{"id":"https://openalex.org/W2730775751","doi":"https://doi.org/10.1016/j.ymben.2017.06.012","title":"A translational synthetic biology platform for rapid access to gram-scale quantities of novel drug-like molecules","display_name":"A translational synthetic biology platform for rapid access to gram-scale quantities of novel drug-like molecules","publication_year":2017,"publication_date":"2017-07-01","ids":{"openalex":"https://openalex.org/W2730775751","doi":"https://doi.org/10.1016/j.ymben.2017.06.012","mag":"2730775751","pmid":"https://pubmed.ncbi.nlm.nih.gov/28687337","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5555447"},"language":"en","primary_location":{"id":"doi:10.1016/j.ymben.2017.06.012","doi":"https://doi.org/10.1016/j.ymben.2017.06.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ymben.2017.06.012","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1096717617300629/pdf","source":{"id":"https://openalex.org/S173328182","display_name":"Metabolic Engineering","issn_l":"1096-7176","issn":["1096-7176","1096-7184"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolic Engineering","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S1096717617300629/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023618309","display_name":"James Reed","orcid":"https://orcid.org/0000-0001-5780-6134","observed_orcids":["https://orcid.org/0000-0001-5780-6134"]},"institutions":[{"id":"https://openalex.org/I100288624","display_name":"John Innes Centre","ror":"https://ror.org/055zmrh94","country_code":"GB","type":"facility","lineage":["https://openalex.org/I100288624","https://openalex.org/I2799693246","https://openalex.org/I4210087105"]},{"id":"https://openalex.org/I2799300731","display_name":"Norwich Research Park","ror":"https://ror.org/0062dz060","country_code":"GB","type":"archive","lineage":["https://openalex.org/I2799300731"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James Reed","raw_affiliation_strings":["Department of Metabolic Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Metabolic Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK","institution_ids":["https://openalex.org/I100288624","https://openalex.org/I2799300731"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060489857","display_name":"Michael J. Stephenson","orcid":"https://orcid.org/0000-0002-2594-1806","observed_orcids":["https://orcid.org/0000-0002-2594-1806"]},"institutions":[{"id":"https://openalex.org/I100288624","display_name":"John Innes Centre","ror":"https://ror.org/055zmrh94","country_code":"GB","type":"facility","lineage":["https://openalex.org/I100288624","https://openalex.org/I2799693246","https://openalex.org/I4210087105"]},{"id":"https://openalex.org/I2799300731","display_name":"Norwich Research Park","ror":"https://ror.org/0062dz060","country_code":"GB","type":"archive","lineage":["https://openalex.org/I2799300731"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael J. Stephenson","raw_affiliation_strings":["Department of Metabolic Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Metabolic Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK","institution_ids":["https://openalex.org/I100288624","https://openalex.org/I2799300731"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006192079","display_name":"Karel Miettinen","orcid":"https://orcid.org/0000-0003-2496-8924","observed_orcids":["https://orcid.org/0000-0003-2496-8924"]},"institutions":[{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]},{"id":"https://openalex.org/I4210098178","display_name":"VIB-UGent Center for Plant Systems Biology","ror":"https://ror.org/01qnqmc89","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950","https://openalex.org/I32597200","https://openalex.org/I4210098178"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Karel Miettinen","raw_affiliation_strings":["Department of Plant Systems Biology, VIB, Ghent University, B-9052 Gent, Belgium; Department of Plant Biotechnology and Bioinformatics, Ghent University, B-9052 Gent, Belgium","Department of Plant Biotechnology and Bioinformatics, Ghent University, B-9052 Gent, Belgium","Department of Plant Systems Biology, VIB, Ghent University, B-9052 Gent, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plant Systems Biology, VIB, Ghent University, B-9052 Gent, Belgium; Department of Plant Biotechnology and Bioinformatics, Ghent University, B-9052 Gent, Belgium","institution_ids":["https://openalex.org/I32597200","https://openalex.org/I4210098178"]},{"raw_affiliation_string":"Department of Plant Biotechnology and Bioinformatics, Ghent University, B-9052 Gent, Belgium","institution_ids":["https://openalex.org/I32597200"]},{"raw_affiliation_string":"Department of Plant Systems Biology, VIB, Ghent University, B-9052 Gent, Belgium","institution_ids":["https://openalex.org/I32597200","https://openalex.org/I4210098178"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005783876","display_name":"Bastiaan Brouwer","orcid":"https://orcid.org/0000-0002-6609-982X","observed_orcids":["https://orcid.org/0000-0002-6609-982X"]},"institutions":[{"id":"https://openalex.org/I100288624","display_name":"John