{"id":"https://openalex.org/W271496066","doi":null,"title":"Opticusgliome bei Kindern mit Neurofibromatose Typ 1: Eine Langzeit-Untersuchung an 38 Patienten","display_name":"Opticusgliome bei Kindern mit Neurofibromatose Typ 1: Eine Langzeit-Untersuchung an 38 Patienten","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W271496066","mag":"271496066"},"language":"de","primary_location":{"id":"pmh:oai:docserv.uni-duesseldorf.de:22244","doi":null,"is_oa":false,"landing_page_url":"https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=22244","pdf_url":null,"source":{"id":"https://openalex.org/S4406922359","display_name":"Univ. Duesseldorf: Duesseldorfer Dokumenten- und Publikationsserver","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017709074","display_name":"Ansgar Thimm","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ansgar Thimm","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5017709074"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.8550000190734863,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.8550000190734863,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.05959999933838844,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.02759999968111515,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/optic-nerve-glioma","display_name":"optic nerve glioma","score":0.9850000143051147},{"id":"https://openalex.org/keywords/neurofibromatosis-type-1","display_name":"neurofibromatosis type 1","score":0.953000009059906},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.5889999866485596},{"id":"https://openalex.org/keywords/long-term-follow-up","display_name":"long-term follow-up","score":0.6759999990463257},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.6430000066757202},{"id":"https://openalex.org/keywords/optic-nerve-involvement","display_name":"optic nerve involvement","score":0.4869999885559082},{"id":"https://openalex.org/keywords/visual-impairment","display_name":"visual impairment","score":0.6370000243186951},{"id":"https://openalex.org/keywords/strabismus","display_name":"strabismus","score":0.9909999966621399},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.5210000276565552},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.3799999952316284},{"id":"https://openalex.org/keywords/optic-nerve-sheath-tumor","display_name":"optic nerve sheath tumor","score":0.46799999475479126},{"id":"https://openalex.org/keywords/optic-tract","display_name":"optic tract","score":0.3330000042915344},{"id":"https://openalex.org/keywords/mri-diagnosis","display_name":"MRI diagnosis","score":0.3779999911785126},{"id":"https://openalex.org/keywords/treatment-outcomes","display_name":"treatment outcomes","score":0.34599998593330383},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.33899998664855957},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.46799999475479126}],"concepts":[{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.7139744758605957},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5092374086380005}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:docserv.uni-duesseldorf.de:22244","doi":null,"is_oa":false,"landing_page_url":"https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=22244","pdf_url":null,"source":{"id":"https://openalex.org/S4406922359","display_name":"Univ. Duesseldorf: Duesseldorfer Dokumenten- und Publikationsserver","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},{"id":"mag:271496066","doi":null,"is_oa":false,"landing_page_url":"https://docserv.uni-duesseldorf.de/servlets/DerivateServlet/Derivate-23730/DISSERTATION%20OPG%20bei%20NF1.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":298,"referenced_works":["https://openalex.org/W20143477","https://openalex.org/W62318947","https://openalex.org/W72738195","https://openalex.org/W75040095","https://openalex.org/W85079489","https://openalex.org/W100252271","https://openalex.org/W115918952","https://openalex.org/W118327753","https://openalex.org/W133015373","https://openalex.org/W197014098","https://openalex.org/W207357698","https://openalex.org/W1487661416","https://openalex.org/W1526738019","https://openalex.org/W1544718788","https://openalex.org/W1566916620","https://openalex.org/W1584418808","https://openalex.org/W1598408272","https://openalex.org/W1615151305","https://openalex.org/W1673160816","https://openalex.org/W1871911763","https://openalex.org/W1900120220","https://openalex.org/W1914432880","https://openalex.org/W1945045077","https://openalex.org/W1959046600","https://openalex.org/W1963621662","https://openalex.org/W1964130185","https://openalex.org/W1964253791","https://openalex.org/W1965741822","https://openalex.org/W1966295969","https://openalex.org/W1966426211","https://openalex.org/W1966980518","https://openalex.org/W1967198299","https