{"id":"https://openalex.org/W2724726558","doi":"https://doi.org/10.1016/j.cllc.2017.06.013","title":"A Review of Regimens Combining Pemetrexed With an Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor in the Treatment of Advanced Nonsquamous Non\u2013Small-Cell Lung Cancer","display_name":"A Review of Regimens Combining Pemetrexed With an Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor in the Treatment of Advanced Nonsquamous Non\u2013Small-Cell Lung Cancer","publication_year":2017,"publication_date":"2017-07-05","ids":{"openalex":"https://openalex.org/W2724726558","doi":"https://doi.org/10.1016/j.cllc.2017.06.013","mag":"2724726558","pmid":"https://pubmed.ncbi.nlm.nih.gov/28743421"},"language":"en","primary_location":{"id":"doi:10.1016/j.cllc.2017.06.013","doi":"https://doi.org/10.1016/j.cllc.2017.06.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cllc.2017.06.013","pdf_url":"http://www.clinical-lung-cancer.com/article/S1525730417302000/pdf","source":{"id":"https://openalex.org/S32518486","display_name":"Clinical Lung Cancer","issn_l":"1525-7304","issn":["1525-7304","1938-0690"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Lung Cancer","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.clinical-lung-cancer.com/article/S1525730417302000/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055074037","display_name":"James Chih\u2010Hsin Yang","orcid":"https://orcid.org/0000-0002-5586-5138","observed_orcids":["https://orcid.org/0000-0002-5586-5138"]},"institutions":[{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"James Chih-Hsin Yang","raw_affiliation_strings":["Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: chihyang@ntu.edu.tw","Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan"],"raw_orcid":"https://orcid.org/0000-0002-5586-5138","affiliations":[{"raw_affiliation_string":"Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: chihyang@ntu.edu.tw","institution_ids":["https://openalex.org/I4210131804"]},{"raw_affiliation_string":"Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210131804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066717752","display_name":"Tony S.K. Mok","orcid":"https://orcid.org/0000-0002-8251-0551","observed_orcids":["https://orcid.org/0000-0002-8251-0551"]},"institutions":[{"id":"https://openalex.org/I4210114914","display_name":"Prince of Wales Hospital","ror":"https://ror.org/02827ca86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210114914"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tony Mok","raw_affiliation_strings":["Department of Clinical Oncology, Prince of Wales Hospital, Sha Tin, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Oncology, Prince of Wales Hospital, Sha Tin, Hong Kong","institution_ids":["https://openalex.org/I4210114914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021139793","display_name":"Baohui Han","orcid":"https://orcid.org/0000-0002-3950-3030","observed_orcids":["https://orcid.org/0000-0002-3950-3030"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2802608112","display_name":"Shanghai Chest Hospital","ror":"https://ror.org/03fjc3817","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802608112"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Baohui Han","raw_affiliation_strings":["Department of Pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2802608112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028033679","display_name":"Mauro Orlando","orcid":"https://orcid.org/0009-0003-5428-0394","observed_orcids":["https://orcid.org/0009-0003-5428-0394"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mauro Orlando","raw_affiliation_strings":["Eli Lilly Interamerica, Inc, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eli Lilly Interamerica, Inc, Buenos Aires, Argentina","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010499363","display_name":"Tarun Puri","orcid":"https://orcid.org/0000-0003-2399-4362","observed_orcids":["https://orcid.org/0000-0003-2399-4362"]},"institutions":[{"id":"https://openalex.org/I4210114640","display_name":"Eli Lilly (India)","ror":"https://ror.org/02156y972","country_code":"IN","type":"company","lineage":["https://openalex.org/I168537998","https://openalex.org/I4210114640"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Tarun Puri","raw_affiliation_strings":["Eli Lilly and Company (India) Pvt Ltd, Gurgaon, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eli Lilly and Company (India) Pvt