{"id":"https://openalex.org/W2732964388","doi":"https://doi.org/10.1016/j.micpath.2017.06.046","title":"A preliminary study on the proinflammatory mechanisms of Treponema pallidum outer membrane protein Tp92 in human macrophages and HMEC-1 cells","display_name":"A preliminary study on the proinflammatory mechanisms of Treponema pallidum outer membrane protein Tp92 in human macrophages and HMEC-1 cells","publication_year":2017,"publication_date":"2017-06-29","ids":{"openalex":"https://openalex.org/W2732964388","doi":"https://doi.org/10.1016/j.micpath.2017.06.046","mag":"2732964388","pmid":"https://pubmed.ncbi.nlm.nih.gov/28668606"},"language":"en","primary_location":{"id":"doi:10.1016/j.micpath.2017.06.046","doi":"https://doi.org/10.1016/j.micpath.2017.06.046","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.micpath.2017.06.046","pdf_url":null,"source":{"id":"https://openalex.org/S113190374","display_name":"Microbial Pathogenesis","issn_l":"0882-4010","issn":["0882-4010","1096-1208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial Pathogenesis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101525272","display_name":"Xi Luo","orcid":"https://orcid.org/0000-0002-1426-0132","observed_orcids":["https://orcid.org/0000-0002-1426-0132"]},"institutions":[{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xi Luo","raw_affiliation_strings":["Institute of Pathogenic Biology, Key Laboratory of Special Pathogen Prevention and Control of Hunan Province, University of South China, Hengyang 421001, PR China; Collaborative Innovation Center for New Molecular Drug Research, Hengyang 421001, PR China","Collaborative Innovation Center for New Molecular Drug Research, Hengyang 421001, PR China","Institute of Pathogenic Biology, Key Laboratory of Special Pathogen Prevention and Control of Hunan Province, University of South China, Hengyang 421001, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathogenic Biology, Key Laboratory of Special Pathogen Prevention and Control of Hunan Province, University of South China, Hengyang 421001, PR China; Collaborative Innovation Center for New Molecular Drug Research, Hengyang 421001, PR China","institution_ids":["https://openalex.org/I91935597"]},{"raw_affiliation_string":"Collaborative Innovation Center for New Molecular Drug Research, Hengyang 421001, PR China","institution_ids":[]},{"raw_affiliation_string":"Institute of Pathogenic Biology, Key Laboratory of Special Pathogen Prevention and Control of Hunan Province, University of South China, Hengyang 421001, PR China","institution_ids":["https://openalex.org/I91935597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103042052","display_name":"Xiaohong Zhang","orcid":"https://orcid.org/0000-0003-4435-8357","observed_orcids":["https://orcid.org/0000-0003-4435-8357"]},"institutions":[{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaohong Zhang","raw_affiliation_strings":["Institute of Pathogenic Biology, Key Laboratory of Special Pathogen Prevention and Control of Hunan Province, University of South China, Hengyang 421001, PR China; Department of Histology and Embryology, School of Medicine, University of South China, Hengyang 421001, PR China","Department of Histology and Embryology, School of Medicine, University of South China, Hengyang 421001, PR China","Institute of Pathogenic Biology, Key Laboratory of Special Pathogen Prevention and Control of Hunan Province, University of South China, Hengyang 421001, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathogenic Biology, Key Laboratory of Special Pathogen Prevention and Control of Hunan Province, University of South China, Hengyang 421001, PR China; Department of Histology and Embryology, School of Medicine, University of South China, Hengyang 421001, PR China","institution_ids":["https://openalex.org/I91935597"]},{"raw_affiliation_string":"Department of Histology and Embryology, School of Medicine, University of South China, Hengyang 421001, PR China","institution_ids":["https://openalex.org/I91935597"]},{"raw_affiliation_string":"Institute of Pathogenic Biology, Key Laboratory of Special Pathogen Prevention and Control of Hunan Province, University of South China, Hengyang 421001, PR China","institution_ids":["https://openalex.org/I91935597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102361191","display_name":"Tie Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tie Zhao","raw_affiliation_strings":["Institute of Pathogenic Biology, Key Laboratory of Special Pathogen Prevention and Control of Hunan Province, University of South China, Hengyang 421001, PR China; Collaborative Innovation Center for New Molecular Drug Research, Hengyang 421001, PR China","Collaborative Innovation Center for New Molecular Drug Research, Hengyang 421001, PR China","Institute of Pathogenic Biology, Key Laboratory of Special Pathogen Prevention and Control of Hunan Province, University of South China, Hengyang 421001, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathogenic Biology, Key Laboratory of Special Pathogen Prevention and Control of Hunan Province, University of South China, Hengyang 421001, PR China; Collaborative Innovation Center for New Molecular Drug Research, Hengyang 421001, PR China","institution_ids":["https://openalex.org/I91935597"]},{"raw_affiliation_string":"Collaborative Innovation Center for New Molecular Drug Research, Hengyang 421001, PR China","institution_ids":[]},{"raw_affiliation_string":"Institute of Pathogenic Biology, Key Laboratory of Special Pathogen Prevention and Control of Hunan Province, University of South China, Hengyang 421001, PR China","institution_ids":["https://openalex.org/I91935597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062700742","display_name":"Tiebing Zeng","orcid":"https://orcid.org/0000-0002-4075-1613","observed_orcids":["https://orcid.org/0000-0002-4075-1613"]},"institutions":[{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tiebing Zeng","raw_affiliation_strings":["Institute of Pathogenic Biology, Key Laboratory of Special Pathogen Prevention and Control of Hunan Province, University of