Innes Centre","ror":"https://ror.org/055zmrh94","country_code":"GB","type":"facility","lineage":["https://openalex.org/I100288624","https://openalex.org/I2799693246","https://openalex.org/I4210087105"]},{"id":"https://openalex.org/I2799300731","display_name":"Norwich Research Park","ror":"https://ror.org/0062dz060","country_code":"GB","type":"archive","lineage":["https://openalex.org/I2799300731"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Bastiaan Brouwer","raw_affiliation_strings":["Department of Metabolic Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Metabolic Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK","institution_ids":["https://openalex.org/I100288624","https://openalex.org/I2799300731"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030534290","display_name":"Aymeric Leveau","orcid":"https://orcid.org/0000-0002-1312-9212","observed_orcids":["https://orcid.org/0000-0002-1312-9212"]},"institutions":[{"id":"https://openalex.org/I100288624","display_name":"John Innes Centre","ror":"https://ror.org/055zmrh94","country_code":"GB","type":"facility","lineage":["https://openalex.org/I100288624","https://openalex.org/I2799693246","https://openalex.org/I4210087105"]},{"id":"https://openalex.org/I2799300731","display_name":"Norwich Research Park","ror":"https://ror.org/0062dz060","country_code":"GB","type":"archive","lineage":["https://openalex.org/I2799300731"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Aymeric Leveau","raw_affiliation_strings":["Department of Metabolic Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Metabolic Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK","institution_ids":["https://openalex.org/I100288624","https://openalex.org/I2799300731"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Paul Brett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100288624","display_name":"John Innes Centre","ror":"https://ror.org/055zmrh94","country_code":"GB","type":"facility","lineage":["https://openalex.org/I100288624","https://openalex.org/I2799693246","https://openalex.org/I4210087105"]},{"id":"https://openalex.org/I2799300731","display_name":"Norwich Research Park","ror":"https://ror.org/0062dz060","country_code":"GB","type":"archive","lineage":["https://openalex.org/I2799300731"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul Brett","raw_affiliation_strings":["Department of Metabolic Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Metabolic Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK","institution_ids":["https://openalex.org/I100288624","https://openalex.org/I2799300731"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073970185","display_name":"Rebecca J. M. Goss","orcid":"https://orcid.org/0000-0001-9869-8205","observed_orcids":["https://orcid.org/0000-0001-9869-8205"]},"institutions":[{"id":"https://openalex.org/I1118541","display_name":"University of East Anglia","ror":"https://ror.org/026k5mg93","country_code":"GB","type":"education","lineage":["https://openalex.org/I1118541"]},{"id":"https://openalex.org/I16835326","display_name":"University of St Andrews","ror":"https://ror.org/02wn5qz54","country_code":"GB","type":"education","lineage":["https://openalex.org/I16835326"]},{"id":"https://openalex.org/I2799300731","display_name":"Norwich Research Park","ror":"https://ror.org/0062dz060","country_code":"GB","type":"archive","lineage":["https://openalex.org/I2799300731"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rebecca J.M. Goss","raw_affiliation_strings":["School of Chemistry, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK; School of Chemistry, University of St Andrews, KY16 9ST, UK","School of Chemistry, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK","School of Chemistry, University of St Andrews, KY16 9ST, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK; School of Chemistry, University of St Andrews, KY16 9ST, UK","institution_ids":["https://openalex.org/I1118541","https://openalex.org/I16835326","https://openalex.org/I2799300731"]},{"raw_affiliation_string":"School of Chemistry, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK","institution_ids":["https://openalex.org/I1118541","https://openalex.org/I2799300731"]},{"raw_affiliation_string":"School of Chemistry, University of St Andrews, KY16 9ST, UK","institution_ids":["https://openalex.org/I16835326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067792630","display_name":"Alain Goossens","orcid":"https://orcid.org/0000-0002-1599-551X","observed_orcids":["https://orcid.org/0000-0002-1599-551X"]},"institutions":[{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]},{"id":"https://openalex.org/I4210098178","display_name":"VIB-UGent Center for Plant Systems Biology","ror":"https://ror.org/01qnqmc89","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950","https://openalex.org/I32597200","https://openalex.org/I4210098178"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Alain Goossens","raw_affiliation_strings":["Department