywords/cell-replacement-therapy","display_name":"cell replacement therapy","score":0.8930000066757202},{"id":"https://openalex.org/keywords/stem-cell-therapy","display_name":"stem cell therapy","score":0.8880000114440918},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.9710000157356262},{"id":"https://openalex.org/keywords/neural-stem-cells","display_name":"neural stem cells","score":0.8650000095367432},{"id":"https://openalex.org/keywords/embryonic-stem-cells","display_name":"embryonic stem cells","score":0.9829999804496765},{"id":"https://openalex.org/keywords/neuronal-differentiation","display_name":"neuronal differentiation","score":0.7580000162124634},{"id":"https://openalex.org/keywords/growth-factors","display_name":"growth factors","score":0.6710000038146973},{"id":"https://openalex.org/keywords/immune-rejection","display_name":"immune rejection","score":0.5630000233650208},{"id":"https://openalex.org/keywords/tumor-formation","display_name":"tumor formation","score":0.8360000252723694},{"id":"https://openalex.org/keywords/clinical-trials","display_name":"clinical trials","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C12713177","wikidata":"https://www.wikidata.org/wiki/Q1900281","display_name":"Perspective (graphical)","level":2,"score":0.6788972616195679},{"id":"https://openalex.org/C2778261627","wikidata":"https://www.wikidata.org/wiki/Q2608695","display_name":"Movement disorders","level":3,"score":0.4309837222099304},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42886584997177124},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.33302730321884155},{"id":"https://openalex.org/C11171543","wikidata":"https://www.wikidata.org/wiki/Q41630","display_name":"Psychoanalysis","level":1,"score":0.3306436240673065},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.328716903924942},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16743752360343933},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.14149165153503418},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.09912684559822083},{"id":"https://openalex.org/C153349607","wikidata":"https://www.wikidata.org/wiki/Q36649","display_name":"Visual arts","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:estudogeral.sib.uc.pt:10316/27934","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10316/27934","pdf_url":"http://hdl.handle.net/10316/27934","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"http://purl.org/coar/resource_type/c_bdcc"},{"id":"pmh:oai:estudogeral.uc.pt:10316/27934","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10316/27934","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},{"id":"mag:2734827181","doi":null,"is_oa":false,"landing_page_url":"https://estudogeral.sib.uc.pt/handle/10316/27934","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:estudogeral.sib.uc.pt:10316/27934","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10316/27934","pdf_url":"http://hdl.handle.net/10316/27934","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"http://purl.org/coar/resource_type/c_bdcc"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2734827181.pdf","grobid_xml":"https://content.openalex.org/works/W2734827181.grobid-xml"},"referenced_works_count":132,"referenced_works":["https://openalex.org/W39369524","https://openalex.org/W99706537","https://openalex.org/W174854816","https://openalex.org/W199354732","https://openalex.org/W1488674536","https://openalex.org/W1568486516","https://openalex.org/W1643680178","https://openalex.org/W1718365317","https://openalex.org/W1811706139","https://openalex.org/W1866157615","https://openalex.org/W1900535849","https://openalex.org/W1964451213","https://openalex.org/W1965842668","https://openalex.org/W1966476278","https://openalex.org/W1966758700","https://openalex.org/W1967828174","https://openalex.org/W1969483326","https://openalex.org/W1970642341","https://openalex.org/W1972640532","https://openalex.org/W1973502470","https://openalex.org/W1973897139","https://openalex.org/W1974989152","https://openalex.org/W1976475378","https://openalex.org/W1980505651","https://openalex.org/W1981862471","https://openalex.org/W1983274440","https://openalex.org/W1985014683","https://openalex.org/W1990131729","https://openalex.org/W1991208841","https://openalex.org/W1993734312","https://openalex.org/W1993736057","https://openalex.org/W1998196329","https://openalex.org/W2000734457","https://openalex.org/W2001159996","https://openalex.org/W2001452983","https://openalex.org/W2002930046","https://openalex.org/W2004275727","https://openalex.org/W2004506436","https://openalex.org/W2005296007","https://openalex.org/W2005927762","https://openalex.org/W2006528781","https://openalex.org/W2009327298","https://openalex.org/W2013393348","https://openalex.org/W2014525534","https://openalex.org/W2015041659","https://openalex.org/W2018235103","https://openalex.org/W2018585440","https://openalex.org/W2021730559","https://openalex.org/W2032744846","https://openalex.org/W2033284482","https://openalex.org/W2033315224","https://openalex.org/W2034369214","https://openalex.org/W2035191477","https://openalex.org/W2035325688","https://openalex.org/W2036094320","https://openalex.org/W2036748407","https://openalex.org/W2039273348","https://openalex.org/W2039551265","https://openalex.org/W2040118612","https://openalex.org/W2043644408","https://openalex.org/W2045853195","https://openalex.org/W2047010447","https://openalex.org/W2048222565","https://openalex.org/W2050636568","https://openalex.org/W2050647292","https://openalex.org/W2052002403","https://openalex.org/W2052302258","https