{"id":"https://openalex.org/W2729969284","doi":"https://doi.org/10.1002/mnfr.201700043","title":"The effect of obesity and repeated exposure on pharmacokinetic response to grape polyphenols in humans","display_name":"The effect of obesity and repeated exposure on pharmacokinetic response to grape polyphenols in humans","publication_year":2017,"publication_date":"2017-06-27","ids":{"openalex":"https://openalex.org/W2729969284","doi":"https://doi.org/10.1002/mnfr.201700043","mag":"2729969284","pmid":"https://pubmed.ncbi.nlm.nih.gov/28654207","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5668187"},"language":"en","primary_location":{"id":"doi:10.1002/mnfr.201700043","doi":"https://doi.org/10.1002/mnfr.201700043","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mnfr.201700043","pdf_url":null,"source":{"id":"https://openalex.org/S27638457","display_name":"Molecular Nutrition & Food Research","issn_l":"1613-4125","issn":["1613-4125","1613-4133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-3","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Nutrition & Food Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC5668187","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042222766","display_name":"Janet A. Novotny","orcid":"https://orcid.org/0000-0002-9121-886X","observed_orcids":["https://orcid.org/0000-0002-9121-886X"]},"institutions":[{"id":"https://openalex.org/I1312222531","display_name":"Agricultural Research Service","ror":"https://ror.org/02d2m2044","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307"]},{"id":"https://openalex.org/I4210088410","display_name":"Beltsville Human Nutrition Research Center","ror":"https://ror.org/004zpe866","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210088410","https://openalex.org/I4210138094"]},{"id":"https://openalex.org/I4210125976","display_name":"Beltsville Agricultural Research Center","ror":"https://ror.org/03b08sh51","country_code":"US","type":"facility","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210125976","https://openalex.org/I4210138094"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Janet A. Novotny","raw_affiliation_strings":["US Department of Agriculture, Agricultural Research Service, Beltsville Human Nutrition Research Center, Building 307B, BARC-East, Beltsville, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"US Department of Agriculture, Agricultural Research Service, Beltsville Human Nutrition Research Center, Building 307B, BARC-East, Beltsville, MD, USA","institution_ids":["https://openalex.org/I1312222531","https://openalex.org/I4210088410","https://openalex.org/I4210125976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101832901","display_name":"Tzu\u2010Ying Chen","orcid":"https://orcid.org/0000-0002-2042-1756","observed_orcids":["https://orcid.org/0000-0002-2042-1756"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tzu\u2010Ying Chen","raw_affiliation_strings":["Department of Food Science, Purdue University, West Lafayette, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science, Purdue University, West Lafayette, IN, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033698251","display_name":"Anton I. Terekhov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anton I. Terekhov","raw_affiliation_strings":["Department of Food Science, Purdue University, West Lafayette, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science, Purdue University, West Lafayette, IN, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004921843","display_name":"Sarah K Gebauer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1312222531","display_name":"Agricultural Research Service","ror":"https://ror.org/02d2m2044","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307"]},{"id":"https://openalex.org/I4210088410","display_name":"Beltsville Human Nutrition Research Center","ror":"https://ror.org/004zpe866","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210088410","https://openalex.org/I4210138094"]},{"id":"https://openalex.org/I4210125976","display_name":"Beltsville Agricultural Research Center","ror":"https://ror.org/03b08sh51","country_code":"US","type":"facility","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210125976","https://openalex.org/I4210138094"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah K. Gebauer","raw_affiliation_strings":["US Department of Agriculture, Agricultural Research Service, Beltsville Human Nutrition Research Center, Building 307B, BARC-East, Beltsville, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"US Department of Agriculture, Agricultural Research Service, Beltsville Human Nutrition Research Center, Building 