of Plant Systems Biology, VIB, Ghent University, B-9052 Gent, Belgium; Department of Plant Biotechnology and Bioinformatics, Ghent University, B-9052 Gent, Belgium","Department of Plant Biotechnology and Bioinformatics, Ghent University, B-9052 Gent, Belgium","Department of Plant Systems Biology, VIB, Ghent University, B-9052 Gent, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plant Systems Biology, VIB, Ghent University, B-9052 Gent, Belgium; Department of Plant Biotechnology and Bioinformatics, Ghent University, B-9052 Gent, Belgium","institution_ids":["https://openalex.org/I32597200","https://openalex.org/I4210098178"]},{"raw_affiliation_string":"Department of Plant Biotechnology and Bioinformatics, Ghent University, B-9052 Gent, Belgium","institution_ids":["https://openalex.org/I32597200"]},{"raw_affiliation_string":"Department of Plant Systems Biology, VIB, Ghent University, B-9052 Gent, Belgium","institution_ids":["https://openalex.org/I32597200","https://openalex.org/I4210098178"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000339438","display_name":"Maria Anne O'Connell","orcid":"https://orcid.org/0000-0002-0267-0951","observed_orcids":["https://orcid.org/0000-0002-0267-0951"]},"institutions":[{"id":"https://openalex.org/I1118541","display_name":"University of East Anglia","ror":"https://ror.org/026k5mg93","country_code":"GB","type":"education","lineage":["https://openalex.org/I1118541"]},{"id":"https://openalex.org/I2799300731","display_name":"Norwich Research Park","ror":"https://ror.org/0062dz060","country_code":"GB","type":"archive","lineage":["https://openalex.org/I2799300731"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Maria A. O\u2019Connell","raw_affiliation_strings":["School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK","institution_ids":["https://openalex.org/I1118541","https://openalex.org/I2799300731"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082572225","display_name":"Anne Osbourn","orcid":"https://orcid.org/0000-0003-2195-5810","observed_orcids":["https://orcid.org/0000-0003-2195-5810"]},"institutions":[{"id":"https://openalex.org/I100288624","display_name":"John Innes Centre","ror":"https://ror.org/055zmrh94","country_code":"GB","type":"facility","lineage":["https://openalex.org/I100288624","https://openalex.org/I2799693246","https://openalex.org/I4210087105"]},{"id":"https://openalex.org/I2799300731","display_name":"Norwich Research Park","ror":"https://ror.org/0062dz060","country_code":"GB","type":"archive","lineage":["https://openalex.org/I2799300731"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Anne Osbourn","raw_affiliation_strings":["Department of Metabolic Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK. Electronic address: anne.osbourn@jic.ac.uk","Department of Metabolic Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Metabolic Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK. Electronic address: anne.osbourn@jic.ac.uk","institution_ids":["https://openalex.org/I100288624","https://openalex.org/I2799300731"]},{"raw_affiliation_string":"Department of Metabolic Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK","institution_ids":["https://openalex.org/I100288624","https://openalex.org/I2799300731"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5082572225"],"corresponding_institution_ids":["https://openalex.org/I100288624","https://openalex.org/I2799300731"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":{"value":4780,"currency":"USD","value_usd":4780},"fwci":7.2089,"has_fulltext":true,"cited_by_count":207,"citation_normalized_percentile":{"value":0.9823764,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"42","issue":null,"first_page":"185","last_page":"193"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10240","display_name":"Plant tissue culture and regeneration","score":0.01590000092983246,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12856","display_name":"Transgenic Plants and Applications","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triterpenoids","display_name":"triterpenoids","score":0.8619999885559082},{"id":"https://openalex.org/keywords/plant-natural-products","display_name":"plant natural products","score":0.6470000147819519},{"id":"https://openalex.org/keywords/pathway-engineering","display_name":"pathway engineering","score":0.7110000252723694},{"id":"https://openalex.org/keywords/combinatorial-biosynthesis","display_name":"combinatorial biosynthesis","score":0.8450000286102295},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.8939999938011169},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":1.0},{"id":"https://openalex.org/keywords/drug-leads","display_name":"drug leads","score":0.48399999737739563},{"id":"https://openalex.org/keywords/plant-synthetic-biology","display_name":"plant synthetic biology","score":0.6200000047683716},{"id":"https://openalex.org/keywords/genome-mining","display_name":"genome mining","score":0.503000020980835},{"id":"https://openalex.org/keywords/heterologous-expression","display_name":"heterologous