{"id":"https://openalex.org/W2732997764","doi":"https://doi.org/10.1093/geroni/igx004.4205","title":"THE EMERGING ANTIMICROBIAL PROTECTION HYPOTHESIS OF ALZHEIMER\u2019S DISEASE","display_name":"THE EMERGING ANTIMICROBIAL PROTECTION HYPOTHESIS OF ALZHEIMER\u2019S DISEASE","publication_year":2017,"publication_date":"2017-06-30","ids":{"openalex":"https://openalex.org/W2732997764","doi":"https://doi.org/10.1093/geroni/igx004.4205","mag":"2732997764"},"language":"en","primary_location":{"id":"doi:10.1093/geroni/igx004.4205","doi":"https://doi.org/10.1093/geroni/igx004.4205","is_oa":true,"landing_page_url":"https://doi.org/10.1093/geroni/igx004.4205","pdf_url":null,"source":{"id":"https://openalex.org/S2735557189","display_name":"Innovation in Aging","issn_l":"2399-5300","issn":["2399-5300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innovation in Aging","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/geroni/igx004.4205","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008848229","display_name":"Robert D. Moir","orcid":"https://orcid.org/0000-0001-5431-3553","observed_orcids":["https://orcid.org/0000-0001-5431-3553"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.D. Moir","raw_affiliation_strings":["Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062580456","display_name":"D. Vijaya Kumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Vijaya Kumar","raw_affiliation_strings":["Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075749836","display_name":"Soon Gang Choi","orcid":"https://orcid.org/0000-0003-0314-3958","observed_orcids":["https://orcid.org/0000-0003-0314-3958"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Choi","raw_affiliation_strings":["Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050004777","display_name":"Rudolph E. Tanzi","orcid":"https://orcid.org/0000-0002-7032-1454","observed_orcids":["https://orcid.org/0000-0002-7032-1454"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.E. Tanzi","raw_affiliation_strings":["Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3977,"currency":"USD","value_usd":3977},"apc_paid":{"value":3977,"currency":"USD","value_usd":3977},"fwci":null,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":"suppl_1","first_page":"1152","last_page":"1152"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9810000061988831},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.9290000200271606},{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":0.8650000095367432},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.621999979019165},{"id":"https://openalex.org/keywords/fungal-infection","display_name":"fungal infection","score":0.4000000059604645},{"id":"https://openalex.org/keywords/bacterial-infection","display_name":"bacterial infection","score":0.9990000128746033},{"id":"https://openalex.org/keywords/viral-infection","display_name":"viral infection","score":0.9700000286102295},{"id":"https://openalex.org/keywords/host-defense-against-pathogens","display_name":"host defense against infection","score":0.6290000081062317},{"id":"https://openalex.org/keywords/metal-ion-binding","display_name":"metal ion binding","score":0.6769999861717224},{"id":"https://openalex.org/keywords/oxygen-free-radicals","display_name":"oxygen free radicals","score":0.6700000166893005},{"id":"https://openalex.org/keywords/carbohydrate-binding","display_name":"carbohydrate binding","score":0.8550000190734863},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.4749999940395355}],"concepts":[{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.7044965624809265},{"id":"https://openalex.org/C540938839","wikidata":"https://www.wikidata.org/wiki/Q1201508","display_name":"Antimicrobial peptides","level":3,"score":0.6764817237854004},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6564008593559265},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.6028900146484375},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5889216661453247},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.5030240416526794},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4799533188343048},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.47888869047164917},{"id":"https://openalex.org/C2776156579","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid