{"id":"https://openalex.org/W2731964189","doi":null,"title":"Directed Adult Neural Stem/Progenitor Cell Fate in Microsphere-loaded Chitosan Channels","display_name":"Directed Adult Neural Stem/Progenitor Cell Fate in Microsphere-loaded Chitosan Channels","publication_year":2012,"publication_date":"2012-01-10","ids":{"openalex":"https://openalex.org/W2731964189","mag":"2731964189"},"language":"en","primary_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/31804","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/31804","pdf_url":"https://utoronto.scholaris.ca/bitstreams/771a5fe4-fa92-4309-b2ba-f892df81e9f6/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://utoronto.scholaris.ca/bitstreams/771a5fe4-fa92-4309-b2ba-f892df81e9f6/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101871753","display_name":"Howard S. Kim","orcid":"https://orcid.org/0000-0002-1123-9485","observed_orcids":["https://orcid.org/0000-0002-1123-9485"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Howard Kim","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1123-9485","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5101871753"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.5365999937057495,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.5365999937057495,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.2379000037908554,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.1388999968767166,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spinal-cord-injury","display_name":"spinal cord injury","score":0.996999979019165},{"id":"https://openalex.org/keywords/neural-stem-progenitor-cells","display_name":"neural stem/progenitor cells","score":0.9210000038146973},{"id":"https://openalex.org/keywords/plga-microspheres","display_name":"PLGA microspheres","score":0.9950000047683716},{"id":"https://openalex.org/keywords/drug-eluting-microspheres","display_name":"drug-eluting microspheres","score":0.8429999947547913},{"id":"https://openalex.org/keywords/dibutyryl-camp","display_name":"dibutyryl cyclic AMP","score":0.8600000143051147},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.9580000042915344},{"id":"https://openalex.org/keywords/controlled-drug-release","display_name":"controlled drug release","score":0.6729999780654907},{"id":"https://openalex.org/keywords/neuronal-differentiation","display_name":"neuronal differentiation","score":0.871999979019165},{"id":"https://openalex.org/keywords/axon-regeneration","display_name":"axon regeneration","score":0.7710000276565552},{"id":"https://openalex.org/keywords/cell-transplantation","display_name":"cell transplantation","score":0.621999979019165},{"id":"https://openalex.org/keywords/functional-recovery","display_name":"functional recovery","score":0.6309999823570251}],"concepts":[{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6757587194442749},{"id":"https://openalex.org/C189942447","wikidata":"https://www.wikidata.org/wiki/Q61186","display_name":"Microsphere","level":2,"score":0.6316837072372437},{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.6110923290252686},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.5576444268226624},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5394824743270874},{"id":"https://openalex.org/C15729860","wikidata":"https://www.wikidata.org/wiki/Q2329919","display_name":"Progenitor","level":4,"score":0.443509578704834},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3907850384712219},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33602821826934814},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3343903422355652},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26196396350860596},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.22885018587112427},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.11630704998970032},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06459712982177734}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:utoronto.scholaris.ca:1807/31804","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/31804","pdf_url":"https://utoronto.scholaris.ca/bitstreams/771a5fe4-fa92-4309-b2ba-f892df81e9f6/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:collectionscanada.gc.ca:OTU.1807/31804","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1807/31804","pdf_url":null,"source":{"id":"https://openalex.org/S4306402307","display_name":"Library and Archives Canada (Government of Canada)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2802286613","host_organization_name":"Government of