{"id":"https://openalex.org/W2724565622","doi":null,"title":"Characterization of an 18F-Growth Hormone Secretagogue Probe for Positron Emission Tomography Imaging of the Growth Hormone Secretagogue Receptor","display_name":"Characterization of an 18F-Growth Hormone Secretagogue Probe for Positron Emission Tomography Imaging of the Growth Hormone Secretagogue Receptor","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2724565622","mag":"2724565622"},"language":"en","primary_location":{"id":"pmh:oai:ir.lib.uwo.ca:etd-6459","doi":null,"is_oa":true,"landing_page_url":"https://ir.lib.uwo.ca/etd/4609","pdf_url":"https://ir.lib.uwo.ca/etd/4609","source":{"id":"https://openalex.org/S4306400648","display_name":"Scholarship@Western (Western University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I125749732","host_organization_name":"Western University","host_organization_lineage":["https://openalex.org/I125749732"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Thesis and Dissertation Repository","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ir.lib.uwo.ca/etd/4609","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Ahmed Abbas","orcid":"https://orcid.org/0000-0001-5107-5924","observed_orcids":["https://orcid.org/0000-0001-5107-5924"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ahmed Abbas","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5107-5924","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.08368688,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.888700008392334,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.888700008392334,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.012900000438094139,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/growth-hormone-secretagogue-receptor-1a","display_name":"growth hormone secretagogue receptor 1a","score":0.9629999995231628},{"id":"https://openalex.org/keywords/ghs-r1a","display_name":"GHS-R1a","score":0.8309999704360962},{"id":"https://openalex.org/keywords/ghrelin","display_name":"ghrelin","score":0.8759999871253967},{"id":"https://openalex.org/keywords/cardiac-biomarkers","display_name":"cardiac biomarkers","score":0.5830000042915344},{"id":"https://openalex.org/keywords/receptor-specificity","display_name":"receptor specificity","score":0.44600000977516174},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.8600000143051147},{"id":"https://openalex.org/keywords/tracer-stability","display_name":"tracer stability","score":0.375},{"id":"https://openalex.org/keywords/myocardial-metabolism","display_name":"myocardial metabolism","score":0.45500001311302185}],"concepts":[{"id":"https://openalex.org/C2780161494","wikidata":"https://www.wikidata.org/wiki/Q3510429","display_name":"Secretagogue","level":3,"score":0.8048032522201538},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.6183425188064575},{"id":"https://openalex.org/C2779168441","wikidata":"https://www.wikidata.org/wiki/Q14914301","display_name":"Growth hormone secretagogue receptor","level":4,"score":0.592864990234375},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5407824516296387},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5059799551963806},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.46014344692230225},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4174259305000305},{"id":"https://openalex.org/C2984496839","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Growth hormone","level":3,"score":0.34727659821510315},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31432467699050903},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.16884690523147583}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:ir.lib.uwo.ca:etd-6459","doi":null,"is_oa":true,"landing_page_url":"https://ir.lib.uwo.ca/etd/4609","pdf_url":"https://ir.lib.uwo.ca/etd/4609","source":{"id":"https://openalex.org/S4306400648","display_name":"Scholarship@Western (Western University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I125749732","host_organization_name":"Western University","host_organization_lineage":["https://openalex.org/I125749732"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Thesis and Dissertation Repository","raw_type":"text"},{"id":"pmh:oai:uwo.scholaris.ca:20.500.14721/34735","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/20.500.14721/34735","pdf_url":null,"source":{"id":"https://openalex.org/S4306400648","display_name":"Scholarship@Western (Western University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I125749732","host_organization_name":"Western University","host_organization_lineage":["https://openalex.org/I125749732"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"thesis"},{"id":"mag:2724565622","doi":null,"is_oa":false,"landing_page_url":"https://ir.lib.uwo.ca/etd/4609/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:ir.lib.uwo.ca:etd-6459","doi":null,"is_oa":true,"landing_page_url":"https://ir.lib.uwo.ca/etd/4609","pdf_url":"https://ir.lib.uwo.ca/etd/4609","source":{"id":"https://openalex.org/S4306400648","display_name":"Scholarship@Western (Western University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I125749732","host_organization_name":"Western University","host_organization_lineage":["https://openalex.org/I125749732"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Thesis and Dissertation Repository","raw_type":"text"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2724565622.pdf","grobid_xml":"https://content.openalex.org/works/W2724565622.grobid-xml"},"referenced_works_count":110,"referenced_works":["https://openalex.org/W26777792","https://openalex.org/W87906273","https://openalex.org/W194267636","https://openalex.org/W649083314","https://openalex.org/W1517588315","https://openalex.org/W1537433484","https://openalex.org/W1569113399","https://openalex.org/W1901716085","https://openalex.org/W1966096666","https://openalex.org/W1973385483","https://openalex.org/W1979517142","https://openalex.org/W1980473459","https://openalex.org/W1983457831","https://openalex.org/W1986016674","https://openalex.org/W1986745253","https://openalex.org/W1989434611","https://openalex.org/W1991720400","https://openalex.org/W1994745817","https://openalex.org/W1995104782","https://openalex.org/W1995734405","https://openalex.org/W2000480501","https://openalex.org/W2001984460","https://openalex.org/W2005972842","https://openalex.org/W2006906877","https://openalex.org/W2007123349","https://openalex.org/W2009044892","https://openalex.org/W2016666546","https://openalex.org/W2016901344","https://openalex.org/W2017105702","https://openalex.org/W2018166308","https://openalex.org/W2019337981","https://openalex.org/W2020219002","https://openalex.org/W2030975932","https://openalex.org/W2031034134","https://openalex.org/W2031481579","https://openalex.org/W2034493897","https://openalex.org/W2041324093","https://openalex.org/W2050864715","https://openalex.org/W2051225574","https://openalex.org/W2051823496","https://openalex.org/W2053202589","https://openalex.org/W2065827975","https://openalex.org/W2066170597","https://openalex.org/W2066820222","https://openalex.org/W2067777670","https://openalex.org/W2070546176","https://openalex.org/W2073982078","https://openalex.org/W2080343884","https://openalex.org/W2085372550","https://openalex.org/W2086307882","https://openalex.org/W2088749722","https://openalex.org/W2088923351","https://openalex.org/W2090441924","https://openalex.org/W2094896667","https://openalex.org/W2102612506","https://openalex.org/W2106934045","https://openalex.org/W2110877561","https://openalex.org/W2111558107","https://openalex.org/W2112202133","https://openalex.org/W2112592817","https://openalex.org/W2113970487","https://openalex.org/W2114109157","https://openalex.org/W2119340816","https://openalex.org/W2119507443","https://openalex.org/W2122289503","https://openalex.org/W2122726438","https://openalex.org/W2124483055","https://openalex.org/W2124549557","https://openalex.org/W2125555829","https://openalex.org/W2127852024","https://openalex.org/W2128155479","https://openalex.org/W2129389766","https://openalex.org/W2129528230","https://openalex.org/W2130517616","https://openalex.org/W2131687335","https://openalex.org/W2134538426","https://openalex.org/W2144240099","https://openalex.org/W2145378489","https://openalex.org/W2150359689","https://openalex.org/W2153246785","https://openalex.org/W2157118250","https://openalex.org/W2157815735","https://openalex.org/W2158534725","https://openalex.org/W2158652922","https://openalex.org/W2159803609","https://openalex.org/W2161106868","https://openalex.org/W2161520695","https://openalex.org/W2161591877","https://openalex.org/W2161939434","https://openalex.org/W2161947705","https://openalex.org/W2163824159","https://openalex.org/W2163865122","https://openalex.org/W2164598823","https://openalex.org/W2