{"id":"https://openalex.org/W2724890884","doi":"https://doi.org/10.21767/2171-6625.1000189","title":"The Role of Folate Dependent Genetic Susceptibility in The Risk of Multiple Sclerosis","display_name":"The Role of Folate Dependent Genetic Susceptibility in The Risk of Multiple Sclerosis","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2724890884","doi":"https://doi.org/10.21767/2171-6625.1000189","mag":"2724890884"},"language":"en","primary_location":{"id":"doi:10.21767/2171-6625.1000189","doi":"https://doi.org/10.21767/2171-6625.1000189","is_oa":true,"landing_page_url":"https://doi.org/10.21767/2171-6625.1000189","pdf_url":"http://www.jneuro.com/neurology-neuroscience/the-role-of-folate-dependent-genetic-susceptibility-in-the-risk-of-multiple-sclerosis.pdf","source":{"id":"https://openalex.org/S2765011904","display_name":"Journal of Neurology and Neuroscience","issn_l":"2171-6625","issn":["2171-6625"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurology and Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jneuro.com/neurology-neuroscience/the-role-of-folate-dependent-genetic-susceptibility-in-the-risk-of-multiple-sclerosis.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039114583","display_name":"Ali Erkan A\u015fc\u0131","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95634034","display_name":"Gazi University","ror":"https://ror.org/054xkpr46","country_code":"TR","type":"education","lineage":["https://openalex.org/I95634034"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ali Erkan Asci","raw_affiliation_strings":["Department of Toxicology, Faculty of Pharmacy, Gazi University, 06330 Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Toxicology, Faculty of Pharmacy, Gazi University, 06330 Ankara, Turkey","institution_ids":["https://openalex.org/I95634034"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025443512","display_name":"Bensu Karahal\u0131l","orcid":"https://orcid.org/0000-0003-1625-6337","observed_orcids":["https://orcid.org/0000-0003-1625-6337"]},"institutions":[{"id":"https://openalex.org/I95634034","display_name":"Gazi University","ror":"https://ror.org/054xkpr46","country_code":"TR","type":"education","lineage":["https://openalex.org/I95634034"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Bensu Karahalil","raw_affiliation_strings":["Department of Toxicology, Faculty of Pharmacy, Gazi University, 06330 Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Toxicology, Faculty of Pharmacy, Gazi University, 06330 Ankara, Turkey","institution_ids":["https://openalex.org/I95634034"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5025443512"],"corresponding_institution_ids":["https://openalex.org/I95634034"],"apc_list":null,"apc_paid":null,"fwci":0.239,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.57976013,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"08","issue":"03","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.011500000022351742,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.9589999914169312},{"id":"https://openalex.org/keywords/folate-dependent-enzymes","display_name":"folate-dependent enzymes","score":0.7300000190734863},{"id":"https://openalex.org/keywords/one-carbon-metabolism","display_name":"one-carbon metabolism","score":0.9900000095367432},{"id":"https://openalex.org/keywords/homocysteine","display_name":"homocysteine","score":0.8989999890327454},{"id":"https://openalex.org/keywords/mthfr-c677t-polymorphism","display_name":"MTHFR C677T polymorphism","score":0.8309999704360962},{"id":"https://openalex.org/keywords/mthfr-a1298c-polymorphism","display_name":"MTHFR A1298C polymorphism","score":0.9819999933242798},{"id":"https://openalex.org/keywords/b-vitamins","display_name":"B vitamins","score":0.671999990940094},{"id":"https://openalex.org/keywords/folic-acid","display_name":"folic acid","score":0.6209999918937683},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.7009999752044678},{"id":"https://openalex.org/keywords/disease-risk","display_name":"disease risk","score":0.8240000009536743}],"concepts":[{"id":"https://openalex.org/C43563269","wikidata":"https://www.wikidata.org/wiki/Q424709","display_name":"Methylenetetrahydrofolate reductase","level":4,"score":0.9505884051322937},{"id":"https://openalex.org/C2777090595","wikidata":"https://www.wikidata.org/wiki/Q192466","display_name":"Homocysteine","level":2,"score":0.6535195708274841},{"id":"https://openalex.org/C67636389","wikidata":"https://www.wikidata.org/wiki/Q784237","display_name":"Genetic predisposition","level":3,"score":0.621046781539917},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47379085421562195},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.4660419523715973},{"id":"https://openalex.org/C47042493","wikidata":"https://www.wikidata.org/wiki/Q265799","display_name":"Human genetics","level":3,"score":0.4521992802619934},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4462489187717438},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37086355686187744},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.363785058259964},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.33989715576171875},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2545458674430847},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22646424174308777}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21767/2171-6625.1000189","doi":"https://doi.org/10.21767/2171-6625.1000189","is_oa":true,"landing_page_url":"https://doi.org/10.21767/2171-6625.1000189","pdf_url":"http://www.jneuro.com/neurology-neuroscience/the-role-of-folate-dependent-genetic-susceptibility-in-the-risk-of-multiple-sclerosis.pdf","source":{"id":"https://openalex.org/S2765011904","display_name":"Journal