{"id":"https://openalex.org/W2731627675","doi":"https://doi.org/10.1016/j.bmcl.2017.07.011","title":"Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor","display_name":"Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor","publication_year":2017,"publication_date":"2017-07-04","ids":{"openalex":"https://openalex.org/W2731627675","doi":"https://doi.org/10.1016/j.bmcl.2017.07.011","mag":"2731627675","pmid":"https://pubmed.ncbi.nlm.nih.gov/28739044"},"language":"en","primary_location":{"id":"doi:10.1016/j.bmcl.2017.07.011","doi":"https://doi.org/10.1016/j.bmcl.2017.07.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmcl.2017.07.011","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016666460","display_name":"Naoshi Yamamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I4405286304","display_name":"International Institute for Integrative Sleep Medicine, University of Tsukuba","ror":"https://ror.org/01s1qrh29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I146399215","https://openalex.org/I4405286304"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoshi Yamamoto","raw_affiliation_strings":["International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan","institution_ids":["https://openalex.org/I146399215","https://openalex.org/I4405286304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014708994","display_name":"Sayaka Ohrui","orcid":"https://orcid.org/0000-0002-0671-1941","observed_orcids":["https://orcid.org/0000-0002-0671-1941"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I4405286304","display_name":"International Institute for Integrative Sleep Medicine, University of Tsukuba","ror":"https://ror.org/01s1qrh29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I146399215","https://openalex.org/I4405286304"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sayaka Ohrui","raw_affiliation_strings":["International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan","institution_ids":["https://openalex.org/I146399215","https://openalex.org/I4405286304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016494036","display_name":"Takahiro Okada","orcid":"https://orcid.org/0000-0001-6375-2443","observed_orcids":["https://orcid.org/0000-0001-6375-2443"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahiro Okada","raw_affiliation_strings":["Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055166643","display_name":"Masahiro Yata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro Yata","raw_affiliation_strings":["Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101795920","display_name":"Tsuyoshi Saitoh","orcid":"https://orcid.org/0000-0001-6105-6292","observed_orcids":["https://orcid.org/0000-0001-6105-6292"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I4405286304","display_name":"International Institute for Integrative Sleep Medicine, University of Tsukuba","ror":"https://ror.org/01s1qrh29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I146399215","https://openalex.org/I4405286304"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsuyoshi Saitoh","raw_affiliation_strings":["International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan","institution_ids":["https://openalex.org/I146399215","https://openalex.org/I4405286304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015846745","display_name":"Noriki Kutsumura","orcid":"https://orcid.org/0000-0002-1494-2133","observed_orcids":["https://orcid.org/0000-0002-1494-2133"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I4405286304","display_name":"International Institute for Integrative Sleep Medicine, University of Tsukuba","ror":"https://ror.org/01s1qrh29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I146399215","https://openalex.org/I4405286304"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Noriki Kutsumura","raw_affiliation_strings":["International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan","institution_ids":["https://openalex.org/I146399215","https://openalex.org/I4405286304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108931801","display_name":"Yasuyuki Nagumo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I4405286304","display_name":"International Institute for Integrative Sleep Medicine, University of Tsukuba","ror":"https://ror.org/01s1qrh29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I146399215","https://openalex.org/I4405286304"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuyuki Nagumo","raw_affiliation_strings":["International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan","institution_ids":["https://openalex.org/I146399215","https://openalex.org/I4405286304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012854197","display_name":"Yoko Irukayama\u2010Tomobe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I4405286304","display_name":"International Institute for Integrative Sleep Medicine, University of Tsukuba","ror":"https://ror.org/01s1qrh29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I146399215","https://openalex.org/I4405286304"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoko Irukayama-Tomobe","raw_affiliation_strings":["International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan","institution_ids":["https://openalex.org/I146399215","https://openalex.org/I4405286304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103129528","display_name":"Yasuhiro