expression","score":0.4950000047683716}],"concepts":[{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.739182710647583},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6745301485061646},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.6628742218017578},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.576103925704956},{"id":"https://openalex.org/C6350086","wikidata":"https://www.wikidata.org/wiki/Q6822347","display_name":"Metabolic engineering","level":3,"score":0.575411856174469},{"id":"https://openalex.org/C2779396153","wikidata":"https://www.wikidata.org/wiki/Q901227","display_name":"Natural product","level":2,"score":0.5286023020744324},{"id":"https://openalex.org/C171852809","wikidata":"https://www.wikidata.org/wiki/Q731154","display_name":"Chemical biology","level":2,"score":0.5074893832206726},{"id":"https://openalex.org/C2780527577","wikidata":"https://www.wikidata.org/wiki/Q2915788","display_name":"Triterpene","level":3,"score":0.4975116550922394},{"id":"https://openalex.org/C99726746","wikidata":"https://www.wikidata.org/wiki/Q906396","display_name":"Chemical space","level":3,"score":0.44803285598754883},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.4232119619846344},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.34300661087036133},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.33608394861221313},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32959675788879395},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014026","descriptor_name":"Nicotiana","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D014026","descriptor_name":"Nicotiana","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014315","descriptor_name":"Triterpenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016679","descriptor_name":"Genome, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017798","descriptor_name":"Comovirus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D017798","descriptor_name":"Comovirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018554","descriptor_name":"Avena","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D018554","descriptor_name":"Avena","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018745","descriptor_name":"Genome, Plant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D058615","descriptor_name":"Synthetic Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":9,"locations":[{"id":"doi:10.1016/j.ymben.2017.06.012","doi":"https://doi.org/10.1016/j.ymben.2017.06.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ymben.2017.06.012","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1096717617300629/pdf","source":{"id":"https://openalex.org/S173328182","display_name":"Metabolic Engineering","issn_l":"1096-7176","issn":["1096-7176","1096-7184"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolic Engineering","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4460396","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5555447","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:28687337","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28687337","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolic engineering","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5555447","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5555447/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metab Eng","raw_type":"Text"},{"id":"pmh:oai:ueaeprints.uea.ac.uk:64081","doi":null,"is_oa":true,"landing_page_url":"https://ueaeprints.uea.ac.uk/id/eprint/64081/7/Published_manuscript.pdf","pdf_url":"https://ueaeprints.uea.ac.uk/id/eprint/64081/7/Published_manuscript.pdf","source":{"id":"https://openalex.org/S4306400384","display_name":"UEA Digital Repository (University of East Anglia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1118541","host_organization_name":"University of East Anglia","host_organization_lineage":["https://openalex.org/I1118541"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:library.wur.nl:wurpubs/536688","doi":null,"is_oa":true,"landing_page_url":"https://research.wur.nl/en/publications/a-translational-synthetic-biology-platform-for-rapid-access-to-gr","pdf_url":null,"source":{"id":"https://openalex.org/S4210201231","display_name":"Socio-Environmental Systems Modeling","issn_l":"2663-3027","issn":["2663-3027"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ISSN: 1096-7176","raw_type":"Article/Letter to editor"},{"id":"pmh:oai:archive.ugent.be:8528589","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1854/LU-8528589","pdf_url":null,"source":{"id":"https://openalex.org/S4306400478","display_name":"Ghent University Academic Bibliography (Ghent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32597200","host_organization_name":"Ghent University","host_organization_lineage":["https://openalex.org/I32597200"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1096-7184","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:research-repository.st-andrews.ac.uk:10023/14876","doi":null,"is_oa":true,"landing_page_url":"http://www.sciencedirect.com/science/article/pii/S1096717617300629#appd002","pdf_url":null,"source":{"id":"https://openalex.org/S4306400230","display_name":"St