beta","level":3,"score":0.45868420600891113},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.44275933504104614},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.36148691177368164},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12790408730506897},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10559967160224915},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1093/geroni/igx004.4205","doi":"https://doi.org/10.1093/geroni/igx004.4205","is_oa":true,"landing_page_url":"https://doi.org/10.1093/geroni/igx004.4205","pdf_url":null,"source":{"id":"https://openalex.org/S2735557189","display_name":"Innovation in Aging","issn_l":"2399-5300","issn":["2399-5300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innovation in Aging","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5209020","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6183144","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6183144","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6183144","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innov Aging","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/geroni/igx004.4205","doi":"https://doi.org/10.1093/geroni/igx004.4205","is_oa":true,"landing_page_url":"https://doi.org/10.1093/geroni/igx004.4205","pdf_url":null,"source":{"id":"https://openalex.org/S2735557189","display_name":"Innovation in Aging","issn_l":"2399-5300","issn":["2399-5300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innovation in Aging","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7167259005","https://openalex.org/W2407359553","https://openalex.org/W2462865208","https://openalex.org/W2108629610","https://openalex.org/W2896921600","https://openalex.org/W2793412161","https://openalex.org/W2557245502","https://openalex.org/W4416038990","https://openalex.org/W7166119751","https://openalex.org/W7095553072"],"abstract_inverted_index":{"A":[0],"considerable":[1],"body":[2],"of":[3,96,105,115,122,134,157],"data":[4,163],"suggests":[5],"the":[6,101,106,110,153,169],"beta-amyloid":[7,118],"peptide":[8,107,129],"(Abeta)":[9],"plays":[10],"a":[11,77,147,186],"key":[12,99],"role":[13,21,79,123],"in":[14,35,46,58,72,82,117],"Alzheimer\u2019s":[15,158],"disease":[16,149],"(AD)":[17],"pathology.":[18],"The":[19,120],"physiological":[20],"for":[22,80,100,124,188],"Abeta":[23,32,97,125,166,190],"has":[24,33,142],"been":[25],"unclear.":[26],"We":[27,42,179],"recently":[28],"showed":[29],"that":[30,50],"synthetic":[31],"potent":[34],"vitro":[36],"antimicrobial":[37,103,128],"activity":[38],"against":[39,53,173],"CNS":[40],"pathogens.":[41,178],"have":[43],"since":[44],"generated":[45],"vivo":[47],"evidence":[48],"showing":[49],"A\u03b2":[51,81,88],"protects":[52],"fungal":[54],"and":[55,64,108,112,131,176,198,204],"bacterial":[56,175],"pathogens":[57],"transgenic":[59],"mouse,":[60],"Drosophila,":[61],"C.":[62],"elegans,":[63],"culture":[65],"cell":[66,194],"infection":[67,93],"models,":[68],"doubling":[69],"host":[70,193],"survival":[71],"some":[73],"cases.":[74],"Consistent":[75],"with":[76,86],"protective":[78,102],"vivo,":[83],"APP-null":[84],"mice":[85],"low":[87],"expression":[89],"also":[90],"show":[91],"attenuated":[92],"resistance.":[94],"Oligomerization":[95],"is":[98],"actions":[104,172],"mediates":[109],"agglutination":[111],"eventual":[113],"entrapment":[114],"microbes":[116],"deposits.":[119],"emergence":[121],"as":[126,138],"an":[127],"(AMP)":[130],"recent":[132],"identification":[133],"innate":[135],"immune":[136,205],"genes":[137],"AD":[139],"risk":[140],"factors":[141],"lead":[143],"us":[144],"to":[145],"propose":[146],"new":[148,183],"model":[150,184],"we":[151,161],"call":[152],"\u201cAntimicrobial":[154],"Protection":[155],"Hypothesis\u201d":[156],"disease.":[159],"Here":[160],"present":[162],"on":[164],"how":[165,181],"activities":[167],"mediate":[168],"peptides":[170],"AMP":[171],"fungal,":[174],"viral":[177],"describe":[180],"our":[182],"provides":[185],"framework":[187],"understanding":[189],"activities,":[191],"including":[192],"cytotoxicity,":[195],"metal":[196],"binding":[197],"oxygen":[199],"radical":[200],"generation,":[201],"carbohydrate":[202],"binding,":[203],"modulatory":[206],"activities.":[207]},"counts_by_year":[{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2017-07-14T00:00:00"}