{"id":"https://openalex.org/W2734582467","doi":null,"title":"In Silico Analysis of the Structural and Biochemical Features of the Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF), Interleukin-3 (IL-3) and Interleukin-5 (IL-5) Receptors Subunit \u03b1","display_name":"In Silico Analysis of the Structural and Biochemical Features of the Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF), Interleukin-3 (IL-3) and Interleukin-5 (IL-5) Receptors Subunit \u03b1","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2734582467","mag":"2734582467"},"language":"en","primary_location":{"id":"mag:2734582467","doi":null,"is_oa":false,"landing_page_url":"http://www.sapub.org/global/showpaperpdf.aspx?doi=10.5923/j.bioinformatics.20170701.03","pdf_url":null,"source":{"id":"https://openalex.org/S4210224639","display_name":"American Journal of Bioinformatics Research","issn_l":"2167-6976","issn":["2167-6976","2167-6992"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"American Journal of Bioinformatics Research","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062821383","display_name":"Elham I. M. Ibrahim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elham I. M. Ibrahim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031010801","display_name":"Rihab A. Omer","orcid":"https://orcid.org/0000-0002-2284-9748","observed_orcids":["https://orcid.org/0000-0002-2284-9748"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rihab A. Omer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2284-9748","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046638439","display_name":"Ahmed H. Elsadig","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ahmed H. Elsadig","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067428794","display_name":"Mohamed Sir Elkhatim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohamed Sir Elkhatim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108118168","display_name":"Sofia B. Mohamed","orcid":"https://orcid.org/0000-0001-6718-3540","observed_orcids":["https://orcid.org/0000-0001-6718-3540"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sofia B. Mohamed","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.06831934,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"1","first_page":"25","last_page":"47"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.6869999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.6869999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.13930000364780426,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.057100001722574234,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gm-csf-receptor-alpha","display_name":"GM-CSF receptor alpha","score":0.8529999852180481},{"id":"https://openalex.org/keywords/cd123","display_name":"CD123","score":0.9570000171661377},{"id":"https://openalex.org/keywords/il-5-receptor-alpha","display_name":"IL-5 receptor alpha","score":1.0},{"id":"https://openalex.org/keywords/cytokine-receptors","display_name":"cytokine receptors","score":0.7429999709129333},{"id":"https://openalex.org/keywords/fibronectin-type-iii-domain","display_name":"fibronectin type III domain","score":0.8550000190734863},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.45399999618530273},{"id":"https://openalex.org/keywords/phosphorylation-sites","display_name":"phosphorylation sites","score":0.8429999947547913},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.8180000185966492},{"id":"https://openalex.org/keywords/sumoylation","display_name":"SUMOylation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/protein-ligand-interactions","display_name":"protein-ligand interactions","score":0.7789999842643738},{"id":"https://openalex.org/keywords/transmembrane-domain","display_name":"transmembrane domain","score":0.5600000023841858},{"id":"https://openalex.org/keywords/protein-structure-prediction","display_name":"protein structure prediction","score":0.5070000290870667},{"id":"https://openalex.org/keywords/physicochemical-properties","display_name":"physicochemical properties","score":0.6539999842643738},{"id":"https://openalex.org/keywords/hematopoietic-growth-factors","display_name":"hematopoietic growth factors","score":0.6610000133514404},{"id":"https://openalex.org/keywords/drug-target-identification","display_name":"drug target identification","score":0.5149999856948853},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.32899999618530273}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.7537977695465088},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6173022389411926},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47406381368637085},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.46065306663513184},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.4529378414154053},{"id":"https://openalex.org/C171350616","wikidata":"https://www.wikidata.org/wiki/Q61506","display_name":"SUMO protein","level":4,"score":0.4402419924736023},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.39924997091293335},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.350525826215744},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32157236337661743},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31741076707839966},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1853070855140686},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.16838330030441284}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2734582467","doi":null,"is_oa":false,"landing_page_url":"http://www.sapub.org/global/showpaperpdf.aspx?doi=10.5923/j.bioinformatics.20170701.03","pdf_url":null,"source":{"id":"https://openalex.org/S4210224639","display_name":"American