South China, Hengyang 421001, PR China; Collaborative Innovation Center for New Molecular Drug Research, Hengyang 421001, PR China","Collaborative Innovation Center for New Molecular Drug Research, Hengyang 421001, PR China","Institute of Pathogenic Biology, Key Laboratory of Special Pathogen Prevention and Control of Hunan Province, University of South China, Hengyang 421001, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathogenic Biology, Key Laboratory of Special Pathogen Prevention and Control of Hunan Province, University of South China, Hengyang 421001, PR China; Collaborative Innovation Center for New Molecular Drug Research, Hengyang 421001, PR China","institution_ids":["https://openalex.org/I91935597"]},{"raw_affiliation_string":"Collaborative Innovation Center for New Molecular Drug Research, Hengyang 421001, PR China","institution_ids":[]},{"raw_affiliation_string":"Institute of Pathogenic Biology, Key Laboratory of Special Pathogen Prevention and Control of Hunan Province, University of South China, Hengyang 421001, PR China","institution_ids":["https://openalex.org/I91935597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100320276","display_name":"Wen Liu","orcid":"https://orcid.org/0000-0002-3748-4526","observed_orcids":["https://orcid.org/0000-0002-3748-4526","https://orcid.org/0000-0001-8982-0344"]},"institutions":[{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wen Liu","raw_affiliation_strings":["Institute of Pathogenic Biology, Key Laboratory of Special Pathogen Prevention and Control of Hunan Province, University of South China, Hengyang 421001, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathogenic Biology, Key Laboratory of Special Pathogen Prevention and Control of Hunan Province, University of South China, Hengyang 421001, PR China","institution_ids":["https://openalex.org/I91935597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112536394","display_name":"Meixia Deng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meixia Deng","raw_affiliation_strings":["Institute of Pathogenic Biology, Key Laboratory of Special Pathogen Prevention and Control of Hunan Province, University of South China, Hengyang 421001, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathogenic Biology, Key Laboratory of Special Pathogen Prevention and Control of Hunan Province, University of South China, Hengyang 421001, PR China","institution_ids":["https://openalex.org/I91935597"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045939790","display_name":"Feijun Zhao","orcid":"https://orcid.org/0000-0001-9542-6896","observed_orcids":["https://orcid.org/0000-0001-9542-6896"]},"institutions":[{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Feijun Zhao","raw_affiliation_strings":["Institute of Pathogenic Biology, Key Laboratory of Special Pathogen Prevention and Control of Hunan Province, University of South China, Hengyang 421001, PR China; Collaborative Innovation Center for New Molecular Drug Research, Hengyang 421001, PR China. Electronic address: nhdxzhfj@163.com","Collaborative Innovation Center for New Molecular Drug Research, Hengyang 421001, PR China","Institute of Pathogenic Biology, Key Laboratory of Special Pathogen Prevention and Control of Hunan Province, University of South China, Hengyang 421001, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathogenic Biology, Key Laboratory of Special Pathogen Prevention and Control of Hunan Province, University of South China, Hengyang 421001, PR China; Collaborative Innovation Center for New Molecular Drug Research, Hengyang 421001, PR China. Electronic address: nhdxzhfj@163.com","institution_ids":["https://openalex.org/I91935597"]},{"raw_affiliation_string":"Collaborative Innovation Center for New Molecular Drug Research, Hengyang 421001, PR China","institution_ids":[]},{"raw_affiliation_string":"Institute of Pathogenic Biology, Key Laboratory of Special Pathogen Prevention and Control of Hunan Province, University of South China, Hengyang 421001, PR China","institution_ids":["https://openalex.org/I91935597"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5045939790"],"corresponding_institution_ids":["https://openalex.org/I91935597"],"apc_list":{"value":3140,"currency":"USD","value_usd":3140},"apc_paid":null,"fwci":1.6801,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.82705718,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"110","issue":null,"first_page":"176","last_page":"183"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11934","display_name":"Syphilis Diagnosis and Treatment","score":0.739300012588501,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11934","display_name":"Syphilis Diagnosis and Treatment","score":0.739300012588501,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.08749999850988388,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.08179999887943268,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/treponema-pallidum","display_name":"Treponema pallidum","score":0.9959999918937683},{"id":"https://openalex.org/keywords/outer-membrane-proteins","display_name":"outer membrane proteins","score":0.9710000157356262},{"id":"https://openalex.org/keywords/early-syphilis","display_name":"early syphilis","score":0.9110000133514404},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8479999899864197},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.8790000081062317},{"id":"https://openalex.org/keywords/caspase-1","display_name":"caspase-1","score":0.9449999928474426},{"id":"https://openalex.org/keywords/hmec-1-endothelial-cells","display_name":"HMEC-1 endothelial cells","score":0.8140000104904175},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9229999780654907},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8109999895095825},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.949999988079071},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9850000143051147},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.996999979019165},{"id":"https://openalex.org/keywords/host-pathogen-interaction","display_name":"host-pathogen