{"id":"https://openalex.org/W2728503045","doi":null,"title":"Nanoparticles for Cancer Detection and Therapy: Towards Diagnostic Applications of Quantum Dots and Rational Design of Drug Delivery Vehicles","display_name":"Nanoparticles for Cancer Detection and Therapy: Towards Diagnostic Applications of Quantum Dots and Rational Design of Drug Delivery Vehicles","publication_year":2011,"publication_date":"2011-08-31","ids":{"openalex":"https://openalex.org/W2728503045","mag":"2728503045"},"language":"en","primary_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/29803","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/29803","pdf_url":"https://utoronto.scholaris.ca/bitstreams/bf101196-731c-4716-a7ec-61b1b782d24f/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://utoronto.scholaris.ca/bitstreams/bf101196-731c-4716-a7ec-61b1b782d24f/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014803162","display_name":"Sawitri Mardyani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sawitri Mardyani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5014803162"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10321","display_name":"Quantum Dots Synthesis And Properties","score":0.6362000107765198,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10321","display_name":"Quantum Dots Synthesis And Properties","score":0.6362000107765198,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.2619999945163727,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.08340000361204147,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quantum-dots","display_name":"quantum dots","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cdse-zns-quantum-dots","display_name":"CdSe/ZnS quantum dots","score":0.8849999904632568},{"id":"https://openalex.org/keywords/fluorescence-quenching","display_name":"fluorescence quenching","score":0.7080000042915344},{"id":"https://openalex.org/keywords/phage-display","display_name":"phage display","score":0.824999988079071},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.6980000138282776},{"id":"https://openalex.org/keywords/microgels","display_name":"microgels","score":0.6899999976158142},{"id":"https://openalex.org/keywords/poly-n-isopropylacrylamide","display_name":"poly(N-isopropylacrylamide)","score":0.8389999866485596},{"id":"https://openalex.org/keywords/chitosan-hydrogel","display_name":"chitosan hydrogel","score":0.9580000042915344},{"id":"https://openalex.org/keywords/ph-responsive-drug-release","display_name":"pH-responsive drug release","score":0.8069999814033508},{"id":"https://openalex.org/keywords/transferrin","display_name":"transferrin","score":0.781000018119812},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.8190000057220459},{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.7329999804496765},{"id":"https://openalex.org/keywords/nanoparticle-quantification","display_name":"nanoparticle quantification","score":0.6060000061988831},{"id":"https://openalex.org/keywords/cancer-detection","display_name":"cancer detection","score":0.3779999911785126}],"concepts":[{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.5473111867904663},{"id":"https://openalex.org/C124657808","wikidata":"https://www.wikidata.org/wiki/Q1133068","display_name":"Quantum dot","level":2,"score":0.5389178395271301},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5174211263656616},{"id":"https://openalex.org/C53105671","wikidata":"https://www.wikidata.org/wiki/Q14777816","display_name":"Rational design","level":2,"score":0.5141768455505371},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.48228123784065247},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.4321579337120056},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.4231290817260742},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3994871973991394},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3386662006378174},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.27600646018981934},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10478252172470093}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:utoronto.scholaris.ca:1807/29803","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/29803","pdf_url":"https://utoronto.scholaris.ca/bitstreams/bf101196-731c-4716-a7ec-61b1b782d24f/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:collectionscanada.gc.ca:OTU.1807/29803","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1807/29803","pdf_url":null,"source":{"id":"https://openalex.org/S4306402307","display_name":"Library and Archives Canada (Government of