{"id":"https://openalex.org/W272881487","doi":null,"title":"Comparison of the frequencies and phenotypes of IL-22-producing T cells from human normal membrane of intestinal tract and peripheral blood mononuclear cells","display_name":"Comparison of the frequencies and phenotypes of IL-22-producing T cells from human normal membrane of intestinal tract and peripheral blood mononuclear cells","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W272881487","mag":"272881487"},"language":"en","primary_location":{"id":"mag:2373927933","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-MYXZ201110010.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764367629","display_name":"Immunological Journal","issn_l":"1000-8861","issn":["1000-8861"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4361730452","host_organization_name":"Army Medical University","host_organization_lineage":["https://openalex.org/P4361730452"],"host_organization_lineage_names":["Army Medical University"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Immunological Journal","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006602110","display_name":"WANG Feng Hui","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"WANG Feng Hui","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091793973","display_name":"\u5218\u6600","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u5218\u6600","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011908415","display_name":"\u4ed8\u7b11\u8fce","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u4ed8\u7b11\u8fce","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071229705","display_name":"\u5170\u5e73","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u5170\u5e73","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071266613","display_name":"\u4f55\u6653\u751f","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u4f55\u6653\u751f","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5081684098","display_name":"\u5434\u957f\u6709","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u5434\u957f\u6709","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02068729,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"10","first_page":"861","last_page":"865"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.5238999724388123,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.5238999724388123,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.3855000138282776,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.03790000081062317,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intestinal-mucosa","display_name":"intestinal mucosa","score":0.9620000123977661},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.9430000185966492},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9399999976158142},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":1.0},{"id":"https://openalex.org/keywords/ccr10","display_name":"CCR10","score":0.8360000252723694},{"id":"https://openalex.org/keywords/ccr7","display_name":"CCR7","score":0.8119999766349792},{"id":"https://openalex.org/keywords/ccr6","display_name":"CCR6","score":0.8009999990463257},{"id":"https://openalex.org/keywords/ccr4","display_name":"CCR4","score":0.9760000109672546},{"id":"https://openalex.org/keywords/cd45ro","display_name":"CD45RO","score":0.8560000061988831},{"id":"https://openalex.org/keywords/l-selectin","display_name":"L-selectin","score":0.8859999775886536},{"id":"https://openalex.org/keywords/memory-t-cells","display_name":"memory T cells","score":0.6520000100135803},{"id":"https://openalex.org/keywords/th17-cells","display_name":"Th17 cells","score":0.7139999866485596},{"id":"https://openalex.org/keywords/th1-cells","display_name":"Th1 cells","score":0.7540000081062317},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.7990000247955322},{"id":"https://openalex.org/keywords/il-17","display_name":"IL-17","score":0.9729999899864197},{"id":"https://openalex.org/keywords/t-cell-subsets","display_name":"T cell subsets","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3261345624923706}],"mesh":[],"locations_count":2,"locations":[{"id":"mag:2373927933","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-MYXZ201110010.