{"id":"https://openalex.org/W2733080155","doi":null,"title":"Role of Reactive Oxygen Species in Mediating the Effect of Oxidized Low Density Lipoprotein on Bone Marrow Stem Cells and Endothelial Progenitor Cells in Hyperlipidemia","display_name":"Role of Reactive Oxygen Species in Mediating the Effect of Oxidized Low Density Lipoprotein on Bone Marrow Stem Cells and Endothelial Progenitor Cells in Hyperlipidemia","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2733080155","mag":"2733080155"},"language":"en","primary_location":{"id":"pmh:oai:etd.ohiolink.edu:osu1397058562","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1397058562","pdf_url":"https://etd.ohiolink.edu/acprod/odb_etd/ws/send_file/send?accession=osu1397058562&disposition=inline","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1397058562","raw_type":"text"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://etd.ohiolink.edu/acprod/odb_etd/ws/send_file/send?accession=osu1397058562&disposition=inline","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017224872","display_name":"Yuqi Cui","orcid":"https://orcid.org/0000-0003-4225-5450","observed_orcids":["https://orcid.org/0000-0003-4225-5450"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yuqi Cui","raw_affiliation_strings":["the Ohio State University"],"raw_orcid":"https://orcid.org/0000-0003-4225-5450","affiliations":[{"raw_affiliation_string":"the Ohio State University","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5017224872"],"corresponding_institution_ids":["https://openalex.org/I52357470"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.33344124,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.46480000019073486,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.46480000019073486,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.23549999296665192,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.17489999532699585,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8429999947547913},{"id":"https://openalex.org/keywords/oxidized-ldl","display_name":"oxidized LDL","score":0.968999981880188},{"id":"https://openalex.org/keywords/bone-marrow-derived-stem-cells","display_name":"bone marrow-derived stem cells","score":0.8980000019073486},{"id":"https://openalex.org/keywords/endothelial-progenitor-cells","display_name":"endothelial progenitor cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hyperlipidemia","display_name":"hyperlipidemia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9300000071525574},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.878000020980835},{"id":"https://openalex.org/keywords/ldl-receptor-knockout-mice","display_name":"LDL receptor knockout mice","score":0.7319999933242798},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.7689999938011169},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.8059999942779541},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.8730000257492065},{"id":"https://openalex.org/keywords/glutathione-peroxidase-1","display_name":"glutathione peroxidase 1","score":0.9190000295639038},{"id":"https://openalex.org/keywords/stem-cell-mobilization","display_name":"stem cell mobilization","score":0.5659999847412109},{"id":"https://openalex.org/keywords/redox-regulation","display_name":"redox regulation","score":0.5270000100135803}],"concepts":[{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.6416195034980774},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.641139566898346},{"id":"https://openalex.org/C2779091943","wikidata":"https://www.wikidata.org/wiki/Q1079120","display_name":"Hyperlipidemia","level":3,"score":0.5337681770324707},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5330209732055664},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5149644017219543},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.5106714367866516},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47096019983291626},{"id":"https://openalex.org/C15729860","wikidata":"https://www.wikidata.org/wiki/Q2329919","display_name":"Progenitor","level":4,"score":0.4492616653442383},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3908608555793762},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35642436146736145},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34964245557785034},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3154420256614685},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2834899425506592},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27160096168518066},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2482653260231018},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.18556609749794006},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:etd.ohiolink.edu:osu1397058562","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1397058562","pdf_url":"https://etd.ohiolink.edu/acprod/odb_etd/ws/send_file/send?accession=osu1397058562&disposition=inline","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1397058562","raw_type":"text"},{"id":"mag:2733080155","doi":null,"is_oa":false,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1397058562","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:etd.ohiolink.edu:osu1397058562","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1397058562","pdf_url":"https://etd.ohiolink.edu/acprod/odb_etd/ws/send_file/send?accession=osu1397058562&disposition=inline","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1397058562","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2733080155.pdf","grobid_xml":"https://content.openalex.org/works/W2733080155.