{"id":"https://openalex.org/W2729610305","doi":"https://doi.org/10.1038/s41598-017-04889-x","title":"An attenuated Machupo virus with a disrupted L-segment intergenic region protects guinea pigs against lethal Guanarito virus infection","display_name":"An attenuated Machupo virus with a disrupted L-segment intergenic region protects guinea pigs against lethal Guanarito virus infection","publication_year":2017,"publication_date":"2017-06-29","ids":{"openalex":"https://openalex.org/W2729610305","doi":"https://doi.org/10.1038/s41598-017-04889-x","mag":"2729610305","pmid":"https://pubmed.ncbi.nlm.nih.gov/28680057","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5498534"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-017-04889-x","doi":"https://doi.org/10.1038/s41598-017-04889-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-017-04889-x","pdf_url":"https://www.nature.com/articles/s41598-017-04889-x.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-017-04889-x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008605683","display_name":"Joseph W. Golden","orcid":"https://orcid.org/0000-0002-9709-313X","observed_orcids":["https://orcid.org/0000-0002-9709-313X"]},"institutions":[{"id":"https://openalex.org/I2801122164","display_name":"United States Army Medical Research Institute of Infectious Diseases","ror":"https://ror.org/01pveve47","country_code":"US","type":"facility","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2801122164","https://openalex.org/I2802581893"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joseph W. Golden","raw_affiliation_strings":["Department of Molecular Virology, Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, 21702, United States. joseph.w.golden.ctr@mail.mil","Department of Molecular Virology, Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, 21702, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Virology, Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, 21702, United States. joseph.w.golden.ctr@mail.mil","institution_ids":["https://openalex.org/I2801122164"]},{"raw_affiliation_string":"Department of Molecular Virology, Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, 21702, United States","institution_ids":["https://openalex.org/I2801122164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024238371","display_name":"Brett F. Beitzel","orcid":"https://orcid.org/0000-0002-3798-6411","observed_orcids":["https://orcid.org/0000-0002-3798-6411"]},"institutions":[{"id":"https://openalex.org/I2801122164","display_name":"United States Army Medical Research Institute of Infectious Diseases","ror":"https://ror.org/01pveve47","country_code":"US","type":"facility","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2801122164","https://openalex.org/I2802581893"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brett Beitzel","raw_affiliation_strings":["Center for Genome Sciences, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, 21702, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Genome Sciences, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, 21702, United States","institution_ids":["https://openalex.org/I2801122164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020680432","display_name":"Jason T. Ladner","orcid":"https://orcid.org/0000-0001-7751-4366","observed_orcids":["https://orcid.org/0000-0001-7751-4366"]},"institutions":[{"id":"https://openalex.org/I2801122164","display_name":"United States Army Medical Research Institute of Infectious Diseases","ror":"https://ror.org/01pveve47","country_code":"US","type":"facility","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2801122164","https://openalex.org/I2802581893"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason T. Ladner","raw_affiliation_strings":["Center for Genome Sciences, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, 21702, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Genome Sciences, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, 21702, United States","institution_ids":["https://openalex.org/I2801122164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032731932","display_name":"Eric M. Mucker","orcid":"https://orcid.org/0000-0002-4656-5379","observed_orcids":["https://orcid.org/0000-0002-4656-5379"]},"institutions":[{"id":"https://openalex.org/I2801122164","display_name":"United States Army Medical Research Institute of Infectious Diseases","ror":"https://ror.org/01pveve47","country_code":"US","type":"facility","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2801122164","https://openalex.org/I2802581893"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric M. Mucker","raw_affiliation_strings":["Department of Molecular Virology, Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, 21702, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Virology, Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, 21702, United States","institution_ids":["https://openalex.org/I2801122164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047874446","display_name":"Steven A. Kwilas","orcid":"https://orcid.org/0000-0003-0383-3879","observed_orcids":["https://orcid.org/0000-0003-0383-3879"]},"institutions":[{"id":"https://openalex.org/I2801122164","display_name":"United States Army Medical Research Institute of Infectious Diseases","ror":"https://ror.org/01pveve47","country_code":"US","type":"facility","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2801122164","https://openalex.org/I2802581893"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven A. Kwilas","raw_affiliation_strings":["Department of Molecular Virology, Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, 21702, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Virology, Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, 21702, United States","institution_ids":["https://openalex.org/I2801122164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081821579","display_name":"Gustavo F. Palacios","orcid":"https://orcid.org/0000-0001-5062-1938","observed_orcids":["https://orcid.org/0000-0001-5062-1938"]},"institutions":[{"id":"https://openalex.org/I2801122164","display_name":"United