{"id":"https://openalex.org/W27280687","doi":null,"title":"Effect of catecholamines on IL-2 production and NK cytotoxicity of rats in vitro.","display_name":"Effect of catecholamines on IL-2 production and NK cytotoxicity of rats in vitro.","publication_year":2004,"publication_date":"2004-10-01","ids":{"openalex":"https://openalex.org/W27280687","mag":"27280687","pmid":"https://pubmed.ncbi.nlm.nih.gov/15456539"},"language":"en","primary_location":{"id":"pmid:15456539","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15456539","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta pharmacologica Sinica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029563117","display_name":"Yu-Ping Peng","orcid":"https://orcid.org/0000-0002-5966-0922","observed_orcids":["https://orcid.org/0000-0002-5966-0922"]},"institutions":[{"id":"https://openalex.org/I4391768045","display_name":"State Key Laboratory of Pharmaceutical Biotechnology","ror":"https://ror.org/043ea4m21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu-Ping Peng","raw_affiliation_strings":["Department of Biological Science and Technology and the State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Science and Technology and the State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, China","institution_ids":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089859116","display_name":"Yihua Qiu","orcid":"https://orcid.org/0000-0003-1243-4810","observed_orcids":["https://orcid.org/0000-0003-1243-4810"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yi-Hua Qiu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017532955","display_name":"Jian\u2010Lan Jiang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jian-Lan Jiang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100410428","display_name":"Jianjun Wang","orcid":"https://orcid.org/0000-0002-6800-3000","observed_orcids":["https://orcid.org/0000-0002-6800-3000"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jian-Jun Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5321,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.614389,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"25","issue":"10","first_page":"1354","last_page":"60"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.6118000149726868,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.6118000149726868,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.2483000010251999,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.0568000003695488,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/catecholamines","display_name":"catecholamines","score":1.0},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.9779999852180481},{"id":"https://openalex.org/keywords/il-2-production","display_name":"IL-2 production","score":0.9430000185966492},{"id":"https://openalex.org/keywords/nk-cell-cytotoxicity","display_name":"NK cell cytotoxicity","score":0.949999988079071},{"id":"https://openalex.org/keywords/alpha-adrenergic-receptors","display_name":"alpha-adrenergic receptors","score":0.8429999947547913},{"id":"https://openalex.org/keywords/beta-adrenergic-receptors","display_name":"beta-adrenergic receptors","score":1.0},{"id":"https://openalex.org/keywords/alpha-methyl-p-tyrosine","display_name":"alpha-methyl-p-tyrosine","score":0.9559999704360962},{"id":"https://openalex.org/keywords/tyrosine-hydroxylase-inhibition","display_name":"tyrosine hydroxylase inhibition","score":0.8970000147819519},{"id":"https://openalex.org/keywords/adrenergic-antagonists","display_name":"adrenergic antagonists","score":0.7080000042915344},{"id":"https://openalex.org/keywords/phentolamine","display_name":"phentolamine","score":0.7879999876022339},{"id":"https://openalex.org/keywords/propranolol","display_name":"propranolol","score":0.9990000128746033},{"id":"https://openalex.org/keywords/concanavalin-a","display_name":"concanavalin A","score":0.8220000267028809},{"id":"https://openalex.org/keywords/lymphocyte-function","display_name":"lymphocyte