Ogawa","orcid":"https://orcid.org/0000-0003-1270-4542","observed_orcids":["https://orcid.org/0000-0003-1270-4542"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I4405286304","display_name":"International Institute for Integrative Sleep Medicine, University of Tsukuba","ror":"https://ror.org/01s1qrh29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I146399215","https://openalex.org/I4405286304"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhiro Ogawa","raw_affiliation_strings":["International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan","institution_ids":["https://openalex.org/I146399215","https://openalex.org/I4405286304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057761124","display_name":"Yukiko Ishikawa","orcid":"https://orcid.org/0000-0003-2688-0782","observed_orcids":["https://orcid.org/0000-0003-2688-0782"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I4405286304","display_name":"International Institute for Integrative Sleep Medicine, University of Tsukuba","ror":"https://ror.org/01s1qrh29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I146399215","https://openalex.org/I4405286304"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukiko Ishikawa","raw_affiliation_strings":["International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan","institution_ids":["https://openalex.org/I146399215","https://openalex.org/I4405286304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101915343","display_name":"Yurie Watanabe","orcid":"https://orcid.org/0009-0009-4234-3507","observed_orcids":["https://orcid.org/0009-0009-4234-3507"]},"institutions":[{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yurie Watanabe","raw_affiliation_strings":["School of Pharmacy, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan","institution_ids":["https://openalex.org/I119182057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007134315","display_name":"Daichi Hayakawa","orcid":"https://orcid.org/0000-0003-1942-2492","observed_orcids":["https://orcid.org/0000-0003-1942-2492"]},"institutions":[{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Daichi Hayakawa","raw_affiliation_strings":["School of Pharmacy, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan","institution_ids":["https://openalex.org/I119182057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110590426","display_name":"Hiroaki Gouda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroaki Gouda","raw_affiliation_strings":["School of Pharmacy, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan","institution_ids":["https://openalex.org/I119182057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006145523","display_name":"Masashi Yanagisawa","orcid":"https://orcid.org/0000-0002-7358-4022","observed_orcids":["https://orcid.org/0000-0002-7358-4022"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I4405286304","display_name":"International Institute for Integrative Sleep Medicine, University of Tsukuba","ror":"https://ror.org/01s1qrh29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I146399215","https://openalex.org/I4405286304"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masashi Yanagisawa","raw_affiliation_strings":["International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan","institution_ids":["https://openalex.org/I146399215","https://openalex.org/I4405286304"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029754237","display_name":"Hiroshi Nagase","orcid":"https://orcid.org/0000-0003-0428-3979","observed_orcids":["https://orcid.org/0000-0003-0428-3979"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I4405286304","display_name":"International Institute for Integrative Sleep Medicine, University of Tsukuba","ror":"https://ror.org/01s1qrh29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I146399215","https://openalex.org/I4405286304"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hiroshi Nagase","raw_affiliation_strings":["International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan; Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571, Japan. Electronic address: nagase.hiroshi.gt@u.tsukuba.ac.jp","Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571, Japan","International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan; Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571, Japan. Electronic address: nagase.hiroshi.gt@u.tsukuba.ac.jp","institution_ids":["https://openalex.org/I146399215","https://openalex.org/I4405286304"]},{"raw_affiliation_string":"Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571, Japan","institution_ids":["https://openalex.org/I146399215"]},{"raw_affiliation_string":"International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan","institution_ids":["https://openalex.org/I146399215","https://openalex.org/I4405286304"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5029754237"],"corresponding_institution_ids":["https://openalex.org/I146399215","https://openalex.org/I4405286304"],"apc_list":{"value":3880,"currency":"USD","value_usd":3880},"apc_paid":null,"fwci":0.7793,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.67428869,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"27","issue":"17","first_page":"4176","last_page":"4179"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.4302000105381012,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.4302000105381012,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.257099986076355,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.04039999842643738,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/orexin-1-receptor","display_name":"orexin-1 