{"id":"https://openalex.org/W2730696646","doi":null,"title":"Tyrosine Phosphorylation of the RUNX1 Transcription Factor by Src Kinase Activates C/EBP-Alpha in Granulopoiesis","display_name":"Tyrosine Phosphorylation of the RUNX1 Transcription Factor by Src Kinase Activates C/EBP-Alpha in Granulopoiesis","publication_year":2016,"publication_date":"2016-03-04","ids":{"openalex":"https://openalex.org/W2730696646","mag":"2730696646"},"language":"en","primary_location":{"id":"mag:2730696646","doi":null,"is_oa":false,"landing_page_url":"https://jscholarship.library.jhu.edu/handle/1774.2/39703","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021729143","display_name":"Wan Yee Leong","orcid":"https://orcid.org/0009-0003-7311-8245","observed_orcids":["https://orcid.org/0009-0003-7311-8245"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Wan Yee Leong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5021729143"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.3589000105857849,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.3589000105857849,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.10689999908208847,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.07370000332593918,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/runx1","display_name":"RUNX1","score":0.9570000171661377},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.8859999775886536},{"id":"https://openalex.org/keywords/src-kinase","display_name":"Src kinase","score":0.953000009059906},{"id":"https://openalex.org/keywords/c-ebpalpha","display_name":"C/EBP\u03b1","score":0.972000002861023},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.7699999809265137},{"id":"https://openalex.org/keywords/granulopoiesis","display_name":"granulopoiesis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/hematopoiesis","display_name":"hematopoiesis","score":0.75},{"id":"https://openalex.org/keywords/transcription-factor-regulation","display_name":"transcription factor regulation","score":0.4410000145435333}],"concepts":[{"id":"https://openalex.org/C2779452902","wikidata":"https://www.wikidata.org/wiki/Q5596845","display_name":"Granulopoiesis","level":4,"score":0.6053115725517273},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.5643927454948425},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5408802628517151},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.49704769253730774},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.47703665494918823},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.41698721051216125},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3323184549808502},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.29649171233177185},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2686992287635803},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24404001235961914},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.15212580561637878},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.08190193772315979},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.06681153178215027},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2730696646","doi":null,"is_oa":false,"landing_page_url":"https://jscholarship.library.jhu.edu/handle/1774.2/39703","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.428600013256073}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W201291539","https://openalex.org/W1575193685","https://openalex.org/W1620920429","https://openalex.org/W1669954301","https://openalex.org/W1806289727","https://openalex.org/W1926039203","https://openalex.org/W1963681345","https://openalex.org/W1967037408","https://openalex.org/W1979431731","https://openalex.org/W1980706177","https://openalex.org/W1980847136","https://openalex.org/W1982721874","https://openalex.org/W1991766825","https://openalex.org/W2000035590","https://openalex.org/W2001409033","https://openalex.org/W2003617876","https://openalex.org/W2013313605","https://openalex.org/W2015474402","https://openalex.org/W2016127034","https://openalex.org/W2016810616","https://openalex.org/W2017703589","https://openalex.org/W2025187528","https://openalex.org/W2025545218","https://openalex.org/W2036716852","https://openalex.org/W2040080187","https://openalex.org/W2046907229","https://openalex.org/W2047945891","https://openalex.org/W2055089337","https://openalex.org/W2066629796","https://openalex.org/W2067098092","https://openalex.org/W2068120597","https://openalex.org/W2068728784","https://openalex.org/W2074506458","https://openalex.org/W2077193261","https://openalex.org/W2085033687","https://openalex.org/W2086370314","https://openalex.org/W2095032938","https://openalex.org/W2095157641","https://openalex.org/W2098553212","https://openalex.org/W2101518963","https://openalex.org/W2101818488","https://openalex.org/W2108718836","https://openalex.org/W2109521356","https://openalex.org/W2110918588","https://openalex.org/W2125148508","https://openalex.org/W2133339791","https://openalex.org/W2135657623","https://openalex.org/W2140277442","https://openalex.org/W2142780571","https://openalex.org/W2144664431","https://openalex.org/W2153953632","https://openalex.org/W2155442828","https://openalex.org/W2170425393","https://openalex.org/W2184881790","https://openalex.org/W2231217801"],"related_works":["https://openalex.org/W2528129701","https://openalex.org/W2231217801","https://openalex.org/W1964103753","https://openalex.org/W7098450199","https://openalex.org/W2550148788","https://openalex.org/W2565751798","https://openalex.org/W3135183640","https://openalex.org/W6913070293","https://openalex.org/W2022815760","https://openalex.org/W190109663"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2017-07-14T00:00:00"}