307B, BARC-East, Beltsville, MD, USA","institution_ids":["https://openalex.org/I1312222531","https://openalex.org/I4210088410","https://openalex.org/I4210125976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038922026","display_name":"David J. Baer","orcid":"https://orcid.org/0000-0003-3454-2097","observed_orcids":["https://orcid.org/0000-0003-3454-2097"]},"institutions":[{"id":"https://openalex.org/I1312222531","display_name":"Agricultural Research Service","ror":"https://ror.org/02d2m2044","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307"]},{"id":"https://openalex.org/I4210088410","display_name":"Beltsville Human Nutrition Research Center","ror":"https://ror.org/004zpe866","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210088410","https://openalex.org/I4210138094"]},{"id":"https://openalex.org/I4210125976","display_name":"Beltsville Agricultural Research Center","ror":"https://ror.org/03b08sh51","country_code":"US","type":"facility","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210125976","https://openalex.org/I4210138094"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David J. Baer","raw_affiliation_strings":["US Department of Agriculture, Agricultural Research Service, Beltsville Human Nutrition Research Center, Building 307B, BARC-East, Beltsville, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"US Department of Agriculture, Agricultural Research Service, Beltsville Human Nutrition Research Center, Building 307B, BARC-East, Beltsville, MD, USA","institution_ids":["https://openalex.org/I1312222531","https://openalex.org/I4210088410","https://openalex.org/I4210125976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108673916","display_name":"Lap Ho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lap Ho","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai, Department of Neurology, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai, Department of Neurology, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048364336","display_name":"Giulio Maria Pasinetti","orcid":"https://orcid.org/0000-0002-1524-5196","observed_orcids":["https://orcid.org/0000-0002-1524-5196"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Giulio M. Pasinetti","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai, Department of Neurology, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai, Department of Neurology, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011726955","display_name":"M\u00e1rio G. Ferruzzi","orcid":"https://orcid.org/0000-0003-1384-2672","observed_orcids":["https://orcid.org/0000-0003-1384-2672"]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mario G. Ferruzzi","raw_affiliation_strings":["Department of Food, Bioprocessing, and Nutrition Sciences, North Carolina State University, Kannapolis, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food, Bioprocessing, and Nutrition Sciences, North Carolina State University, Kannapolis, NC, USA","institution_ids":["https://openalex.org/I137902535"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5042222766"],"corresponding_institution_ids":["https://openalex.org/I1312222531","https://openalex.org/I4210088410","https://openalex.org/I4210125976"],"apc_list":{"value":4880,"currency":"USD","value_usd":4880},"apc_paid":null,"fwci":3.9238,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.94220524,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"61","issue":"11","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12638","display_name":"Pomegranate: compositions and health benefits","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9120000004768372},{"id":"https://openalex.org/keywords/grape-polyphenols","display_name":"grape polyphenols","score":0.8309999704360962},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9309999942779541},{"id":"https://openalex.org/keywords/repeated-dosing","display_name":"repeated dosing","score":0.9259999990463257},{"id":"https://openalex.org/keywords/resveratrol","display_name":"resveratrol","score":0.953000009059906},{"id":"https://openalex.org/keywords/catechins","display_name":"catechins","score":0.800000011920929},{"id":"https://openalex.org/keywords/epicatechin","display_name":"epicatechin","score":0.9729999899864197},{"id":"https://openalex.org/keywords/quercetin","display_name":"quercetin","score":0.9900000095367432},{"id":"https://openalex.org/keywords/polyphenol-metabolism","display_name":"polyphenol metabolism","score":0.984000027179718},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.7319999933242798},{"id":"https://openalex.org/keywords/dietary-polyphenols","display_name":"dietary