{"id":"https://openalex.org/W2724237471","doi":"https://doi.org/10.1161/circulationaha.116.023711","title":"Transcription Factor RUNX1 Regulates Platelet PCTP (Phosphatidylcholine Transfer Protein): Implications for Cardiovascular Events","display_name":"Transcription Factor RUNX1 Regulates Platelet PCTP (Phosphatidylcholine Transfer Protein): Implications for Cardiovascular Events","publication_year":2017,"publication_date":"2017-07-05","ids":{"openalex":"https://openalex.org/W2724237471","doi":"https://doi.org/10.1161/circulationaha.116.023711","mag":"2724237471","pmid":"https://pubmed.ncbi.nlm.nih.gov/28676520","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5591032"},"language":"en","primary_location":{"id":"doi:10.1161/circulationaha.116.023711","doi":"https://doi.org/10.1161/circulationaha.116.023711","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circulationaha.116.023711","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.116.023711","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.116.023711","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108619915","display_name":"Guangfen Mao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Guangfen Mao","raw_affiliation_strings":["From Sol Sherry Thrombosis Research Center (G.M., N.S., F.E.D.C.-C., L.E.G., A.K.R.), Hematology Section, Department of Medicine (N.S., A.K.R.), and Department of Anatomy and Cell Biology (L.E.G.), Lewis Katz School of Medicine at Temple University, Philadelphia, PA; and Duke Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC (D.V., R.A.M.)","Duke Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC (D.V., R.A.M.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Sol Sherry Thrombosis Research Center (G.M., N.S., F.E.D.C.-C., L.E.G., A.K.R.), Hematology Section, Department of Medicine (N.S., A.K.R.), and Department of Anatomy and Cell Biology (L.E.G.), Lewis Katz School of Medicine at Temple University, Philadelphia, PA; and Duke Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC (D.V., R.A.M.)","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I84392919"]},{"raw_affiliation_string":"Duke Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC (D.V., R.A.M.)","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024693198","display_name":"Natthapol Songdej","orcid":"https://orcid.org/0000-0001-6545-7931","observed_orcids":["https://orcid.org/0000-0001-6545-7931"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Natthapol Songdej","raw_affiliation_strings":["From Sol Sherry Thrombosis Research Center (G.M., N.S., F.E.D.C.-C., L.E.G., A.K.R.), Hematology Section, Department of Medicine (N.S., A.K.R.), and Department of Anatomy and Cell Biology (L.E.G.), Lewis Katz School of Medicine at Temple University, Philadelphia, PA; and Duke Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC (D.V., R.A.M.)","Duke Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC (D.V., R.A.M.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Sol Sherry Thrombosis Research Center (G.M., N.S., F.E.D.C.-C., L.E.G., A.K.R.), Hematology Section, Department of Medicine (N.S., A.K.R.), and Department of Anatomy and Cell Biology (L.E.G.), Lewis Katz School of Medicine at Temple University, Philadelphia, PA; and Duke Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC (D.V., R.A.M.)","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I84392919"]},{"raw_affiliation_string":"Duke Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC (D.V., R.A.M.)","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039284929","display_name":"Deepak Voora","orcid":"https://orcid.org/0000-0003-0015-5179","observed_orcids":["https://orcid.org/0000-0003-0015-5179"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Deepak Voora","raw_affiliation_strings":["From Sol Sherry Thrombosis Research Center (G.M., N.S., F.E.D.C.-C., L.E.G., A.K.R.), Hematology Section, Department of Medicine (N.S., A.K.R.), and Department of Anatomy and Cell Biology (L.E.G.), Lewis Katz School of Medicine at Temple University, Philadelphia, PA; and Duke Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC (D.V., R.A.M.)","Duke Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC (D.V., R.A.M.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Sol Sherry Thrombosis Research Center (G.M., N.S., F.E.D.C.-C., L.E.G., A.K.R.), Hematology Section, Department of Medicine (N.S., A.K.R.), and Department of Anatomy and Cell Biology (L.E.G.), Lewis Katz School of Medicine at Temple University, Philadelphia, PA; and Duke Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC (D.V., R.A.M.)","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I84392919"]},{"raw_affiliation_string":"Duke Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC (D.V., R.A.M.)","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003137587","display_name":"Lawrence E. Goldfinger","orcid":"https://orcid.org/0000-0003-0525-6008","observed_orcids":["https://orcid.org/0000-0003-0525-6008"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lawrence E. Goldfinger","raw_affiliation_strings":["From Sol Sherry Thrombosis Research Center (G.M., N.S., F.E.D.C.