{"id":"https://openalex.org/W2717570","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.1072.15","title":"The anti\u2010inflammatory effect of Alloferon on UVB irradiated human skin keratinocyte cell line, HaCaT via the regulation of pro\u2010inflammatory cytokine production","display_name":"The anti\u2010inflammatory effect of Alloferon on UVB irradiated human skin keratinocyte cell line, HaCaT via the regulation of pro\u2010inflammatory cytokine production","publication_year":2008,"publication_date":"2008-03-01","ids":{"openalex":"https://openalex.org/W2717570","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.1072.15","mag":"2717570"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.22.1_supplement.1072.15","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.1072.15","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.22.1_supplement.1072.15","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2717570"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100615388","display_name":"Seung Koo Lee","orcid":"https://orcid.org/0000-0001-9279-8176","observed_orcids":["https://orcid.org/0000-0001-9279-8176"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seung Koo Lee","raw_affiliation_strings":["Seoul National University College of Medicine Seoul Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seoul National University College of Medicine Seoul Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006743757","display_name":"Jae Seung Kang","orcid":"https://orcid.org/0000-0001-6587-9579","observed_orcids":["https://orcid.org/0000-0001-6587-9579","https://orcid.org/0000-0001-7675-9134","https://orcid.org/0000-0001-6865-1350"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jae Seung Kang","raw_affiliation_strings":["Seoul National University College of Medicine Seoul Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seoul National University College of Medicine Seoul Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080493382","display_name":"Jee Eun Kim","orcid":"https://orcid.org/0000-0003-0795-5742","observed_orcids":["https://orcid.org/0000-0003-0795-5742"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jee Eun Kim","raw_affiliation_strings":["Seoul National University College of Medicine Seoul Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seoul National University College of Medicine Seoul Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103200105","display_name":"Da Jung Jung","orcid":"https://orcid.org/0000-0002-5167-7738","observed_orcids":["https://orcid.org/0000-0002-5167-7738"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Da Jung Jung","raw_affiliation_strings":["Seoul National University College of Medicine Seoul Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seoul National University College of Medicine Seoul Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113638310","display_name":"Seyeon Bae","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seyeon Bae","raw_affiliation_strings":["Seoul National University College of Medicine Seoul Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seoul National University College of Medicine Seoul Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075284741","display_name":"Na Eun Lee","orcid":"https://orcid.org/0000-0002-3791-3933","observed_orcids":["https://orcid.org/0000-0002-3791-3933"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Na Eun Lee","raw_affiliation_strings":["Seoul National University College of Medicine Seoul Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seoul National University College of Medicine Seoul Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034344357","display_name":"Joo Myoung Kong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Joo Myoung Kong","raw_affiliation_strings":["Seoul National University College of Medicine Seoul Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seoul National University College of Medicine Seoul Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028558485","display_name":"Seon A Lee","orcid":"https://orcid.org/0000-0002-0124-6964","observed_orcids":["https://orcid.org/0000-0002-0124-6964"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seona Lee","raw_affiliation_strings":["Seoul National University College of Medicine Seoul Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seoul National University College of Medicine Seoul Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103260853","display_name":"Dong Hoon Shin","orcid":"https://orcid.org/0000-0003-4712-1267","observed_orcids":["https://orcid.org/0000-0003-4712-1267"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dong Hoon Shin","raw_affiliation_strings":["Seoul National University College of Medicine Seoul Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seoul National University College of Medicine Seoul Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102802022","display_name":"Young\u2010il Hwang","orcid":"https://orcid.org/0000-0002-5777-7983","observed_orcids":["https://orcid.org/0000-0002-5777-7983"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Young\u2010il Hwang","raw_affiliation_strings":["Seoul National University College of Medicine Seoul Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seoul National University College of Medicine Seoul Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101959883","display_name":"Wang Jae Lee","orcid":"https://orcid.org/0000-0003-2541-6101","observed_orcids":["https://orcid.org/0000-0003-2541-6101"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Wang Jae Lee","raw_affiliation_strings":["Seoul National University College of Medicine Seoul Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seoul National University College of Medicine