164664409","https://openalex.org/W2168955249","https://openalex.org/W2169065043","https://openalex.org/W2170748529","https://openalex.org/W2171527314","https://openalex.org/W2186142551","https://openalex.org/W2296530379","https://openalex.org/W2320016798","https://openalex.org/W2392222391","https://openalex.org/W2410387477","https://openalex.org/W2476982521","https://openalex.org/W2488337536","https://openalex.org/W2510006795","https://openalex.org/W2604419714","https://openalex.org/W2763466129","https://openalex.org/W3128370515","https://openalex.org/W4293084779"],"related_works":["https://openalex.org/W2899729594","https://openalex.org/W2951466958","https://openalex.org/W2759434567","https://openalex.org/W2979971321","https://openalex.org/W2912042853","https://openalex.org/W3096927527","https://openalex.org/W2053202589","https://openalex.org/W2065827975","https://openalex.org/W2055655974","https://openalex.org/W2621664584"],"abstract_inverted_index":{"Cardiovascular":[0],"disease":[1],"affects":[2],"1.6":[3],"million":[4],"Canadians,":[5],"of":[6,21,25,39,100,117,128,153,170,214,246],"whom":[7],"one-third":[8],"have":[9],"heart":[10,165,241],"failure":[11],"(HF).":[12],"HF":[13,93],"is":[14,61,68,85,90,243],"diagnosed":[15],"by":[16,87,120,134,208,221],"imaging":[17,28,40,138,276],"investigations":[18],"and":[19,32,55,89,142,151,166,184,191,203,218,228,249,267,273],"detection":[20],"circulating":[22,171],"biomarkers.":[23],"Most":[24],"the":[26,82,98,101,164,188,240],"current":[27],"strategies":[29],"study":[30,96,280],"morphologic":[31],"gross":[33],"functional":[34],"changes,":[35],"but":[36],"fall":[37],"short":[38],"molecular":[41,48],"abnormalities":[42],"associated":[43],"with":[44],"HF.":[45,297],"Biomarkers":[46],"offer":[47],"targets;":[49],"however,":[50],"clinical":[51],"biomarkers":[52],"circulate":[53],"systemically":[54],"are":[56],"not":[57,161,253],"cardiac-specific.":[58],"Thus,":[59],"there":[60,233],"critical":[62],"need":[63],"for":[64],"a":[65,209,236,255,282,286],"biomarker":[66],"that":[67,124,157,232,242,250,291],"endogenous":[69],"to":[70,106,163,295],"myocardial":[71],"tissues.":[72],"The":[73],"growth":[74],"hormone":[75,83],"secretagogue":[76],"receptor":[77,129],"1a":[78],"(GHSR1a),":[79],"which":[80,131],"binds":[81],"ghrelin,":[84],"expressed":[86],"cardiomyocytes":[88],"elevated":[91],"in":[92,135,139,178,187,224,239,258,261,274,278],"patients.":[94],"This":[95],"characterized":[97],"specificity":[99,119,150],"novel":[102],"tracer":[103,290],"[1-Nal4,":[104,158,175],"Lys5(4-[18F]-FB)]G-7039":[105,159,176],"target":[107],"GHSR1a":[108,216,251,288],"using":[109],"Positron":[110],"Emission":[111],"Tomography":[112],"(PET).":[113],"In":[114,264],"vitro":[115,179,265],"analysis":[116],"probe":[118,199],"cellular":[121,268],"uptake":[122,167,183,186],"determined":[123],"binding":[125],"was":[126,132,168],"independent":[127,169],"expression,":[130],"confirmed":[133],"vivo":[136,147,271,275],"PET":[137,289],"GHSR1a-wildtype":[140],"(wt)":[141],"-knockout":[143],"(ghsr-/-)":[144],"mice.":[145,263],"Ex":[146],"biodistribution":[148],"comparing":[149],"effects":[152],"nutritional":[154],"state":[155],"showed":[156],"did":[160],"distribute":[162],"ghrelin":[172],"levels.":[173],"Although":[174],"demonstrated":[177],"stability,":[180],"negligible":[181],"cardiac":[182,215,259],"high":[185],"liver,":[189],"intestines":[190],"kidneys":[192],"within":[193],"1":[194],"h":[195],"post-injection":[196],"indicated":[197],"rapid":[198],"elimination":[200],"through":[201],"hepatobiliary":[202],"renal":[204],"echanisms,":[205],"possibly":[206],"explained":[207],"highly":[210],"lipophilic":[211],"tracer.":[212],"Analysis":[213],"expression":[217],"metabolic":[219],"markers":[220],"fluorescence":[222],"microscopy":[223],"fasted,":[225],"fed,":[226],"wt":[227],"ghsr-/-":[229],"mice":[230],"suggests":[231],"may":[234,292],"be":[235,293],"ghrelin/GHSR1a":[237],"system":[238],"regulated":[244],"independently":[245],"systemic":[247],"ghrelin/GHSR1a,":[248],"does":[252],"play":[254],"significant":[256],"role":[257],"metabolism":[260],"healthy":[262],"stability":[266],"uptake,":[269],"ex":[270],"iodistribution":[272],"conducted":[277],"this":[279],"present":[281],"step":[283],"towards":[284],"characterizing":[285],"suitable":[287],"used":[294],"detect":[296]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2017-07-14T00:00:00"}