-C., L.E.G., A.K.R.), Hematology Section, Department of Medicine (N.S., A.K.R.), and Department of Anatomy and Cell Biology (L.E.G.), Lewis Katz School of Medicine at Temple University, Philadelphia, PA; and Duke Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC (D.V., R.A.M.)","Duke Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC (D.V., R.A.M.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Sol Sherry Thrombosis Research Center (G.M., N.S., F.E.D.C.-C., L.E.G., A.K.R.), Hematology Section, Department of Medicine (N.S., A.K.R.), and Department of Anatomy and Cell Biology (L.E.G.), Lewis Katz School of Medicine at Temple University, Philadelphia, PA; and Duke Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC (D.V., R.A.M.)","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I84392919"]},{"raw_affiliation_string":"Duke Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC (D.V., R.A.M.)","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019070698","display_name":"Fabiola Elizabeth Del Carpio\u2010Cano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fabiola E. Del Carpio-Cano","raw_affiliation_strings":["From Sol Sherry Thrombosis Research Center (G.M., N.S., F.E.D.C.-C., L.E.G., A.K.R.), Hematology Section, Department of Medicine (N.S., A.K.R.), and Department of Anatomy and Cell Biology (L.E.G.), Lewis Katz School of Medicine at Temple University, Philadelphia, PA; and Duke Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC (D.V., R.A.M.)","Duke Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC (D.V., R.A.M.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Sol Sherry Thrombosis Research Center (G.M., N.S., F.E.D.C.-C., L.E.G., A.K.R.), Hematology Section, Department of Medicine (N.S., A.K.R.), and Department of Anatomy and Cell Biology (L.E.G.), Lewis Katz School of Medicine at Temple University, Philadelphia, PA; and Duke Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC (D.V., R.A.M.)","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I84392919"]},{"raw_affiliation_string":"Duke Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC (D.V., R.A.M.)","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021314824","display_name":"Rachel A. Myers","orcid":"https://orcid.org/0000-0003-0086-8339","observed_orcids":["https://orcid.org/0000-0003-0086-8339"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel A. Myers","raw_affiliation_strings":["From Sol Sherry Thrombosis Research Center (G.M., N.S., F.E.D.C.-C., L.E.G., A.K.R.), Hematology Section, Department of Medicine (N.S., A.K.R.), and Department of Anatomy and Cell Biology (L.E.G.), Lewis Katz School of Medicine at Temple University, Philadelphia, PA; and Duke Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC (D.V., R.A.M.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Sol Sherry Thrombosis Research Center (G.M., N.S., F.E.D.C.-C., L.E.G., A.K.R.), Hematology Section, Department of Medicine (N.S., A.K.R.), and Department of Anatomy and Cell Biology (L.E.G.), Lewis Katz School of Medicine at Temple University, Philadelphia, PA; and Duke Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC (D.V., R.A.M.)","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I84392919"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061115846","display_name":"A. Koneti Rao","orcid":"https://orcid.org/0000-0002-3078-7778","observed_orcids":["https://orcid.org/0000-0002-3078-7778"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Koneti Rao","raw_affiliation_strings":["From Sol Sherry Thrombosis Research Center (G.M., N.S., F.E.D.C.-C., L.E.G., A.K.R.), Hematology Section, Department of Medicine (N.S., A.K.R.), and Department of Anatomy and Cell Biology (L.E.G.), Lewis Katz School of Medicine at Temple University, Philadelphia, PA; and Duke Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC (D.V., R.A.M.)","Duke Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC (D.V., R.A.M.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Sol Sherry Thrombosis Research Center (G.M., N.S., F.E.D.C.