interaction","score":0.5329999923706055},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.4740000069141388},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.4880000054836273}],"concepts":[{"id":"https://openalex.org/C2780187896","wikidata":"https://www.wikidata.org/wiki/Q134745","display_name":"Treponema","level":4,"score":0.8762327432632446},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.8409361243247986},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5560780167579651},{"id":"https://openalex.org/C146587185","wikidata":"https://www.wikidata.org/wiki/Q258248","display_name":"Bacterial outer membrane","level":4,"score":0.5058595538139343},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.4591670632362366},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43626317381858826},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39740800857543945},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3956708610057831},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.3485338091850281},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.27849704027175903},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23863977193832397},{"id":"https://openalex.org/C2776983459","wikidata":"https://www.wikidata.org/wiki/Q41083","display_name":"Syphilis","level":3,"score":0.1832428276538849},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.18199580907821655},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16778969764709473},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13877564668655396},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.09488028287887573},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.0700598657131195}],"mesh":[{"descriptor_ui":"D000071199","descriptor_name":"NLR Family, Pyrin Domain-Containing 3 Protein","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000071199","descriptor_name":"NLR Family, Pyrin Domain-Containing 3 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000074084","descriptor_name":"THP-1 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000590","descriptor_name":"Amino Acid Chloromethyl Ketones","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000954","descriptor_name":"Antigens, Surface","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000954","descriptor_name":"Antigens, Surface","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D007770","descriptor_name":"L-Lactate Dehydrogenase","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007770","descriptor_name":"L-Lactate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011759","descriptor_name":"Pyrrolidines","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013859","descriptor_name":"Thiocarbamates","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D014210","descriptor_name":"Treponema pallidum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014210","descriptor_name":"Treponema pallidum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020170","descriptor_name":"Caspase 1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020170","descriptor_name":"Caspase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020929","descriptor_name":"Mitogen-Activated Protein Kinase Kinases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020929","descriptor_name":"Mitogen-Activated Protein Kinase Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053594","descriptor_name":"Myeloid Differentiation Factor 88","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053594","descriptor_name":"Myeloid Differentiation Factor 88","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.micpath.2017.06.046","doi":"https://doi.org/10.1016/j.micpath.2017.06.046","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.micpath.2017.06.046","pdf_url":null,"source":{"id":"https://openalex.org/S113190374","display_name":"Microbial Pathogenesis","issn_l":"0882-4010","issn":["0882-4010","1096-1208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial Pathogenesis","raw_type":"journal-article"},{"id":"pmid:28668606","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28668606","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial pathogenesis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G396105799","display_name":null,"funder_award_id":"81373230","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4421074246","display_name":null,"funder_award_id":"81301470","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1496602679","https://openalex.org/W1521734634","https://openalex.org/W1582810658","https://openalex.org/W1589689998","https://openalex.org/W1849156717","https://openalex.org/W1940543181","https://openalex.org/W1976934520","https://openalex.org/W1993664236","https://openalex.org/W2009559192","https://openalex.org/W2025787566","https://openalex.org/W2027294776","https://openalex.org/W2045859481","https://openalex.org/W2058633294","https://openalex.org/W2077953047","https://openalex.org/W2103253838","https://openalex.org/W2104764812","https://openalex.org/W2118127165","https://openalex.org/W2134840969","https://openalex.org/W2137068139","https://openalex.org/W2146899109","https://openalex.org/W2148403797","https://openalex.org/W2152203347","https://openalex.org/W2160124608","https://openalex.org/W2163062571","https://openalex.org/W2170052461","https://openalex.org/W2226637529","https://openalex.org/W2293079459","https://openalex.org/W2318590768","https://openalex.org/W2338087590","https://openalex.org/W2344179800","https://openalex.org/W2401140130","https://openalex.org/W2418600762","https://openalex.org/W2428725216","https://openalex.org/W2470526163","https://openalex.org/W2483104112","https://openalex.org/W2518573949","https://openalex.org/W2548769086"],"related_works":["https://openalex.org/W2414080207","https://openalex.org/W2889889797","https://openalex.org/W2058633294","https://openalex.org/W3101322982","https://openalex.org/W7138165167","https://openalex.org/W4386817698","https://openalex.org/W2380147109","https://openalex.org/W4415303160","https://openalex.org/W2797285306","https://openalex.org/W4309471947"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2017-07-14T00:00:00"}