Canada)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2802286613","host_organization_name":"Government of Canada","host_organization_lineage":["https://openalex.org/I2802286613"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2728503045","doi":null,"is_oa":false,"landing_page_url":"https://tspace.library.utoronto.ca/bitstream/1807/29803/1/Mardyani_Sawitri_201106_PhD_thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/29803","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/29803","pdf_url":"https://utoronto.scholaris.ca/bitstreams/bf101196-731c-4716-a7ec-61b1b782d24f/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2728503045.pdf","grobid_xml":"https://content.openalex.org/works/W2728503045.grobid-xml"},"referenced_works_count":130,"referenced_works":["https://openalex.org/W91373279","https://openalex.org/W599985367","https://openalex.org/W1491459594","https://openalex.org/W1530276086","https://openalex.org/W1561712812","https://openalex.org/W1586085231","https://openalex.org/W1597370315","https://openalex.org/W1607406251","https://openalex.org/W1629830706","https://openalex.org/W1871308790","https://openalex.org/W1903778810","https://openalex.org/W1963495128","https://openalex.org/W1964868194","https://openalex.org/W1965097716","https://openalex.org/W1973758418","https://openalex.org/W1975204478","https://openalex.org/W1976902173","https://openalex.org/W1977278222","https://openalex.org/W1977417867","https://openalex.org/W1979232921","https://openalex.org/W1982250810","https://openalex.org/W1982555806","https://openalex.org/W1984232298","https://openalex.org/W1985858988","https://openalex.org/W1987924718","https://openalex.org/W1988217789","https://openalex.org/W1989195046","https://openalex.org/W1990094816","https://openalex.org/W1990558842","https://openalex.org/W1992215904","https://openalex.org/W1996139192","https://openalex.org/W1996427305","https://openalex.org/W1996498428","https://openalex.org/W1998162097","https://openalex.org/W1999046940","https://openalex.org/W2002807224","https://openalex.org/W2003336829","https://openalex.org/W2004128120","https://openalex.org/W2005825728","https://openalex.org/W2006777623","https://openalex.org/W2007885480","https://openalex.org/W2009679818","https://openalex.org/W2011032800","https://openalex.org/W2012867962","https://openalex.org/W2014705530","https://openalex.org/W2015497529","https://openalex.org/W2016857312","https://openalex.org/W2019555018","https://openalex.org/W2025669689","https://openalex.org/W2027175712","https://openalex.org/W2028834783","https://openalex.org/W2029749273","https://openalex.org/W2030522563","https://openalex.org/W2031630601","https://openalex.org/W2032706441","https://openalex.org/W2032760352","https://openalex.org/W2035152288","https://openalex.org/W2038980827","https://openalex.org/W2039855332","https://openalex.org/W2040958578","https://openalex.org/W2042205576","https://openalex.org/W2042411465","https://openalex.org/W2042452418","https://openalex.org/W2043009832","https://openalex.org/W2043701906","https://openalex.org/W2044543075","https://openalex.org/W2046890107","https://openalex.org/W2046968083","https://openalex.org/W2047296853","https://openalex.org/W2047553030","https://openalex.org/W2048053977","https://openalex.org/W2049288477","https://openalex.org/W2052580681","https://openalex.org/W2055222641","https://openalex.org/W2056120938","https://openalex.org/W2056217957","https://openalex.org/W2057627099","https://openalex.org/W2059529313","https://openalex.org/W2061655961","https://openalex.org/W2062052698","https://openalex.org/W2062387698","https://openalex.org/W2063356565","https://openalex.org/W2063393943","https://openalex.org/W2063672659","https://openalex.org/W2065108131","https://openalex.org/W2065706045","https://openalex.org/W2070360032","https://openalex.org/W2071224672","https://openalex.org/W2071671615","https://openalex.org/W2073601106","https://openalex.org/W2078820160","https://openalex.org/W2079229575","https://openalex.org/W2079321730","https://openalex.org/W2080376276","https://openalex.org/W2080392890","https://openalex.org/W2082174135","https://openalex.org/W2084429764","https://openalex.org/W2085064207","https://openalex.org/W2087269569","https://openalex.org/W2088268027","https://openalex.org/W2088397685","https://openalex.org/W2088410504","https://openalex.org/W2091684294","https://openalex.org/W2094437628","https://openalex.org/W2094842452","https://openalex.org/W2095248480","https://openalex.org/W2095392714","https://openalex.org/W2096179028","https://openalex.org/W2097535374","https://openalex.