{"id":"https://openalex.org/W2730265207","doi":"https://doi.org/10.1073/pnas.1621457114","title":"Autoantibody profiling on a plasmonic nano-gold chip for the early detection of hypertensive heart disease","display_name":"Autoantibody profiling on a plasmonic nano-gold chip for the early detection of hypertensive heart disease","publication_year":2017,"publication_date":"2017-06-19","ids":{"openalex":"https://openalex.org/W2730265207","doi":"https://doi.org/10.1073/pnas.1621457114","mag":"2730265207","pmid":"https://pubmed.ncbi.nlm.nih.gov/28630342","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5502602"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1621457114","doi":"https://doi.org/10.1073/pnas.1621457114","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.1621457114","pdf_url":"https://www.pnas.org/content/pnas/114/27/7089.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.pnas.org/content/pnas/114/27/7089.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100606927","display_name":"Xiaoyang Li","orcid":"https://orcid.org/0000-0003-3684-2106","observed_orcids":["https://orcid.org/0000-0003-3684-2106"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoyang Li","raw_affiliation_strings":["Department of Chemistry, Stanford University, Stanford, CA 94305;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Stanford University, Stanford, CA 94305;","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048024665","display_name":"Tatiana Kuznetsova","orcid":"https://orcid.org/0000-0003-4293-4576","observed_orcids":["https://orcid.org/0000-0003-4293-4576","https://orcid.org/0000-0002-6278-1979","https://orcid.org/0000-0002-8032-1132","https://orcid.org/0000-0001-5403-3885"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Tatiana Kuznetsova","raw_affiliation_strings":["Research Unit Hypertension and Cardiovascular Epidemiology, Department of Cardiovascular Sciences, University of Leuven, Leuven 3000, Belgium;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Unit Hypertension and Cardiovascular Epidemiology, Department of Cardiovascular Sciences, University of Leuven, Leuven 3000, Belgium;","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005033171","display_name":"Nicholas Cauwenberghs","orcid":"https://orcid.org/0000-0001-8059-7692","observed_orcids":["https://orcid.org/0000-0001-8059-7692"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Nicholas Cauwenberghs","raw_affiliation_strings":["Research Unit Hypertension and Cardiovascular Epidemiology, Department of Cardiovascular Sciences, University of Leuven, Leuven 3000, Belgium;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Unit Hypertension and Cardiovascular Epidemiology, Department of Cardiovascular Sciences, University of Leuven, Leuven 3000, Belgium;","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053510600","display_name":"Matthew Thomas Wheeler","orcid":"https://orcid.org/0000-0001-8721-3022","observed_orcids":["https://orcid.org/0000-0001-8721-3022"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I4405269264","display_name":"Stanford Cardiovascular Institute","ror":"https://ror.org/03kk52s14","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4405269264","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Wheeler","raw_affiliation_strings":["Stanford Cardiovascular Institute, Stanford, CA 94305;","Stanford University School of Medicine, Stanford, CA 94305;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Cardiovascular Institute, Stanford, CA 94305;","institution_ids":["https://openalex.org/I4405269264"]},{"raw_affiliation_string":"Stanford University School of Medicine, Stanford, CA 94305;","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068399737","display_name":"Holden Terry Maecker","orcid":"https://orcid.org/0000-0003-0795-9946","observed_orcids":["https://orcid.org/0000-0003-0795-9946","https://orcid.org/0000-0001-5389-0906"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Holden Maecker","raw_affiliation_strings":["Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047561254","display_name":"Joseph C. Wu","orcid":"https://orcid.org/0000-0002-6068-8041","observed_orcids":["https://orcid.org/0000-0002-6068-8041","https://orcid.org/0000-0003-4274-0413"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I4405269264","display_name":"Stanford Cardiovascular Institute","ror":"https://ror.org/03kk52s14","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4405269264","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph C. Wu","raw_affiliation_strings":["Stanford Cardiovascular Institute, Stanford, CA 94305;","Stanford University School of Medicine, Stanford, CA 94305;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Cardiovascular Institute, Stanford, CA 94305;","institution_ids":["https://openalex.org/I4405269264"]},{"raw_affiliation_string":"Stanford University School of Medicine, Stanford, CA 94305;","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001067636","display_name":"Fran\u00e7ois