{"id":"https://openalex.org/W2732079","doi":"https://doi.org/10.1007/978-1-59259-125-1_4","title":"Positive Mediators of Cell Proliferation in Neoplastic Transformation","display_name":"Positive Mediators of Cell Proliferation in Neoplastic Transformation","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W2732079","doi":"https://doi.org/10.1007/978-1-59259-125-1_4","mag":"2732079"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-59259-125-1_4","doi":"https://doi.org/10.1007/978-1-59259-125-1_4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-59259-125-1_4","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Molecular Basis of Human Cancer","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W624924830","display_name":"The Molecular Basis of Human Cancer"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030369554","display_name":"James N. Welch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James N. Welch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5011200436","display_name":"Susan A. Chrysogelos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susan A. Chrysogelos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.00188147,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":"65","last_page":"79"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.923799991607666,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.923799991607666,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.012199999764561653,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oncogenic-transformation","display_name":"oncogenic transformation","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9829999804496765},{"id":"https://openalex.org/keywords/growth-regulation","display_name":"growth regulation","score":0.5410000085830688},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.7440000176429749},{"id":"https://openalex.org/keywords/clonal-evolution","display_name":"clonal evolution","score":0.7390000224113464},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.8389999866485596},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.7710000276565552},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.6480000019073486},{"id":"https://openalex.org/keywords/acquired-mutations","display_name":"acquired mutations","score":0.3499999940395355}],"concepts":[{"id":"https://openalex.org/C204241405","wikidata":"https://www.wikidata.org/wiki/Q461499","display_name":"Transformation (genetics)","level":3,"score":0.6607853174209595},{"id":"https://openalex.org/C2993273003","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Neoplastic transformation","level":4,"score":0.48219242691993713},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3596593141555786},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3460139036178589},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23568889498710632},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17724788188934326},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15703418850898743},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08977136015892029},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.08153945207595825},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.04182282090187073},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-59259-125-1_4","doi":"https://doi.org/10.1007/978-1-59259-125-1_4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-59259-125-1_4","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Molecular Basis of Human Cancer","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":123,"referenced_works":["https://openalex.org/W1249747","https://openalex.org/W86876272","https://openalex.org/W88212981","https://openalex.org/W118213103","https://openalex.org/W119017381","https://openalex.org/W140240943","https://openalex.org/W168778824","https://openalex.org/W170175212","https://openalex.org/W178326966","https://openalex.org/W203023708","https://openalex.org/W1504301934","https://openalex.org/W1509850974","https://openalex.org/W1546589729","https://openalex.org/W1546870776","https://openalex.org/W1556926745","https://openalex.org/W1576004006","https://openalex.org/W1589258126","https://openalex.org/W1603700062","https://openalex.org/W1650807611","https://openalex.org/W1750672576","https://openalex.org/W1763096406","https://openalex.org/W1777592494","https://openalex.org/W1790917912","https://openalex.org/W1858438615","https://openalex.org/W1894541755","https://openalex.org/W1895834181","https://openalex.org/W1967882942","https://openalex.org/W1976697969","https://openalex.org/W1976940983","https://openalex.org/W1977560897","https://openalex.org/W1983060585","https://openalex.org/W1987566228","https://openalex.org/W1990427456","https://openalex.org/W1991009778","https://openalex.org/W1993799644","https://openalex.org/W1994141611","https://openalex.org/W1995388191","https://openalex.org/W1997204305","https://openalex.org/W1999053228","https://openalex.org/W1999824494","https://openalex.org/W2002853501","https://openalex.org/W2004147779","https://openalex.org/W2005113904","https://openalex.org/W2005786175","https://openalex.org/W2005847816","https://openalex.org/W2007966406","https://openalex.org/W2013