org/W2100461371","https://openalex.org/W2104558356","https://openalex.org/W2108524724","https://openalex.org/W2108611432","https://openalex.org/W2112101570","https://openalex.org/W2115907801","https://openalex.org/W2123605247","https://openalex.org/W2125123295","https://openalex.org/W2133391229","https://openalex.org/W2148924929","https://openalex.org/W2150412194","https://openalex.org/W2153992927","https://openalex.org/W2155329472","https://openalex.org/W2163294691","https://openalex.org/W2164845223","https://openalex.org/W2166866769","https://openalex.org/W2169711173","https://openalex.org/W2170083676","https://openalex.org/W2171083652","https://openalex.org/W2953030345","https://openalex.org/W3145545648"],"related_works":["https://openalex.org/W7097074577","https://openalex.org/W4386162879","https://openalex.org/W2972916742","https://openalex.org/W1510985504","https://openalex.org/W2066025713","https://openalex.org/W2905458023","https://openalex.org/W4242193662","https://openalex.org/W2136263023","https://openalex.org/W2571219094","https://openalex.org/W4283210552"],"abstract_inverted_index":{"This":[0,118],"thesis":[1],"describes":[2],"observations,":[3],"techniques":[4],"and":[5,16,22,31,88,215,226,236,259,270,286],"strategies,":[6],"which":[7,111,127,148,173,193,253],"contribute":[8],"towards":[9,27],"the":[10,36,76,82,85,92,196,227,296,308],"development":[11],"of":[12,18,39,48,63,78,90,199,307],"nanoparticle":[13],"based":[14],"detection":[15,30],"treatment":[17],"cancer.":[19],"Quantum":[20],"dots":[21,50,67],"biorecognition":[23,201,242],"molecules":[24,202,243],"were":[25,33,94,128,156,210,230,244,254,278],"studied":[26],"applications":[28],"in":[29,35,53,57,131,137,276,288,299],"microgels":[32],"used":[34,56,101,168,217],"rational":[37],"design":[38],"a":[40,153,171,204,220],"targeted":[41],"drug":[42,250],"delivery":[43,251],"vehicle.":[44],"The":[45,60,224],"fluorescence":[46,61,97,142,237],"intensity":[47,62],"quantum":[49,66],"was":[51,69,109,167,174,190],"examined":[52],"buffers":[54],"commonly":[55],"molecular":[58,154],"biology.":[59],"ZnS-capped":[64],"CdSe":[65],"(QDs)":[68],"found":[70],"to":[71,102,123,134,152,169,178,212,218,248,256,284,314],"vary":[72],"significantly,":[73],"depending":[74],"on":[75,81,115,164,290],"amount":[77],"ZnS":[79],"capping":[80],"QDs":[83,93,136,177],"or":[84,141],"concentration,":[86],"pH":[87,267],"type":[89],"buffer":[91],"in.":[95],"Since":[96],"cannot":[98],"reliably":[99],"be":[100,315],"quantify":[103,135],"QDs,":[104],"an":[105,132,265],"alternative":[106],"quantification":[107],"method":[108,119],"developed,":[110,192],"does":[112],"not":[113],"rely":[114],"their":[116],"fluorescence.":[117],"employs":[120],"phage":[121,160,186,221,229],"display":[122,163,187,222],"identify":[124,170],"nanoparticle-specific":[125],"bacteriophage":[126],"then":[129,216,231,260],"applied":[130],"assay":[133],"environments":[138],"where":[139],"absorbance":[140],"spectroscopy":[143],"are":[144],"ineffective.":[145],"Biorecognition":[146],"molecules,":[147],"can":[149],"direct":[150],"nanoparticles":[151,247],"target,":[155],"also":[157,191],"identified":[158],"through":[159,264],"display.":[161],"Phage":[162],"whole":[165],"cells":[166],"peptide,":[172],"conjugated":[175,211,283],"with":[176,246,280],"stain":[179],"HeLa":[180,291],"(cervical":[181],"cancer)":[182],"cells.":[183,292],"A":[184],"high-throughput":[185],"screening":[188],"strategy":[189],"could":[194],"enable":[195],"simultaneous":[197],"identification":[198],"multiple":[200],"from":[203],"single":[205],"library.":[206,223],"QD-encoded":[207],"microbead":[208],"barcodes":[209],"protein":[213],"targets":[214],"screen":[219],"beads":[225],"binding":[228],"separated":[232],"using":[233],"flow":[234],"cytometry":[235],"assisted":[238],"cell":[239],"sorting.":[240],"Finally,":[241],"combined":[245],"create":[249],"vehicles,":[252],"designed":[255],"protect,":[257],"deliver":[258],"release":[261],"chemotherapeutic":[262,281],"drugs":[263],"intracellular":[266],"trigger.":[268],"PolyNIPAAm":[269],"chitosan":[271],"hydrogels,":[272],"under":[273],"200":[274],"nm":[275],"diameter,":[277],"loaded":[279],"drugs,":[282],"transferrin":[285],"tested":[287],"vitro":[289],"These":[293],"projects":[294],"demonstrate":[295],"great":[297],"potential":[298],"this":[300],"growing":[301],"field":[302],"as":[303,305],"well":[304],"some":[306],"many":[309],"challenges":[310],"that":[311],"have":[312],"yet":[313],"overcome.":[316]},"counts_by_year":[],"updated_date":"2026-09-11T09:22:31.653822","created_date":"2017-07-14T00:00:00"}