Haddad","orcid":"https://orcid.org/0000-0002-9648-7671","observed_orcids":["https://orcid.org/0000-0002-9648-7671"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I4405269264","display_name":"Stanford Cardiovascular Institute","ror":"https://ror.org/03kk52s14","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4405269264","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francois Haddad","raw_affiliation_strings":["Stanford Cardiovascular Institute, Stanford, CA 94305;","Stanford University School of Medicine, Stanford, CA 94305;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Cardiovascular Institute, Stanford, CA 94305;","institution_ids":["https://openalex.org/I4405269264"]},{"raw_affiliation_string":"Stanford University School of Medicine, Stanford, CA 94305;","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102781933","display_name":"Hongjie Dai","orcid":"https://orcid.org/0000-0002-4906-4502","observed_orcids":["https://orcid.org/0000-0002-4906-4502","https://orcid.org/0000-0003-3239-0835","https://orcid.org/0000-0002-8541-5752"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongjie Dai","raw_affiliation_strings":["Department of Chemistry, Stanford University, Stanford, CA 94305;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Stanford University, Stanford, CA 94305;","institution_ids":["https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8925,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.70395629,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"114","issue":"27","first_page":"7089","last_page":"7094"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.7856000065803528,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.7856000065803528,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10131","display_name":"Gold and Silver Nanoparticles Synthesis and Applications","score":0.05510000139474869,"subfield":{"id":"https://openalex.org/subfields/2504","display_name":"Electronic, Optical and Magnetic Materials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.05209999904036522,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypertensive-heart-disease","display_name":"hypertensive heart disease","score":0.9110000133514404},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.7829999923706055},{"id":"https://openalex.org/keywords/early-detection","display_name":"early detection","score":0.6169999837875366},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.890999972820282},{"id":"https://openalex.org/keywords/troponin-i","display_name":"troponin I","score":0.9020000100135803},{"id":"https://openalex.org/keywords/annexin-v","display_name":"annexin V","score":0.9549999833106995},{"id":"https://openalex.org/keywords/biomarker-profiling","display_name":"biomarker profiling","score":0.6389999985694885},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.5339999794960022},{"id":"https://openalex.org/keywords/myocarditis","display_name":"myocarditis","score":0.593999981880188},{"id":"https://openalex.org/keywords/heart-transplantation","display_name":"heart transplantation","score":0.9470000267028809}],"concepts":[{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.8392490148544312},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7990981936454773},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.6532526612281799},{"id":"https://openalex.org/C2780875844","wikidata":"https://www.wikidata.org/wiki/Q186235","display_name":"Myocarditis","level":2,"score":0.629822850227356},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4943399429321289},{"id":"https://openalex.org/C2778849806","wikidata":"https://www.wikidata.org/wiki/Q643396","display_name":"Heart transplantation","level":3,"score":0.4793977737426758},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.472469300031662},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.44138047099113464},{"id":"https://openalex.org/C115725540","wikidata":"https://www.wikidata.org/wiki/Q7846263","display_name":"Troponin I","level":3,"score":0.43740761280059814},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23792386054992676},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.17641815543174744},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004452","descriptor_name":"Echocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006046","descriptor_name":"Gold","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006331","descriptor_name":"Heart Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006331","descriptor_name":"Heart Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015551","descriptor_name":"Autoimmunity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017304","descriptor_name":"Annexin A5","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018342","descriptor_name":"Receptors, Adrenergic, beta-1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019210","descriptor_name":"Troponin I","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D036103","descriptor_name":"Nanotechnology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053768","descriptor_name":"Metal Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1073/pnas.1621457114","doi":"https://doi.org/10.1073/pnas.1621457114","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.1621457114","pdf_url":"https://www.pnas.org/content/pnas/114/27/7089.