{"id":"https://openalex.org/W2731863237","doi":null,"title":"Structure-based Subfamily Classification of Homeodomains","display_name":"Structure-based Subfamily Classification of Homeodomains","publication_year":2008,"publication_date":"2008-07-30","ids":{"openalex":"https://openalex.org/W2731863237","mag":"2731863237"},"language":"en","primary_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/11169","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/11169","pdf_url":"https://utoronto.scholaris.ca/bitstreams/628a9119-9941-4c84-94a7-cf8cdea247e3/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://utoronto.scholaris.ca/bitstreams/628a9119-9941-4c84-94a7-cf8cdea247e3/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025918983","display_name":"Jennifer Tsai","orcid":"https://orcid.org/0000-0001-7055-4146","observed_orcids":["https://orcid.org/0000-0001-7055-4146"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jennifer Tsai","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7055-4146","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5025918983"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.02410000003874302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.013199999928474426,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/homeodomain","display_name":"homeodomain","score":0.8600000143051147},{"id":"https://openalex.org/keywords/dna-binding-proteins","display_name":"DNA-binding proteins","score":0.7910000085830688},{"id":"https://openalex.org/keywords/protein-structure","display_name":"protein structure","score":0.7049999833106995},{"id":"https://openalex.org/keywords/protein-dna-interactions","display_name":"protein-DNA interactions","score":0.6899999976158142},{"id":"https://openalex.org/keywords/dna-binding-specificity","display_name":"DNA binding specificity","score":0.8510000109672546},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.753000020980835},{"id":"https://openalex.org/keywords/embryonic-development","display_name":"embryonic development","score":0.6069999933242798}],"concepts":[{"id":"https://openalex.org/C50929876","wikidata":"https://www.wikidata.org/wiki/Q164280","display_name":"Subfamily","level":3,"score":0.8414855003356934},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.40671977400779724},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3409271240234375},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3395553231239319},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33777904510498047},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.3342375159263611},{"id":"https://openalex.org/C53553401","wikidata":"https://www.wikidata.org/wiki/Q47307","display_name":"Genealogy","level":1,"score":0.3201243281364441},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.251707524061203},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.06997871398925781},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05566966533660889}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:utoronto.scholaris.ca:1807/11169","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/11169","pdf_url":"https://utoronto.scholaris.ca/bitstreams/628a9119-9941-4c84-94a7-cf8cdea247e3/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:collectionscanada.gc.ca:OTU.1807/11169","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1807/11169","pdf_url":null,"source":{"id":"https://openalex.org/S4306402307","display_name":"Library and Archives Canada (Government of Canada)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2802286613","host_organization_name":"Government of Canada","host_organization_lineage":["https://openalex.org/I2802286613"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2731863237","doi":null,"is_oa":false,"landing_page_url":"https://tspace.library.utoronto.ca/bitstream/1807/11169/1/Tsai_Jennifer_MJ_200801_MSc_thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/11169","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/11169","pdf_url":"https://utoronto.scholaris.ca/bitstreams/628a9119-9941-4c84-94a7-cf8cdea247e3/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322015","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2731863237.pdf","grobid_xml":"https://content.openalex.org/works/W2731863237.grobid-xml"},"referenced