{"id":"https://openalex.org/W2726633869","doi":"https://doi.org/10.1093/jac/dkx185","title":"Baicalein acts as a nephroprotectant that ameliorates colistin-induced nephrotoxicity by activating the antioxidant defence mechanism of the kidneys and down-regulating the inflammatory response","display_name":"Baicalein acts as a nephroprotectant that ameliorates colistin-induced nephrotoxicity by activating the antioxidant defence mechanism of the kidneys and down-regulating the inflammatory response","publication_year":2017,"publication_date":"2017-05-24","ids":{"openalex":"https://openalex.org/W2726633869","doi":"https://doi.org/10.1093/jac/dkx185","mag":"2726633869","pmid":"https://pubmed.ncbi.nlm.nih.gov/28859441","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5890707"},"language":"en","primary_location":{"id":"doi:10.1093/jac/dkx185","doi":"https://doi.org/10.1093/jac/dkx185","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jac/dkx185","pdf_url":"https://academic.oup.com/jac/article-pdf/72/9/2562/24332246/dkx185.pdf","source":{"id":"https://openalex.org/S124275759","display_name":"Journal of Antimicrobial Chemotherapy","issn_l":"0305-7453","issn":["0305-7453","1460-2091"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Antimicrobial Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/jac/article-pdf/72/9/2562/24332246/dkx185.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044344398","display_name":"Chongshan Dai","orcid":"https://orcid.org/0000-0002-4677-0524","observed_orcids":["https://orcid.org/0000-0002-4677-0524"]},"institutions":[{"id":"https://openalex.org/I52158045","display_name":"China Agricultural University","ror":"https://ror.org/04v3ywz14","country_code":"CN","type":"education","lineage":["https://openalex.org/I52158045"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chongshan Dai","raw_affiliation_strings":["Department of Pharmacology and Toxicology, College of Veterinary Medicine, China Agricultural University, No.2 Yuanmingyuan West Road, Beijing 100193, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, College of Veterinary Medicine, China Agricultural University, No.2 Yuanmingyuan West Road, Beijing 100193, P. R. China","institution_ids":["https://openalex.org/I52158045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009391844","display_name":"Shusheng Tang","orcid":"https://orcid.org/0000-0003-1860-3582","observed_orcids":["https://orcid.org/0000-0003-1860-3582"]},"institutions":[{"id":"https://openalex.org/I52158045","display_name":"China Agricultural University","ror":"https://ror.org/04v3ywz14","country_code":"CN","type":"education","lineage":["https://openalex.org/I52158045"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shusheng Tang","raw_affiliation_strings":["Department of Pharmacology and Toxicology, College of Veterinary Medicine, China Agricultural University, No.2 Yuanmingyuan West Road, Beijing 100193, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, College of Veterinary Medicine, China Agricultural University, No.2 Yuanmingyuan West Road, Beijing 100193, P. R. China","institution_ids":["https://openalex.org/I52158045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100322731","display_name":"Yang Wang","orcid":"https://orcid.org/0000-0002-5928-9377","observed_orcids":["https://orcid.org/0000-0002-5928-9377"]},"institutions":[{"id":"https://openalex.org/I52158045","display_name":"China Agricultural University","ror":"https://ror.org/04v3ywz14","country_code":"CN","type":"education","lineage":["https://openalex.org/I52158045"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Wang","raw_affiliation_strings":["Department of Pharmacology and Toxicology, College of Veterinary Medicine, China Agricultural University, No.2 Yuanmingyuan West Road, Beijing 100193, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, College of Veterinary Medicine, China Agricultural University, No.2 Yuanmingyuan West Road, Beijing 100193, P. R. China","institution_ids":["https://openalex.org/I52158045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020748618","display_name":"Tony Velkov","orcid":"https://orcid.org/0000-0002-0017-7952","observed_orcids":["https://orcid.org/0000-0002-0017-7952"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Tony Velkov","raw_affiliation_strings":["Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101556834","display_name":"Xilong Xiao","orcid":"https://orcid.org/0000-0002-8218-4186","observed_orcids":["https://orcid.org/0000-0002-8218-4186"]},"institutions":[{"id":"https://openalex.org/I52158045","display_name":"China Agricultural University","ror":"https://ror.org/04v3ywz14","country_code":"CN","type":"education","lineage":["https://openalex.org/I52158045"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU","CN"],"is_corresponding":true,"raw_author_name":"Xilong Xiao","raw_affiliation_strings":["Department of Pharmacology and Toxicology, College of Veterinary Medicine, China Agricultural University, No.2 Yuanmingyuan West Road, Beijing 100193, P. R. China","Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, College of Veterinary Medicine, China Agricultural University, No.2 Yuanmingyuan West Road, Beijing 