://openalex.org/W1968648408","https://openalex.org/W1969906543","https://openalex.org/W1970574581","https://openalex.org/W1971040203","https://openalex.org/W1972009650","https://openalex.org/W1972122268","https://openalex.org/W1972758053","https://openalex.org/W1973022022","https://openalex.org/W1973164955","https://openalex.org/W1974804399","https://openalex.org/W1976535560","https://openalex.org/W1977070397","https://openalex.org/W1979529318","https://openalex.org/W1980352202","https://openalex.org/W1980444437","https://openalex.org/W1980787482","https://openalex.org/W1981521768","https://openalex.org/W1982936413","https://openalex.org/W1983127995","https://openalex.org/W1985746223","https://openalex.org/W1986125814","https://openalex.org/W1986525916","https://openalex.org/W1987693740","https://openalex.org/W1987885030","https://openalex.org/W1988366226","https://openalex.org/W1989491109","https://openalex.org/W1989602074","https://openalex.org/W1989667066","https://openalex.org/W1990814386","https://openalex.org/W1991862374","https://openalex.org/W1992485297","https://openalex.org/W1992860337","https://openalex.org/W1995607634","https://openalex.org/W1995971741","https://openalex.org/W1996020282","https://openalex.org/W1996711982","https://openalex.org/W1998273087","https://openalex.org/W1999157018","https://openalex.org/W2001005232","https://openalex.org/W2002421751","https://openalex.org/W2002999352","https://openalex.org/W2003391946","https://openalex.org/W2003427988","https://openalex.org/W2003746700","https://openalex.org/W2004055506","https://openalex.org/W2005768105","https://openalex.org/W2005873273","https://openalex.org/W2006979538","https://openalex.org/W2007194256","https://openalex.org/W2007789874","https://openalex.org/W2007944515","https://openalex.org/W2009235369","https://openalex.org/W2009957442","https://openalex.org/W2011270087","https://openalex.org/W2012053348","https://openalex.org/W2012444013","https://openalex.org/W2012918037","https://openalex.org/W2013717470","https://openalex.org/W2014448084","https://openalex.org/W2014556137","https://openalex.org/W2015396002","https://openalex.org/W2016042686","https://openalex.org/W2016318689","https://openalex.org/W2017444651","https://openalex.org/W2018186473","https://openalex.org/W2018702242","https://openalex.org/W2019923676","https://openalex.org/W2020231002","https://openalex.org/W2020623316","https://openalex.org/W2020741946","https://openalex.org/W2021078043","https://openalex.org/W2023201591","https://openalex.org/W2024363055","https://openalex.org/W2026695355","https://openalex.org/W2027030412","https://openalex.org/W2027552988","https://openalex.org/W2028302105","https://openalex.org/W2028465059","https://openalex.org/W2028516762","https://openalex.org/W2029001253","https://openalex.org/W2030907153","https://openalex.org/W2031749466","https://openalex.org/W2031965377","https://openalex.org/W2033181122","https://openalex.org/W2033432342","https://openalex.org/W2033533375","https://openalex.org/W2034029713","https://openalex.org/W2035132554","https://openalex.org/W2035515514","https://openalex.org/W2036647391","https://openalex.org/W2037208574","https://openalex.org/W2037538572","https://openalex.org/W2037549485","https://openalex.org/W2037877093","https://openalex.org/W2037920362","https://openalex.org/W2038124560","https://openalex.org/W2039224718","https://openalex.org/W2039548321","https://openalex.org/W2040064088","https://openalex.org/W2040260667","https://openalex.org/W2041609008","https://openalex.org/W2045138259","https://openalex.org/W2045465906","https://openalex.org/W2045959624","https://openalex.org/W2047312365","https://openalex.org/W2047323745","https://openalex.org/W2049222757","https://openalex.org/W2049229548","https://openalex.org/W2049602461","https://openalex.org/W2049721164","https://openalex.org/W2050503537","https://openalex.org/W2052186241","https://openalex.org/W2052556648","https://openalex.org/W2053380373","https://openalex.org/W2053726612","https://openalex.org/W2054027679","https://openalex.org/W2054215033","https://openalex.org/W2054674800","https://openalex.org/W2055359753","https://openalex.org/W2056992995","https://openalex.org/W2058794693","https://openalex.org/W2059840844","https://openalex.org/W2061152871","https://openalex.org/W2061655178","https://openalex.org/W2061828561","https://openalex.org/W2062509982","https://openalex.org/W2062915993","https://openalex.org/W2063358256","https://openalex.org/W2064895552","https://openalex.org/W2065563429","https://openalex.org/W2066441128","https://openalex.org/W2066914787","https://openalex.org/W2067034998","https://openalex.org/W2067394054","https://openalex.org/W2068360425","https://openalex.org/W2069637023","https://openalex.org/W2069813411","https