_works_count":181,"referenced_works":["https://openalex.org/W63747042","https://openalex.org/W319819633","https://openalex.org/W337785430","https://openalex.org/W846762052","https://openalex.org/W1495099700","https://openalex.org/W1500214331","https://openalex.org/W1508885706","https://openalex.org/W1531430623","https://openalex.org/W1553017085","https://openalex.org/W1671919605","https://openalex.org/W1730776587","https://openalex.org/W1879108791","https://openalex.org/W1911274639","https://openalex.org/W1952548524","https://openalex.org/W1966735041","https://openalex.org/W1970138467","https://openalex.org/W1971210068","https://openalex.org/W1973455484","https://openalex.org/W1973578915","https://openalex.org/W1974050623","https://openalex.org/W1977922844","https://openalex.org/W1979147581","https://openalex.org/W1981159651","https://openalex.org/W1982038383","https://openalex.org/W1989039494","https://openalex.org/W1990453950","https://openalex.org/W1995904887","https://openalex.org/W1995924392","https://openalex.org/W1996895509","https://openalex.org/W1997324386","https://openalex.org/W2001770641","https://openalex.org/W2002195659","https://openalex.org/W2003248828","https://openalex.org/W2004360551","https://openalex.org/W2004575181","https://openalex.org/W2005313213","https://openalex.org/W2008386840","https://openalex.org/W2009851083","https://openalex.org/W2011598430","https://openalex.org/W2012943750","https://openalex.org/W2013298312","https://openalex.org/W2014243211","https://openalex.org/W2014719716","https://openalex.org/W2014756294","https://openalex.org/W2015292449","https://openalex.org/W2017035463","https://openalex.org/W2017790928","https://openalex.org/W2020202389","https://openalex.org/W2021591029","https://openalex.org/W2023385944","https://openalex.org/W2024997450","https://openalex.org/W2027301728","https://openalex.org/W2030027182","https://openalex.org/W2032293502","https://openalex.org/W2035378222","https://openalex.org/W2035792284","https://openalex.org/W2036848170","https://openalex.org/W2041862730","https://openalex.org/W2042454166","https://openalex.org/W2043230502","https://openalex.org/W2043543538","https://openalex.org/W2043679962","https://openalex.org/W2044128233","https://openalex.org/W2045777307","https://openalex.org/W2048987277","https://openalex.org/W2049324939","https://openalex.org/W2051085340","https://openalex.org/W2051575557","https://openalex.org/W2052668971","https://openalex.org/W2053072162","https://openalex.org/W2053927782","https://openalex.org/W2054274383","https://openalex.org/W2055043387","https://openalex.org/W2057113688","https://openalex.org/W2060528969","https://openalex.org/W2062258948","https://openalex.org/W2069770806","https://openalex.org/W2070166332","https://openalex.org/W2070312499","https://openalex.org/W2070919193","https://openalex.org/W2071189076","https://openalex.org/W2071586059","https://openalex.org/W2071753317","https://openalex.org/W2074097929","https://openalex.org/W2074231493","https://openalex.org/W2075036182","https://openalex.org/W2081719547","https://openalex.org/W2081933515","https://openalex.org/W2082554284","https://openalex.org/W2084974511","https://openalex.org/W2085277871","https://openalex.org/W2087064593","https://openalex.org/W2088512249","https://openalex.org/W2090530814","https://openalex.org/W2094920743","https://openalex.org/W2095724872","https://openalex.org/W2096630760","https://openalex.org/W2097382368","https://openalex.org/W2097506564","https://openalex.org/W2097706568","https://openalex.org/W2099057076","https://openalex.org/W2099111195","https://openalex.org/W2100412820","https://openalex.org/W2100990314","https://openalex.org/W2101285899","https://openalex.org/W2101797035","https://openalex.org/W2102464076","https://openalex.org/W2103660241","https://openalex.org/W2106094988","https://openalex.org/W2106814707","https://openalex.org/W2107087429","https://openalex.org/W2107302432","https://openalex.org/W2108067237","https://openalex.org/W2109936378","https://openalex.org/W2110397834","https://openalex.org/W2112162865","https://openalex.org/W2115415644","https://openalex.org/W2115925427","https://openalex.org/W2115998090","https://openalex.org/W2116104082","https://openalex.org/W2117752525","https://openalex.org/W2118360831","https://openalex.org/W2119195082","https://openalex.org/W2119743029","https://openalex.org/W2120248467","https://openalex.org/W2121297744","https://openalex.org/W2121663884","https://openalex.org/W2122854841","https://openalex.org/W2124145810","https://openalex.org/W2124975729","https://openalex.org/W2125121305","https://openalex.org/W2125310307","https://openalex.org/W2125533958","https://openalex.org/W2126730189","https://openalex.org/W2127201083","https://openalex.org/W2127358442","https://openalex.org/W2130479394","https://openalex.org/W2132717858","https://openalex.org/W2132926880","https://openalex.org/W2133335149","https://openalex.org/W2133790733","https://openalex.org/W2134910640","https://openalex.org/W2135030836","https://openalex.org/W2135043797","https://openalex.org/W2136446084","https://openalex.org/W2137503746","https://openalex.org/W2137991504","https://openalex.org/W2138263042","https://openalex.org/W2140560927","https://openalex.org/W2140938071","https://openalex.org/W2141885858","https://openalex.org/W2143173841","https://openalex.org/W2143210482","https://openalex.org/W2143518155","https://openalex.org/W2144362290","https://openalex.org/W2144792857","https://openalex.org/W2146139510","https://openalex.org/W2148171419","https://openalex.org/W2148515217","https://openalex.org/W2148792677","https://openalex.org/W2150297520","https://openalex.org/W2150402280","https://openalex.org/W2151550848","https://openalex.org/W2152134406","https://openalex.org/W2152580193","https://openalex.org/W2156856635","https://openalex.org/W2158714788","https://openalex.org/W2159368494","https://openalex.org/W2159400443","https://openalex.org/W2161283204","https://openalex.org/W2161647617","https://openalex.org/W2162829784","https://openalex.org/W2164130591","https://openalex.org/W2168223461","https://openalex.org/W2168253026","https://openalex.org/W2169002161","https://openalex.org/W2171353359","https://openalex.org/W2183248836","https://openalex.org/W2765633603","https://openalex.org/W2767273820","https://openalex.org/W3199943451"],"related_works":["https://openalex.org/W2111826611","https://openalex.org/W2084412933","https://openalex.org/W4402647844","https://openalex.org/W2110652556","https://openalex.org/W1996938470","https://openalex.org/W2186524075","https://openalex.org/W4285045268","https://openalex.org/W7096514670","https://openalex.org/W2046477359","https://openalex.org/W2080152736"],"abstract_inverted_index":{"Eukaryotic":[0],"DNA-binding":[1,45],"proteins":[2,19,46],"mediate":[3],"many":[4],"important":[5],"steps":[6],"in":[7,49,66,76,111],"embryonic":[8],"development":[9],"and":[10,69,108,125],"gene":[11,28],"regulation.":[12],"Consequently,":[13],"a":[14,23,36,56,140],"better":[15],"understanding":[16],"of":[17,27,40,44,55,71,87],"these":[18,137],"would":[20],"hopefully":[21],"allow":[22],"more":[24],"complete":[25],"picture":[26],"regulation":[29],"to":[30,51,64,78,93,101,117],"be":[31,60,118],"determined.":[32],"In":[33],"this":[34],"study,":[35],"structure-based":[37],"subfamily":[38],"classification":[39],"the":[41,88,112,122,133],"homeodomain":[42],"family":[43,58],"was":[47,74],"undertaken":[48],"order":[50,77],"determine":[52],"whether":[53],"sub-groupings":[54],"protein":[57],"could":[59],"identified":[61],"that":[62],"corresponded":[63],"differences":[65,84],"specific":[67,96],"function,":[68],"identification":[70],"subfamily-determining":[72],"residues":[73,115,138],"performed":[75],"gain":[79],"some":[80],"insight":[81],"on":[82],"functional":[83],"via":[85,130],"analysis":[86],"residue":[89],"properties.":[90],"Subfamilies":[91],"appear":[92,116],"have":[94],"different":[95],"DNA":[97,102,128,134],"binding":[98,129],"properties,":[99],"according":[100],"profiles":[103],"obtained":[104],"from":[105],"TRANSFAC":[106],"[1]":[107],"other":[109],"sources":[110],"literature.":[113],"Subfamily-specific":[114],"frequently":[119],"associated":[120],"with":[121,132],"protein-DNA":[123],"interface":[124],"may":[126],"influence":[127],"interactions":[131],"phosphate":[135],"backbone;":[136],"form":[139],"conserved":[141],"profile":[142],"uniquely":[143],"identifying":[144],"each":[145],"subfamily.":[146]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-07-14T00:00:00"}