{"id":"https://openalex.org/W2730397238","doi":null,"title":"Association of Androgen Receptor Gene Polymorphisms at three SNPs and their Haplotypes with Severe Oligozoospermia Risk in Iraqi Patients","display_name":"Association of Androgen Receptor Gene Polymorphisms at three SNPs and their Haplotypes with Severe Oligozoospermia Risk in Iraqi Patients","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2730397238","mag":"2730397238"},"language":"en","primary_location":{"id":"pmh:oai:ojs2.jige.uobaghdad.edu.iq:article/64","doi":null,"is_oa":true,"landing_page_url":"https://jige.uobaghdad.edu.iq/index.php/IJB/article/view/64","pdf_url":"https://jige.uobaghdad.edu.iq/index.php/IJB/article/download/64/37","source":{"id":"https://openalex.org/S7407059197","display_name":"Numerical Methods in Civil Engineering","issn_l":"1815-4794","issn":["1815-4794"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319170","host_organization_name":"University of Baghdad","host_organization_lineage":["https://openalex.org/P4310319170"],"host_organization_lineage_names":["University of Baghdad"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1815-4794","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jige.uobaghdad.edu.iq/index.php/IJB/article/download/64/37","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090165361","display_name":"Mustafa F. Khadhim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mustafa F. Khadhim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5023782703","display_name":"Ismail A. Abdul-Hassan","orcid":"https://orcid.org/0000-0003-1583-1870","observed_orcids":["https://orcid.org/0000-0003-1583-1870"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ismail A. Abdul-Hassan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1583-1870","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"16","issue":"1","first_page":"16","last_page":"28"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/androgen-receptor-gene","display_name":"androgen receptor gene","score":0.921999990940094},{"id":"https://openalex.org/keywords/androgen-receptor-polymorphism","display_name":"androgen receptor polymorphism","score":0.734000027179718},{"id":"https://openalex.org/keywords/severe-oligozoospermia","display_name":"severe oligozoospermia","score":0.8519999980926514},{"id":"https://openalex.org/keywords/male-infertility","display_name":"male infertility","score":0.9810000061988831},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.953000009059906},{"id":"https://openalex.org/keywords/haplotypes","display_name":"haplotypes","score":0.8769999742507935},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.7080000042915344},{"id":"https://openalex.org/keywords/iraqi-patients","display_name":"Iraqi patients","score":0.9150000214576721}],"concepts":[{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.8494670391082764},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.7512869834899902},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6733542680740356},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5723901987075806},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5156601667404175},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.500126838684082},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.37207484245300293},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3625514507293701},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.2816212773323059},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.08057504892349243}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:ojs2.jige.uobaghdad.edu.iq:article/64","doi":null,"is_oa":true,"landing_page_url":"https://jige.uobaghdad.edu.iq/index.php/IJB/article/view/64","pdf_url":"https://jige.uobaghdad.edu.iq/index.php/IJB/article/download/64/37","source":{"id":"https://openalex.org/S7407059197","display_name":"Numerical Methods in Civil Engineering","issn_l":"1815-4794","issn":["1815-4794"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319170","host_organization_name":"University of Baghdad","host_organization_lineage":["https://openalex.org/P4310319170"],"host_organization_lineage_names":["University of Baghdad"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1815-4794","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2730397238","doi":null,"is_oa":false,"landing_page_url":"https://www.iasj.net/iasj?func=article&aId=122202","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:ojs2.jige.uobaghdad.edu.iq:article/64","doi":null,"is_oa":true,"landing_page_url":"https://jige.uobaghdad.edu.iq/index.php/IJB/article/view/64","pdf_url":"https://jige.uobaghdad.edu.iq/index.php/IJB/article/download/64/37","source":{"id":"https://openalex.org/S7407059197","display_name":"Numerical