{"id":"https://openalex.org/W2726136233","doi":null,"title":"The Study of Pancreatic Circulating Tumor Cells via Isolation with an Integrated Microfluidic Immunomagnetic (IMI) Device","display_name":"The Study of Pancreatic Circulating Tumor Cells via Isolation with an Integrated Microfluidic Immunomagnetic (IMI) Device","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2726136233","mag":"2726136233"},"language":"en","primary_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/135916","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/135916","pdf_url":"https://hdl.handle.net/2027.42/135916","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/2027.42/135916","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112355946","display_name":"Rhonda M. Jack","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rhonda Jack","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5112355946"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circulating-tumor-cells","display_name":"circulating tumor cells","score":0.9649999737739563},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ctc-isolation","display_name":"CTC isolation","score":0.7429999709129333},{"id":"https://openalex.org/keywords/microfluidic-cell-sorting","display_name":"microfluidic cell sorting","score":0.7680000066757202},{"id":"https://openalex.org/keywords/immunomagnetic-separation","display_name":"immunomagnetic separation","score":0.7910000085830688},{"id":"https://openalex.org/keywords/ctc-enrichment","display_name":"CTC enrichment","score":0.8190000057220459},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6740000247955322},{"id":"https://openalex.org/keywords/mrna-profiling","display_name":"mRNA expression profiling","score":0.7149999737739563},{"id":"https://openalex.org/keywords/microrna-expression-profiling","display_name":"miRNA expression profiling","score":0.9649999737739563},{"id":"https://openalex.org/keywords/ctc-heterogeneity","display_name":"CTC heterogeneity","score":0.8980000019073486},{"id":"https://openalex.org/keywords/epcam","display_name":"EpCAM","score":0.9649999737739563},{"id":"https://openalex.org/keywords/rare-cell-detection","display_name":"rare cell detection","score":0.6800000071525574}],"concepts":[{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.6560585498809814},{"id":"https://openalex.org/C2775941552","wikidata":"https://www.wikidata.org/wiki/Q25212305","display_name":"Isolation (microbiology)","level":2,"score":0.6449519991874695},{"id":"https://openalex.org/C61238886","wikidata":"https://www.wikidata.org/wiki/Q5121689","display_name":"Circulating tumor cell","level":4,"score":0.6112174391746521},{"id":"https://openalex.org/C2781053203","wikidata":"https://www.wikidata.org/wiki/Q1660182","display_name":"Immunomagnetic separation","level":2,"score":0.5471935272216797},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.46008965373039246},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3548104763031006},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34109172224998474},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3363150954246521},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3217359185218811},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2829912304878235},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2808326482772827},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.27676382660865784},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2744419574737549},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2204260230064392},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.19490790367126465},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.15531539916992188},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.09731864929199219}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/135916","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/135916","pdf_url":"https://hdl.handle.net/2027.42/135916","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2726136233","doi":null,"is_oa":false,"landing_page_url":"https://deepblue.lib.umich.edu/handle/2027.42/135916","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/135916","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/135916","pdf_url":"https://hdl.handle.net/2027.42/135916","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2726136233.pdf","grobid_xml":"https://content.openalex.org/works/W2726136233.grobid-xml"},"referenced_works_count":141,"referenced_works":["https://openalex.org/W82508993","https://openalex.org/W95463455","https://openalex.org/W1529735656","https://openalex.org/W1548015278","https://openalex.org/W1805834977","https://openalex.org/W1906566368","https://openalex.org/W1951193055","https://openalex.org/W1964575191","https://openalex.org/W1964763549","https://openalex.org/W1967489571","https://openalex.org/W1967625972","https://openalex.org/W1968562444","https://openalex.org/W1970655967","https://openalex.org/W1976078521","https://openalex.org/W1977594022","https://openalex.org/W1985748412","https://openalex.org/W1987370132","https://openalex.org/W1989215251","https://openalex.org/W1993410470","https://openalex.org/W1993913242","https://openalex.org/W1995338489","https://openalex.org/W1996128188","https://openalex.org/W1999095025","https://openalex.org/W2000326450","https://openalex.org/W2001014168","https://openalex.org/W2004935845","https://openalex.org/W2007453896","https://openalex.org/W2008157693","https://openalex.org/W2012091269","https://openalex.org/W2012987872","https://openalex.org/W2013282239","https://openalex.org/W2015424377","https://openalex.org/W2015828645","https://openalex.org/W2016350600","https://openalex.org/W2017435904","https://openalex.org/W2019214567","https://openalex.org/W2019264784","https://openalex.org/W2020442157","https://openalex.org/W2021452615","https://openalex.org/W2022488821","https://openalex.org/W2022616393","https://openalex.org/W2023771000","https://openalex.org/W2024561801","https://openalex.org/W2024834932","https://openalex.org/W2026729621","https://openalex.org/W2027765160","https://openalex.org/W2030593367","https://openalex.org/W2035869340","https://openalex.org/W2035987476","https://openalex.org/W2040394747","https://openalex.org/W2041142042","https://openalex.org/W2042198997","https://openalex.org/W2045209734","https://openalex.org/W2050126859","https://openalex.org/W2050547995","https://openalex.org/W2050827942","https://openalex.org/W2051147120","https://openalex.org/W2051227958","https://openalex.org/W2051572649","https://openalex.org/W2056952640","https://openalex.org/W2057142830","https://openalex.org/W2058935670","https://openalex.org/W2059223510","https://openalex.org/W2059490612","https://openalex.org/W2059542621","https://openalex.org/W2061143120","https://openalex.org/W2062109911","https://openalex.org/W2064956185","https://openalex.org/W2066135299","https://openalex.org/W2066554589","https://openalex.org/W2067904749","https://openalex.org/W2068547732","https://openalex.org/W2071261883","https://openalex.org/W2073358150","https://openalex.org/W2074687081","https://openalex.org/W2076356973","https://openalex.org/W2078904004","https://openalex.org/W2079251691","https://openalex.org/W2080217598","https://openalex.org/W2086916836","https://openalex.org/W2087685591","https://openalex.org/W2088580309","https://openalex.org/W2089135124","https://openalex.org/W2091102810","https://openalex.org/W2092241568","https://openalex.org/W2097950721","https://openalex.org/W2098990516","https://openalex.org/W2099023480","https://openalex.org/W2100118850","https://openalex.org/W2102198783","https://openalex.org/W2102864709","https://openalex.org/W2103736766","https://openalex.org/W2104457974","https://openalex.org/W2106145320","https://openalex.org/W2106513086","https://openalex.org/W2108122736","https://openalex.org/W2108296770","https://openalex.org/W2108816382","https://openalex.org/W2110611961","https://openalex.org/W2111976640","https://openalex.org/W2113248685","https://openalex.org/W2113851997","https://openalex.org/W2115158793","https://openalex.org/W2116053761","https://openalex.org/W2116483002","https://openalex.org/W2116731538","https://openalex.org/W2117304513","https://openalex.org/W2119494825","https://openalex.org/W2121690903","https://openalex.org/W2129478209","https://openalex.org/W2131170195","https://openalex.org/W2138665978","https://openalex.org/W2148703808","https://openalex.org/W2148874508","https://openalex.org/W2151941496","https://openalex.org/W2152393478","https://openalex.org/W2152393981","https://openalex.org/W2153768374","https://openalex.org/W2154790710","https://openalex.org/W2155828430","https://openalex.org/W2158027291","https://openalex.org/W2159024004","https://openalex.org/W2161021183","https://openalex.org/W2161514295","https://openalex.org/W2161862739","https://openalex.org/W2161884651","https://openalex.org/W2162444401","https://openalex.org/W2162502060","https://openalex.org/W2165418538","https://openalex.org/W2166471103","https://openalex.org/W2166779888","https://openalex.org/W2167511369","https://openalex.org/W2168097779","https://openalex.org/W2168645747","https://openalex.org/W2168705567","https://openalex.org/W2171237493","https://openalex.org/W2