Journal of Bioinformatics Research","issn_l":"2167-6976","issn":["2167-6976","2167-6992"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"American Journal of Bioinformatics Research","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2335523652","https://openalex.org/W1983129976","https://openalex.org/W2806807923","https://openalex.org/W2035002043","https://openalex.org/W2944248454","https://openalex.org/W2165341915","https://openalex.org/W17068450","https://openalex.org/W7208496542","https://openalex.org/W2489139209","https://openalex.org/W3123115535"],"abstract_inverted_index":{"Computational":[0],"analysis":[1,48,113,376],"has":[2],"become":[3],"an":[4],"indispensable":[5],"bioinformatics":[6,85],"approaches":[7],"for":[8,34,41,52,74,193,231,390,401],"the":[9,14,35,58,64,68,81,91,96,103,120,124,142,152,185,190,208,221,232,235,245,267,285,289,358,362,392],"characterization":[10,105,122],"of":[11,18,27,38,67,95,123,211,234,366,372,377,394],"proteins":[12,76,176,200,212,255,367],"regarding":[13],"physicochemical":[15],"properties,":[16],"prediction":[17,140,351],"signal":[19],"peptides":[20,192],"and":[21,55,71,93,99,127,133,141,151,155,162,174,187,198,247,260,298,312,328,330,336,342,344,380,387,397,405],"3D":[22,209],"structure.":[23],"Additionally,":[24],"computational":[25,47,79],"studies":[26],"protein\u2013ligand":[28],"interactions":[29,157],"provide":[30,388],"a":[31,229,370,384],"rational":[32],"basis":[33,66],"speedy":[36],"identification":[37],"novel":[39,399],"leads":[40],"drug.":[42],"To":[43],"date":[44],"no":[45],"any":[46],"evaluating":[49],"such":[50],"parameters":[51],"GM-CSF-R\u03b1,":[53,97,172,196,306,378],"IL-3-R\u03b1":[54,311,335,379],"IL-5-R\u03b1.":[56,316],"Hence,":[57],"present":[59,82],"work":[60],"aimed":[61],"at":[62],"identifying":[63],"theoretical":[65],"physicochemical,":[69],"structural":[70],"functional":[72,121],"proprieties":[73],"these":[75,280,395],"using":[77,130,184,225],"online":[78,205],"tools.In":[80],"study,":[83],"different":[84],"tools":[86],"were":[87,147,158,181,201,223,322],"used":[88],"to":[89,288],"characterize":[90],"properties":[92],"structure":[94,139,210,350,365],"IL3R\u03b1,":[98],"IL5R\u03b1":[100,248],"proteins.":[101,253,281],"Firstly,":[102],"Physico-chemical":[104],"was":[106,114,213,277],"computed":[107],"by":[108,119,149,160,183,203,215],"ExPasy\u2019s":[109],"(ProtParam).":[110],"Then":[111],"Fingerprinting":[112],"done":[115],"with":[116,264,324,338],"ScanProsite.":[117],"Followed":[118],"transmembrane":[125],"regions":[126],"phosphorylation":[128],"sites":[129,321,333],"SOSUI":[131],"server":[132,135],"NetPhos":[134],"respectively.":[136,348],"Afterwards,":[137],"secondary":[138],"protein-ligand":[143],"binding":[144,320,332],"site":[145],"residues":[146,170],"predicted":[148,191],"PDBSUM,":[150],"detected":[153,182,202,278,284,302,323],"ligands":[154,326],"their":[156],"visualized":[159],"LIGPLOT":[161],"Protein":[163],"ligand":[164,346],"interaction":[165],"profiler":[166],"(PILP)":[167],"softwares.":[168],"The":[169],"in":[171,195,262,305,310,315,334,369],"IL-3R\u03b1":[173,197],"IL-5R\u03b1":[175,199],"that":[177,240,353],"may":[178],"undergo":[179],"ubiquitination":[180],"UbPred":[186],"BDM-PUB":[188],"programs,":[189],"sumoylation":[194],"GPS-SUMO":[204],"service.":[206],"Finally,":[207],"built":[214],"Chimera":[216],"1.8":[217],"program.":[218],"In":[219,317],"addition,":[220],"models":[222],"surveyed":[224],"ERRAT":[226],"server;":[227],"as":[228,251],"confirmation":[230],"quality":[233,371],"models.":[236],"Our":[237],"results":[238],"revealed":[239],"GM-CSF-R\u03b1":[241,318],"is":[242],"stable":[243],"whereas":[244],"IL3R\u03b1":[246],"are":[249,256],"classified":[250],"unstable":[252],"All":[254],"membrane":[257],"proteins,":[258,396],"acidic":[259],"hydrophilic":[261],"nature,":[263],"serine":[265],"being":[266],"most":[268],"phosphorylated":[269],"amino":[270],"acid.":[271],"Interestingly,":[272],"fibronectin":[273],"type-III":[274],"(FN3)":[275],"domain":[276],"among":[279],"Also,":[282],"we":[283,301],"sequences":[286],"belonging":[287],"following":[290],"families:":[291],"HEMATOPO_REC_S_F2,":[292],"ASN_GLYCOSYLATION,":[293],"CK2_PHOSPHO_SITE,":[294],"PKC_PHOSPHO_SITE,":[295],"MYRISTYL,":[296],"CAMP_PHOSPHO_SITE,":[297],"TYR_PHOSPHO.":[299],"Moreover,":[300],"9":[303],"kinases":[304,309,314],"while":[307],"13":[308],"15":[313],"3":[319,363],"two":[325],"(GOL":[327],"NAG),":[329],"5":[331],"IL-5-R\u03b1":[337,381],"3ligands":[339],"(NAG,":[340],"FUL":[341],"BMA)":[343],"one":[345],"(BGC)":[347],"Secondary":[349],"showed":[352],"Beta":[354],"sheet":[355],"dominated":[356],"all":[357],"other":[359],"conformations.":[360],"Modeling":[361],"D":[364],"resulted":[368],"less":[373],"than":[374],"90%.computational":[375],"will":[382],"give":[383],"deep":[385],"insight":[386],"opportunities":[389],"understanding":[391],"function":[393],"developing":[398],"therapeutics":[400],"treating":[402],"certain":[403],"leukemia":[404],"inflammatory":[406],"diseases.":[407]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2017-07-21T00:00:00"}
