{"id":"https://openalex.org/W2732928906","doi":null,"title":"The Pathogenesis and Prevention of Endometrial Polyps","display_name":"The Pathogenesis and Prevention of Endometrial Polyps","publication_year":2017,"publication_date":"2017-05-14","ids":{"openalex":"https://openalex.org/W2732928906","mag":"2732928906"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/10197032","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/The_Pathogenesis_and_Prevention_of_Endometrial_Polyps/10197032","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085622331","display_name":"Sarah Philip","orcid":"https://orcid.org/0000-0003-3320-9719","observed_orcids":["https://orcid.org/0000-0003-3320-9719"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sarah Philip","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3320-9719","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5085622331"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11589","display_name":"Gynecological conditions and treatments","score":0.6226000189781189,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11589","display_name":"Gynecological conditions and treatments","score":0.6226000189781189,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.18299999833106995,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.08009999990463257,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endometrial-polyps","display_name":"endometrial polyps","score":1.0},{"id":"https://openalex.org/keywords/tamoxifen","display_name":"tamoxifen","score":0.7730000019073486},{"id":"https://openalex.org/keywords/levonorgestrel-releasing-intrauterine-system","display_name":"levonorgestrel-releasing intrauterine system","score":0.902999997138977},{"id":"https://openalex.org/keywords/decidualization","display_name":"decidualization","score":0.8349999785423279},{"id":"https://openalex.org/keywords/igfbp-1","display_name":"IGFBP-1","score":0.8799999952316284},{"id":"https://openalex.org/keywords/estrogen-receptor-beta","display_name":"estrogen receptor beta","score":0.7559999823570251},{"id":"https://openalex.org/keywords/abnormal-uterine-bleeding","display_name":"abnormal uterine bleeding","score":0.8510000109672546},{"id":"https://openalex.org/keywords/malignant-transformation","display_name":"malignant transformation","score":0.7850000262260437},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.6610000133514404},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.9070000052452087},{"id":"https://openalex.org/keywords/notch2","display_name":"Notch2","score":0.9399999976158142},{"id":"https://openalex.org/keywords/medroxyprogesterone-acetate","display_name":"medroxyprogesterone acetate","score":0.9559999704360962},{"id":"https://openalex.org/keywords/levonorgestrel","display_name":"levonorgestrel","score":0.8989999890327454},{"id":"https://openalex.org/keywords/desogestrel","display_name":"desogestrel","score":0.9850000143051147},{"id":"https://openalex.org/keywords/endometrial-stroma","display_name":"endometrial stroma","score":0.6389999985694885}],"concepts":[{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.6894934773445129},{"id":"https://openalex.org/C2909633097","wikidata":"https://www.wikidata.org/wiki/Q3083434","display_name":"Endometrial Polyp","level":3,"score":0.5904833674430847},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49801063537597656},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3362959325313568},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3043075203895569},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23444205522537231},{"id":"https://openalex.org/C2779742232","wikidata":"https://www.wikidata.org/wiki/Q839508","display_name":"Endometrium","level":2,"score":0.226779967546463}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/10197032","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/The_Pathogenesis_and_Prevention_of_Endometrial_Polyps/10197032","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"pmh:oai:lra.le.ac.uk:2381/40044","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2381/40044","pdf_url":null,"source":{"id":"https://openalex.org/S4306402365","display_name":"Leicester Research Archive (University of Leicester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I153648349","host_organization_name":"University of