{"id":"https://openalex.org/W2734415599","doi":"https://doi.org/10.1016/j.trsl.2017.07.002","title":"New approaches for the enhancement of chimeric antigen receptors for the treatment of HIV","display_name":"New approaches for the enhancement of chimeric antigen receptors for the treatment of HIV","publication_year":2017,"publication_date":"2017-07-15","ids":{"openalex":"https://openalex.org/W2734415599","doi":"https://doi.org/10.1016/j.trsl.2017.07.002","mag":"2734415599","pmid":"https://pubmed.ncbi.nlm.nih.gov/28755872"},"language":"en","primary_location":{"id":"doi:10.1016/j.trsl.2017.07.002","doi":"https://doi.org/10.1016/j.trsl.2017.07.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.trsl.2017.07.002","pdf_url":null,"source":{"id":"https://openalex.org/S122935314","display_name":"Translational research","issn_l":"1878-1810","issn":["1878-1810","1931-5244"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Research","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076613467","display_name":"Mayra A. Carrillo","orcid":"https://orcid.org/0000-0003-3430-1226","observed_orcids":["https://orcid.org/0000-0003-3430-1226"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mayra A. Carrillo","raw_affiliation_strings":["Division of Hematology & Oncology, Department of Medicine, UCLA AIDS Institute, David Geffen School of Medicine University of California, Los Angeles, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology & Oncology, Department of Medicine, UCLA AIDS Institute, David Geffen School of Medicine University of California, Los Angeles, Calif","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084141775","display_name":"Anjie Zhen","orcid":"https://orcid.org/0000-0001-6139-7820","observed_orcids":["https://orcid.org/0000-0001-6139-7820"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anjie Zhen","raw_affiliation_strings":["Division of Hematology & Oncology, Department of Medicine, UCLA AIDS Institute, David Geffen School of Medicine University of California, Los Angeles, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology & Oncology, Department of Medicine, UCLA AIDS Institute, David Geffen School of Medicine University of California, Los Angeles, Calif","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072471885","display_name":"Jerome A. Zack","orcid":"https://orcid.org/0000-0001-5486-8495","observed_orcids":["https://orcid.org/0000-0001-5486-8495"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerome A. Zack","raw_affiliation_strings":["Division of Hematology & Oncology, Department of Medicine, UCLA AIDS Institute, David Geffen School of Medicine University of California, Los Angeles, Calif; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Calif","Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Calif","Division of Hematology & Oncology, Department of Medicine, UCLA AIDS Institute, David Geffen School of Medicine University of California, Los Angeles, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology & Oncology, Department of Medicine, UCLA AIDS Institute, David Geffen School of Medicine University of California, Los Angeles, Calif; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Calif","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Calif","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Division of Hematology & Oncology, Department of Medicine, UCLA AIDS Institute, David Geffen School of Medicine University of California, Los Angeles, Calif","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067454357","display_name":"Scott G. Kitchen","orcid":"https://orcid.org/0000-0001-6182-6082","observed_orcids":["https://orcid.org/0000-0001-6182-6082"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Scott G. Kitchen","raw_affiliation_strings":["Division of Hematology & Oncology, Department of Medicine, UCLA AIDS Institute, David Geffen School of Medicine University of California, Los Angeles, Calif. Electronic address: skitchen@ucla.edu","Division of Hematology & Oncology, Department of Medicine, UCLA AIDS Institute, David Geffen School of Medicine University of California, Los Angeles, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology & Oncology, Department of Medicine, UCLA AIDS Institute, David Geffen School of Medicine University of California, Los Angeles, Calif. Electronic address: skitchen@ucla.edu","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Division of Hematology & Oncology, Department of Medicine, UCLA AIDS Institute, David Geffen School of Medicine University of California, Los Angeles, Calif","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5067454357"],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":{"value":4690,"currency":"USD","value_usd":4690},"apc_paid":null,"fwci":0.2292,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.2821933,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"187","issue":null,"first_page":"83","last_page":"92"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.8511000275611877,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.8511000275611877,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.13120000064373016,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chimeric-antigen-receptor","display_name":"chimeric antigen receptor","score":0.8460000157356262},{"id":"https://openalex.org/keywords/hiv-infection","display_name":"HIV infection","score":0.8489999771118164},{"id":"https://openalex.org/keywords/car-t-cell-therapy","display_name":"CAR T-cell therapy","score":0.9399999976158142},{"id":"https://openalex.org/keywords/functional-cure","display_name":"functional cure","score":0.6759999990463257},{"id":"https://openalex.org/keywords/hiv-specific-cytotoxic-t-lymphocytes","display_name":"HIV-specific cytotoxic T lymphocytes","score":0.8610000014305115},{"id":"https://openalex.org/keywords/antiviral-efficacy","display_name":"antiviral efficacy","score":0.8119999766349792}],"concepts":[{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.7486931681632996},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.687289834022522},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.593292236328125},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.516546905040741},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4834533631801605},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.47806456685066223},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4332989454269409},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.4111723005771637},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.34017282724380493},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.32753849029541016},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3029899597167969},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12929752469062805}],"mesh":[{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011946","descriptor_name":"Receptors, Antigen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011946","descriptor_name":"Receptors, Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D015704","descriptor_name":"CD4 Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016219","descriptor_name":"Immunotherapy, Adoptive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.trsl.2017.07.002","doi":"https://doi.org/10.1016/j.trsl.2017.07.