States Army Medical Research Institute of Infectious Diseases","ror":"https://ror.org/01pveve47","country_code":"US","type":"facility","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2801122164","https://openalex.org/I2802581893"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gustavo Palacios","raw_affiliation_strings":["Center for Genome Sciences, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, 21702, United States"],"raw_orcid":"https://orcid.org/0000-0001-5062-1938","affiliations":[{"raw_affiliation_string":"Center for Genome Sciences, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, 21702, United States","institution_ids":["https://openalex.org/I2801122164"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083611548","display_name":"Jay W. Hooper","orcid":"https://orcid.org/0000-0002-4475-0415","observed_orcids":["https://orcid.org/0000-0002-4475-0415"]},"institutions":[{"id":"https://openalex.org/I2801122164","display_name":"United States Army Medical Research Institute of Infectious Diseases","ror":"https://ror.org/01pveve47","country_code":"US","type":"facility","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2801122164","https://openalex.org/I2802581893"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jay W. Hooper","raw_affiliation_strings":["Department of Molecular Virology, Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, 21702, United States"],"raw_orcid":"https://orcid.org/0000-0002-4475-0415","affiliations":[{"raw_affiliation_string":"Department of Molecular Virology, Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, 21702, United States","institution_ids":["https://openalex.org/I2801122164"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5008605683"],"corresponding_institution_ids":["https://openalex.org/I2801122164"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":2.0224,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.85470901,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"7","issue":"1","first_page":"4679","last_page":"4679"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11767","display_name":"Poxvirus research and outbreaks","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/machupo-virus","display_name":"Machupo virus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/guanarito-virus","display_name":"Guanarito virus","score":0.9779999852180481},{"id":"https://openalex.org/keywords/bolivian-hemorrhagic-fever","display_name":"Bolivian hemorrhagic fever","score":0.9409999847412109},{"id":"https://openalex.org/keywords/new-world-arenaviruses","display_name":"New World arenaviruses","score":0.8899999856948853},{"id":"https://openalex.org/keywords/heterologous-protection","display_name":"heterologous protection","score":0.878000020980835},{"id":"https://openalex.org/keywords/guinea-pig-model","display_name":"guinea pig model","score":0.6019999980926514},{"id":"https://openalex.org/keywords/virus-attenuation","display_name":"viral attenuation","score":0.6190000176429749},{"id":"https://openalex.org/keywords/point-mutations","display_name":"point mutations","score":0.4690000116825104},{"id":"https://openalex.org/keywords/nucleotide-deletion","display_name":"nucleotide deletion","score":0.8360000252723694},{"id":"https://openalex.org/keywords/polymerase-gene","display_name":"polymerase gene","score":0.6539999842643738}],"concepts":[{"id":"https://openalex.org/C2779574689","wikidata":"https://www.wikidata.org/wiki/Q2368907","display_name":"Arenavirus","level":5,"score":0.8066664934158325},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7910267114639282},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7630546689033508},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6338105201721191},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.5734565854072571},{"id":"https://openalex.org/C2775955205","wikidata":"https://www.wikidata.org/wiki/Q51929761","display_name":"Junin virus","level":5,"score":0.5104929208755493},{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.4945954978466034},{"id":"https://openalex.org/C54602769","wikidata":"https://www.wikidata.org/wiki/Q1810913","display_name":"Attenuated vaccine","level":4,"score":0.46913832426071167},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3607524633407593},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2936372458934784},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.2887204587459564},{"id":"https://openalex.org/C2780190958","wikidata":"https://www.wikidata.org/wiki/Q1878776","display_name":"Lymphocytic choriomeningitis","level":4,"score":0.2800934314727783},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.11541497707366943},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001117","descriptor_name":"Arenaviridae Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006477","descriptor_name":"Arenaviruses, New World","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006477","descriptor_name":"Arenaviruses, New World","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D006477","descriptor_name":"Arenaviruses, New World","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014613","descriptor_name":"Vaccines, Attenuated","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014613","descriptor_name":"Vaccines, Attenuated","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D014709","descriptor_name":"Vero Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017384","descriptor_name":"Sequence Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D021901","descriptor_name":"DNA, Intergenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D061307","descriptor_name":"Human Umbilical Vein Endothelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41598-017-04889-x","doi":"https://doi.org/10.1038/s41598-017-04889-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-017-04889-x","pdf_url":"https://www.nature.com/articles/s41598-017-04889-x.