{"id":"https://openalex.org/W27195751","doi":null,"title":"Rat myoblastic sarcoma cell lines. A model for the study of invasion, metastasis, and myogenic differentiation.","display_name":"Rat myoblastic sarcoma cell lines. A model for the study of invasion, metastasis, and myogenic differentiation.","publication_year":1994,"publication_date":"1994-06-01","ids":{"openalex":"https://openalex.org/W27195751","mag":"27195751","pmid":"https://pubmed.ncbi.nlm.nih.gov/8015294"},"language":"en","primary_location":{"id":"pmid:8015294","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8015294","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002412006","display_name":"F\u00e9ridoun Baba\u00ef","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"F Baba\u00ef","raw_affiliation_strings":["D\u00e9partement de Pathologie, Universit\u00e9 de Montr\u00e9al, Qu\u00e9bec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement de Pathologie, Universit\u00e9 de Montr\u00e9al, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I70931966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112802616","display_name":"Andr\u00e9 Royal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Royal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9997,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.77000541,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"70","issue":"6","first_page":"907","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.6646000146865845,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.6646000146865845,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.20430000126361847,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.1046999990940094,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rhabdomyosarcoma","display_name":"rhabdomyosarcoma","score":0.9819999933242798},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8709999918937683},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.9240000247955322},{"id":"https://openalex.org/keywords/myogenesis","display_name":"myogenesis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/desmin","display_name":"desmin","score":0.671999990940094},{"id":"https://openalex.org/keywords/vimentin","display_name":"vimentin","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cytoskeletal-proteins","display_name":"cytoskeletal proteins","score":0.878000020980835},{"id":"https://openalex.org/keywords/metastatic-potential","display_name":"metastatic potential","score":0.5210000276565552},{"id":"https://openalex.org/keywords/fischer-344-rats","display_name":"F344 rats","score":0.8090000152587891}],"concepts":[{"id":"https://openalex.org/C147447768","wikidata":"https://www.wikidata.org/wiki/Q411624","display_name":"Vimentin","level":3,"score":0.8166024684906006},{"id":"https://openalex.org/C2779072444","wikidata":"https://www.wikidata.org/wiki/Q425146","display_name":"Desmin","level":4,"score":0.7143101096153259},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.6661437153816223},{"id":"https://openalex.org/C2780844630","wikidata":"https://www.wikidata.org/wiki/Q1898141","display_name":"Rhabdomyosarcoma","level":3,"score":0.6300662755966187},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5809142589569092},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5632153749465942},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5563294291496277},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.4531930685043335},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4527450501918793},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4404314160346985},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4304673969745636},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3558236360549927},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.3341575264930725},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24401170015335083},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21149012446403503},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08453062176704407},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06285274028778076}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D003893","descriptor_name":"Desmin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012208","descriptor_name":"Rhabdomyosarcoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012208","descriptor_name":"Rhabdomyosarcoma","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D012518","descriptor_name":"Sarcomeres","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014746","descriptor_name":"Vimentin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8015294","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8015294","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Comparative