Ltd, Gurgaon, India","institution_ids":["https://openalex.org/I4210114640"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030107272","display_name":"Keunchil Park","orcid":"https://orcid.org/0000-0002-4846-7449","observed_orcids":["https://orcid.org/0000-0002-4846-7449"]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Keunchil Park","raw_affiliation_strings":["Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I848706"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5055074037"],"corresponding_institution_ids":["https://openalex.org/I4210131804"],"apc_list":{"value":3200,"currency":"USD","value_usd":3200},"apc_paid":{"value":3200,"currency":"USD","value_usd":3200},"fwci":0.6007,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.51515152,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"19","issue":"1","first_page":"27","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pemetrexed","display_name":"pemetrexed","score":1.0},{"id":"https://openalex.org/keywords/egfr-tyrosine-kinase-inhibitors","display_name":"EGFR tyrosine kinase inhibitors","score":0.9700000286102295},{"id":"https://openalex.org/keywords/non-squamous-non-small-cell-lung-cancer","display_name":"non-squamous non-small cell lung cancer","score":0.925000011920929},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.6660000085830688},{"id":"https://openalex.org/keywords/egfr-mutation","display_name":"EGFR mutation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.7239999771118164},{"id":"https://openalex.org/keywords/second-line-treatment","display_name":"second-line therapy","score":0.9850000143051147},{"id":"https://openalex.org/keywords/sequential-therapy","display_name":"sequential therapy","score":0.968999981880188},{"id":"https://openalex.org/keywords/concurrent-treatment","display_name":"concurrent treatment","score":0.9610000252723694},{"id":"https://openalex.org/keywords/treatment-related-adverse-events","display_name":"treatment-related adverse events","score":0.7979999780654907},{"id":"https://openalex.org/keywords/synergistic-antitumor-effect","display_name":"synergistic antitumor effect","score":0.7850000262260437}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8500142097473145},{"id":"https://openalex.org/C2777240266","wikidata":"https://www.wikidata.org/wiki/Q415220","display_name":"Pemetrexed","level":4,"score":0.8326699733734131},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.7552089691162109},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.6063923835754395},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6003364324569702},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.5957851409912109},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5838286280632019},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5434172749519348},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44387465715408325},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.33119624853134155},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32311952114105225},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.24761894345283508},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2351212501525879},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000068437","descriptor_name":"Pemetrexed","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cllc.2017.06.013","doi":"https://doi.org/10.1016/j.cllc.2017.06.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cllc.2017.06.013","pdf_url":"http://www.clinical-lung-cancer.com/article/S1525730417302000/pdf","source":{"id":"https://openalex.org/S32518486","display_name":"Clinical Lung Cancer","issn_l":"1525-7304","issn":["1525-7304","1938-0690"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Lung Cancer","raw_type":"journal-article"},{"id":"pmid:28743421","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28743421","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical lung cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.cllc.2017.06.013","doi":"https://doi.org/10.1016/j.cllc.2017.06.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cllc.2017.06.013","pdf_url":"http://www.clinical-lung-cancer.com/article/S1525730417302000/pdf","source":{"id":"https://openalex.org/S32518486","display_name":"Clinical Lung Cancer","issn_l":"1525-7304","issn":["1525-7304","1938-0690"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Lung Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2724726558.pdf","grobid_xml":"https://content.openalex.org/works/W2724726558.