{"id":"https://openalex.org/W272579771","doi":"https://doi.org/10.1182/blood.v91.5.1706","title":"Natural Killer Cell\u2013Mediated Eradication of Neuroblastoma Metastases to Bone Marrow by Targeted Interleukin-2 Therapy","display_name":"Natural Killer Cell\u2013Mediated Eradication of Neuroblastoma Metastases to Bone Marrow by Targeted Interleukin-2 Therapy","publication_year":1998,"publication_date":"1998-03-01","ids":{"openalex":"https://openalex.org/W272579771","doi":"https://doi.org/10.1182/blood.v91.5.1706","mag":"272579771","pmid":"https://pubmed.ncbi.nlm.nih.gov/9473237"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v91.5.1706","doi":"https://doi.org/10.1182/blood.v91.5.1706","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.v91.5.1706","pdf_url":"https://ashpublications.org/blood/article-pdf/91/5/1706/1045356/1706.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ashpublications.org/blood/article-pdf/91/5/1706/1045356/1706.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018970052","display_name":"Holger N. Lode","orcid":"https://orcid.org/0000-0002-1201-208X","observed_orcids":["https://orcid.org/0000-0002-1201-208X"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Holger N. Lode","raw_affiliation_strings":["From The Scripps Research Institute, Department of Immunology; the University of California, Cancer Center, La Jolla, CA; and Fuji ImmunoPharmaceuticals Corp, Lexington, MA","Fuji ImmunoPharmaceuticals Corp, Lexington, MA","the University of California, Cancer Center, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From The Scripps Research Institute, Department of Immunology; the University of California, Cancer Center, La Jolla, CA; and Fuji ImmunoPharmaceuticals Corp, Lexington, MA","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Fuji ImmunoPharmaceuticals Corp, Lexington, MA","institution_ids":[]},{"raw_affiliation_string":"the University of California, Cancer Center, La Jolla, CA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021561362","display_name":"Rong Xiang","orcid":"https://orcid.org/0000-0003-3487-7348","observed_orcids":["https://orcid.org/0000-0003-3487-7348","https://orcid.org/0009-0003-2941-4397"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rong Xiang","raw_affiliation_strings":["From The Scripps Research Institute, Department of Immunology; the University of California, Cancer Center, La Jolla, CA; and Fuji ImmunoPharmaceuticals Corp, Lexington, MA","Fuji ImmunoPharmaceuticals Corp, Lexington, MA","the University of California, Cancer Center, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From The Scripps Research Institute, Department of Immunology; the University of California, Cancer Center, La Jolla, CA; and Fuji ImmunoPharmaceuticals Corp, Lexington, MA","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Fuji ImmunoPharmaceuticals Corp, Lexington, MA","institution_ids":[]},{"raw_affiliation_string":"the University of California, Cancer Center, La Jolla, CA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086777523","display_name":"Torsten Dreier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Torsten Dreier","raw_affiliation_strings":["From The Scripps Research Institute, Department of Immunology; the University of California, Cancer Center, La Jolla, CA; and Fuji ImmunoPharmaceuticals Corp, Lexington, MA","Fuji ImmunoPharmaceuticals Corp, Lexington, MA","the University of California, Cancer Center, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From The Scripps Research Institute, Department of Immunology; the University of California, Cancer Center, La Jolla, CA; and Fuji ImmunoPharmaceuticals Corp, Lexington, MA","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Fuji ImmunoPharmaceuticals Corp, Lexington, MA","institution_ids":[]},{"raw_affiliation_string":"the University of California, Cancer Center, La Jolla, CA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049683557","display_name":"Nissi M. Varki","orcid":"https://orcid.org/0000-0001-9839-1254","observed_orcids":["https://orcid.org/0000-0001-9839-1254"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nissi M. Varki","raw_affiliation_strings":["From The Scripps Research Institute, Department of Immunology; the University of California, Cancer Center, La Jolla, CA; and Fuji ImmunoPharmaceuticals Corp, Lexington, MA","Fuji ImmunoPharmaceuticals Corp, Lexington, MA","the University of California, Cancer Center, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From The Scripps Research Institute, Department of Immunology; the University of California, Cancer Center, La Jolla, CA; and Fuji ImmunoPharmaceuticals Corp, Lexington, MA","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Fuji ImmunoPharmaceuticals Corp, Lexington, MA","institution_ids":[]},{"raw_affiliation_string":"the University of California, Cancer Center, La Jolla, CA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000263428","display_name":"Stephen D. Gillies","orcid":"https://orcid.org/0000-0002-2080-4220","observed_orcids":["https://orcid.org/0000-0002-2080-4220"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen D. Gillies","raw_affiliation_strings":["From The Scripps Research Institute, Department of Immunology; the University of California, Cancer Center, La Jolla, CA; and Fuji ImmunoPharmaceuticals Corp, Lexington, MA","Fuji ImmunoPharmaceuticals Corp, Lexington, MA","the University of California, Cancer