receptor","score":0.9449999928474426},{"id":"https://openalex.org/keywords/orexin-receptor-antagonists","display_name":"orexin receptor antagonists","score":0.7760000228881836},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.7229999899864197},{"id":"https://openalex.org/keywords/kappa-opioid-receptor","display_name":"kappa opioid receptor","score":0.7139999866485596},{"id":"https://openalex.org/keywords/receptor-conformation","display_name":"receptor conformation","score":0.6010000109672546},{"id":"https://openalex.org/keywords/ligand-design","display_name":"ligand design","score":0.8309999704360962}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7969385385513306},{"id":"https://openalex.org/C2779680196","wikidata":"https://www.wikidata.org/wiki/Q410857","display_name":"Orexin","level":4,"score":0.7906635999679565},{"id":"https://openalex.org/C2778439535","wikidata":"https://www.wikidata.org/wiki/Q188777","display_name":"Amide","level":2,"score":0.7420540452003479},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.6870298385620117},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.6355695128440857},{"id":"https://openalex.org/C2780378348","wikidata":"https://www.wikidata.org/wiki/Q25351438","display_name":"Ring (chemistry)","level":2,"score":0.5990435481071472},{"id":"https://openalex.org/C2781039511","wikidata":"https://www.wikidata.org/wiki/Q3208529","display_name":"Sulfonamide","level":2,"score":0.42341890931129456},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.371049165725708},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1307733654975891},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.12372660636901855},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.09407117962837219}],"mesh":[{"descriptor_ui":"D000068796","descriptor_name":"Orexin Receptor Antagonists","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000068796","descriptor_name":"Orexin Receptor Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000068796","descriptor_name":"Orexin Receptor Antagonists","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004852","descriptor_name":"Epoxy Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004852","descriptor_name":"Epoxy Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009019","descriptor_name":"Morphinans","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D009019","descriptor_name":"Morphinans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009019","descriptor_name":"Morphinans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064446","descriptor_name":"Orexin Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bmcl.2017.07.011","doi":"https://doi.org/10.1016/j.bmcl.2017.07.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmcl.2017.07.011","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry Letters","raw_type":"journal-article"},{"id":"pmid:28739044","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28739044","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & medicinal chemistry letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3849557511","display_name":"Development of novel molecular tool for controlling sleep/wake cycle and feeding behavior","funder_award_id":"15K16557","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4189837525","display_name":"Development of novel orexin ligand and its pharmacological activity","funder_award_id":"16H05098","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5078116074","display_name":null,"funder_award_id":"15H05935","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6400963134","display_name":null,"funder_award_id":"15H05942","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7546261634","display_name":"Elucidation of sleep/wakefulness regulation using forward genetic approach","funder_award_id":"17H06095","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320324230","display_name":"Toray Industries","ror":"https://ror.org/029xh1r47"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1239436365","https://openalex.org/W1498679715","https://openalex.org/W1902706583","https://openalex.org/W1980363663","https://openalex.org/W1996497736","https://openalex.org/W2001453572","https://openalex.org/W2002518106","https://openalex.org/W2008852855","https://openalex.org/W2020469752","https://openalex.org/W2026264690","https://openalex.org/W2027740042","https://openalex.org/W2086378665","https://openalex.org/W2088682619","https://openalex.org/W2095108407","https://openalex.org/W2115861749","https://openalex.org/W2129357751","https://openalex.org/W2152211310","https://openalex.org/W2321068107","https://openalex.org/W2568178450","https://openalex.org/W2950657421"],"related_works":["https://openalex.org/W2963354076","https://openalex.org/W2918739196","https://openalex.org/W2780974634","https://openalex.org/W2995396055","https://openalex.org/W870632595","https://openalex.org/W3155605937","https://openalex.org/W4205213523","https://openalex.org/W4206843600","https://openalex.org/W4220652845","https://openalex.org/W7208272686"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-07-14T00:00:00"}