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1585392281","https://openalex.org/W1689900089","https://openalex.org/W1984047229","https://openalex.org/W1994403941","https://openalex.org/W2005244154","https://openalex.org/W2019331695","https://openalex.org/W2029505022","https://openalex.org/W2037632369","https://openalex.org/W2040559224","https://openalex.org/W2041814933","https://openalex.org/W2043696829","https://openalex.org/W2047986057","https://openalex.org/W2049274590","https://openalex.org/W2058917939","https://openalex.org/W2075039476","https://openalex.org/W2083404706","https://openalex.org/W2086913687","https://openalex.org/W2089111387","https://openalex.org/W2097026987","https://openalex.org/W2099725888","https://openalex.org/W2105904054","https://openalex.org/W2106372363","https://openalex.org/W2110023367","https://openalex.org/W2110835998","https://openalex.org/W2112602910","https://openalex.org/W2112621029","https://openalex.org/W2116142233","https://openalex.org/W2125665528","https://openalex.org/W2127101185","https://openalex.org/W2131891275","https://openalex.org/W2134667653","https://openalex.org/W2134964659","https://openalex.org/W2138939757","https://openalex.org/W2139236349","https://openalex.org/W2139939379","https://openalex.org/W2143859186","https://openalex.org/W2144180913","https://openalex.org/W2145842917","https://openalex.org/W2148174696","https://openalex.org/W2152755651","https://openalex.org/W2156983594","https://openalex.org/W2161821474","https://openalex.org/W2162575834","https://openalex.org/W2162724777","https://openalex.org/W2166084034","https://openalex.org/W2167191456","https://openalex.org/W2172192264","https://openalex.org/W2202284815","https://openalex.org/W2224661523","https://openalex.org/W2299729500","https://openalex.org/W2343576357","https://openalex.org/W2483135501","https://openalex.org/W2518488558","https://openalex.org/W6722306095"],"related_works":["https://openalex.org/W1689900089","https://openalex.org/W2797645911","https://openalex.org/W2343576357","https://openalex.org/W1900440034","https://openalex.org/W2166477181","https://openalex.org/W4304092520","https://openalex.org/W2898123782","https://openalex.org/W2892116079","https://openalex.org/W2365849565","https://openalex.org/W4380589449"],"abstract_inverted_index":{"Pemetrexed":[0,36],"is":[1,52,72],"a":[2,24,135,166],"standard":[3,25],"first-line":[4,26],"treatment":[5,27,89,105,195],"for":[6,28,87],"advanced":[7,29,91],"nonsquamous":[8,30,92],"non-small-cell":[9],"lung":[10],"cancer":[11],"(NSCLC),":[12],"and":[13,37,45,97,103],"epidermal":[14],"growth":[15],"factor":[16],"receptor":[17],"(EGFR)":[18],"tyrosine":[19],"kinase":[20],"inhibitors":[21],"(TKIs)":[22],"are":[23],"NSCLC":[31,93],"with":[32,83,118,124,139,165,199],"activating":[33,120,200],"EGFR":[34,38,85,121,128,144,201],"mutations.":[35,202],"TKIs":[39],"have":[40],"different":[41],"mechanisms":[42],"of":[43,79,90,169,187],"action":[44],"minimally":[46],"overlapping":[47],"toxicity":[48],"profiles;":[49],"therefore,":[50],"it":[51],"hypothesized":[53],"that":[54,63,133],"their":[55],"combination":[56,82,138,150],"might":[57],"result":[58],"in":[59,69,81,94,116,197],"acceptable":[60],"toxicity,":[61],"provided":[62],"the":[64,88,95,119,131,143,147,155,176],"synergistic":[65],"antitumor":[66],"activity":[67],"observed":[68],"preclinical":[70],"studies":[71,132,186],"achieved.":[73],"This":[74],"review":[75],"summarizes":[76],"clinical":[77],"trials":[78],"pemetrexed":[80,140],"an":[84,127],"TKI":[86,137,145,149,160,189],"first-":[96],"second-line":[98],"settings,":[99],"using":[100],"intercalated,":[101],"sequential,":[102],"concurrent":[104],"strategies.":[106],"As":[107],"would":[108],"be":[109],"expected,":[110],"such":[111,180],"strategies":[112,196],"were":[113,162,182],"most":[114],"efficacious":[115,153],"patients":[117,198],"mutations":[122],"associated":[123,164],"response":[125],"to":[126],"TKI.":[129],"In":[130],"compared":[134],"pemetrexed-EGFR":[136,148,159,188],"alone":[141],"or":[142],"alone,":[146],"was":[151],"more":[152],"than":[154,175],"single-agent":[156,177],"regimens.":[157],"The":[158],"combinations":[161,190],"generally":[163],"higher":[167],"incidence":[168],"grade":[170],"3/4":[171],"treatment-related":[172],"adverse":[173],"events":[174],"regimens;":[178],"however,":[179],"toxicities":[181],"clinically":[183],"manageable.":[184],"Future":[185],"should":[191],"focus":[192],"on":[193],"optimizing":[194]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-07-14T00:00:00"}