-C., L.E.G., A.K.R.), Hematology Section, Department of Medicine (N.S., A.K.R.), and Department of Anatomy and Cell Biology (L.E.G.), Lewis Katz School of Medicine at Temple University, Philadelphia, PA; and Duke Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC (D.V., R.A.M.)","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I84392919"]},{"raw_affiliation_string":"Duke Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC (D.V., R.A.M.)","institution_ids":["https://openalex.org/I170897317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5024693198","https://openalex.org/A5039284929","https://openalex.org/A5108619915"],"corresponding_institution_ids":["https://openalex.org/I170897317","https://openalex.org/I84392919"],"apc_list":null,"apc_paid":null,"fwci":1.2601,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.80760974,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"136","issue":"10","first_page":"927","last_page":"939"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/runx1","display_name":"RUNX1","score":0.9879999756813049},{"id":"https://openalex.org/keywords/phosphatidylcholine-transfer-protein","display_name":"phosphatidylcholine transfer protein","score":0.9670000076293945},{"id":"https://openalex.org/keywords/platelets","display_name":"platelets","score":0.9110000133514404},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.9150000214576721},{"id":"https://openalex.org/keywords/alternative-promoter-usage","display_name":"alternative promoters","score":0.7540000081062317},{"id":"https://openalex.org/keywords/p1-promoter","display_name":"P1 promoter","score":0.6110000014305115},{"id":"https://openalex.org/keywords/p2-promoter","display_name":"P2 promoter","score":0.8629999756813049},{"id":"https://openalex.org/keywords/cardiovascular-events","display_name":"cardiovascular events","score":0.5239999890327454},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.9629999995231628},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.796999990940094},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.781000018119812},{"id":"https://openalex.org/keywords/protease-activated-receptor-4","display_name":"PAR4","score":0.8550000190734863},{"id":"https://openalex.org/keywords/protease-activated-receptor-1","display_name":"protease-activated receptor 1","score":0.6010000109672546},{"id":"https://openalex.org/keywords/racial-differences","display_name":"racial differences","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.785610556602478},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7143762707710266},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5002100467681885},{"id":"https://openalex.org/C2776081396","wikidata":"https://www.wikidata.org/wiki/Q1724405","display_name":"Phospholipid transfer protein","level":4,"score":0.4934920072555542},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.4404584467411041},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.42936956882476807},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.38237836956977844},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15826353430747986},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.0948750376701355},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049294","descriptor_name":"Phospholipid Transfer Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049294","descriptor_name":"Phospholipid Transfer Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050676","descriptor_name":"Core Binding Factor Alpha 2 Subunit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1161/circulationaha.116.023711","doi":"https://doi.org/10.1161/circulationaha.116.023711","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circulationaha.116.023711","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.116.023711","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},{"id":"pmid:28676520","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28676520","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5072735","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5591032","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5591032","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5591032","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Circulation","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1161/circulationaha.116.023711","doi":"https://doi.org/10.1161/circulationaha.116.023711","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circulationaha.116.023711","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.116.023711","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8299999833106995,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G3030771748","display_name":"Novel small G protein pathway regulators of GPVI signaling in platelets","funder_award_id":"R01HL137207","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3082540444","display_name":"Human Platelet Defects in Transcription Factor RUNX1 Haplodeficiency","funder_award_id":"R01HL109568","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4255038921","display_name":"Aberrant Platelet Mechanisms in Inherited Human Platelet Function Disorders","funder_award_id":"R01HL085422","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6056340424","display_name":"Development Of Prognostic Platelet RNA Biomarkers To Tailor Antiplatelet Therapy","funder_award_id":"R01HL118049","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2724237471.pdf","grobid_xml":"https://content.openalex.org/works/W2724237471.