Canada","host_organization_lineage":["https://openalex.org/I2802286613"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2731964189","doi":null,"is_oa":false,"landing_page_url":"https://tspace.library.utoronto.ca/bitstream/1807/31804/1/Kim_Howard_201111_PhD_thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/31804","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/31804","pdf_url":"https://utoronto.scholaris.ca/bitstreams/771a5fe4-fa92-4309-b2ba-f892df81e9f6/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2731964189.pdf","grobid_xml":"https://content.openalex.org/works/W2731964189.grobid-xml"},"referenced_works_count":303,"referenced_works":["https://openalex.org/W15561732","https://openalex.org/W48770542","https://openalex.org/W82040228","https://openalex.org/W231269100","https://openalex.org/W283469004","https://openalex.org/W1214980466","https://openalex.org/W1483365010","https://openalex.org/W1549414615","https://openalex.org/W1816772540","https://openalex.org/W1826719783","https://openalex.org/W1863551998","https://openalex.org/W1957468634","https://openalex.org/W1965552267","https://openalex.org/W1967455232","https://openalex.org/W1967677292","https://openalex.org/W1968381062","https://openalex.org/W1970568734","https://openalex.org/W1971249619","https://openalex.org/W1971426179","https://openalex.org/W1971448220","https://openalex.org/W1972163765","https://openalex.org/W1972979183","https://openalex.org/W1973501593","https://openalex.org/W1973773154","https://openalex.org/W1973956475","https://openalex.org/W1975219368","https://openalex.org/W1975805379","https://openalex.org/W1979447754","https://openalex.org/W1981621010","https://openalex.org/W1981875126","https://openalex.org/W1982262292","https://openalex.org/W1982548383","https://openalex.org/W1983222557","https://openalex.org/W1983273439","https://openalex.org/W1983302129","https://openalex.org/W1983509147","https://openalex.org/W1983843529","https://openalex.org/W1985297297","https://openalex.org/W1987408946","https://openalex.org/W1987467507","https://openalex.org/W1988326421","https://openalex.org/W1988875977","https://openalex.org/W1989075367","https://openalex.org/W1989145720","https://openalex.org/W1989493703","https://openalex.org/W1989707738","https://openalex.org/W1989910000","https://openalex.org/W1989920563","https://openalex.org/W1990228542","https://openalex.org/W1992155535","https://openalex.org/W1992267774","https://openalex.org/W1992372196","https://openalex.org/W1992564176","https://openalex.org/W1992621114","https://openalex.org/W1993108487","https://openalex.org/W1993209680","https://openalex.org/W1993965974","https://openalex.org/W1995063875","https://openalex.org/W1996243257","https://openalex.org/W1996938297","https://openalex.org/W1996967454","https://openalex.org/W1997721049","https://openalex.org/W1997750937","https://openalex.org/W1998061495","https://openalex.org/W1998380582","https://openalex.org/W1999587164","https://openalex.org/W1999968637","https://openalex.org/W2000043284","https://openalex.org/W2000255951","https://openalex.org/W2000466483","https://openalex.org/W2000645862","https://openalex.org/W2000953475","https://openalex.org/W2001917342","https://openalex.org/W2002095196","https://openalex.org/W2003464973","https://openalex.org/W2003873431","https://openalex.org/W2005966406","https://openalex.org/W2006132770","https://openalex.org/W2006408401","https://openalex.org/W2006531632","https://openalex.org/W2006613154","https://openalex.org/W2008346615","https://openalex.org/W2009076777","https://openalex.org/W2009459640","https://openalex.org/W2010231868","https://openalex.org/W2010234007","https://openalex.org/W2010450195","https://openalex.org/W2011039855","https://openalex.org/W2011440234","https://openalex.org/W2014203854","https://openalex.org/W2015277484","https://openalex.org/W2016104434","https://openalex.org/W2017025515","https://openalex.org/W2017599428","https://openalex.org/W2019605249","https://openalex.org/W2021916242","https://openalex.org/W2023072321","https://openalex.org/W2023181690","https://openalex.org/W2023904895","https://openalex.org/W2024659682","https://openalex.org/W2026844853","https://openalex.org/W2027094814","https://openalex.org/W2027274730","https://openalex.org/W2028190741","https://openalex.org/W2028311590","https://openalex.org/W2028417000","https://openalex.org/W2029768920","https://openalex.org/W2030508161","https://openalex.org/W2031023695","https://openalex.org/W2031155651","https://openalex.org/W2031268185","https://openalex.org/W2032053462","https://openalex.org/W2032145250","https://openalex.org/W2032413495","https://openalex.org/W2032989272","https://openalex.org/W2033503301","https://openalex.org/W2033507194","https://openalex.org/W2033612649","https