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.trsl.2017.07.002","pdf_url":null,"source":{"id":"https://openalex.org/S122935314","display_name":"Translational research","issn_l":"1878-1810","issn":["1878-1810","1931-5244"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Research","raw_type":"journal-article"},{"id":"pmid:28755872","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28755872","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational research : the journal of laboratory and clinical medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1747417977","display_name":"Interdisciplinary Training in Virology and Gene Therapy","funder_award_id":"T32AI060567","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4091027626","display_name":"Anti-HIV Gene Therapy: Defend and Attack","funder_award_id":"U19AI117941","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":127,"referenced_works":["https://openalex.org/W26333867","https://openalex.org/W1530935993","https://openalex.org/W1555553634","https://openalex.org/W1555983429","https://openalex.org/W1574443686","https://openalex.org/W1590468645","https://openalex.org/W1598217555","https://openalex.org/W1655739002","https://openalex.org/W1841220820","https://openalex.org/W1878178257","https://openalex.org/W1905863650","https://openalex.org/W1932046647","https://openalex.org/W1953898917","https://openalex.org/W1967517831","https://openalex.org/W1975094254","https://openalex.org/W1977949161","https://openalex.org/W1978436252","https://openalex.org/W1981636515","https://openalex.org/W1982047006","https://openalex.org/W1982795546","https://openalex.org/W1983757979","https://openalex.org/W1985025284","https://openalex.org/W1989762371","https://openalex.org/W1996210947","https://openalex.org/W1999843922","https://openalex.org/W2000906356","https://openalex.org/W2002393791","https://openalex.org/W2008284182","https://openalex.org/W2010607826","https://openalex.org/W2012451048","https://openalex.org/W2017304478","https://openalex.org/W2021227042","https://openalex.org/W2022431494","https://openalex.org/W2026541616","https://openalex.org/W2030648131","https://openalex.org/W2035852466","https://openalex.org/W2037337367","https://openalex.org/W2037343680","https://openalex.org/W2044455803","https://openalex.org/W2048787904","https://openalex.org/W2050076858","https://openalex.org/W2050110588","https://openalex.org/W2064377018","https://openalex.org/W2066547625","https://openalex.org/W2068515633","https://openalex.org/W2073001017","https://openalex.org/W2074350814","https://openalex.org/W2074773259","https://openalex.org/W2075106941","https://openalex.org/W2076991609","https://openalex.org/W2078992149","https://openalex.org/W2079777665","https://openalex.org/W2083431965","https://openalex.org/W2087091972","https://openalex.org/W2087179955","https://openalex.org/W2089367009","https://openalex.org/W2092796940","https://openalex.org/W2094652659","https://openalex.org/W2099106733","https://openalex.org/W2099570622","https://openalex.org/W2102909663","https://openalex.org/W2104958625","https://openalex.org/W2105400883","https://openalex.org/W2106074514","https://openalex.org/W2106083290","https://openalex.org/W2107806760","https://openalex.org/W2108460245","https://openalex.org/W2110260408","https://openalex.org/W2110305039","https://openalex.org/W2111763401","https://openalex.org/W2112072045","https://openalex.org/W2112680373","https://openalex.org/W2114725279","https://openalex.org/W2116615247","https://openalex.org/W2118015571","https://openalex.org/W2118796952","https://openalex.org/W2119866079","https://openalex.org/W2122653395","https://openalex.org/W2124969212","https://openalex.org/W2125881252","https://openalex.org/W2125927970","https://openalex.org/W2130338247","https://openalex.org/W2130768495","https://openalex.org/W2132401721","https://openalex.org/W2133057192","https://openalex.org/W2135135539","https://openalex.org/W2137180811","https://openalex.org/W2138579509","https://openalex.org/W2139257243","https://openalex.org/W2142616877","https://openalex.org/W2143626441","https://openalex.org/W2144882745","https://openalex.org/W2146161844","https://openalex.org/W2148354356","https://openalex.org/W2149608750","https://openalex.org/W2152089409","https://openalex.org/W2153520524","https://openalex.org/W2154705046","https://openalex.org/W2160724571","https://openalex.org/W2163775969","https://openalex.org/W2165580475","https://openalex.org/W2166295153","https://openalex.org/W2167457277","https://openalex.org/W2204861433","https://openalex.org/W2219506342","https://openalex.org/W2225639217","https://openalex.org/W2268141202","https://openalex.org/W2270775403","https://openalex.org/W2342423058","https://openalex.org/W2378737549","https://openalex.org/W2394566891","https://openalex.org/W2408097265","https://openalex.org/W2410601385","https://openalex.org/W2472962727","https://openalex.org/W2473608950","https://openalex.org/W2504729294","https://openalex.org/W2512878063","https://openalex.org/W2515679023","https://openalex.org/W2521810353","https://openalex.org/W2535413030","https://openalex.org/W2538566824","https://openalex.org/W2546886586","https://openalex.org/W2550086728","https://openalex.org/W2551182280","https://openalex.org/W2557039928","https://openalex.org/W2562017637","https://openalex.org/W2576155338"],"related_works":["https://openalex.org/W2562740157","https://openalex.org/W3110594505","https://openalex.org/W2599813933","https://openalex.org/W2762583307","https://openalex.org/W4386028212","https://openalex.org/W1841220820","https://openalex.org/W3151526545","https://openalex.org/W3139128090","https://openalex.org/W3087220664","https://openalex.org/W4388419735"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-07-21T00:00:00"}