Center, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From The Scripps Research Institute, Department of Immunology; the University of California, Cancer Center, La Jolla, CA; and Fuji ImmunoPharmaceuticals Corp, Lexington, MA","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Fuji ImmunoPharmaceuticals Corp, Lexington, MA","institution_ids":[]},{"raw_affiliation_string":"the University of California, Cancer Center, La Jolla, CA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103782744","display_name":"Ralph A. Reisfeld","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralph A. Reisfeld","raw_affiliation_strings":["From The Scripps Research Institute, Department of Immunology; the University of California, Cancer Center, La Jolla, CA; and Fuji ImmunoPharmaceuticals Corp, Lexington, MA","Fuji ImmunoPharmaceuticals Corp, Lexington, MA","the University of California, Cancer Center, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From The Scripps Research Institute, Department of Immunology; the University of California, Cancer Center, La Jolla, CA; and Fuji ImmunoPharmaceuticals Corp, Lexington, MA","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Fuji ImmunoPharmaceuticals Corp, Lexington, MA","institution_ids":[]},{"raw_affiliation_string":"the University of California, Cancer Center, La Jolla, CA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I123431417"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":3.4676,"has_fulltext":true,"cited_by_count":177,"citation_normalized_percentile":{"value":0.93267902,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"91","issue":"5","first_page":"1706","last_page":"1715"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.6855000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.6855000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.2897999882698059,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.9399999976158142},{"id":"https://openalex.org/keywords/bone-marrow-metastasis","display_name":"bone marrow metastasis","score":0.8519999980926514},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.6869999766349792},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.9010000228881836},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.8939999938011169},{"id":"https://openalex.org/keywords/gd2-antibody","display_name":"GD2 antibody","score":0.7120000123977661},{"id":"https://openalex.org/keywords/nk-cell-deficiency","display_name":"NK cell deficiency","score":0.671999990940094},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.7509999871253967},{"id":"https://openalex.org/keywords/poly-i-c","display_name":"poly(I:C)","score":0.8399999737739563},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9940000176429749},{"id":"https://openalex.org/keywords/measurable-residual-disease","display_name":"minimal residual disease","score":0.7960000038146973},{"id":"https://openalex.org/keywords/high-dose-chemotherapy","display_name":"high-dose chemotherapy","score":0.7400000095367432}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6221284866333008},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5639852285385132},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5596468448638916},{"id":"https://openalex.org/C149532602","wikidata":"https://www.wikidata.org/wiki/Q2409681","display_name":"Interleukin 12","level":4,"score":0.5264687538146973},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5071899890899658},{"id":"https://openalex.org/C129374314","wikidata":"https://www.wikidata.org/wiki/Q909381","display_name":"Interleukin 21","level":4,"score":0.5051568150520325},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.502968966960907},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4864201545715332},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.47705546021461487},{"id":"https://openalex.org/C98119934","wikidata":"https://www.wikidata.org/wiki/Q14907167","display_name":"Interleukin 15","level":4,"score":0.46696096658706665},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4537794888019562},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.449752539396286},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3950648903846741},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.35465723276138306},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3428804874420166},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.31059983372688293},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.278103232383728},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.21953025460243225},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005732","descriptor_name":"Gangliosides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019046","descriptor_name":"Bone Marrow Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D019046","descriptor_name":"Bone Marrow Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood.v91.5.1706","doi":"https://doi.org/10.1182/blood.v91.5.1706","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.v91.5.1706","pdf_url":"https://ashpublications.org/blood/article-pdf/91/5/1706/1045356/1706.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"doi:10.1182/blood.v91.5.1706.1706_1706_1715","doi":"https://doi.org/10.1182/blood.v91.5.1706.1706_1706_1715","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.v91.5.1706.1706_1706_1715","pdf_url":"https://ashpublications.org/blood/article-pdf/91/5/1706/239028/1706.