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1508152421","https://openalex.org/W1533539152","https://openalex.org/W1588211608","https://openalex.org/W1739103212","https://openalex.org/W1964591425","https://openalex.org/W1975066390","https://openalex.org/W1980706177","https://openalex.org/W1984710714","https://openalex.org/W1986750183","https://openalex.org/W1987155809","https://openalex.org/W2001242972","https://openalex.org/W2024574320","https://openalex.org/W2030113244","https://openalex.org/W2045934073","https://openalex.org/W2054749702","https://openalex.org/W2062591664","https://openalex.org/W2064813555","https://openalex.org/W2066629796","https://openalex.org/W2081098333","https://openalex.org/W2087544355","https://openalex.org/W2089242137","https://openalex.org/W2090915512","https://openalex.org/W2135891958","https://openalex.org/W2136011731","https://openalex.org/W2149137596","https://openalex.org/W2165397654","https://openalex.org/W2175133709","https://openalex.org/W2266966492","https://openalex.org/W2280416781","https://openalex.org/W2464458682","https://openalex.org/W2511571370","https://openalex.org/W2524030707","https://openalex.org/W2576473448","https://openalex.org/W2605567733","https://openalex.org/W2733686209"],"related_works":["https://openalex.org/W2612354625","https://openalex.org/W2979311693","https://openalex.org/W4399894639","https://openalex.org/W7099754155","https://openalex.org/W2524030707","https://openalex.org/W2013945342","https://openalex.org/W2054749702","https://openalex.org/W2592617216","https://openalex.org/W1588211608","https://openalex.org/W2562002722"],"abstract_inverted_index":{"Background:":[0],"PCTP":[1,13,45,82,94,101,114,138,144,163,185,187,205,224,227,289,305,308,316,331],"(phosphatidylcholine":[2],"transfer":[3,8],"protein)":[4],"regulates":[5],"the":[6,41,81,91,113,133,166,301,337],"intermembrane":[7],"of":[9,23,43,48,68,80,184,214,285,314,330,339],"phosphatidylcholine.":[10],"Higher":[11],"platelet":[12,19,44,61],"expression":[14,66,102,188,219,228,261,290,317],"is":[15,38,55,95,103,206,262,309,318],"associated":[16,56,239,319],"with":[17,34,57,71,85,105,158,191,196,223,234,240,291,320,325],"increased":[18,190],"responses":[20,62],"on":[21,63,288],"activation":[22],"protease-activated":[24],"receptor":[25],"4":[26],"thrombin":[27],"receptors":[28],"noted":[29],"in":[30,139,150,165,181,199,211,220,231,295,323,336],"black":[31,232],"subjects":[32,236],"compared":[33,84,233],"white":[35,235],"subjects.":[36],"Little":[37],"known":[39,263],"about":[40],"regulation":[42,329],".":[46],"Haplodeficiency":[47],"RUNX1,":[49],"a":[50,69,72,77,270,274,292,310,334],"major":[51],"hematopoietic":[52],"transcription":[53],"factor,":[54],"thrombocytopenia":[58],"and":[59,99,120,124,137,143,145,194,237,249,273,304],"impaired":[60],"activation.":[64],"Platelet":[65,162],"profiling":[67],"patient":[70,153,167,279],"RUNX1":[73,98,110,136,176,192,197,218,260,286,298,328],"loss-of-function":[74],"mutation":[75],"revealed":[76],"10-fold":[78],"downregulation":[79],"gene":[83,225],"healthy":[86],"controls.":[87],"Methods:":[88],"We":[89,108,131],"pursued":[90],"hypothesis":[92],"that":[93,100,204,217],"regulated":[96,207],"by":[97,170,208],"correlated":[104,222],"cardiovascular":[106,159,326,341],"events.":[107,342],"studied":[109],"binding":[111,118,173,177],"to":[112,178,264],"promoter":[115,125,303],"using":[116,127],"DNA-protein":[117,172],"studies":[119,174],"human":[121,200],"erythroleukemia":[122,201],"cells":[123],"activity":[126],"luciferase":[128],"reporter":[129],"studies.":[130],"assessed":[132],"relationship":[134],"between":[135,297],"peripheral":[140],"blood":[141,221,296],"RNA":[142],"death":[146],"or":[147],"myocardial":[148],"infarction":[149,243,322],"2":[151,212,267],"separate":[152],"cohorts":[154,213],"(587":[155],"total":[156],"patients)":[157],"disease.":[160,327],"Results:":[161],"protein":[164],"was":[168,189,229,238],"reduced":[169,195],"\u224850%.":[171],"showed":[175,216],"consensus":[179],"sites":[180],"\u22481":[182],"kB":[183],"promoter.":[186,277],"overexpression":[193],"knockdown":[198],"cells,":[202],"indicating":[203],"RUNX1.":[209,315],"Studies":[210],"patients":[215,324],"expression;":[226],"higher":[230],"future":[241],"death/myocardial":[242,321],"after":[244],"adjustment":[245],"for":[246],"age,":[247],"sex,":[248],"race":[250],"(odds":[251],"ratio,":[252],"2.05;":[253],"95%":[254],"confidence":[255],"interval":[256],"1.6\u20132.7;":[257],"P":[258],"<0.0001).":[259],"initiate":[265],"at":[266],"alternative":[268],"promoters,":[269],"distal":[271],"P1":[272,302],"proximal":[275],"P2":[276],"In":[278],"cohorts,":[280],"there":[281],"were":[282],"differential":[283],"effects":[284],"isoforms":[287],"negative":[293],"correlation":[294],"expressed":[299],"from":[300],"expression.":[306],"Conclusions:":[307],"direct":[311],"transcriptional":[312],"target":[313],"may":[332],"play":[333],"role":[335],"pathogenesis":[338],"platelet-mediated":[340]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-07-14T00:00:00"}