{"id":"https://openalex.org/W2724294239","doi":"https://doi.org/10.1182/blood.v128.22.541.541","title":"The Interplay of GATA1 with Heme Regulates an Erythroid Cell's Differentiation","display_name":"The Interplay of GATA1 with Heme Regulates an Erythroid Cell's Differentiation","publication_year":2016,"publication_date":"2016-12-02","ids":{"openalex":"https://openalex.org/W2724294239","doi":"https://doi.org/10.1182/blood.v128.22.541.541","mag":"2724294239"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v128.22.541.541","doi":"https://doi.org/10.1182/blood.v128.22.541.541","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v128.22.541.541","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030160514","display_name":"Raymond T. Doty","orcid":"https://orcid.org/0000-0002-9312-8622","observed_orcids":["https://orcid.org/0000-0002-9312-8622"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raymond T Doty","raw_affiliation_strings":["Department of Medicine/Hematology Division, University of Washington, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine/Hematology Division, University of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055046842","display_name":"Xiaowei Sherry Yan","orcid":"https://orcid.org/0000-0003-4215-1395","observed_orcids":["https://orcid.org/0000-0003-4215-1395"]},"institutions":[{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaowei Yan","raw_affiliation_strings":["Institute for Systems Biology, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Systems Biology, Seattle, WA","institution_ids":["https://openalex.org/I3148997608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037957654","display_name":"Christopher G. Lausted","orcid":"https://orcid.org/0000-0003-3073-9212","observed_orcids":["https://orcid.org/0000-0003-3073-9212"]},"institutions":[{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Lausted","raw_affiliation_strings":["Institute for Systems Biology, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Systems Biology, Seattle, WA","institution_ids":["https://openalex.org/I3148997608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101855925","display_name":"Zhantao Yang","orcid":"https://orcid.org/0000-0002-3259-4400","observed_orcids":["https://orcid.org/0000-0002-3259-4400"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhantao Yang","raw_affiliation_strings":["Department of Medicine/Hematology Division, University of Washington, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine/Hematology Division, University of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115621207","display_name":"Li Liu","orcid":"https://orcid.org/0000-0002-0504-418X","observed_orcids":["https://orcid.org/0000-0002-0504-418X"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Liu","raw_affiliation_strings":["Department of Medicine/Hematology Division, University of Washington, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine/Hematology Division, University of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037538576","display_name":"Neda Jabbari","orcid":"https://orcid.org/0000-0002-3252-0655","observed_orcids":["https://orcid.org/0000-0002-3252-0655"]},"institutions":[{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neda Jabbari","raw_affiliation_strings":["Institute for Systems Biology, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Systems Biology, Seattle, WA","institution_ids":["https://openalex.org/I3148997608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091777632","display_name":"Sio\u1e03\u00e1n Keel","orcid":"https://orcid.org/0000-0002-9599-8226","observed_orcids":["https://orcid.org/0000-0002-9599-8226"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Siob\u00e1n B. Keel","raw_affiliation_strings":["Department of Medicine, Division of Hematology, University of Washington, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Hematology, University