polyphenols","score":0.5960000157356262}],"concepts":[{"id":"https://openalex.org/C70899900","wikidata":"https://www.wikidata.org/wiki/Q290439","display_name":"Polyphenol","level":3,"score":0.8064912557601929},{"id":"https://openalex.org/C2779431889","wikidata":"https://www.wikidata.org/wiki/Q415007","display_name":"Catechin","level":4,"score":0.7219871282577515},{"id":"https://openalex.org/C2776816829","wikidata":"https://www.wikidata.org/wiki/Q407329","display_name":"Resveratrol","level":2,"score":0.7077226042747498},{"id":"https://openalex.org/C2781263971","wikidata":"https://www.wikidata.org/wiki/Q409478","display_name":"Quercetin","level":3,"score":0.6988290548324585},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5979302525520325},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.525322437286377},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.5099664926528931},{"id":"https://openalex.org/C2776971262","wikidata":"https://www.wikidata.org/wiki/Q5597007","display_name":"Grape seed extract","level":3,"score":0.4887425899505615},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43917882442474365},{"id":"https://openalex.org/C2780586474","wikidata":"https://www.wikidata.org/wiki/Q332428","display_name":"Overweight","level":3,"score":0.4383775591850281},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4273647367954254},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3767969012260437},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2267550528049469},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22297576069831848},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.10572478175163269},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000067030","descriptor_name":"Fruit and Vegetable Juices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077185","descriptor_name":"Resveratrol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005638","descriptor_name":"Fruit","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012639","descriptor_name":"Seeds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013267","descriptor_name":"Stilbenes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013267","descriptor_name":"Stilbenes","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013267","descriptor_name":"Stilbenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013267","descriptor_name":"Stilbenes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019440","descriptor_name":"Anti-Obesity Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D019440","descriptor_name":"Anti-Obesity Agents","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019440","descriptor_name":"Anti-Obesity Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019440","descriptor_name":"Anti-Obesity Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D027843","descriptor_name":"Vitis","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D050177","descriptor_name":"Overweight","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D050177","descriptor_name":"Overweight","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":false},{"descriptor_ui":"D050177","descriptor_name":"Overweight","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D059808","descriptor_name":"Polyphenols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D059808","descriptor_name":"Polyphenols","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D059808","descriptor_name":"Polyphenols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059808","descriptor_name":"Polyphenols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/mnfr.201700043","doi":"https://doi.org/10.1002/mnfr.201700043","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mnfr.201700043","pdf_url":null,"source":{"id":"https://openalex.org/S27638457","display_name":"Molecular Nutrition & Food Research","issn_l":"1613-4125","issn":["1613-4125","1613-4133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-3","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Nutrition & Food Research","raw_type":"journal-article"},{"id":"pmid:28654207","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28654207","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular nutrition & food research","raw_type":"Comparative Study"},{"id":"pmh:oai:europepmc.org:5152975","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5668187","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5668187","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5668187","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Mol Nutr Food Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5152975","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5668187","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G471346905","display_name":null,"funder_award_id":"2014\u201067017\u201021837","funder_id":"https://openalex.org/F4320332299","funder_display_name":"National