Study"},{"id":"mag:27195751","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8015294","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W120579310","https://openalex.org/W122121821","https://openalex.org/W596440378","https://openalex.org/W1482981691","https://openalex.org/W1597871923","https://openalex.org/W1621378635","https://openalex.org/W1690550543","https://openalex.org/W1721966521","https://openalex.org/W1758637643","https://openalex.org/W1833197594","https://openalex.org/W1865246179","https://openalex.org/W1951603230","https://openalex.org/W1975037005","https://openalex.org/W1979618547","https://openalex.org/W1982451770","https://openalex.org/W1986047097","https://openalex.org/W1994302922","https://openalex.org/W2000799528","https://openalex.org/W2003399513","https://openalex.org/W2008576197","https://openalex.org/W2032201303","https://openalex.org/W2037693298","https://openalex.org/W2039169978","https://openalex.org/W2044032429","https://openalex.org/W2055751817","https://openalex.org/W2057790401","https://openalex.org/W2068900626","https://openalex.org/W2075941589","https://openalex.org/W2078273904","https://openalex.org/W2084339233","https://openalex.org/W2091535870","https://openalex.org/W2096267219","https://openalex.org/W2099606247","https://openalex.org/W2101667804","https://openalex.org/W2103313207","https://openalex.org/W2114885023","https://openalex.org/W2117239217","https://openalex.org/W2118695925","https://openalex.org/W2119436573","https://openalex.org/W2120803238","https://openalex.org/W2122188617","https://openalex.org/W2124867347","https://openalex.org/W2126745022","https://openalex.org/W2134006584","https://openalex.org/W2138162621","https://openalex.org/W2148723902","https://openalex.org/W2152940522","https://openalex.org/W2160454548","https://openalex.org/W2161370807","https://openalex.org/W2161617192","https://openalex.org/W2167728305","https://openalex.org/W2178606730","https://openalex.org/W2183644045","https://openalex.org/W2187630416","https://openalex.org/W2212581039","https://openalex.org/W2233459329","https://openalex.org/W2620860085"],"related_works":["https://openalex.org/W2008933887","https://openalex.org/W2049093311","https://openalex.org/W2463405103","https://openalex.org/W2361420515","https://openalex.org/W2407921324","https://openalex.org/W2046256823","https://openalex.org/W1566606307","https://openalex.org/W2472588474","https://openalex.org/W2093804120","https://openalex.org/W2042126548"],"abstract_inverted_index":{"BACKGROUND:":[0],"To":[1],"understand":[2],"the":[3,78,91,108,135,158,163,196,202,208,229,243,253],"relation":[4,244],"between":[5,90,195,245],"differentiation":[6,129,200,251,257],"and":[7,9,32,47,70,93,117,126,184,201,224,250],"metastasis":[8],"to":[10,25,114,240],"identify":[11],"genes":[12],"involved":[13],"in":[14,30,33,57,122,123,127,148,157,207,222,225],"invasive":[15,69,246],"or":[16,247],"metastatic":[17,42,51,92,105,149,205,230,248],"potential":[18,106,206,231,249],"of":[19,53,104,107,134,137,180,187,198,204,228,232,242,255],"cancer":[20],"cells":[21,178],"it":[22,153],"is":[23,66,82,146,154],"necessary":[24],"develop":[26],"experimental":[27],"models":[28],"allowing":[29],"vivo":[31,223],"vitro":[34,124,226],"studies.":[35],"EXPERIMENTAL":[36],"DESIGN:":[37],"Cell":[38],"lines":[39,97,166],"with":[40],"definite":[41],"potentials":[43],"have":[44,98],"been":[45,99],"established":[46],"cloned":[48],"from":[49,77],"a":[50],"nodule":[52],"an":[54,193],"induced":[55],"rhabdomyosarcoma":[56],"syngeneic":[58],"F344":[59],"rats.":[60],"The":[61,102],"parental":[62,79],"cell":[63,73,80,96,110,165,210],"line,":[64,74,81],"SMF-A,":[65],"tumorigenic,":[67],"highly":[68],"metastatic.":[71,87],"Another":[72],"SMF-D,":[75],"derived":[76],"also":[83,237],"tumorigenic":[84],"but":[85,169],"not":[86,170],"Biopathologic":[88],"differences":[89],"nonmetastatic":[94,159],"SMF":[95],"studied.":[100],"RESULTS:":[101],"loss":[103,203],"SMF-D":[109,160,185,209],"line":[111],"was":[112,118],"found":[113],"be":[115],"stable":[116],"accompanied":[119],"by":[120],"changes":[121],"invasiveness":[125],"myogenic":[128,199,256],"state.":[130],"An":[131],"immunohistochemical":[132],"study":[133,191],"expression":[136],"cytoskeletal":[138],"proteins":[139],"(vimentin,":[140],"desmin,":[141],"alpha-actins)":[142],"indicates":[143],"that":[144,176],"desmin":[145],"undetectable":[147],"SMF-A":[150,177],"cells,":[151,186],"whereas":[152],"strongly":[155],"expressed":[156],"cells.":[161,234],"However,":[162],"two":[164],"express":[167],"vimentin":[168],"sarcomeric":[171],"alpha-actin.":[172],"These":[173],"observations":[174],"suggest":[175],"are":[179,258],"undifferentiated":[181],"premyoblastic":[182],"type":[183],"myoblastic":[188,215],"type.":[189],"Our":[190],"suggests":[192],"association":[194],"appearance":[197],"line.":[211],"CONCLUSIONS:":[212],"This":[213,235],"rat":[214],"sarcoma":[216],"model":[217,236],"may":[218],"prove":[219],"useful":[220],"for":[221],"studies":[227,241],"tumor":[233],"lends":[238],"itself":[239],"since":[252],"steps":[254],"well":[259],"known.":[260]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