of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101438829","display_name":"Qiang Tian","orcid":"https://orcid.org/0000-0002-1924-6217","observed_orcids":["https://orcid.org/0000-0002-1924-6217"]},"institutions":[{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qiang Tian","raw_affiliation_strings":["Institute for Systems Biology, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Systems Biology, Seattle, WA","institution_ids":["https://openalex.org/I3148997608"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055816987","display_name":"Janis L. Abkowitz","orcid":"https://orcid.org/0000-0002-1820-5341","observed_orcids":["https://orcid.org/0000-0002-1820-5341"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janis L. Abkowitz","raw_affiliation_strings":["Department of Medicine/Hematology Division, University of Washington, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine/Hematology Division, University of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.21759587,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"128","issue":"22","first_page":"541","last_page":"541"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.7675999999046326,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.7675999999046326,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.07729999721050262,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.05009999871253967,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heme","display_name":"heme","score":0.7990000247955322},{"id":"https://openalex.org/keywords/erythroid-differentiation","display_name":"erythroid differentiation","score":0.9879999756813049},{"id":"https://openalex.org/keywords/erythropoiesis","display_name":"erythropoiesis","score":0.9330000281333923},{"id":"https://openalex.org/keywords/flvcr1","display_name":"FLVCR1","score":0.9229999780654907},{"id":"https://openalex.org/keywords/heme-export","display_name":"heme export","score":0.8410000205039978},{"id":"https://openalex.org/keywords/alas2","display_name":"ALAS2","score":0.7089999914169312},{"id":"https://openalex.org/keywords/ter119","display_name":"Ter119","score":0.7749999761581421},{"id":"https://openalex.org/keywords/single-cell-rna-sequencing","display_name":"single-cell RNA sequencing","score":0.5580000281333923},{"id":"https://openalex.org/keywords/ineffective-erythropoiesis","display_name":"ineffective erythropoiesis","score":0.7450000047683716},{"id":"https://openalex.org/keywords/macrocytic-anemia","display_name":"macrocytic anemia","score":0.906000018119812},{"id":"https://openalex.org/keywords/heme-biosynthesis","display_name":"heme biosynthesis","score":0.6759999990463257},{"id":"https://openalex.org/keywords/ribosome-pathway","display_name":"ribosome pathway","score":0.5770000219345093},{"id":"https://openalex.org/keywords/gene-co-regulation","display_name":"gene co-regulation","score":0.5979999899864197},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.3930000066757202},{"id":"https://openalex.org/keywords/p53-signaling-pathway","display_name":"p53 pathway","score":0.5360000133514404},{"id":"https://openalex.org/keywords/cfu-e","display_name":"CFU-E","score":0.4099999964237213}],"concepts":[{"id":"https://openalex.org/C2779703530","wikidata":"https://www.wikidata.org/wiki/Q837174","display_name":"Erythropoiesis","level":3,"score":0.7755825519561768},{"id":"https://openalex.org/C192196715","wikidata":"https://www.wikidata.org/wiki/Q14916151","display_name":"GATA1","level":4,"score":0.7235968112945557},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6979274749755859},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.642987847328186},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6007127165794373},{"id":"https://openalex.org/C125996951","wikidata":"https://www.wikidata.org/wiki/Q412234","display_name":"Globin","level":3,"score":0.5769873261451721},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5057735