Institute of Food and Agriculture"},{"id":"https://openalex.org/G5002497260","display_name":"Pasinetti:  Overall; Dietary Botanicals in the Preservation of Cognitive and Psychological Resilience (Pasinetti)","funder_award_id":"P50AT008661","funder_id":"https://openalex.org/F4320337593","funder_display_name":"National Center for Complementary and Integrative Health"}],"funders":[{"id":"https://openalex.org/F4320306114","display_name":"U.S. Department of Agriculture","ror":"https://ror.org/01na82s61"},{"id":"https://openalex.org/F4320332299","display_name":"National Institute of Food and Agriculture","ror":"https://ror.org/05qx3fv49"},{"id":"https://openalex.org/F4320332605","display_name":"Agricultural Research Service","ror":"https://ror.org/02d2m2044"},{"id":"https://openalex.org/F4320337593","display_name":"National Center for Complementary and Integrative Health","ror":"https://ror.org/00190t495"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1481670920","https://openalex.org/W1539910536","https://openalex.org/W1929090128","https://openalex.org/W1960192585","https://openalex.org/W1973332527","https://openalex.org/W1981171010","https://openalex.org/W1982216915","https://openalex.org/W1989907045","https://openalex.org/W2001758981","https://openalex.org/W2014165277","https://openalex.org/W2016977901","https://openalex.org/W2020277903","https://openalex.org/W2030860654","https://openalex.org/W2041174332","https://openalex.org/W2045157582","https://openalex.org/W2051852913","https://openalex.org/W2072625098","https://openalex.org/W2074542118","https://openalex.org/W2103317698","https://openalex.org/W2105408725","https://openalex.org/W2117720005","https://openalex.org/W2118756389","https://openalex.org/W2132539868","https://openalex.org/W2157894767","https://openalex.org/W2160741950","https://openalex.org/W2170029874","https://openalex.org/W2223868498","https://openalex.org/W2268809926","https://openalex.org/W2331929003","https://openalex.org/W2431710049"],"related_works":["https://openalex.org/W3166147453","https://openalex.org/W4307553312","https://openalex.org/W2588317839","https://openalex.org/W3174263359","https://openalex.org/W4406533076","https://openalex.org/W3115063262","https://openalex.org/W3026985055","https://openalex.org/W2064207652","https://openalex.org/W3027824202","https://openalex.org/W2062269191"],"abstract_inverted_index":{"SCOPE:":[0],"Evidence":[1],"suggests":[2],"that":[3,185,186],"dietary":[4],"pattern":[5],"may":[6,191],"affect":[7],"polyphenol":[8,102,117,193],"absorption":[9,194],"and/or":[10,195],"metabolism.":[11],"Further,":[12,148],"obesity":[13,187],"is":[14,23],"associated":[15],"with":[16,68,165],"lower":[17],"circulating":[18],"nutrients,":[19],"though":[20],"the":[21,27,101,115],"reason":[22],"unclear.":[24],"We":[25],"investigated":[26],"pharmacokinetic":[28],"(PK)":[29],"response":[30],"of":[31,43,65],"polyphenols":[32],"in":[33,54,197],"obese/overweight":[34],"versus":[35,133,158],"lean":[36],"individuals":[37,139,161],"before":[38,60],"and":[39,61,80,91,104,111,128,154,188],"after":[40,62,100],"repeated":[41,66,189],"dosing":[42,67],"grape":[44,77,81],"polyphenols.":[45,69],"METHODS":[46],"AND":[47],"RESULTS:":[48],"A":[49],"pilot":[50],"study":[51],"was":[52],"conducted":[53],"which":[55],"PK":[56],"challenges":[57],"were":[58,95,123,150],"administered":[59],"10":[63],"days":[64,89],"Volunteers":[70],"(6":[71],"lean,":[72],"6":[73,98],"overweight/obese)":[74],"consumed":[75],"resveratrol,":[76,110],"seed":[78],"extract,":[79],"juice":[82],"(2125":[83],"mg":[84],"total":[85],"polyphenols)":[86],"daily.":[87],"On":[88],"1":[90,135],"11,":[92],"blood":[93],"samples":[94],"collected":[96],"for":[97,106,125,136,152,156,169],"h":[99],"dose":[103],"analyzed":[105],"deconjugated":[107],"catechin,":[108,126],"epicatechin,":[109,127],"quercetin.":[112],"Area":[113],"under":[114],"plasma":[116],"mass":[118],"by":[119],"time":[120],"curves":[121],"(AUCs)":[122],"greater":[124,151],"quercetin":[129],"on":[130,174],"day":[131,134,175,179],"11":[132,176],"low":[137,157],"BMI":[138,146,160],"(p":[140,162,171],"=":[141,163,172],"0.039)":[142],"but":[143,177],"not":[144,178],"high":[145,159],"individuals.":[147],"AUCs":[149],"epicatechin":[153],"resveratrol":[155],"0.041),":[164],"a":[166],"similar":[167],"trend":[168],"catechin":[170],"0.065),":[173],"1.":[180],"CONCLUSION:":[181],"These":[182],"results":[183],"suggest":[184],"exposure":[190],"modify":[192],"metabolism":[196],"humans.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":11}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-07-14T00:00:00"}