function","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C2780253649","wikidata":"https://www.wikidata.org/wiki/Q420360","display_name":"Phentolamine","level":3,"score":0.8858001232147217},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.6497635245323181},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5919743180274963},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.5557785630226135},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5553513765335083},{"id":"https://openalex.org/C19869320","wikidata":"https://www.wikidata.org/wiki/Q419277","display_name":"Concanavalin A","level":3,"score":0.5544037818908691},{"id":"https://openalex.org/C2778151854","wikidata":"https://www.wikidata.org/wiki/Q423364","display_name":"Propranolol","level":2,"score":0.504845917224884},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4931477904319763},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.44432294368743896},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.4243800640106201},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.42310068011283875},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3652271628379822},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30406084656715393},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.24661359190940857},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21198073029518127},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16109159588813782}],"mesh":[{"descriptor_ui":"D000316","descriptor_name":"Adrenergic alpha-Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000317","descriptor_name":"Adrenergic alpha-Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000319","descriptor_name":"Adrenergic beta-Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002469","descriptor_name":"Cell Separation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010646","descriptor_name":"Phentolamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011433","descriptor_name":"Propranolol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019805","descriptor_name":"alpha-Methyltyrosine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:15456539","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15456539","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta pharmacologica Sinica","raw_type":"Journal Article"},{"id":"mag:1582111052","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/qk/95561A/200410/11033565.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306542255","display_name":"\u4e2d\u56fd\u836f\u7406\u5b66\u62a5\uff1a\u82f1\u6587\u7248","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u56fd\u836f\u7406\u5b66\u62a5\uff1a\u82f1\u6587\u7248","raw_type":null},{"id":"mag:27280687","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15456539","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W30612853","https://openalex.org/W55074486","https://openalex.org/W72697230","https://openalex.org/W79466244","https://openalex.org/W1484042664","https://openalex.org/W1500478004","https://openalex.org/W1548605804","https://openalex.org/W1968853225","https://openalex.org/W1970252369","https://openalex.org/W1976232121","https://openalex.org/W1982902233","https://openalex.org/W1984996259","https://openalex.org/W1994747498","https://openalex.org/W1995712554","https://openalex.org/W1996572448","https://openalex.org/W1997482864","https://openalex.org/W1999425425","https://openalex.org/W2002050544","https://openalex.org/W2005640657","https://openalex.org/W2007622813","https://openalex.org/W2012196695","https://openalex.org/W2014594657","https://openalex.org/W2015230474","https://openalex.org/W2020257768","https://openalex.org/W2020341791","https://openalex.org/W2020954963","https://openalex.org/W2024102779","https://openalex.org/W2026990654","https://openalex.org/W2031047943","https://openalex.org/W2032971951","https://openalex.org/W2035809865","https://openalex.org/W2041663579","https://openalex.org/W2043792809","https://openalex.org/W2044707231","https://openalex.org/W2056336771","https://openalex.org/W2056380758","https://openalex.org/W2056768166","https://openalex.org/W2057519110","https://openalex.org/W2062558899","https://openalex.org/W2066012308","https://openalex.org/W2071030419","https://openalex.org/W2078707624","https://openalex.org/W2079724669","https://openalex.org/W2079926187","https://openalex.org/W2083249633","https://openalex.org/W2085099489","https://openalex.org/W2085549876","https://openalex.org/W2086487142","https://openalex