100193, P. R. China","institution_ids":["https://openalex.org/I52158045"]},{"raw_affiliation_string":"Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I56590836"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101556834"],"corresponding_institution_ids":["https://openalex.org/I52158045","https://openalex.org/I56590836"],"apc_list":{"value":2869,"currency":"GBP","value_usd":3784},"apc_paid":null,"fwci":4.294,"has_fulltext":true,"cited_by_count":72,"citation_normalized_percentile":{"value":0.94666825,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"72","issue":"9","first_page":"2562","last_page":"2569"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.026200000196695328,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/baicalein","display_name":"baicalein","score":1.0},{"id":"https://openalex.org/keywords/colistin","display_name":"colistin","score":0.824999988079071},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.9950000047683716},{"id":"https://openalex.org/keywords/renal-protection","display_name":"renal protection","score":0.9810000061988831},{"id":"https://openalex.org/keywords/scutellaria-baicalensis","display_name":"Scutellaria baicalensis","score":0.8840000033378601},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8560000061988831},{"id":"https://openalex.org/keywords/nitrative-stress","display_name":"nitrative stress","score":0.843999981880188},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6930000185966492},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6290000081062317},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.9290000200271606},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.9670000076293945},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9990000128746033},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.875},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.4740000069141388}],"concepts":[{"id":"https://openalex.org/C2781466915","wikidata":"https://www.wikidata.org/wiki/Q2879363","display_name":"Baicalein","level":2,"score":0.9462172389030457},{"id":"https://openalex.org/C126189478","wikidata":"https://www.wikidata.org/wiki/Q1468324","display_name":"Nephrotoxicity","level":3,"score":0.8195820450782776},{"id":"https://openalex.org/C2779259085","wikidata":"https://www.wikidata.org/wiki/Q418946","display_name":"Colistin","level":3,"score":0.7976182699203491},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.7760113477706909},{"id":"https://openalex.org/C2778153525","wikidata":"https://www.wikidata.org/wiki/Q803769","display_name":"Scutellaria baicalensis","level":4,"score":0.7712587118148804},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6282000541687012},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5054764747619629},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.45978644490242004},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.43989020586013794},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4200001060962677},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34371402859687805},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.2858119010925293},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1280907690525055},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11468204855918884},{"id":"https://openalex.org/C188947578","wikidata":"https://www.wikidata.org/wiki/Q200253","display_name":"Traditional Chinese medicine","level":3,"score":0.11427927017211914},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09008923172950745},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D003091","descriptor_name":"Colistin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003091","descriptor_name":"Colistin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D007677","descriptor_name":"Kidney Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020011","descriptor_name":"Protective Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D020011","descriptor_name":"Protective Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D044950","descriptor_name":"Flavanones","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D044950","descriptor_name":"Flavanones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/jac/dkx185","doi":"https://doi.org/10.1093/jac/dkx185","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jac/dkx185","pdf_url":"https://academic.oup.com/jac/article-pdf/72/9/2562/24332246/dkx185.pdf","source":{"id":"https://openalex.org/S124275759","display_name":"Journal of Antimicrobial Chemotherapy","issn_l":"0305-7453","issn":["0305-7453","1460-2091"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Antimicrobial Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5070151","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5890707","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5890707","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5890707","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Antimicrob Chemother","raw_type":"Text"},{"id":"pmid:28859441","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28859441","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of antimicrobial chemotherapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/jac/dkx185","doi":"https://doi.org/10.1093/jac/dkx185","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jac/dkx185","pdf_url":"https://academic.oup.com/jac/article-pdf/72/9/2562/24332246/dkx185.pdf","source":{"id":"https://openalex.org/S124275759","display_name":"Journal