Andrews Research Repository (St Andrews Research Repository)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I16835326","host_organization_name":"University of St Andrews","host_organization_lineage":["https://openalex.org/I16835326"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal article"},{"id":"pmh:wur:oai:library.wur.nl:wurpubs/536688","doi":null,"is_oa":true,"landing_page_url":"https://research.wur.nl/en/publications/a-translational-synthetic-biology-platform-for-rapid-access-to-gr","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Metabolic Engineering, 42, 185 - 193","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.ymben.2017.06.012","doi":"https://doi.org/10.1016/j.ymben.2017.06.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ymben.2017.06.012","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1096717617300629/pdf","source":{"id":"https://openalex.org/S173328182","display_name":"Metabolic Engineering","issn_l":"1096-7176","issn":["1096-7176","1096-7184"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolic Engineering","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1491051197","display_name":"An integrated pipeline for accelerated plant natural product discovery","funder_award_id":"U01GM110699","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1600231218","display_name":null,"funder_award_id":"BB/KEC1740/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G2111243252","display_name":"OpenPlant","funder_award_id":"BB/L014130/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G2602236700","display_name":null,"funder_award_id":"BB/J004561/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G2605859761","display_name":null,"funder_award_id":"FP7/2007\u20132013/ERC","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3207356259","display_name":null,"funder_award_id":"2007\u20132013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3245340846","display_name":null,"funder_award_id":"L014130/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G393177772","display_name":null,"funder_award_id":"FP7 2007-2013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3933816714","display_name":"Products and Pathways","funder_award_id":"BBS/E/J/000PR9790","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G497134808","display_name":null,"funder_award_id":"BB/J004561","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G5098103463","display_name":null,"funder_award_id":"KBBE-2013-7","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5315601087","display_name":null,"funder_award_id":"BBS/E/J/00000614","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G561220631","display_name":"A pipeline for the discovery, sustainable production and commercial utilisation of known and novel highvalue triterpenes with new or superior biological activities","funder_award_id":"BBS/E/J/000CA533","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G5702163051","display_name":null,"funder_award_id":"FP7/2007","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G6058970702","display_name":"Enhanced Research Capacity","funder_award_id":"BBS/E/J/000PR9794","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G6169048166","display_name":"Industrial saponins","funder_award_id":"BB/M028712/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G7130091639","display_name":"GenoChemetics: Gene eXpression enabling selective Chemical functionalisation of natural products","funder_award_id":"614779","funder_id":"https://openalex.org/F4320338352","funder_display_name":"FP7 Ideas: European Research Council"},{"id":"https://openalex.org/G7331214210","display_name":"Industrial Saponins","funder_award_id":"BB/M028860/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G8275834155","display_name":null,"funder_award_id":"BB/L014130/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320320274","display_name":"University of East Anglia","ror":"https://ror.org/026k5mg93"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320322302","display_name":"John Innes Foundation","ror":"https://ror.org/04kg99k11"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320338352","display_name":"FP7 Ideas: European Research Council","ror":"https://ror.org/0472cxd90"},{"id":"https://openalex.org/F4320338366","display_name":"FP7 Food, Agriculture and Fisheries, Biotechnology","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2730775751.pdf","grobid_xml":"https://content.openalex.org/works/W2730775751.