{"id":"https://openalex.org/W2734673299","doi":"https://doi.org/10.1016/j.cellsig.2017.07.006","title":"Impact of paroxetine on proximal \u03b2-adrenergic receptor signaling","display_name":"Impact of paroxetine on proximal \u03b2-adrenergic receptor signaling","publication_year":2017,"publication_date":"2017-07-12","ids":{"openalex":"https://openalex.org/W2734673299","doi":"https://doi.org/10.1016/j.cellsig.2017.07.006","mag":"2734673299","pmid":"https://pubmed.ncbi.nlm.nih.gov/28711716","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5646168"},"language":"en","primary_location":{"id":"doi:10.1016/j.cellsig.2017.07.006","doi":"https://doi.org/10.1016/j.cellsig.2017.07.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cellsig.2017.07.006","pdf_url":null,"source":{"id":"https://openalex.org/S113768434","display_name":"Cellular Signalling","issn_l":"0898-6568","issn":["0898-6568","1873-3913"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Signalling","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC5646168","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103068414","display_name":"Shuchi Guo","orcid":"https://orcid.org/0000-0002-8319-7122","observed_orcids":["https://orcid.org/0000-0002-8319-7122"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shuchi Guo","raw_affiliation_strings":["Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041675291","display_name":"Rhonda L. Carter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rhonda L. Carter","raw_affiliation_strings":["Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056007957","display_name":"Laurel A. Grisanti","orcid":"https://orcid.org/0000-0001-9780-1784","observed_orcids":["https://orcid.org/0000-0001-9780-1784"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laurel A. Grisanti","raw_affiliation_strings":["Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075648082","display_name":"Walter J. Koch","orcid":"https://orcid.org/0000-0002-8522-530X","observed_orcids":["https://orcid.org/0000-0002-8522-530X","https://orcid.org/0000-0002-0609-8649"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Walter J. Koch","raw_affiliation_strings":["Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066173797","display_name":"Douglas G. Tilley","orcid":"https://orcid.org/0000-0002-9681-3377","observed_orcids":["https://orcid.org/0000-0002-9681-3377"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Douglas G. Tilley","raw_affiliation_strings":["Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA. Electronic address: douglas.tilley@temple.edu","Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA. Electronic address: douglas.tilley@temple.edu","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I84392919"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5066173797"],"corresponding_institution_ids":["https://openalex.org/I84392919"],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":1.5239,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.81978695,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"38","issue":null,"first_page":"127","last_page":"133"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paroxetine","display_name":"paroxetine","score":1.0},{"id":"https://openalex.org/keywords/beta-adrenergic-receptors","display_name":"beta-adrenergic receptors","score":0.9039999842643738},{"id":"https://openalex.org/keywords/grk2-inhibition","display_name":"GRK2 inhibition","score":0.8379999995231628},{"id":"https://openalex.org/keywords/receptor-desensitization","display_name":"receptor desensitization","score":0.9700000286102295},{"id":"https://openalex.org/keywords/beta-arrestin-2-recruitment","display_name":"\u03b2-arrestin2 recruitment","score":0.8859999775886536},{"id":"https://openalex.org/keywords/receptor-internalization","display_name":"receptor internalization","score":0.9950000047683716},{"id":"https://openalex.org/keywords/selective-serotonin-reuptake-inhibitors","display_name":"selective serotonin reuptake inhibitors","score":0.8140000104904175},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.7149999737739563},{"id":"https://openalex.org/keywords/myocardial-contractility","display_name":"cardiac contractility","score":0.7049999833106995},{"id":"https://openalex.org/keywords/g-protein-coupled-receptor-signaling","display_name":"G protein-coupled receptor signaling","score":0.8529999852180481}],"concepts":[{"id":"https://openalex.org/C2777828372","wikidata":"https://www.wikidata.org/wiki/Q408471","display_name":"Paroxetine","level":4,"score":0.7596233487129211},{"id":"https://openalex.org/C78976303","wikidata":"https://www.wikidata.org/wiki/Q14907967","display_name":"Beta adrenergic receptor kinase","level":4,"score":0.750198483467102},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.6531195640563965},{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.5893672108650208},{"id":"https://openalex.org/C33235085","wikidata":"https://www.wikidata.org/wiki/Q4355943","display_name":"G protein-coupled receptor kinase","level":4,"score":0.5534067749977112},{"id":"https://openalex.org/C2779779143","wikidata":"https://www.wikidata.org/wiki/Q3493547","display_name":"Desensitization (medicine)","level":3,"score":0.5204770565032959},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5042978525161743},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4919319152832031},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.45589637756347656},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45183098316192627},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4107094407081604},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.404996395111084},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38590723276138306},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33216971158981323},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.28292253613471985},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27684783935546875}],"mesh":[{"descriptor_ui":"D000071560","descriptor_name":"beta-Arrestin 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000318","descriptor_name":"Adrenergic beta-Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011943","descriptor_name":"Receptors, Adrenergic, beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017374","descriptor_name":"Paroxetine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.cellsig.2017.07.006","doi":"https://doi.org/10.1016/j.cellsig.2017.07.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cellsig.2017.07.006","pdf_url":null,"source":{"id":"https://openalex.org/S113768434","display_name":"Cellular Signalling","issn_l":"0898-6568","issn":["0898-6568","1873-3913"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Signalling","raw_type":"journal-article"},{"id":"pmid:28711716","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28711716","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular signalling","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5108326","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5646168","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5646168","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5646168","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cell Signal","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5108326","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5646168","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.779699981212616,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2304097895","display_name":"Novel Mechanisms of Cardiac Injury and Repair","funder_award_id":"P01HL091799","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2944223717","display_name":"Targeting GRK2 in the Heart","funder_award_id":"R01HL061690","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5704933474","display_name":"b1AR-mediated EGFR transactivation in the heart","funder_award_id":"R01HL105414","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5716696222","display_name":"Targeting GRK2 (BARK1) in Heart Failure","funder_award_id":"R37HL061690","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1906216417","https://openalex.org/W1985470432","https://openalex.org/W2017096331","https://openalex.org/W2053071903","https://openalex.org/W2060207881","https://openalex.org/W2062655974","https://openalex.org/W2070078751","https://openalex.org/W2070837896","https://openalex.org/W2086617442","https://openalex.org/W2125102696","https://openalex.org/W2137595253","https://openalex.org/W2139918394","https://openalex.org/W2145335113","https://openalex.org/W2155007822","https://openalex.org/W2158723512","https://openalex.org/W2163371429","https://openalex.org/W2166137616","https://openalex.org/W2335583226","https://openalex.org/W2468709186","https://openalex.org/W2472492028","https://openalex.org/W2527600172","https://openalex.org/W2566243011","https://openalex.org/W2577306510","https://openalex.org/W2588171450","https://openalex.org/W2599080348","https://openalex.org/W2602317535","https://openalex.org/W4245103782","https://openalex.org/W6683423354"],"related_works":["https://openalex.org/W2017096331","https://openalex.org/W2602317535","https://openalex.org/W1929973281","https://openalex.org/W2589304322","https://openalex.org/W4251416602","https://openalex.org/W3007873705","https://openalex.org/W2162008803","https://openalex.org/W2155432244","https://openalex.org/W2625014830","https://openalex.org/W2057166044"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-07-21T00:00:00"}