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4662443","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5502602","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5502602","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5502602","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:28630342","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28630342","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/602633","doi":null,"is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/123456789/602633","pdf_url":"https://lirias.kuleuven.be/retrieve/35f5f713-3c8d-4980-a1e9-254964dc271f","source":{"id":"https://openalex.org/S7407055369","display_name":"Lirias","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proceedings Of The National Academy Of Sciences Of The United States Of America, vol. 114 (27), (7089-7094)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1073/pnas.1621457114","doi":"https://doi.org/10.1073/pnas.1621457114","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.1621457114","pdf_url":"https://www.pnas.org/content/pnas/114/27/7089.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G5168061592","display_name":null,"funder_award_id":"13EIA14420025","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"}],"funders":[{"id":"https://openalex.org/F4320306133","display_name":"Burroughs Wellcome Fund","ror":"https://ror.org/01d35cw23"},{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320338011","display_name":"Stanford Cardiovascular Institute, School of Medicine, Stanford University","ror":"https://ror.org/03kk52s14"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2730265207.pdf","grobid_xml":"https://content.openalex.org/works/W2730265207.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1536015665","https://openalex.org/W1986918198","https://openalex.org/W2000702854","https://openalex.org/W2002751190","https://openalex.org/W2007246930","https://openalex.org/W2010877065","https://openalex.org/W2022179089","https://openalex.org/W2023195146","https://openalex.org/W2023606650","https://openalex.org/W2024073441","https://openalex.org/W2024205217","https://openalex.org/W2028036560","https://openalex.org/W2038584568","https://openalex.org/W2041143359","https://openalex.org/W2077067449","https://openalex.org/W2100812517","https://openalex.org/W2113811481","https://openalex.org/W2116496248","https://openalex.org/W2127688157","https://openalex.org/W2129584432","https://openalex.org/W2133559066","https://openalex.org/W2133930954","https://openalex.org/W2142170866","https://openalex.org/W2144303447","https://openalex.org/W2152776328","https://openalex.org/W2164285209","https://openalex.org/W2171092233","https://openalex.org/W2182978734","https://openalex.org/W2196489477","https://openalex.org/W2263970784","https://openalex.org/W2305912340","https://openalex.org/W2324476825","https://openalex.org/W2337019381","https://openalex.org/W2343190481","https://openalex.org/W2461482347","https://openalex.org/W2519939054","https://openalex.org/W2547258180","https://openalex.org/W2590445414"],"related_works":["https://openalex.org/W2899368428","https://openalex.org/W2937265738","https://openalex.org/W2549346249","https://openalex.org/W3010751803","https://openalex.org/W3015172528","https://openalex.org/W4297988883","https://openalex.org/W4390264344","https://openalex.org/W7139825298","https://openalex.org/W4401632155","https://openalex.org/W2612277143"],"abstract_inverted_index":{"Significance":[0],"Hypertension":[1],"affects":[2],"one":[3],"in":[4,7,42,111],"four":[5],"adults":[6],"the":[8,33],"United":[9],"States":[10],"and":[11,27,75,94,115],"is":[12,29],"a":[13,55],"major":[14],"risk":[15],"factor":[16],"for":[17,98],"heart":[18,52,81,102,113],"failure.":[19,103],"A":[20],"plasmonic":[21],"nano-gold":[22],"platform":[23,86,106],"with":[24,49,64],"excellent":[25],"reproducibility":[26],"sensitivity":[28],"developed":[30],"to":[31,69,90],"address":[32],"currently":[34],"unmet":[35],"need":[36],"of":[37,58,101],"profiling":[38],"circulating":[39],"cardiovascular":[40,59],"autoantibodies":[41,60,93],"hypertensive":[43,51,62,80],"patients.":[44],"We":[45],"observed":[46],"that":[47],"patients":[48,63,97],"early-stage":[50],"diseases":[53],"displayed":[54],"higher":[56],"level":[57],"than":[61],"normal":[65],"cardiac":[66],"function.":[67],"Autoantibodies":[68],"troponin":[70],"I,":[71],"adrenergic":[72],"beta-1":[73],"receptor,":[74],"annexin-A5":[76],"could":[77,87,107],"best":[78],"discriminate":[79],"disease.":[82],"Ultimately,":[83],"this":[84,105],"nanoscience-based":[85],"be":[88],"deployed":[89],"facilitate":[91],"screening":[92],"identify":[95],"at-risk":[96],"early":[99],"stages":[100],"Furthermore,":[104],"have":[108],"broad":[109],"applications":[110],"myocarditis,":[112],"transplantation,":[114],"other":[116],"autoimmune":[117],"diseases.":[118]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2017-07-14T00:00:00"}