Seoul Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I139264467"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.6891,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.69681152,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"22","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/uv-b-irradiation","display_name":"UVB irradiation","score":0.906000018119812},{"id":"https://openalex.org/keywords/skin-inflammation","display_name":"skin inflammation","score":0.8209999799728394},{"id":"https://openalex.org/keywords/hacat-cells","display_name":"HaCaT keratinocytes","score":0.9330000281333923},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9589999914169312},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.753000020980835},{"id":"https://openalex.org/keywords/interleukin-1","display_name":"interleukin-1","score":0.7400000095367432},{"id":"https://openalex.org/keywords/il-18","display_name":"IL-18","score":0.9399999976158142},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.9229999780654907},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.7020000219345093},{"id":"https://openalex.org/keywords/topical-application","display_name":"topical application","score":0.7329999804496765},{"id":"https://openalex.org/keywords/epidermal-thickness","display_name":"epidermal thickness","score":0.8809999823570251},{"id":"https://openalex.org/keywords/sunburn","display_name":"sunburn","score":0.5419999957084656},{"id":"https://openalex.org/keywords/calliphora-vicina","display_name":"Calliphora vicina","score":0.8659999966621399}],"concepts":[{"id":"https://openalex.org/C2779156968","wikidata":"https://www.wikidata.org/wiki/Q17141495","display_name":"Hairless","level":2,"score":0.9521645307540894},{"id":"https://openalex.org/C118995209","wikidata":"https://www.wikidata.org/wiki/Q5636366","display_name":"HaCaT","level":3,"score":0.8978882431983948},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6795706748962402},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.6008939146995544},{"id":"https://openalex.org/C2777074287","wikidata":"https://www.wikidata.org/wiki/Q1473931","display_name":"Keratinocyte","level":3,"score":0.5284906625747681},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47595998644828796},{"id":"https://openalex.org/C2777459323","wikidata":"https://www.wikidata.org/wiki/Q5259911","display_name":"Human skin","level":2,"score":0.46181121468544006},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4488001763820648},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.4355507493019104},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32247138023376465},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25380411744117737},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10855486989021301},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.06278723478317261},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.22.1_supplement.1072.15","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.1072.15","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.22.1_supplement.1072.15","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2030186434","https://openalex.org/W2015313035","https://openalex.org/W1996153269","https://openalex.org/W1997420388","https://openalex.org/W2031790034","https://openalex.org/W4255986288","https://openalex.org/W2396785664","https://openalex.org/W18794933","https://openalex.org/W2077954260","https://openalex.org/W2187227309"],"abstract_inverted_index":{"UVB":[0,118,132,148,197],"irradiation":[1],"modulates":[2],"immune":[3],"responses":[4],"and":[5,32,42,80,102,182],"activates":[6],"inflammatory":[7],"reactions,":[8],"leading":[9],"to":[10,57,131,188],"skin":[11,129,193],"damage":[12],"like":[13],"sunburn.":[14],"Alloferon":[15],"is":[16],"isolated":[17],"from":[18,196],"the":[19,26,46,51,65,86,100,111,121,141,159,175,179],"blood":[20],"of":[21,36,53,67,88,113,124,137,143,146,158,192],"an":[22,185],"experimentally":[23],"infected":[24],"insect,":[25],"blow":[27],"fly":[28],"Calliphora":[29],"vicina":[30],"(Diptera),":[31],"shows":[33],"a":[34],"variety":[35],"biomedical":[37],"efficacies":[38],"such":[39,92],"as":[40,93],"antiviral":[41],"antitumoral":[43],"capabilities.":[44],"However,":[45],"specific":[47],"molecular":[48],"mechanisms":[49],"for":[50],"action":[52],"alloferon":[54,68,125,138,154],"still":[55],"remain":[56],"be":[58],"clarified.":[59],"In":[60,152],"this":[61],"study,":[62],"we":[63],"investigated":[64],"effects":[66,173],"on":[69,99,126,174,178],"cutaneous":[70,180],"inflammation":[71,181,194],"induced":[72,116],"by":[73,117],"UVB\u2010irradiation":[74],"in":[75,161],"human":[76],"HaCaT":[77],"keratinocytes.":[78],"RPA":[79],"ELISA":[81],"data":[82],"showed":[83,108],"alleferon":[84,109,169],"decreased":[85],"production":[87,157],"UVB\u2010induced":[89,176],"pro\u2010inflammatory":[90],"cytokine,":[91],"IL\u20101\u03b1,":[94],"IL\u20101\u03b2,":[95],"IL\u20106,":[96],"IL\u201018,":[97],"both":[98],"mRNA":[101],"protein":[103],"level.":[104],"Western":[105],"blot":[106],"analysis":[107],"inhibited":[110,155],"activation":[112],"p38":[114],"MAPK":[115],"irradiation.":[119,198],"Furthermore,":[120],"topical":[122],"application":[123],"hairless":[127,162],"mouse":[128],"exposed":[130,149],"has":[133,170],"shown":[134],"that":[135,168],"post\u2010treatment":[136],"significantly":[139],"reduced":[140],"thickness":[142],"epidermal":[144],"layer":[145],"chronically":[147],"mice":[150,163],"skin.":[151,164],"addition,":[153],"increased":[156],"IL\u20106":[160],"These":[165],"findings":[166],"suggest":[167],"significant":[171],"anti\u2010inflammatory":[172],"response":[177],"may":[183],"offer":[184],"effective":[186],"approach":[187],"reduction":[189],"or":[190],"prevention":[191],"resulting":[195]},"counts_by_year":[{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2016-06-24T00:00:00"}