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4349487","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5498534","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5498534","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5498534","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:28680057","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28680057","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Comparative Study"},{"id":"pmh:oai:doaj.org/article:4f7b5bc0b3ea44f68846a16a888e462d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4f7b5bc0b3ea44f68846a16a888e462d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-017-04889-x","doi":"https://doi.org/10.1038/s41598-017-04889-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-017-04889-x","pdf_url":"https://www.nature.com/articles/s41598-017-04889-x.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320332186","display_name":"Defense Threat Reduction Agency","ror":"https://ror.org/04tz64554"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2729610305.pdf","grobid_xml":"https://content.openalex.org/works/W2729610305.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W19594754","https://openalex.org/W23350850","https://openalex.org/W42674045","https://openalex.org/W99508895","https://openalex.org/W130305887","https://openalex.org/W189417540","https://openalex.org/W1252554981","https://openalex.org/W1550650272","https://openalex.org/W1949143643","https://openalex.org/W1965289127","https://openalex.org/W1965517496","https://openalex.org/W1966760652","https://openalex.org/W1973497192","https://openalex.org/W1977944577","https://openalex.org/W1984309722","https://openalex.org/W1986616798","https://openalex.org/W1991447057","https://openalex.org/W1997832880","https://openalex.org/W2004693780","https://openalex.org/W2015023269","https://openalex.org/W2015792243","https://openalex.org/W2026020811","https://openalex.org/W2029620587","https://openalex.org/W2034616315","https://openalex.org/W2036897871","https://openalex.org/W2038390244","https://openalex.org/W2040369045","https://openalex.org/W2054484042","https://openalex.org/W2054762996","https://openalex.org/W2075684392","https://openalex.org/W2078785883","https://openalex.org/W2084813607","https://openalex.org/W2089036427","https://openalex.org/W2090628788","https://openalex.org/W2091678991","https://openalex.org/W2093657159","https://openalex.org/W2095680943","https://openalex.org/W2095967124","https://openalex.org/W2099418758","https://openalex.org/W2100586710","https://openalex.org/W2108927671","https://openalex.org/W2109096389","https://openalex.org/W2116024971","https://openalex.org/W2116947182","https://openalex.org/W2121180999","https://openalex.org/W2121251963","https://openalex.org/W2125755947","https://openalex.org/W2127883868","https://openalex.org/W2129279927","https://openalex.org/W2136868849","https://openalex.org/W2139122528","https://openalex.org/W2145258477","https://openalex.org/W2148440555","https://openalex.org/W2151030563","https://openalex.org/W2192959099","https://openalex.org/W2223716708","https://openalex.org/W2237299765","https://openalex.org/W2240428267","https://openalex.org/W2257486357","https://openalex.org/W2301316477","https://openalex.org/W2425840421","https://openalex.org/W2556485530","https://openalex.org/W2747979339","https://openalex.org/W4394666350"],"related_works":["https://openalex.org/W2807224107","https://openalex.org/W4200244102","https://openalex.org/W4220937744","https://openalex.org/W4399777084","https://openalex.org/W2517778933","https://openalex.org/W6902446528","https://openalex.org/W4406786080","https://openalex.org/W2213652511","https://openalex.org/W7099744993","https://openalex.org/W3135098056"],"abstract_inverted_index":{"Abstract":[0],"Machupo":[1],"virus":[2,117],"(MACV)":[3],"is":[4],"a":[5,21,49,53,66,72,119,160],"New":[6],"World":[7],"(NW)":[8],"arenavirus":[9],"and":[10,71,81,164,177],"causative":[11],"agent":[12],"of":[13,23,36,43,132,191],"Bolivian":[14],"hemorrhagic":[15],"fever":[16],"(HF).":[17],"Here,":[18],"we":[19,107],"identified":[20],"variant":[22],"MACV":[24,144],"strain":[25],"Carvallo":[26],"termed":[27,45],"Car91":[28,64,110],"that":[29,60,89,142],"was":[30,105],"attenuated":[31,143],"in":[32,48,85,155,183],"guinea":[33,37,113,135],"pigs.":[34],"Infection":[35],"pigs":[38,114,136],"with":[39,52],"an":[40],"earlier":[41],"passage":[42],"Carvallo,":[44],"Car68,":[46,63],"resulted":[47],"lethal":[50],"disease":[51],"63%":[54],"mortality":[55],"rate.":[56],"Sequencing":[57],"analysis":[58],"revealed":[59],"compared":[61],"to":[62,128],"had":[65],"35":[67,165],"nucleotide":[68],"(nt)":[69],"deletion":[70],"point":[73,162],"mutation":[74],"within":[75],"the":[76,86,101,133,156,170,189],"L-segment":[77,157],"intergenic":[78],"region":[79],"(IGR),":[80],"three":[82],"silent":[83],"changes":[84,97],"polymerase":[87],"gene":[88],"did":[90],"not":[91],"impact":[92],"amino":[93],"acid":[94],"coding.":[95],"No":[96],"were":[98,137,169],"found":[99],"on":[100],"S-segment.":[102],"Because":[103],"it":[104],"apathogenic,":[106],"determined":[108],"if":[109],"could":[111],"protect":[112],"against":[115,150],"Guanarito":[116],"(GTOV),":[118],"distantly":[120],"related":[121],"NW":[122,151],"arenavirus.":[123],"While":[124],"na\u00efve":[125],"animals":[126],"succumbed":[127],"GTOV":[129],"infection,":[130],"88%":[131],"Car91-exposed":[134],"protected.":[138],"These":[139],"findings":[140],"indicate":[141],"vaccines":[145],"can":[146],"provide":[147],"heterologous":[148],"protection":[149],"arenaviruses.":[152],"The":[153],"disruption":[154],"IGR,":[158],"including":[159],"single":[161],"mutant":[163],"nt":[166],"partial":[167],"deletion,":[168],"only":[171],"major":[172],"variance":[173],"detected":[174],"between":[175],"virulent":[176],"avirulent":[178],"isolates,":[179],"implicating":[180],"its":[181],"role":[182],"attenuation.":[184],"Overall,":[185],"our":[186],"data":[187],"support":[188],"development":[190],"live-attenuated":[192],"arenaviruses":[193],"as":[194],"broadly":[195],"protective":[196],"pan-arenavirus":[197],"vaccines.":[198]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-07-14T00:00:00"}