172203250","https://openalex.org/W2262797342","https://openalex.org/W2276975311","https://openalex.org/W2318673272","https://openalex.org/W3166886805"],"related_works":["https://openalex.org/W2137866043","https://openalex.org/W2748425929","https://openalex.org/W2567146210","https://openalex.org/W2237233166","https://openalex.org/W4299625073","https://openalex.org/W2892891167","https://openalex.org/W4393085299","https://openalex.org/W2594540956","https://openalex.org/W4413809718","https://openalex.org/W3036421523"],"abstract_inverted_index":{"In":[0,266,287],"2016":[1],"alone,":[2],"it":[3],"is":[4,80,138],"projected":[5],"that":[6,17,49,153,225,337],"over":[7],"40,000":[8],"Americans":[9],"will":[10],"succumb":[11],"to":[12,29,54,66,103,109,133,273,313,330],"pancreatic":[13,194,208],"cancer.":[14,345],"One":[15],"avenue":[16],"holds":[18],"promise":[19],"in":[20,34,86,159,205,341],"developing":[21],"accurate":[22],"predictive":[23],"tools":[24],"and":[25,60,75,89,170,316,334],"effective":[26],"therapeutic":[27],"agents":[28],"mitigate":[30],"cancer":[31,209],"mortality":[32],"lies":[33],"the":[35,52,63,87,121,131,143,213,254,328,342],"analysis":[36],"of":[37,46,91,123,145,157,167,179,184,188,197,200,207,218,229,248,276,284,304,308],"circulating":[38],"tumor":[39,47,59],"cells":[40,48,115,191],"(CTCs).":[41],"CTCs":[42,93,158,185,269,290],"describe":[43],"a":[44,57,83,160,274,280,296,302],"subset":[45],"have":[50,263,291,310],"acquired":[51],"ability":[53],"disseminate":[55],"from":[56,77,186,237],"primary":[58],"intravasate":[61],"into":[62],"circulatory":[64],"system":[65],"subsequently":[67],"spur":[68],"new":[69],"metastases.":[70],"As":[71],"such":[72],"their":[73],"detection":[74],"isolation":[76,178],"peripheral":[78],"blood":[79,100,128,190],"recognized":[81],"as":[82,180,182,325],"potent":[84],"tool":[85],"study":[88],"treatment":[90],"metastasis.":[92],"are":[94,116],"accessible":[95],"via":[96],"facile,":[97],"non-invasive":[98],"patient":[99,210,239],"draws":[101],"compared":[102],"complex":[104],"surgical":[105],"procedures":[106],"traditionally":[107],"employed":[108],"obtain":[110],"tissue":[111],"biopsies.":[112],"However":[113],"these":[114,318],"quite":[117],"rare,":[118],"occurring":[119],"on":[120,260,295],"order":[122],"1:1":[124],"billion":[125],"among":[126],"other":[127,189,238],"cells.":[129,320],"Therefore":[130],"need":[132],"enrich":[134,315],"them,":[135],"though":[136],"challenging,":[137],"exigent.":[139],"This":[140,174],"thesis":[141],"delineates":[142],"development":[144],"an":[146],"integrated":[147],"polymer-based":[148],"microfluidic":[149],"CTC":[150,195,235,243,261,281,323],"sorting":[151],"device":[152],"facilitates":[154],"significant":[155],"enrichment":[156],"continuous,":[161],"high-throughput":[162],"manner":[163],"through":[164,242],"strategic":[165],"combination":[166,303],"size-based":[168],"inertial":[169],"magnetic":[171],"cell":[172],"sorting.":[173],"process":[175],"enables":[176],"targeted":[177],"few":[181],"10s":[183],"billions":[187],"with":[192],"average":[193],"purity":[196],"82.5%\u00b123.5.":[198],"Detection":[199],">13":[201],"CTCs/mL":[202],"was":[203,251],"observed":[204,252],"100%":[206],"samples.":[211],"Subsequently,":[212],"work":[214],"describes":[215],"molecular":[216,335],"characterization":[217],"CTCs.":[219],"Specifically,":[220],"messenger":[221],"RNA":[222],"profiling":[223],"revealed":[224],"significantly":[226],"higher":[227],"expression":[228,247],"seven":[230],"mRNAs":[231],"could":[232],"distinguish":[233],"metastatic":[234],"profiles":[236],"profiles.":[240],"Moreover,":[241],"micro-RNA":[244],"profiling,":[245],"high":[246],"several":[249],"miRNAs":[250],"for":[253],"first":[255],"time.":[256],"Additionally,":[257],"preliminary":[258],"studies":[259],"heterogeneity":[262],"been":[264,292,311],"reported.":[265],"one":[267],"study,":[268,289],"were":[270],"sorted":[271],"according":[272],"continuum":[275],"EpCAM":[277],"protein":[278,283,298],"expression,":[279],"surface":[282,306],"paramount":[285],"interest.":[286],"another":[288],"isolated":[293],"based":[294],"dual":[297],"marker":[299],"approach":[300],"where":[301],"two":[305],"proteins":[307],"interest":[309],"used":[312],"immunomagnetically":[314],"probe":[317],"rare":[319],"Overall,":[321],"sensitive":[322],"interrogation":[324],"described":[326],"opens":[327],"doorway":[329],"identifying":[331],"biological":[332],"pathways":[333],"targets":[336],"can":[338],"be":[339],"exploited":[340],"fight":[343],"against":[344]},"counts_by_year":[],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2017-07-14T00:00:00"}