of Neurology and Neuroscience","issn_l":"2171-6625","issn":["2171-6625"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurology and Neuroscience","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.21767/2171-6625.1000189","doi":"https://doi.org/10.21767/2171-6625.1000189","is_oa":true,"landing_page_url":"https://doi.org/10.21767/2171-6625.1000189","pdf_url":"http://www.jneuro.com/neurology-neuroscience/the-role-of-folate-dependent-genetic-susceptibility-in-the-risk-of-multiple-sclerosis.pdf","source":{"id":"https://openalex.org/S2765011904","display_name":"Journal of Neurology and Neuroscience","issn_l":"2171-6625","issn":["2171-6625"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurology and Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2724890884.pdf","grobid_xml":"https://content.openalex.org/works/W2724890884.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W324244079","https://openalex.org/W1560343627","https://openalex.org/W1878788353","https://openalex.org/W1973562097","https://openalex.org/W1986559703","https://openalex.org/W1986561336","https://openalex.org/W1994735079","https://openalex.org/W2005339378","https://openalex.org/W2005870520","https://openalex.org/W2007826215","https://openalex.org/W2011089854","https://openalex.org/W2017016252","https://openalex.org/W2044170424","https://openalex.org/W2044701820","https://openalex.org/W2045712876","https://openalex.org/W2048558976","https://openalex.org/W2050130395","https://openalex.org/W2052211882","https://openalex.org/W2054480528","https://openalex.org/W2057523452","https://openalex.org/W2057680971","https://openalex.org/W2061820118","https://openalex.org/W2065168778","https://openalex.org/W2083204749","https://openalex.org/W2086739279","https://openalex.org/W2088072554","https://openalex.org/W2102324717","https://openalex.org/W2119058044","https://openalex.org/W2135717200","https://openalex.org/W2146934684","https://openalex.org/W2147039789","https://openalex.org/W2164911583","https://openalex.org/W2166522205","https://openalex.org/W2167574472","https://openalex.org/W2171472230","https://openalex.org/W2183097515","https://openalex.org/W2221150273","https://openalex.org/W2254677065","https://openalex.org/W2306142023","https://openalex.org/W2330375578","https://openalex.org/W2333411548","https://openalex.org/W2347023637","https://openalex.org/W2404807578","https://openalex.org/W2527072578","https://openalex.org/W2566444265","https://openalex.org/W4253177015"],"related_works":["https://openalex.org/W4393580378","https://openalex.org/W2938481812","https://openalex.org/W4402341000","https://openalex.org/W4417431175","https://openalex.org/W2947957273","https://openalex.org/W4411730296","https://openalex.org/W2089279295","https://openalex.org/W4413857757","https://openalex.org/W4415680904","https://openalex.org/W1971634147"],"abstract_inverted_index":{"Background:":[0],"Multiple":[1],"sclerosis":[2],"(MS)":[3],"is":[4],"a":[5,71],"chronic":[6],"inflammatory":[7],"disease":[8,259],"of":[9,15,32,66,84,127,142,160,173,185,234,248,257],"the":[10,30,57,64,100,125,130,136,140,158,171,183,246,253,258],"central":[11],"nervous":[12],"system":[13],"(CNS)":[14],"unknown":[16],"cause.":[17],"Epidemiological":[18],"studies":[19,118,227],"implicate":[20],"that":[21,229],"genetic":[22,60,106,122,137,145,168,230],"and":[23,41,44,62,87,94,105,170,208,241,255],"environmental":[24,78],"factors":[25,79,107,231,243],"interplay":[26],"major":[27,239],"roles":[28,240],"in":[29,48,51,56,70,111,252],"etiology":[31],"MS.":[33,49,67,128,249],"Several":[34],"investigators":[35],"have":[36,54,134,195,238],"reported":[37],"elevated":[38],"plasma":[39],"homocysteine":[40],"reduced":[42,82],"folate":[43,88,95,112],"B":[45,86,92,162],"vitamin":[46,85,93],"levels":[47,83,159],"Aberrations":[50],"one-carbon":[52],"metabolism":[53,73,150,221],"impact":[55],"pathophysiology":[58],"by":[59],"susceptibility":[61,138,189],"increased":[63],"risk":[65,126,141,172],"Furthermore,":[68],"abnormalities":[69],"carbon":[72,149,220,236],"pathway":[74,237],"may":[75],"result":[76],"from":[77,97],"such":[80,108],"as":[81,109],"due":[89,166],"to":[90,139,167,245],"inadequate":[91],"intake":[96],"foods":[98],"or":[99],"problems":[101],"on":[102,124,147,154,157,197,218,232],"their":[103],"synthesis,":[104],"polymorphism":[110],"\u2013":[113],"dependent":[114],"enzymes.":[115],"Results:":[116],"Many":[117],"showed":[119,228],"conflictive":[120],"results":[121],"polymorphisms":[123,146,200],"In":[129],"present":[131],"review,":[132],"we":[133],"emphasized":[135],"MS,":[143],"especially":[144],"one":[148,219,235],"pathway.":[151,222],"The":[152],"associations":[153],"individual":[155,188],"differences":[156,251],"homocysteine,":[161],"vitamin,":[163],"folic":[164],"acid":[165],"make-up":[169],"MS":[174,186],"will":[175],"be":[176,192,262],"discussed.":[177],"There":[178],"are":[179,215],"numerous":[180],"reasons":[181],"causing":[182],"development":[184,247,254],"especially,":[187],"should":[190,260],"not":[191,261],"neglected.":[193],"We":[194],"focused":[196],"three":[198],"gene":[199],"namely":[201],"Methylene":[202],"tetrahydrofolate":[203],"reductase":[204],"(MTHFR)":[205],"C677T,":[206],"A1298C":[207],"Methionine":[209],"synthase":[210],"(MTR)":[211],"G66A":[212],"since":[213],"they":[214],"key":[216],"enzymes":[217],"Conclusion:":[223],"So":[224],"far":[225],"conducted":[226],"products":[233],"these":[242],"contribute":[244],"Individual":[250],"treatment":[256],"overlooked.":[263]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2017-07-14T00:00:00"}