://openalex.org/W2033855927","https://openalex.org/W2034387102","https://openalex.org/W2034558908","https://openalex.org/W2035616055","https://openalex.org/W2036883176","https://openalex.org/W2037306331","https://openalex.org/W2037991237","https://openalex.org/W2038159444","https://openalex.org/W2038303536","https://openalex.org/W2038754539","https://openalex.org/W2040272006","https://openalex.org/W2040281629","https://openalex.org/W2040673667","https://openalex.org/W2041993072","https://openalex.org/W2042190760","https://openalex.org/W2042578427","https://openalex.org/W2042983677","https://openalex.org/W2043050395","https://openalex.org/W2043168279","https://openalex.org/W2043789726","https://openalex.org/W2044430876","https://openalex.org/W2045264711","https://openalex.org/W2045853195","https://openalex.org/W2046006021","https://openalex.org/W2046232200","https://openalex.org/W2046620605","https://openalex.org/W2047246701","https://openalex.org/W2047824475","https://openalex.org/W2051062618","https://openalex.org/W2051215326","https://openalex.org/W2051531636","https://openalex.org/W2051763162","https://openalex.org/W2051959542","https://openalex.org/W2052091795","https://openalex.org/W2052196137","https://openalex.org/W2052654829","https://openalex.org/W2052750818","https://openalex.org/W2052751067","https://openalex.org/W2053571388","https://openalex.org/W2053860494","https://openalex.org/W2057922246","https://openalex.org/W2058500387","https://openalex.org/W2059493571","https://openalex.org/W2060675402","https://openalex.org/W2061077667","https://openalex.org/W2061347235","https://openalex.org/W2061709697","https://openalex.org/W2062375268","https://openalex.org/W2063079110","https://openalex.org/W2063219873","https://openalex.org/W2065507307","https://openalex.org/W2066061791","https://openalex.org/W2066740692","https://openalex.org/W2066762198","https://openalex.org/W2067019666","https://openalex.org/W2067274865","https://openalex.org/W2068578338","https://openalex.org/W2069548263","https://openalex.org/W2069978113","https://openalex.org/W2070043893","https://openalex.org/W2071494502","https://openalex.org/W2071553413","https://openalex.org/W2071663291","https://openalex.org/W2071783567","https://openalex.org/W2072251801","https://openalex.org/W2074020057","https://openalex.org/W2074163427","https://openalex.org/W2074504395","https://openalex.org/W2074547304","https://openalex.org/W2074895192","https://openalex.org/W2074930445","https://openalex.org/W2074959702","https://openalex.org/W2075284481","https://openalex.org/W2075424224","https://openalex.org/W2075913023","https://openalex.org/W2077138603","https://openalex.org/W2077568317","https://openalex.org/W2078297537","https://openalex.org/W2078648601","https://openalex.org/W2079356804","https://openalex.org/W2079538438","https://openalex.org/W2079616858","https://openalex.org/W2079835022","https://openalex.org/W2080054035","https://openalex.org/W2080325936","https://openalex.org/W2083534507","https://openalex.org/W2083910200","https://openalex.org/W2084094544","https://openalex.org/W2084116832","https://openalex.org/W2084924803","https://openalex.org/W2084989826","https://openalex.org/W2085363859","https://openalex.org/W2085462946","https://openalex.org/W2087175486","https://openalex.org/W2087193323","https://openalex.org/W2087609924","https://openalex.org/W2087872716","https://openalex.org/W2087887113","https://openalex.org/W2088196028","https://openalex.org/W2088490610","https://openalex.org/W2088696734","https://openalex.org/W2088855906","https://openalex.org/W2089287863","https://openalex.org/W2089537633","https://openalex.org/W2089863147","https://openalex.org/W2091315047","https://openalex.org/W2091487450","https://openalex.org/W2091734064","https://openalex.org/W2092110899","https://openalex.org/W2092520967","https://openalex.org/W2093738970","https://openalex.org/W2095830961","https://openalex.org/W2096988407","https://openalex.org/W2099166156","https://openalex.org/W2100859388","https://openalex.org/W2100938404","https://openalex.org/W2101662835","https://openalex.org/W2101996466","https://openalex.org/W2102084306","https://openalex.org/W2102557362","https://openalex.org/W2103328966","https://openalex.org/W2104231587","https://openalex.org/W2104907082","https://openalex.org/W2104948210","https://openalex.org/W2105337889","https://openalex.org/W2107446553","https://openalex.org/W2107514110","https://openalex.org/W2108258113","https://openalex.org/W2109396041","https://openalex.org/W2110466351","https://openalex.org/W2110695873","https://openalex.org/W2114279479","https://openalex.org/W2116183504","https://openalex.org/W2117555288","https://openalex.org/W2119281544","https://openalex.org/W2120992807","https://openalex.org/W2121013308","https://openalex.org/W2121318353","https://openalex.org/W2122271812","https://openalex.org/W2123450039","https://openalex.org/W2126194593","https://openalex.org/W2126858586","https://openalex.org/W2127732414","https://openalex.org/W2128441790","https://openalex.org/W2128638598","https://openalex.org/W2128791326","https://openalex.org/W2129560569","https://openalex.org/W2130056515","https://openalex.org/W2130731229","https://openalex.org/W2133565976","https://openalex.org/W2134675585","https://openalex.org/W2137586660","https://openalex.org/W2139208934","https://openalex.org/W2141695741","https://openalex.org/W2143932413","https://openalex.org/W2144722561","https://openalex.org/W2150320891","https://openalex.org/W2152111944","https://openalex.org/W2152276464","https://openalex.org/W2154309821","https://openalex.org/W2155734183","https://openalex.org/W2157783914","https://openalex.org/W2160460092","https://openalex.org/W2160817510","https://openalex.org/W2164047895","https://openalex.org/W2164406367","https://openalex.org/W2164466707","https://openalex.org/W2166274173","https://openalex.org/W2166450428","https://openalex.org/W2167208176","https://openalex.org/W2167370432","https://openalex.org/W2167815042","https://openalex.org/W2168017921","https://openalex.org/W2169044352","https://openalex.org/W2170560272","https://openalex.org/W2170645579","https://openalex.org/W2170828389","https://openalex.org/W2225440776","https://openalex.org/W2329616841","https://openalex.org/W2346489503","https://openalex.org/W2419011157","https://openalex.org/W2488101972","https://openalex.org/W3170532588","https://openalex.org/W4242114372","https://openalex.org/W4252930791"],"related_works":["https://openalex.org/W7097580588","https://openalex.org/W2087193323","https://openalex.org/W2120992807","https://openalex.org/W2068578338","https://openalex.org/W2888183927","https://openalex.org/W3029967385","https://openalex.org/W1971249619","https://openalex.org/W3038813172","https://openalex.org/W4223525533","https://openalex.org/W2059493571"],"abstract_inverted_index":{"Spinal":[0],"cord":[1,34,71,160],"injury":[2],"(SCI)":[3],"is":[4,35],"a":[5,57,65,79,102,166],"devastating":[6],"condition":[7],"characterized":[8],"by":[9,101],"the":[10,23,26,29,62,109,117,129],"loss":[11],"of":[12,28,64,116,128,152],"neuronal":[13,154],"pathways":[14],"responsible":[15],"for":[16,69,82,111],"coordinating":[17],"motor":[18],"and":[19,25,50,88,124,192],"sensory":[20],"information":[21],"between":[22],"brain":[24],"rest":[27],"body.":[30],"The":[31,150],"mammalian":[32],"spinal":[33,70,159],"limited":[36],"in":[37,144,162,165,169,181],"its":[38],"ability":[39,110],"to":[40,46,136,139],"repair":[41],"itself,":[42],"so":[43],"treatments":[44],"devised":[45],"replace":[47],"damaged":[48],"tissue":[49,183],"promote":[51],"regeneration":[52,191],"are":[53],"essential":[54],"towards":[55],"developing":[56],"cure.":[58],"This":[59],"work":[60],"describes":[61],"development":[63],"guidance":[66,74],"channel":[67],"strategy":[68],"transection.":[72],"Chitosan":[73],"channels":[75,100,107,174],"were":[76,96,134],"designed":[77],"as":[78],"delivery":[80],"vehicle":[81],"neural":[83],"stem/progenitor":[84],"cell":[85],"(NSPC)":[86],"transplants":[87],"drug-eluting":[89],"poly(lactic-co-glycolic":[90],"acid)":[91],"(PLGA)":[92],"microspheres.":[93],"PLGA":[94],"microspheres":[95],"embedded":[97],"into":[98,148],"chitosan":[99],"spin-coating":[103],"method.":[104],"These":[105],"microsphere-loaded":[106],"demonstrated":[108],"controlled":[112],"short-term":[113],"bioactive":[114,126],"release":[115,127],"small":[118],"molecule":[119],"drug":[120],"dibutyryl":[121],"cyclic-AMP":[122],"(dbcAMP)":[123],"long-term":[125],"protein":[130],"alkaline":[131],"phosphatase.":[132],"NSPCs":[133,176],"shown":[135],"be":[137],"responsive":[138],"dbcAMP":[140,179],"delivery,":[141],"which":[142],"results":[143],"greatly":[145],"enhanced":[146],"differentiation":[147,155],"neurons.":[149],"effect":[151],"directed":[153],"was":[156],"investigated":[157],"after":[158,186],"transection":[161],"rat,":[163],"resulting":[164],"dramatic":[167],"increase":[168],"NSPC":[170],"transplant":[171],"survival.":[172],"Guidance":[173],"containing":[175],"treated":[177],"with":[178],"resulted":[180],"robust":[182],"bridge":[184],"formation":[185],"SCI,":[187],"demonstrating":[188],"extensive":[189],"axonal":[190],"promoting":[193],"functional":[194],"recovery.":[195]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2017-07-14T00:00:00"}