Methods in Civil Engineering","issn_l":"1815-4794","issn":["1815-4794"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319170","host_organization_name":"University of Baghdad","host_organization_lineage":["https://openalex.org/P4310319170"],"host_organization_lineage_names":["University of Baghdad"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1815-4794","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2730397238.pdf","grobid_xml":"https://content.openalex.org/works/W2730397238.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W655074629","https://openalex.org/W1546185806","https://openalex.org/W1684460249","https://openalex.org/W1971003087","https://openalex.org/W1987850248","https://openalex.org/W1988517067","https://openalex.org/W1992988015","https://openalex.org/W1995944861","https://openalex.org/W2009882596","https://openalex.org/W2016960934","https://openalex.org/W2042646867","https://openalex.org/W2070132032","https://openalex.org/W2078566940","https://openalex.org/W2101190811","https://openalex.org/W2140766436","https://openalex.org/W2339132647","https://openalex.org/W3108854080"],"related_works":["https://openalex.org/W7053138920","https://openalex.org/W4303879224","https://openalex.org/W7015500058","https://openalex.org/W7218314023","https://openalex.org/W4378375466","https://openalex.org/W2371783939","https://openalex.org/W4285009203","https://openalex.org/W1992988015","https://openalex.org/W1964540301","https://openalex.org/W7217463170"],"abstract_inverted_index":{"Infertility":[0],"in":[1,93,102,110,168,190,220,237,262],"otherwise":[2],"healthy":[3,153],"males":[4],"be":[5,36,256],"caused":[6],"by":[7,71],"a":[8,72,100],"variety":[9],"of":[10,22,26,49,51,63,89,105,117,121,129,158,161,180,183,201,211,249],"disorders.":[11],"These":[12],"include":[13],"acquired,":[14],"as":[15,17,47],"well":[16],"heritable":[18],"conditions.":[19],"Genetic":[20],"causes":[21],"male":[23,52,65],"infertility":[24,53],"are":[25,45,55,69],"special":[27],"interest":[28],"to":[29,39,82,85,99,114,125],"reproductive":[30],"biology,":[31],"because":[32],"these":[33],"disorders":[34],"can":[35,112],"passed":[37],"on":[38],"the":[40,61,64,83,87,103,106,127,178],"offspring,":[41],"single":[42,73],"nucleotide":[43],"polymorphisms":[44],"considered":[46],"one":[48],"reason":[50],"Androgens":[54],"critical":[56],"steroid":[57],"hormones":[58],"that":[59],"determine":[60,126],"expression":[62,88],"phenotype.":[66],"Their":[67],"actions":[68],"mediated":[70],"androgen":[74,94,107],"receptor":[75,95,108],"(AR)":[76],"which,":[77,109],"upon":[78],"ligand":[79],"binding,":[80],"translocate":[81],"nucleus":[84],"regulate":[86],"androgen-responsive":[90],"genes.":[91],"Mutations":[92],"gene":[96],"may":[97,255],"lead":[98,113],"disturbance":[101],"function":[104],"turn,":[111],"several":[115],"forms":[116],"infertility.":[118],"The":[119,156,199,209],"aim":[120],"this":[122],"study":[123,142],"was":[124,143,163,185,215,233],"frequency":[128,157,179,210,232],"rs962458(SNP1),":[130],"rs6152(SNP2)":[131],"and":[132,150,173,194,203,224,241,251],"rs2361634(SNP3)and":[133],"test":[134],"their":[135],"associations":[136],"with":[137,258],"severe":[138,147,259],"oligozoospermia":[139,148,260],"risk":[140,261],".This":[141],"conducted":[144],"using":[145],"50":[146,151],"patients":[149,169,191,221,238],"apparently":[152],"subjects":[154],"(Control).":[155],"GA":[159,247],"genotype":[160,182,248],"SNP2":[162,184],"significantly":[164,186,216,234],"(p\u2264":[165,187,217,235],"0.05)":[166],"increased":[167],"versus":[170,192,222,239],"control":[171],"(10":[172],"0%,":[174],"respectively,":[175,196,226],"OR=0.561,":[176],"X2=4.329),while":[177],"GG":[181],"0.01)":[188,218],"decreased":[189,219],"control(84":[193],"100%,":[195,225],"OR=0.871,":[197],"X2=6.524).":[198],"results":[200],"TAA":[202],"TAG":[204],"haplotypes":[205],"were":[206],"not":[207],"significant.":[208],"TAG/TAG":[212],"haplotype":[213,230,253],"combination":[214,231,254],"control(78":[223],"OR=1.072,":[227],"X2=8.35),while":[228],"TAG/TAA":[229,252],"0.05)increased":[236],"control(14":[240],"0%,respectively,":[242],"OR=0.664,X2=4.69).":[243],"In":[244],"conclusion,":[245],"both":[246],"rs6152A>G":[250],"correlated":[257],"Iraqi":[263],"patients.":[264]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2017-07-14T00:00:00"}