://openalex.org/W2053911973","https://openalex.org/W2055337057","https://openalex.org/W2062682951","https://openalex.org/W2062849851","https://openalex.org/W2063503250","https://openalex.org/W2063755561","https://openalex.org/W2068227312","https://openalex.org/W2068431865","https://openalex.org/W2069465086","https://openalex.org/W2073377890","https://openalex.org/W2073812826","https://openalex.org/W2079474396","https://openalex.org/W2081235375","https://openalex.org/W2082890051","https://openalex.org/W2083939751","https://openalex.org/W2084334114","https://openalex.org/W2084412384","https://openalex.org/W2084652820","https://openalex.org/W2084883226","https://openalex.org/W2086943348","https://openalex.org/W2087972264","https://openalex.org/W2088827109","https://openalex.org/W2096803705","https://openalex.org/W2099800342","https://openalex.org/W2100479578","https://openalex.org/W2103899142","https://openalex.org/W2104793567","https://openalex.org/W2105688544","https://openalex.org/W2107522917","https://openalex.org/W2108488819","https://openalex.org/W2108724455","https://openalex.org/W2108851964","https://openalex.org/W2109563242","https://openalex.org/W2111191613","https://openalex.org/W2111525324","https://openalex.org/W2112877380","https://openalex.org/W2114410594","https://openalex.org/W2116715929","https://openalex.org/W2120564562","https://openalex.org/W2122191105","https://openalex.org/W2125987139","https://openalex.org/W2126499376","https://openalex.org/W2126851387","https://openalex.org/W2128087515","https://openalex.org/W2135189917","https://openalex.org/W2135907949","https://openalex.org/W2138340289","https://openalex.org/W2138977668","https://openalex.org/W2139661803","https://openalex.org/W2141115444","https://openalex.org/W2142940829","https://openalex.org/W2146267270","https://openalex.org/W2147015050","https://openalex.org/W2148483524","https://openalex.org/W2154069538","https://openalex.org/W2157635332","https://openalex.org/W2157645703","https://openalex.org/W2162811821","https://openalex.org/W2165526364","https://openalex.org/W2165867905","https://openalex.org/W2166496419","https://openalex.org/W2170661153","https://openalex.org/W2334461448","https://openalex.org/W2411162213","https://openalex.org/W3152410314"],"related_works":["https://openalex.org/W2797089497","https://openalex.org/W4313192734","https://openalex.org/W7132200453","https://openalex.org/W7045818380","https://openalex.org/W7097989992","https://openalex.org/W1986709098","https://openalex.org/W7015867777","https://openalex.org/W2806929653","https://openalex.org/W4243463526","https://openalex.org/W2885687031"],"abstract_inverted_index":{"Neurodegenerative":[0],"movement":[1],"disorders":[2],"such":[3],"as":[4],"Parkinson\u00b4s":[5,91],"disease":[6,9],"or":[7,155],"Huntington\u00b4s":[8,93],"share":[10],"the":[11,55,68,84,106,127,153,184],"same":[12],"progressive":[13],"and":[14,25,38,64,92,115,134,196,210,226,229],"relentless":[15],"course":[16],"with":[17,22,54,193,203],"increasing":[18],"motor":[19],"disability":[20],"coupled":[21],"neuropsyquiatric":[23],"impairment":[24],"have":[26,50],"been,":[27],"over":[28],"these":[29],"last":[30],"few":[31],"decades,":[32],"a":[33,144,163],"passionate":[34],"topic":[35],"of":[36,45,57,78,129,212],"experimental":[37],"clinical":[39,74,175,201,236],"research":[40],"due":[41],"to":[42,60,82,89,142,152,161,172],"their":[43,96,99],"lack":[44],"therapeutic":[46],"options.":[47],"Restorative":[48],"therapies":[49,87],"brought":[51],"both":[52,90],"enthusiasm":[53],"prospect":[56],"its":[58],"potential":[59,192],"restore":[61],"brain":[62],"damage":[63],"also":[65],"disbelief":[66],"for":[67,218],"less":[69],"than":[70],"compelling":[71],"results":[72],"from":[73,102],"trials.":[75],"The":[76,215],"aim":[77],"this":[79],"review":[80],"is":[81,177],"discuss":[83],"cell":[85,120,130,186,220],"replacement":[86],"applied":[88],"diseases":[94],"since":[95],"beginning,":[97],"following":[98],"natural":[100],"sequence":[101],"animal":[103],"studies":[104],"into":[105],"early":[107],"human":[108],"trials,":[109],"addressing":[110],"fetal":[111],"neural":[112,133],"tissue":[113],"transplantation":[114],"other":[116],"more":[117],"recent":[118],"prominent":[119],"sources.":[121],"Nowadays,":[122],"stem":[123,137,185,219],"cells":[124,138,158],"became":[125],"at":[126],"forefront":[128],"therapy.":[131],"Embryonic,":[132],"induced":[135],"pluripotent":[136],"were":[139],"successfully":[140],"able":[141],"generate":[143],"desired":[145],"neuron":[146],"phenotype":[147],"and/or":[148],"provide":[149],"growth":[150],"factors":[151],"vulnerable":[154],"degenerating":[156],"host":[157],"allowing":[159],"researchers":[160],"enter":[162],"new":[164],"pre-clinical":[165,230],"era.":[166],"There":[167],"are":[168,222],"still":[169],"many":[170],"barriers":[171],"overcome":[173],"before":[174,235],"application":[176,237],"possible,":[178],"it":[179],"must":[180,232],"be":[181,233],"assured":[182],"that":[183],"source":[187],"has":[188],"an":[189],"optimal":[190],"differentiation":[191],"full":[194],"integration":[195],"functional":[197],"enhancement,":[198],"bears":[199],"measurable":[200],"benefits":[202],"minimum":[204],"impact":[205],"on":[206],"hosts":[207],"immune":[208],"system":[209],"absence":[211],"tumor":[213],"formation.":[214],"future":[216],"prospects":[217],"therapy":[221],"overwhelming":[223],"but":[224],"steady":[225],"solid":[227],"basic":[228],"progresses":[231],"held":[234],"becomes":[238],"eligible.":[239]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2017-07-21T00:00:00"}