Leicester","host_organization_lineage":["https://openalex.org/I153648349"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2732928906","doi":null,"is_oa":false,"landing_page_url":"https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.718782","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":156,"referenced_works":["https://openalex.org/W42029185","https://openalex.org/W127895279","https://openalex.org/W173407026","https://openalex.org/W1480090408","https://openalex.org/W1486139411","https://openalex.org/W1511353870","https://openalex.org/W1525826143","https://openalex.org/W1569704074","https://openalex.org/W1579407907","https://openalex.org/W1589178582","https://openalex.org/W1590737685","https://openalex.org/W1655441320","https://openalex.org/W1672621735","https://openalex.org/W1693359619","https://openalex.org/W1749633728","https://openalex.org/W1822129150","https://openalex.org/W1896311502","https://openalex.org/W1898939708","https://openalex.org/W1961026612","https://openalex.org/W1965956804","https://openalex.org/W1966488185","https://openalex.org/W1966716045","https://openalex.org/W1968268802","https://openalex.org/W1968716821","https://openalex.org/W1969253763","https://openalex.org/W1970174988","https://openalex.org/W1970416243","https://openalex.org/W1973150388","https://openalex.org/W1973717764","https://openalex.org/W1974282761","https://openalex.org/W1976660314","https://openalex.org/W1977100927","https://openalex.org/W1981192373","https://openalex.org/W1981258435","https://openalex.org/W1981476886","https://openalex.org/W1982412998","https://openalex.org/W1983626262","https://openalex.org/W1984792664","https://openalex.org/W1989037251","https://openalex.org/W1992814996","https://openalex.org/W1993837779","https://openalex.org/W1998401995","https://openalex.org/W2000110875","https://openalex.org/W2000133498","https://openalex.org/W2000516822","https://openalex.org/W2003360566","https://openalex.org/W2003905042","https://openalex.org/W2004222974","https://openalex.org/W2004668461","https://openalex.org/W2007230666","https://openalex.org/W2008271455","https://openalex.org/W2009137349","https://openalex.org/W2011149735","https://openalex.org/W2011480812","https://openalex.org/W2012202913","https://openalex.org/W2014987264","https://openalex.org/W2015553510","https://openalex.org/W2016434692","https://openalex.org/W2018502844","https://openalex.org/W2019586039","https://openalex.org/W2019684999","https://openalex.org/W2020493551","https://openalex.org/W2023527032","https://openalex.org/W2024827041","https://openalex.org/W2025508342","https://openalex.org/W2027729206","https://openalex.org/W2028467077","https://openalex.org/W2029146706","https://openalex.org/W2029812480","https://openalex.org/W2033522005","https://openalex.org/W2037161237","https://openalex.org/W2038587859","https://openalex.org/W2039737646","https://openalex.org/W2041744126","https://openalex.org/W2041926443","https://openalex.org/W2042485683","https://openalex.org/W2043216348","https://openalex.org/W2044060855","https://openalex.org/W2044297772","https://openalex.org/W2048498173","https://openalex.org/W2048610237","https://openalex.org/W2049697532","https://openalex.org/W2049910117","https://openalex.org/W2052238358","https://openalex.org/W2054828894","https://openalex.org/W2055035644","https://openalex.org/W2058843217","https://openalex.org/W2058917128","https://openalex.org/W2060506834","https://openalex.org/W2060991245","https://openalex.org/W2063894934","https://openalex.org/W2063910869","https://openalex.org/W2064370309","https://openalex.org/W2065643273","https://openalex.org/W2066259813","https://openalex.org/W2069498095","https://openalex.org/W2070900245","https://openalex.org/W2072591586","https://openalex.org/W2074344979","https://openalex.org/W2078094549","https://openalex.org/W2085023437","https://openalex.org/W2085118587","https://openalex.org/W2087069707","https://openalex.org/W2089600337","https://openalex.org/W2091327765","https://openalex.org/W2092601575","https://openalex.org/W2093419745","https://openalex.org/W2093754998","https://openalex.org/W2094129745","https://openalex.org/W2094220317","https://openalex.org/W2094512954","https://openalex.org/W2097421553","https://openalex.org/W2097743604","https://openalex.org/W2098544956","https://openalex.org/W2101734337","https://openalex.org/W2104687197","https://openalex.org/W2107277218","https://openalex.org/W2108773317","https://openalex.org/W2109525253","https://openalex.org/W2110112697","https://openalex.org/W2112909942","https://openalex.org/W2115217563