012981","https://openalex.org/W2015063786","https://openalex.org/W2018094311","https://openalex.org/W2018256754","https://openalex.org/W2019896687","https://openalex.org/W2021295480","https://openalex.org/W2022418758","https://openalex.org/W2024065989","https://openalex.org/W2028645555","https://openalex.org/W2029733430","https://openalex.org/W2032709586","https://openalex.org/W2035090582","https://openalex.org/W2038586807","https://openalex.org/W2044868069","https://openalex.org/W2047379150","https://openalex.org/W2047846174","https://openalex.org/W2048428832","https://openalex.org/W2053356104","https://openalex.org/W2060138882","https://openalex.org/W2063140925","https://openalex.org/W2064240326","https://openalex.org/W2069875580","https://openalex.org/W2070873203","https://openalex.org/W2071887421","https://openalex.org/W2072230642","https://openalex.org/W2074198937","https://openalex.org/W2081441817","https://openalex.org/W2083043624","https://openalex.org/W2085672381","https://openalex.org/W2088333322","https://openalex.org/W2090556864","https://openalex.org/W2093094352","https://openalex.org/W2095325371","https://openalex.org/W2095423377","https://openalex.org/W2101151768","https://openalex.org/W2101257013","https://openalex.org/W2107900791","https://openalex.org/W2113048425","https://openalex.org/W2113578923","https://openalex.org/W2118057643","https://openalex.org/W2118601909","https://openalex.org/W2123071074","https://openalex.org/W2132097023","https://openalex.org/W2133124453","https://openalex.org/W2137510087","https://openalex.org/W2139666587","https://openalex.org/W2139937771","https://openalex.org/W2152561142","https://openalex.org/W2154191201","https://openalex.org/W2159594827","https://openalex.org/W2165862139","https://openalex.org/W2180795626","https://openalex.org/W2232660545","https://openalex.org/W2280221639","https://openalex.org/W2311299351","https://openalex.org/W2314793712","https://openalex.org/W2330992281","https://openalex.org/W2339422318","https://openalex.org/W2394713835","https://openalex.org/W2399763242","https://openalex.org/W2402620951","https://openalex.org/W2406783951","https://openalex.org/W2407795195","https://openalex.org/W2411889855","https://openalex.org/W2412522667","https://openalex.org/W2413245665","https://openalex.org/W2414886398","https://openalex.org/W2414963575","https://openalex.org/W2417408054","https://openalex.org/W2423286303","https://openalex.org/W2423742687","https://openalex.org/W2478775991","https://openalex.org/W4211261801","https://openalex.org/W4245635197","https://openalex.org/W4254015982","https://openalex.org/W4285719527","https://openalex.org/W4299823644"],"related_works":["https://openalex.org/W4388156540","https://openalex.org/W983216431","https://openalex.org/W2137329286","https://openalex.org/W207842770","https://openalex.org/W2905730667","https://openalex.org/W2418402999","https://openalex.org/W2136170193","https://openalex.org/W3118896670","https://openalex.org/W4247345859","https://openalex.org/W110543481"],"abstract_inverted_index":{"Cancer":[0,27],"is":[1,55,176],"not":[2,170],"a":[3,7,17,30,42,48,56,151,155],"single":[4,43],"disease,":[5,32],"but":[6],"collection":[8],"of":[9,12,23,41,47,66,71,77,161],"diseases":[10],"all":[11],"which":[13],"are":[14],"related":[15],"by":[16,167,171],"common":[18],"root":[19],"cause:":[20],"the":[21,38,52,64,75,131,135,145,172,179,185],"loss":[22],"controlled":[24],"cell":[25,50,143],"growth.":[26],"begins":[28],"as":[29,184],"clonal":[31,152],"that":[33],"is,":[34],"it":[35],"stems":[36],"from":[37,96,141,150],"genetic":[39,68,137],"corruption":[40],"cell.":[44],"This":[45,174],"conversion":[46],"normal":[49,97],"into":[51],"neoplastic":[53,60],"state":[54],"multi-step":[57],"phenomenon":[58],"called":[59],"transformation":[61],"and":[62,110,116,127,157,169,178],"requires":[63],"accumulation":[65],"several":[67],"mutations.":[69],"Some":[70],"these":[72],"mutations":[73,83,123,138],"enhance":[74],"activity":[76],"growth-promoting":[78],"cellular":[79,111],"processes,":[80],"whereas":[81],"other":[82],"undermine":[84],"regulatory":[85],"mechanisms":[86,119],"designed":[87],"to":[88,101,114,124,128,144,154],"keep":[89],"replication":[90],"in":[91,107],"check.":[92],"Transformed":[93],"cells":[94,98],"differ":[95],"with":[99],"respect":[100],"many":[102],"observable":[103],"characteristics,":[104],"including":[105],"alterations":[106],"growth":[108],"parameters":[109],"behavior.":[112],"Damage":[113],"growth-regulation":[115],"DNA":[117],"repair":[118],"permit":[120],"acquired":[121,139],"somatic":[122],"remain":[125],"uncorrected":[126],"accumulate.":[129],"As":[130],"tumor":[132,148],"population":[133,160],"grows,":[134],"specific":[136],"vary":[140],"one":[142],"next,":[146],"causing":[147],"progression":[149],"entity":[153],"genetically":[156],"phenotypically":[158],"heterogeneous":[159],"cells.":[162],"These":[163],"keywords":[164,180],"were":[165],"added":[166],"machine":[168],"authors.":[173],"process":[175],"experimental":[177],"may":[181],"be":[182],"updated":[183],"learning":[186],"algorithm":[187],"improves.":[188]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2016-06-24T00:00:00"}