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1968192919","https://openalex.org/W190622473","https://openalex.org/W1439441401","https://openalex.org/W561464924","https://openalex.org/W2308805428","https://openalex.org/W2746411366","https://openalex.org/W2368308723","https://openalex.org/W1974133556","https://openalex.org/W2284053913","https://openalex.org/W861426928"],"abstract_inverted_index":{"Reactive":[0],"oxygen":[1],"species":[2],"(ROS)":[3],"are":[4,549,557],"a":[5,34,59,71,285,529],"group":[6],"of":[7,40,65,74,102,115,151,242,259,267,276,284,287,304,341,353,381,447,485,502,509,535,562],"small":[8],"molecules":[9],"that":[10,91,229,364,556],"regulate":[11],"tissue":[12],"redox":[13],"status":[14],"and":[15,27,29,49,98,105,129,170,207,218,220,245,250,269,295,306,313,317,383,388,407,410,419,442,480,504,512,517,537,564],"oxidative":[16,30],"stress.Redox":[17],"regulation":[18,39],"is":[19],"an":[20],"important":[21,371],"determinant":[22],"for":[23],"cell":[24,316,328,344,391,415,568],"development,":[25],"activities,":[26],"function.ROS":[28],"stress":[31],"also":[32,425,546],"have":[33],"significant":[35,72,203,262],"impact":[36,266],"on":[37,271,308,385,539,566],"the":[38,63,89,100,136,159,212,240,265,302,309,321,324,357,362,373,379,386,411,445,461,483,507,515,533,554,560],"stem":[41,46,103,243,315,510],"cells":[42,47,53,104,244,511],"including":[43],"bone":[44],"marrow":[45],"(BMSCs)":[48],"BM-derived":[50],"endothelial":[51],"progenitor":[52],"(EPCs).Oxidized":[54],"low":[55],"density":[56],"lipoprotein":[57],"(ox-LDL),":[58],"key":[60],"contributor":[61],"to":[62,87,167,253,336,360,460,520,552,571,579],"development":[64],"atherosclerosis":[66],"in":[67,77,135,163,173,186,194,199,205,211,221,247,264,273,311,323,377,398,403,413,431,454,471,477,487,498,514,532,559],"hyperlipidemic":[68,222,408,432,472,488],"state,":[69],"produces":[70],"amount":[73],"ROS":[75,209,277,337,354,366,375,401,526],"spontaneously":[76],"vitro":[78],"at":[79,140],"clinically":[80],"relevant":[81],"concentrations.The":[82],"present":[83],"project":[84],"was":[85,93,121,154,197,395,451,492],"designed":[86],"test":[88],"hypothesis":[90],"ox-LDL":[92,133,153,180,185,195,219,237,268,305,331,348,382,418,469,536,563],"generated":[94,494],"from":[95,495],"native":[96,117,216,496],"LDL":[97,118,144,217,223,478,497],"altered":[99,239],"populations":[101,241,416,508],"EPCs":[106,246,450,486,513],"via":[107],"(at":[108],"least":[109],"partially)":[110],"ROS-mediated":[111],"mechanism.A":[112],"single":[113],"dose":[114],"human":[116,152,288],"(25":[119],"\u03bcg)":[120],"injected":[122],"intravenously":[123],"into":[124],"male":[125],"C57BL/6":[126],"mice":[127,228],"with":[128,182,215,233,236,279,436,438,456,464,474,500],"without":[130],"NAC":[131,234,280,465],"treatment.Human":[132],"levels":[134,470],"blood":[137,187,251,314,326,389,518],"were":[138,202,230,334,351,421,545],"measured":[139],"different":[141],"time":[142],"after":[143,158,190],"injection":[145],"using":[146],"ELISA":[147],"kit.Measurable":[148],"serum":[149,179,468],"level":[150,181],"detected":[155],"30":[156],"min":[157],"injection,":[160],"reached":[161],"peak":[162],"3":[164],"hours,":[165],"started":[166],"decline":[168],"afterwards,":[169],"became":[171],"undetectable":[172],"12":[174],"hours.NAC":[175],"treatment":[176,281,424],"significantly":[177,238,426,452,466,481,505],"reduced":[178,427],"no":[183,396,475],"detectable":[184],"6":[188],"hours":[189],"injection.No":[191],"difference":[192],"iii":[193],"clearance":[196],"observed":[198],"NAC-treated":[200],"animals.There":[201],"increases":[204],"intracellular":[206,365,400,525],"extracellular":[208,293,374],"production":[210,278,376,501],"animals":[213,406],"treated":[214],"receptor":[224],"knockout":[225],"(LDLR":[226],"-/-)":[227],"completely":[231],"prevented":[232],"treatment.Treatment":[235],"both":[248,404],"BM":[249,312,342,387,399,414,516],"similar":[252,519],"chronic":[254,521],"hyperlipidemia":[255,270,307,333,384,420,443,457,538,565],"(with":[256],"4":[257],"months":[258],"HFD),":[260],"although":[261,542],"differences":[263],"stem/progenitors":[272],"vivo":[274,499],"exist.Inhibition":[275],"or":[282,332,349],"expression":[283],"combination":[286],"copper/zinc":[289],"superoxide":[290],"dismutase":[291],"(SOD),":[292],"SOD,":[294],"cellular":[296],"glutathione":[297],"peroxidase":[298],"(Gpx-1)":[299],"partially":[300],"reversed":[301],"effect":[303],"changes":[310,322,346,412],"EPCs.Interestingly,":[318],"almost":[319],"all":[320],"mouse":[325],"stem/progenitor":[327,343,390,540],"population":[329,345],"by":[330,347,417],"related":[335],"production,":[338],"while":[339],"most":[340],"hypherlipedima":[350],"independent":[352],"generation.Of":[355],"note,":[356],"data":[358],"appeared":[359],"support":[361],"concept":[363],"generation":[367,402],"might":[368],"be":[369],"more":[370],"than":[372],"mediating":[378],"effects":[380],"population,":[392],"since":[393],"there":[394],"increase":[397],"ox-LDL-treated":[405],"mice,":[409],"largely":[422],"ROS-independent.NAC":[423],"atherosclerotic":[428],"plaque":[429],"formation":[430,527],"LDLR":[433],"-/-mice.Clinical":[434],"study":[435],"patients":[437,455,473],"coronary":[439],"artery":[440],"disease":[441],"showed":[444],"number":[446,484],"iv":[448],"circulating":[449],"decreased":[453,467],"as":[458],"compared":[459],"healthy":[462],"individual.Treatment":[463],"change":[476],"level,":[479],"increased":[482],"patients.In":[489],"conclusion:":[490],"Ox-LDL":[491],"indeed":[493],"ROS,":[503],"interrupted":[506],"hyperlipidemia.ROS-mediated":[522],"mechanisms":[523,544,555],"especially":[524],"played":[528],"critical":[530],"role":[531],"actions":[534,561],"cells,":[541],"ROS-independent":[543],"important.Further":[547],"studies":[548],"certainly":[550],"needed":[551],"investigate":[553],"involved":[558],"individual":[567],"populations.v":[569],"Dedication":[570],"my":[572,576,580],"family":[573],"I":[574],"dedicate":[575],"dissertation":[577],"work":[578]},"counts_by_year":[],"updated_date":"2026-09-09T07:26:56.047234","created_date":"2017-07-14T00:00:00"}