","https://openalex.org/W2115412264","https://openalex.org/W2117890841","https://openalex.org/W2119767373","https://openalex.org/W2121454015","https://openalex.org/W2125652739","https://openalex.org/W2127957499","https://openalex.org/W2128900968","https://openalex.org/W2133010239","https://openalex.org/W2133596893","https://openalex.org/W2136461156","https://openalex.org/W2141647078","https://openalex.org/W2143778718","https://openalex.org/W2144662988","https://openalex.org/W2145396414","https://openalex.org/W2151155898","https://openalex.org/W2151806794","https://openalex.org/W2152629654","https://openalex.org/W2156991169","https://openalex.org/W2159711475","https://openalex.org/W2160756193","https://openalex.org/W2166969772","https://openalex.org/W2168215385","https://openalex.org/W2169354513","https://openalex.org/W2170976149","https://openalex.org/W2171467390","https://openalex.org/W2187452737","https://openalex.org/W2208972825","https://openalex.org/W2279243896","https://openalex.org/W2330521161","https://openalex.org/W2335301976","https://openalex.org/W2411439374","https://openalex.org/W2417430527","https://openalex.org/W2593169453","https://openalex.org/W4253530840"],"related_works":["https://openalex.org/W1506048792","https://openalex.org/W42029185","https://openalex.org/W2028467077","https://openalex.org/W2359212608","https://openalex.org/W1968716821","https://openalex.org/W2595827928","https://openalex.org/W3013689852","https://openalex.org/W7119334568","https://openalex.org/W2081180408","https://openalex.org/W2006494620"],"abstract_inverted_index":{"Endometrial":[0],"polyps":[1,29,54,71,87,128,153,164,173],"are":[2,174],"bothersome":[3],"lesions,":[4],"commonly":[5],"seen":[6],"in":[7,53,57,66,70,81,85,152,163,176,196,207,215,218,238,264],"clinical":[8],"practice":[9],"causing":[10],"abnormal":[11],"uterine":[12],"bleeding":[13],"and":[14,51,55,61,78,100,129,135,158,235,240,261],"concern":[15],"about":[16],"the":[17,26,45,111,156,167,181,188,205,223,228,255,280],"risk":[18],"of":[19,28,34,47,140,190,225,257],"malignant":[20],"transformation.":[21],"The":[22,32],"mechanisms":[23,169],"leading":[24],"to":[25,43,76,89,97,104,109,116,155,166,185,211,253],"growth":[27],"is":[30,102,183],"unclear.":[31],"role":[33],"altered":[35,95],"steroid":[36],"receptor":[37],"expression":[38,46,69,84,217,229],"was":[39,122,144,194,244],"studied":[40],"using":[41,180,209,249],"immunohistochemistry":[42,210],"examine":[44,110],"ER-\u03b1":[48],"ER-\u03b2":[49,68],"PR-A":[50],"PR-B":[52,83],"endometrium":[56,91,130],"women":[58,132,179,203],"treated":[59,133,178,202],"with":[60,134,204,266],"without":[62,136],"tamoxifen.":[63,137,270],"A":[64,138],"reduction":[65,80],"stromal":[67,82,220,242],"from":[72,131,200],"both":[73],"groups":[74],"compared":[75,88],"endometrium,":[77,157],"a":[79,119],"tamoxifen":[86,90,177,201],"suggests":[92],"that":[93,114,125,274],"an":[94,213,250],"sensitivity":[96],"these":[98,284],"estrogen":[99,268],"progesterone":[101],"key":[103],"polyp":[105,117,142,232,241,281],"formation.":[106],"In":[107],"order":[108],"genetic":[112],"pathways":[113],"lead":[115],"formation,":[118],"cross-platform":[120],"microarray":[121],"carried":[123],"out":[124],"similarly":[126],"examined":[127,245],"subset":[139],"3272":[141],"genes":[143,149,160],"identified.":[145],"Of":[146],"these,":[147],"1659":[148],"were":[150],"upregulated":[151],"relative":[154,165],"1613":[159],"down":[161],"regulated":[162],"endometrium.\\nThe":[168],"by":[170,246],"which":[171],"endometrial":[172,197,239],"prevented":[175],"LNG-IUS":[182,206],"thought":[184],"be":[186],"via":[187],"mechanism":[189],"decidualisation.":[191],"Firstly,":[192],"decidualisation":[193,226],"confirmed":[195],"biopsy":[198],"samples":[199],"situ":[208],"demonstrate":[212],"increase":[214],"IGFBP-1":[216],"decidualised":[219],"cells.":[221],"Finally,":[222],"effect":[224,282],"on":[227,283],"levels":[230],"2":[231,237],"genes,":[233],"beta-catenin":[234],"Notch":[236],"cells,":[243],"quantitative":[247],"RTPCR":[248],"in-vitro":[251],"model":[252],"test":[254],"effects":[256],"medroxyprogesterone":[258],"acetate,":[259],"levonorgestrel":[260],"desogestrel":[262],"treatment":[263,276],"combination":[265],"either":[267],"or":[269],"This":[271],"study":[272],"demonstrated":[273],"progestin":[275],"did":[277],"in-part":[278],"reverse":[279],"genes.":[285]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-07-14T00:00:00"}