443115234},{"id":"https://openalex.org/C43821964","wikidata":"https://www.wikidata.org/wiki/Q18025461","display_name":"GATA2","level":4,"score":0.49916887283325195},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4802306294441223},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.463875412940979},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.42689943313598633},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4179144501686096},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2872421145439148},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21409791707992554},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.07107576727867126},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06924167275428772},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v128.22.541.541","doi":"https://doi.org/10.1182/blood.v128.22.541.541","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v128.22.541.541","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2904090459","https://openalex.org/W2201401723","https://openalex.org/W2160451402","https://openalex.org/W2584419614","https://openalex.org/W2913492905","https://openalex.org/W2353161831","https://openalex.org/W2046192494","https://openalex.org/W1850764057","https://openalex.org/W2588499715","https://openalex.org/W2022334625"],"abstract_inverted_index":{"Abstract":[0],"GATA1":[1,308,383,407,418,572,583,595],"promotes":[2],"the":[3,7,17,67,80,144,219,233,241,275,281,287,344,380,412,424,437,467,482,522,536,579,612,622],"transcription":[4,18,29,141,181,468],"of":[5,13,19,123,147,218,232,240,325,414,436,469,521,624,639],"ALAS2,":[6],"first":[8],"and":[9,16,38,49,73,76,107,135,138,173,179,195,227,237,260,329,338,362,372,392,416,465,477,511,549,577,620,630],"rate":[10],"limiting":[11],"step":[12],"heme":[14,68,72,103,109,213,221,247,283,351,377,405,453,485,575,585,592,602],"synthesis,":[15],"many":[20],"other":[21],"erythroid-specific":[22],"genes.":[23,244],"It":[24],"also":[25,610],"increases":[26],"its":[27],"own":[28],"while":[30],"silencing":[31],"proliferation":[32],"genes":[33,224,250,279,301,310,422,441,472],"active":[34],"in":[35,58,84,115,187,197,215,254,265,271,280,291,316,319,343,400,411,423,431,457,501,525,535,618],"early":[36,125],"progenitors":[37],"thus":[39],"assures":[40,486],"that":[41,150,404,484,530],"erythroid":[42,117,126,228,277,332,365,460,580],"differentiation":[43,114,229,278,581],"correctly":[44],"initiates.":[45],"Heme":[46],"then":[47],"transcriptionally":[48,158],"translationally":[50],"upregulates":[51],"globin":[52,491],"to":[53,112,129,143,208,374,443,566,596,603,641],"guarantee":[54],"adequate":[55],"hemoglobin":[56],"production":[57,489],"each":[59,587],"cell":[60,401],"as":[61,191,474],"it":[62],"matures.":[63],"In":[64,379],"mice":[65,137,545,554,567],"lacking":[66,546,568],"exporter,":[69],"FLVCR1,":[70],"excess":[71,102,212,350,541,601],"ROS":[74],"accumulate":[75],"erythropoiesis":[77,106,503,538,617],"fails":[78],"at":[79],"CFU-E/proerythroblast":[81],"stage,":[82],"resulting":[83,410],"a":[85,498],"severe":[86,556],"macrocytic":[87,557],"anemia":[88,445,558],"(HGB":[89,559],"4.4\u00b10.97":[90],"vs":[91,96],"14.8\u00b10.57":[92],"g/dL;":[93,561],"MCV":[94,562],"66.9\u00b16.2":[95],"48.4\u00b10.65":[97],"fL).":[98],"To":[99,347,528],"determine":[100,348],"how":[101],"causes":[104],"ineffective":[105,502,537,613],"whether":[108],"is":[110,497],"key":[111,499],"terminating":[113],"normal":[116],"cells,":[118,189,382,433],"we":[119,358,543],"performed":[120],"RNA":[121],"sequencing":[122],"single":[124],"cells":[127,168,207,210,257,267,318,333,367,462],"(BFU-E":[128],"basophilic":[130],"erythroblasts)":[131],"from":[132,258,327],"wildtype":[133],"control":[134,206,259,328],"Flvcr1-deleted":[136,198,209,261,266,292,317,330,345,432,526],"linked":[139,442],"this":[140],"data":[142,608],"total":[145],"quantity":[146],"Ter119":[148,175,192],"on":[149,574],"cell.