of Antimicrobial Chemotherapy","issn_l":"0305-7453","issn":["0305-7453","1460-2091"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Antimicrobial Chemotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2482007926","display_name":null,"funder_award_id":"AI111965","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3393262977","display_name":"New Tricks for 'Old' Drugs: PK/PD of Polymyxin Nonantibiotic Combinations","funder_award_id":"R01AI111965","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8212801049","display_name":null,"funder_award_id":"31422055","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2726633869.pdf","grobid_xml":"https://content.openalex.org/works/W2726633869.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1727558111","https://openalex.org/W1919988710","https://openalex.org/W1963528029","https://openalex.org/W1974225058","https://openalex.org/W1978724961","https://openalex.org/W1985664608","https://openalex.org/W1987171993","https://openalex.org/W1990421417","https://openalex.org/W1993044982","https://openalex.org/W1995612252","https://openalex.org/W1997173332","https://openalex.org/W2003750565","https://openalex.org/W2034404481","https://openalex.org/W2052899239","https://openalex.org/W2083571917","https://openalex.org/W2084382866","https://openalex.org/W2086667809","https://openalex.org/W2108969659","https://openalex.org/W2113024198","https://openalex.org/W2123135656","https://openalex.org/W2138233204","https://openalex.org/W2141954143","https://openalex.org/W2143694994","https://openalex.org/W2145892893","https://openalex.org/W2148912594","https://openalex.org/W2150502003","https://openalex.org/W2151685719","https://openalex.org/W2154266222","https://openalex.org/W2167477126","https://openalex.org/W2180093027","https://openalex.org/W2225133767","https://openalex.org/W2236841698","https://openalex.org/W2269832447","https://openalex.org/W2358053226","https://openalex.org/W2467527170","https://openalex.org/W2513532815"],"related_works":["https://openalex.org/W4416355998","https://openalex.org/W4229050471","https://openalex.org/W7131099084","https://openalex.org/W1995612252","https://openalex.org/W3163468014","https://openalex.org/W3128451957","https://openalex.org/W4417297497","https://openalex.org/W1719950912","https://openalex.org/W4283375611","https://openalex.org/W2116660179"],"abstract_inverted_index":{"Background:":[0],"Nephrotoxicity":[1],"is":[2,186],"the":[3,35,43,62,93,131,151,165,174,180,187,191,203,211],"major":[4],"adverse":[5],"effect":[6,37,193],"patients":[7,225],"experience":[8],"during":[9,22],"colistin":[10,71,77,175],"therapy.":[11,228],"The":[12,104],"development":[13],"of":[14,38,42,45,95,106,133,158,167,182,194],"effective":[15],"nephroprotective":[16,36],"agents":[17],"that":[18,217],"can":[19],"be":[20],"co-administered":[21],"polymyxin":[23,227],"therapy":[24],"remains":[25],"a":[26,40,52],"priority":[27],"area":[28],"in":[29,139,150,173,207,224],"antimicrobial":[30],"chemotherapy.":[31],"Objectives:":[32],"To":[33,179],"investigate":[34],"baicalein,":[39],"component":[41],"root":[44],"Scutellaria":[46],"baicalensis,":[47],"against":[48],"colistin-induced":[49,125,197],"nephrotoxicity":[50,198,223],"using":[51,116],"mouse":[53],"model.":[54],"Methods:":[55],"C57BL/6":[56],"mice":[57],"were":[58,102,112],"randomly":[59],"divided":[60],"into":[61],"following":[63],"groups:":[64],"control,":[65],"baicalein":[66,81,195,219],"100":[67,85],"mg/kg/day":[68,73],"(administered":[69],"orally),":[70],"(18":[72,78],"administered":[74],"intraperitoneally)":[75],"and":[76,84,100,109,127,136,141,160,163,199,209],"mg/kg/day)":[79],"plus":[80],"(25,":[82],"50":[83],"mg/kg/day).":[86],"After":[87],"7":[88],"day":[89],"treatments,":[90],"histopathological":[91],"damage,":[92],"markers":[94],"renal":[96],"functions,":[97],"oxidative":[98,126],"stress":[99],"inflammation":[101],"examined.":[103],"expressions":[105],"Nrf2,":[107],"HO-1":[108,161],"NF-\u03baB":[110,168],"mRNAs":[111,162],"also":[113],"further":[114],"examined":[115],"quantitative":[117],"RT-PCR":[118],"examination.":[119],"Results:":[120],"Baicalein":[121,154],"co-administration":[122,155],"markedly":[123],"attenuated":[124],"nitrative":[128],"stress,":[129],"apoptosis,":[130],"infiltration":[132],"inflammatory":[134,212],"cells,":[135],"caused":[137],"decreases":[138],"IL-1\u03b2":[140],"TNF-\u03b1":[142],"levels":[143],"(all":[144],"P":[145],"<":[146],"0.05":[147],"or":[148],"0.01)":[149],"kidney":[152],"tissues.":[153],"up-regulated":[156],"expression":[157,166],"Nrf2":[159],"down-regulated":[164],"mRNA,":[169],"compared":[170],"with":[171],"those":[172],"alone":[176],"group.":[177],"Conclusions:":[178],"best":[181],"our":[183],"knowledge,":[184],"this":[185],"first":[188],"study":[189,215],"demonstrating":[190],"protective":[192],"on":[196],"apoptosis":[200],"by":[201],"activating":[202],"antioxidant":[204],"defence":[205],"mechanism":[206],"kidneys":[208],"down-regulating":[210],"response.":[213],"Our":[214],"highlights":[216],"oral":[218],"could":[220],"potentially":[221],"ameliorate":[222],"undergoing":[226]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-07-14T00:00:00"}