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764367629","display_name":"Immunological Journal","issn_l":"1000-8861","issn":["1000-8861"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4361730452","host_organization_name":"Army Medical University","host_organization_lineage":["https://openalex.org/P4361730452"],"host_organization_lineage_names":["Army Medical University"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Immunological Journal","raw_type":null},{"id":"mag:272881487","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/90206X/201110/39529210.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306543734","display_name":"\u514d\u75ab\u5b66\u6742\u5fd7","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u514d\u75ab\u5b66\u6742\u5fd7","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2373927933","https://openalex.org/W820305653","https://openalex.org/W2328514480","https://openalex.org/W2915440852","https://openalex.org/W2465974855","https://openalex.org/W2152077818","https://openalex.org/W2058380192","https://openalex.org/W2598302258","https://openalex.org/W2509779239","https://openalex.org/W2011507447"],"abstract_inverted_index":{"\u76ee\u7684\u6bd4\u8f83\u4eba\u80a0\u9053\u6b63\u5e38\u7c98\u819c\u7ec4\u7ec7\u4e0e\u5916\u5468\u8840\u4e2dIL-22\uff0bT\u6dcb\u5df4\u7ec6\u80de\u7684\u9891\u7387\u53ca\u5176\u8868\u578b\u7279\u5f81\u3002\u65b9\u6cd5\u5206\u79bb\u4eba\u80a0\u9053\u6b63\u5e38\u7c98\u819c\u4e0e\u5916\u5468\u8840\u4e2d\u5355\u4e2a\u6838\u7ec6\u80de,anti-CD3\uff0banti-CD28\u523a\u6fc0\u540e,\u91c7\u7528\u6d41\u5f0f\u7ec6\u80de\u672f\uff08FACS\uff09\u68c0\u6d4bIL-22\u7684\u4ea7\u751f\u53ca\u5176\u4e0eIFN-\u03b3\u3001IL-17\u7684\u5173\u7cfb,\u5206\u6790IL-22\uff0bT\u6dcb\u5df4\u7ec6\u80deCD45RO,CD62L,CCR7,CCR6,CCR10,CCR4\u7b49\u8868\u9762\u5206\u5b50\u7684\u8868\u8fbe\u3002\u7ed3\u679c\u4e0eanti-CD3\uff0banti-CD28\u523a\u6fc0\u5916\u5468\u8840\u4e2dCD4\uff0b\u548cCD8\uff0bT\u6dcb\u5df4\u7ec6\u80de\u4ea7\u751f\u5c11\u91cf\u7684IL-22\uff080.6%;0.57%\uff09\u76f8\u6bd4,\u80a0\u9053\u7c98\u819cCD4\uff0bT\u7ec6\u80de\u4ea7\u751f\u5927\u7ea63.15%\u7684IL-22,CD8\uff0bT\u6dcb\u5df4\u7ec6\u80de\u4ea7\u751f4%\u5de6\u53f3\u7684IL-22\u3002\u6b64\u5916,\u80a0\u9053\u7c98\u819cCD4\uff0b\u548cCD8\uff0bT\u7ec6\u80de\u4e2d\u5b58\u5728\u4e00\u7fa4\u4ea7\u751fIL-22\u5e76\u72ec\u7acb\u4e8eTh1\u3001Th17,Tc1\u3001Tc17\u7684\u7ec6\u80de\u4e9a\u7fa4\u3002\u80a0\u9053\u7c98\u819cIL-22\uff0bT\u7ec6\u80de\u8868\u8fbe\u8f83\u9ad8\u6bd4\u4f8b\u7684CD45RO,\u5176\u4e2d\u90e8\u5206\u7ec6\u80de\u8868\u8fbeCCR7,\u800c\u8f83\u5c11\u8868\u8fbeCD62L\u3002\u8fdb\u4e00\u6b65\u7814\u7a76\u8868\u660e,\u80a0\u9053\u7c98\u819cCD4\uff0bIL-22\uff0b\u548cCD8\uff0bIL-22\uff0bT\u7ec6\u80de\u8868\u8fbe\u8f83\u9ad8\u6c34\u5e73\u7684CCR10\uff0855.3%;73.9%\uff09,\u90e8\u5206\u7ec6\u80de\u8868\u8fbeCCR6\u6216CCR4\u3002\u7ed3\u8bba\u4eba\u80a0\u9053\u6b63\u5e38\u7c98\u819c\u7ec4\u7ec7\u4e2dIL-22\u4e3b\u8981\u7531\u6548\u5e94\u578b\u6216\u4e2d\u592e\u578b\u8bb0\u5fc6T\u7ec6\u80de\u4ea7\u751f,\u90e8\u5206IL-22\uff0bT\u7ec6\u80de\u72ec\u7acb\u4e8eTh1\u3001Th17,Tc1\u3001Tc17\u7ec6\u80de\u4e9a\u7fa4\u3002":[0]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}