.org/W2087213531","https://openalex.org/W2089150369","https://openalex.org/W2093135147","https://openalex.org/W2095738477","https://openalex.org/W2098691880","https://openalex.org/W2098910999","https://openalex.org/W2099172760","https://openalex.org/W2099463369","https://openalex.org/W2100709790","https://openalex.org/W2112489310","https://openalex.org/W2114215066","https://openalex.org/W2114704077","https://openalex.org/W2114918609","https://openalex.org/W2117119768","https://openalex.org/W2117677020","https://openalex.org/W2126039851","https://openalex.org/W2129271736","https://openalex.org/W2132861593","https://openalex.org/W2135514207","https://openalex.org/W2147204790","https://openalex.org/W2148086787","https://openalex.org/W2162405407","https://openalex.org/W2164072021","https://openalex.org/W2206690131","https://openalex.org/W2319032954","https://openalex.org/W2337865973","https://openalex.org/W2375648073","https://openalex.org/W2393053926"],"related_works":["https://openalex.org/W2035640227","https://openalex.org/W1990687236","https://openalex.org/W1500377663","https://openalex.org/W2067107470","https://openalex.org/W2419554469","https://openalex.org/W2020257768","https://openalex.org/W2016853043","https://openalex.org/W2052203008","https://openalex.org/W2166866341","https://openalex.org/W1995315107"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"explore":[2],"effects":[3],"of":[4,11,21,66,96,101,118,122,127,146,194,217],"exogenous":[5],"and":[6,13,37,46,57,76,82,130,137,158,170,182,219,228,232],"endogenous":[7],"catecholamines":[8,239],"on":[9,248],"function":[10],"lymphocytes":[12,242,250],"primary":[14],"mechanisms":[15,231],"mediating":[16],"the":[17,161,223,233,249],"effects.":[18],"METHODS:":[19],"Splenocytes":[20],"rats":[22],"were":[23,52,73,87,134,140],"exposed":[24],"to":[25],"norepinephrine":[26],"(NE),":[27],"alpha-":[28,227],"or":[29,34,111],"beta-adrenoceptor":[30,114,229],"antagonists":[31],"plus":[32],"NE,":[33],"alpha-methyl-p-tyrosine":[35],"(alpha-MT),":[36],"then":[38],"concanavalin":[39],"A":[40],"(Con":[41],"A)-induced":[42],"interleukin-2":[43],"(IL-2)":[44],"production":[45],"natural":[47],"killer":[48],"(NK)":[49],"cell":[50],"cytotoxicity":[51,151,196],"determined":[53],"by":[54,105,155,197,201,205,241],"MTT":[55],"assay":[56],"LDH":[58],"assay,":[59],"respectively.":[60],"RESULTS:":[61],"Optical":[62],"density":[63],"(OD)":[64],"values":[65,117],"NE-treated":[67],"groups,":[68],"which":[69,139],"reflected":[70],"IL-2":[71],"production,":[72],"0.63,":[74],"0.61,":[75],"0.60,":[77],"respectively":[78,133],"for":[79,176,188],"10(-10),":[80,128],"10(-9),":[81,129],"10(-8)":[83,131],"mol/L":[84,132],"NE.":[85],"They":[86],"all":[88,141,190],"significantly":[89],"reduced":[90],"in":[91,214],"comparison":[92],"with":[93,222],"control":[94,147],"value":[95],"0.68":[97],"(P<0.01).":[98],"The":[99,192],"effect":[100,247],"NE":[102,157,198,209],"was":[103,152,199],"blocked":[104],"either":[106],"phentolamine":[107],"(an":[108],"alpha-adrenoceptor":[109],"antagonist)":[110],"propanolol":[112],"(a":[113],"antagonist).":[115],"OD":[116],"alpha-MT,":[119],"an":[120,245],"inhibitor":[121],"tyrosine":[123],"hydroxylase,":[124],"at":[125,160],"doses":[126,163],"0.71,":[135,136],"0.69,":[138],"notably":[142],"higher":[143],"than":[144],"that":[145],"(0.65,":[148],"P<0.01).":[149,191],"NK":[150,195,220],"markedly":[153],"attenuated":[154],"both":[156,226],"alpha-MT":[159],"three":[162],"mentioned":[164],"above":[165],"(17.69":[166],"%,":[167,169,179,181],"17.06":[168],"16.89":[171],"%":[172,175,184,187],"versus":[173,185],"25.18":[174],"NE;":[177],"18.85":[178],"18.44":[180],"17.04":[183],"23.22":[186],"alpha-MT;":[189],"suppression":[193],"prevented":[200],"propranolol":[202],"but":[203],"not":[204],"phentolamine.":[206],"CONCLUSION:":[207],"Exogenous":[208],"exerts":[210],"a":[211],"suppressive":[212],"action":[213],"modulating":[215],"functions":[216],"T":[218],"cells,":[221],"former":[224],"via":[225],"mediated":[230],"later":[234],"mainly":[235],"through":[236],"beta-adrenoceptors.":[237],"Endogenous":[238],"synthesized":[240],"have":[243],"also":[244],"autoregulatory":[246],"themselves.":[251]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}