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:9473237","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9473237","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1182/blood.v91.5.1706","doi":"https://doi.org/10.1182/blood.v91.5.1706","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.v91.5.1706","pdf_url":"https://ashpublications.org/blood/article-pdf/91/5/1706/1045356/1706.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7900000214576721,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1602455367","display_name":null,"funder_award_id":"CA-42508","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6076592392","display_name":"MOLECULAR PROFILE OF MELANOMA AND NEUROBLASTOMA ANTIGENS","funder_award_id":"5r35ca042508-14","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W272579771.pdf","grobid_xml":"https://content.openalex.org/works/W272579771.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W109754485","https://openalex.org/W1515642134","https://openalex.org/W1562430079","https://openalex.org/W1576018417","https://openalex.org/W1583511232","https://openalex.org/W1965605868","https://openalex.org/W1966474027","https://openalex.org/W1969298752","https://openalex.org/W1969752769","https://openalex.org/W1973805241","https://openalex.org/W1975568557","https://openalex.org/W1999459089","https://openalex.org/W2000943743","https://openalex.org/W2005557434","https://openalex.org/W2007527741","https://openalex.org/W2027159794","https://openalex.org/W2036031859","https://openalex.org/W2036275492","https://openalex.org/W2042123531","https://openalex.org/W2044848214","https://openalex.org/W2046628826","https://openalex.org/W2048281897","https://openalex.org/W2050905376","https://openalex.org/W2068441417","https://openalex.org/W2068616418","https://openalex.org/W2072313116","https://openalex.org/W2081219792","https://openalex.org/W2087810903","https://openalex.org/W2087863947","https://openalex.org/W2096398040","https://openalex.org/W2097856087","https://openalex.org/W2099748840","https://openalex.org/W2102913940","https://openalex.org/W2118326757","https://openalex.org/W2121421904","https://openalex.org/W2122042627","https://openalex.org/W2124446900","https://openalex.org/W2138985980","https://openalex.org/W2141090147","https://openalex.org/W2155392902","https://openalex.org/W2168364779","https://openalex.org/W2168637154","https://openalex.org/W2208092455","https://openalex.org/W2398837573","https://openalex.org/W2412763372","https://openalex.org/W6604468110","https://openalex.org/W6630914897","https://openalex.org/W6633752043","https://openalex.org/W6634957118"],"related_works":["https://openalex.org/W2122042627","https://openalex.org/W2161447795","https://openalex.org/W2783472266","https://openalex.org/W2419291966","https://openalex.org/W2098548611","https://openalex.org/W2109876118","https://openalex.org/W2173218561","https://openalex.org/W2061516685","https://openalex.org/W1499249521","https://openalex.org/W4319293313"],"abstract_inverted_index":{"Targeted":[0],"interleukin-2":[1],"(IL-2)":[2],"therapy":[3],"with":[4,116,172],"a":[5,14,28,93,142],"genetically":[6],"engineered":[7],"antidisialoganglioside":[8],"GD2":[9],"antibody-IL-2":[10],"fusion":[11,52,110],"protein":[12,53,111],"induced":[13],"cell-mediated":[15],"antitumor":[16,47],"response":[17,151],"that":[18,132],"effectively":[19],"eradicated":[20],"established":[21],"bone":[22],"marrow":[23],"and":[24],"liver":[25],"metastases":[26],"in":[27,57,69,80,188],"syngeneic":[29],"model":[30],"of":[31,65,74,83,87,108,135,170],"neuroblastoma.":[32,158],"The":[33,105],"mechanism":[34],"involved":[35],"is":[36],"exclusively":[37],"natural":[38],"killer":[39],"(NK)":[40],"cell-dependent,":[41],"because":[42],"NK-cell":[43,75],"deficiency":[44],"abrogated":[45],"the":[46,51,58,84,109,138,168],"effect.":[48],"In":[49,127],"contrast,":[50],"remained":[54],"completely":[55],"effective":[56,148],"T-cell-deficient":[59],"mice":[60,63,91],"or":[61,123],"immunocompetent":[62],"depleted":[64],"CD8+":[66,102],"T":[67,103],"cells":[68,98,155],"vivo.":[70],"A":[71],"strong":[72,94],"stimulation":[73],"activity":[76],"was":[77,112],"also":[78],"shown":[79],"vitro.":[81],"Immunohistology":[82],"leukocytic":[85],"infiltrate":[86],"livers":[88],"from":[89,178],"treated":[90],"revealed":[92],"staining":[95],"for":[96,101,167],"NK":[97,154,189],"but":[99,184],"not":[100,186],"cells.":[104,190],"therapeutic":[106,160],"effect":[107,161],"increased":[113],"when":[114],"combined":[115],"NK-cell-stimulating":[117],"agents,":[118],"such":[119],"as":[120],"poly":[121],"I:C":[122],"recombinant":[124],"mouse":[125],"interferon-gamma.":[126],"conclusion,":[128],"these":[129],"data":[130],"show":[131],"targeted":[133],"delivery":[134],"cytokines":[136],"to":[137,145],"tumor":[139],"microenvironment":[140],"offers":[141],"new":[143],"strategy":[144],"elicit":[146],"an":[147],"cellular":[149],"immune":[150],"mediated":[152],"by":[153],"against":[156],"metastatic":[157],"This":[159],"may":[162],"have":[163],"general":[164],"clinical":[165],"implications":[166],"treatment":[169],"patients":[171],"minimal":[173],"residual":[174],"disease":[175],"who":[176],"suffer":[177],"T-cell":[179],"suppression":[180],"after":[181],"high-dose":[182],"chemotherapy":[183],"are":[185],"deficient":[187]},"counts_by_year":[{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":10}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