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W187082877","https://openalex.org/W1433145980","https://openalex.org/W1540714253","https://openalex.org/W1777456466","https://openalex.org/W1973577260","https://openalex.org/W1977109110","https://openalex.org/W1983433251","https://openalex.org/W1987384526","https://openalex.org/W1990226486","https://openalex.org/W2007647639","https://openalex.org/W2011945340","https://openalex.org/W2012111825","https://openalex.org/W2023075963","https://openalex.org/W2057745527","https://openalex.org/W2059041677","https://openalex.org/W2059392661","https://openalex.org/W2070429529","https://openalex.org/W2072553353","https://openalex.org/W2073082596","https://openalex.org/W2073430126","https://openalex.org/W2076962157","https://openalex.org/W2087644906","https://openalex.org/W2088226047","https://openalex.org/W2097693284","https://openalex.org/W2099852670","https://openalex.org/W2108479449","https://openalex.org/W2109449758","https://openalex.org/W2141542965","https://openalex.org/W2148058118","https://openalex.org/W2150283664","https://openalex.org/W2155758567","https://openalex.org/W2158359278","https://openalex.org/W2166323054","https://openalex.org/W2206786119","https://openalex.org/W2223798378","https://openalex.org/W2241030903","https://openalex.org/W2277034243","https://openalex.org/W2284275798","https://openalex.org/W2286908285","https://openalex.org/W2293809279","https://openalex.org/W2463962543","https://openalex.org/W2466338408","https://openalex.org/W2466635249","https://openalex.org/W2469380440","https://openalex.org/W2552766887","https://openalex.org/W2586211853","https://openalex.org/W2615632419","https://openalex.org/W4211227222"],"related_works":["https://openalex.org/W2085268061","https://openalex.org/W3046215410","https://openalex.org/W2885667319","https://openalex.org/W2444500095","https://openalex.org/W2892253780","https://openalex.org/W4396841368","https://openalex.org/W7223128597","https://openalex.org/W7223413009","https://openalex.org/W4294719365","https://openalex.org/W3182432504"],"abstract_inverted_index":{"Plants":[0],"are":[1,113,174],"an":[2,164],"excellent":[3],"source":[4,15],"of":[5,31,39,79,90,93,101,119,141,159,169,187,203,205],"drug":[6,49,252],"leads.":[7],"However":[8],"availability":[9],"is":[10,27,64],"limited":[11],"by":[12],"access":[13,239],"to":[14,21,66,72,115,129,167,176,183,236,250],"species,":[16],"low":[17],"abundance":[18],"and":[19,88,96,108,150,191,196,210,225,238,244,246],"recalcitrance":[20],"chemical":[22,177],"synthesis.":[23,178],"Although":[24],"plant":[25,80,102,222,228],"genomics":[26],"yielding":[28],"a":[29,52,124,185],"wealth":[30],"genes":[32],"for":[33,46,60,84,148,157,208,221],"natural":[34,103,242],"product":[35],"biosynthesis,":[36],"the":[37,57,77,94,142,155,248],"translation":[38],"this":[40,134,181,206,231],"genetic":[41],"information":[42],"into":[43],"small":[44],"molecules":[45],"evaluation":[47],"as":[48],"leads":[50],"represents":[51],"major":[53],"bottleneck.":[54],"For":[55],"example,":[56],"yeast":[58],"platform":[59,182],"artemisinic":[61],"acid":[62],"production":[63],"estimated":[65],"have":[67],"taken":[68],">150":[69],"person":[70],"years":[71],"develop.":[73],"Here":[74],"we":[75,112],"demonstrate":[76,192],"power":[78],"transient":[81],"transfection":[82],"technology":[83],"rapid,":[85],"scalable":[86],"biosynthesis":[87,153],"isolation":[89],"triterpenes,":[91],"one":[92],"largest":[95],"most":[97],"structurally":[98],"diverse":[99],"families":[100],"products.":[104],"Using":[105],"pathway":[106,223],"engineering":[107],"improved":[109],"agro-infiltration":[110],"methodology":[111],"able":[114],"generate":[116],"gram-scale":[117],"quantities":[118],"purified":[120],"triterpene":[121,189],"in":[122,132,194,199,227],"just":[123],"few":[125],"weeks.":[126],"In":[127],"contrast":[128],"heterologous":[130],"expression":[131],"microbes,":[133],"system":[135,207],"does":[136],"not":[137],"depend":[138],"on":[139],"re-engineering":[140],"host.":[143],"We":[144,179],"next":[145],"exploit":[146],"agro-infection":[147],"quick":[149],"easy":[151,165],"combinatorial":[152],"without":[154],"need":[156],"generation":[158],"multi-gene":[160],"constructs,":[161],"so":[162],"affording":[163],"entr\u00e9e":[166],"suites":[168],"molecules,":[170],"some":[171],"new-to-nature,":[172],"that":[173],"recalcitrant":[175],"use":[180],"purify":[184],"suite":[186],"bespoke":[188],"analogs":[190,245],"differences":[193],"anti-proliferative":[195],"anti-inflammatory":[197],"activity":[198],"bioassays,":[200],"providing":[201],"proof":[202],"concept":[204],"accessing":[209],"evaluating":[211],"medicinally":[212],"important":[213],"bioactives.":[214],"Together":[215],"with":[216],"new":[217,234],"genome":[218],"mining":[219],"algorithms":[220],"discovery":[224,253],"advances":[226],"synthetic":[229],"biology,":[230],"advance":[232],"provides":[233],"routes":[235],"synthesize":[237],"previously":[240],"inaccessible":[241],"products":[243],"has":[247],"potential":[249],"reinvigorate":[251],"pipelines.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":23},{"year":2025,"cited_by_count":23},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":22},{"year":2022,"cited_by_count":26},{"year":2021,"cited_by_count":20},{"year":2020,"cited_by_count":22},{"year":2019,"cited_by_count":24},{"year":2018,"cited_by_count":20},{"year":2017,"cited_by_count":8}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2017-07-14T00:00:00"}