":[151],"Principal":[152],"component":[153],"analysis":[154,203,297,324],"(PCA)":[155],"identified":[156,299],"4":[157],"unique":[159],"clusters":[160,272,320],"A,":[161],"B,":[162],"C,":[163],"&":[164],"D,":[165],"which":[166,311],"contained":[167],"with":[169,303,368,463,584],"negative,":[170],"low,":[171],"intermediate,":[172],"high":[174],"levels":[176],"respectively.":[177],"\u03b1-":[178],"\u03b2-globin":[180],"were":[182,251,312,428],"highly":[183],"correlated":[184],"(r=0.975),":[185],"occurred":[186],"all":[188,313],"increased":[190,519],"expression":[193,264,342],"increased,":[194,479],"upregulated":[196,315,430],"cells.":[199,293,346,527],"Gene":[200],"set":[201],"enrichment":[202],"(GSEA)":[204],"comparing":[205],"revealed":[211],"results":[214],"significant":[216],"downregulation":[217],"hallmark":[220,282],"metabolism":[222],"pathway":[223,235,243,524],"(heme":[225],"biosynthesis":[226],"genes),":[230],"upregulation":[231],"ribosome":[234,425,470,488],"genes,":[236],"no":[238],"alteration":[239],"P53":[242,495,523,531,548],"All":[245],"eight":[246],"biosynthetic":[248],"enzyme":[249],"expressed":[252],"equivalently":[253],"cluster":[255],"A":[256],"mice;":[262],"however":[263],"was":[268,352,455,532],"significantly":[269,429],"reduced":[270,417],"B-D.":[273,321],"Of":[274,420],"181":[276],"pathway,":[284,426],"Gata1":[285,304,336,356],"had":[286,555],"greatest":[288],"reduction":[289],"(67%)":[290],"Coupled":[294],"two-way":[295],"clustering":[296],"(CTWC)":[298],"150":[300],"co-regulated":[302],"including":[305,434],"106":[306],"known":[307],"target":[309],"poorly":[314],"Independent":[322],"microarray":[323],"mRNA":[326,337],"CD71+":[331],"confirmed":[334],"low":[335,339,605],"GATA1-dependent":[340],"gene":[341],"if":[349],"directly":[353],"responsible":[354],"for":[355,490],"downregulation,":[357],"treated":[359],"K562,":[360],"HEL-R,":[361],"primary":[363,381,458],"human":[364,459],"marrow":[366,461],"aminolevulinic":[369],"acid":[370],"(ALA)":[371],"iron":[373],"increase":[375],"endogenous":[376],"synthesis.":[378,493],"protein":[384,408,440,471,492,507],"decreased":[385],"by":[386,394,505,540],"30-43%":[387],"(p=0.03)":[388],"within":[389],"15":[390],"minutes":[391,396],"66%":[393],"90":[395],"(similar":[397],"decreases":[398],"observed":[399],"lines),":[402],"suggesting":[403],"disrupts":[406],"function":[409],"loss":[413],"autoregulation":[415],"mRNA.":[419],"88":[421],"73":[427],"16":[435],"17":[438],"ribosomal":[439,506],"Diamond-Blackfan":[444],"(DBA)":[446],"or":[447],"del(5q)":[448,512],"myelodysplastic":[449],"syndrome":[450],"(MDS).":[451],"When":[452],"synthesis":[454,576],"induced":[456],"ALA":[464],"iron,":[466],"such":[473],"Rps19,":[475],"Rps14,":[476],"Rpl35":[478],"further":[480],"supporting":[481],"concept":[483],"sufficient":[487],"While":[494],"activation":[496,520],"factor":[500],"caused":[504,539],"imbalance":[508],"(i.e.,":[509],"DBA":[510,619],"MDS),":[513],"GSEA":[514],"did":[515],"not":[516,533],"reveal":[517],"any":[518],"confirm":[529],"involved":[534],"heme,":[542],"generated":[544],"both":[547],"FLVCR1.":[550,570],"These":[551],"double":[552],"mutant":[553],"2.4\u00b10.70":[560],"56.5\u00b14.3":[563],"fL)":[564],"comparable":[565],"just":[569],"Thus,":[571],"turns":[573,593],"initiates":[578],"program.":[582],"assure":[586],"cell's":[588],"appropriate":[589],"progression.":[590],"Then":[591],"off":[594],"end":[597],"differentiation.":[598],"By":[599],"linking":[600],"prematurely":[604],"GATA1,":[606],"our":[607],"may":[609],"explain":[611],"(early":[614],"termination":[615],"of)":[616],"reconcile":[621],"observations":[623],"Sci":[625],"Transl":[626],"Med":[627,632],"8:338ra67,":[628],"2016":[629],"Nat":[631],"20:748,":[633],"2014.":[634],"Disclosures":[635],"No":[636],"relevant":[637],"conflicts":[638],"interest":[640],"declare.":[642]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2017-07-14T00:00:00"}