://openalex.org/W2069935187","https://openalex.org/W2072107742","https://openalex.org/W2072260031","https://openalex.org/W2072478579","https://openalex.org/W2072549970","https://openalex.org/W2072758688","https://openalex.org/W2073302657","https://openalex.org/W2073468932","https://openalex.org/W2073786389","https://openalex.org/W2073998405","https://openalex.org/W2075540776","https://openalex.org/W2075768836","https://openalex.org/W2076794162","https://openalex.org/W2079876585","https://openalex.org/W2081228385","https://openalex.org/W2081961106","https://openalex.org/W2082521106","https://openalex.org/W2082612174","https://openalex.org/W2082615324","https://openalex.org/W2082994442","https://openalex.org/W2084045735","https://openalex.org/W2084488354","https://openalex.org/W2084612017","https://openalex.org/W2085185944","https://openalex.org/W2085752522","https://openalex.org/W2086250170","https://openalex.org/W2087776546","https://openalex.org/W2088178265","https://openalex.org/W2088339166","https://openalex.org/W2089252994","https://openalex.org/W2090170771","https://openalex.org/W2091573307","https://openalex.org/W2092016860","https://openalex.org/W2092620022","https://openalex.org/W2093423802","https://openalex.org/W2093578558","https://openalex.org/W2093653219","https://openalex.org/W2094055652","https://openalex.org/W2094467405","https://openalex.org/W2099018273","https://openalex.org/W2099938621","https://openalex.org/W2100719429","https://openalex.org/W2102014830","https://openalex.org/W2102858476","https://openalex.org/W2103629665","https://openalex.org/W2106234246","https://openalex.org/W2106742000","https://openalex.org/W2107395655","https://openalex.org/W2110737893","https://openalex.org/W2111752247","https://openalex.org/W2112123453","https://openalex.org/W2113048420","https://openalex.org/W2113643093","https://openalex.org/W2114956112","https://openalex.org/W2116056936","https://openalex.org/W2117072026","https://openalex.org/W2120180603","https://openalex.org/W2120667391","https://openalex.org/W2121828378","https://openalex.org/W2122203586","https://openalex.org/W2122340058","https://openalex.org/W2123383209","https://openalex.org/W2124624490","https://openalex.org/W2125433565","https://openalex.org/W2128888443","https://openalex.org/W2131651845","https://openalex.org/W2132335987","https://openalex.org/W2135347359","https://openalex.org/W2136765779","https://openalex.org/W2138390014","https://openalex.org/W2139144917","https://openalex.org/W2139478740","https://openalex.org/W2139747993","https://openalex.org/W2140375000","https://openalex.org/W2140983428","https://openalex.org/W2143904504","https://openalex.org/W2144283038","https://openalex.org/W2145069280","https://openalex.org/W2145423090","https://openalex.org/W2146623365","https://openalex.org/W2150132470","https://openalex.org/W2151451197","https://openalex.org/W2152165396","https://openalex.org/W2152943473","https://openalex.org/W2154295173","https://openalex.org/W2157178968","https://openalex.org/W2157618479","https://openalex.org/W2157655290","https://openalex.org/W2159096148","https://openalex.org/W2159099714","https://openalex.org/W2161551028","https://openalex.org/W2162372366","https://openalex.org/W2163193409","https://openalex.org/W2163864783","https://openalex.org/W2163923192","https://openalex.org/W2165541661","https://openalex.org/W2165717665","https://openalex.org/W2165913220","https://openalex.org/W2167453812","https://openalex.org/W2167650288","https://openalex.org/W2171375672","https://openalex.org/W2182768752","https://openalex.org/W2224591778","https://openalex.org/W2288912204","https://openalex.org/W2302679355","https://openalex.org/W2318867735","https://openalex.org/W2319887569","https://openalex.org/W2323317437","https://openalex.org/W2334787303","https://openalex.org/W2335203612","https://openalex.org/W2339678451","https://openalex.org/W2342844055","https://openalex.org/W2394943379","https://openalex.org/W2396067560","https://openalex.org/W2396746017","https://openalex.org/W2399370803","https://openalex.org/W2406064017","https://openalex.org/W2412712329","https://openalex.org/W2415773533","https://openalex.org/W2416682745","https://openalex.org/W2416715144","https://openalex.org/W2418193209","https://openalex.org/W2425824611","https://openalex.org/W2464174570","https://openalex.org/W2465554112","https://openalex.org/W2473970815","https://openalex.org/W4233423789","https://openalex.org/W4245587302","https://openalex.org/W7096186325"],"related_works":["https://openalex.org/W2033145034","https://openalex.org/W7216661985","https://openalex.org/W2072880098","https://openalex.org/W2002421751","https://openalex.org/W4387232308","https://openalex.org/W2053191369","https://openalex.org/W4281670454","https://openalex.org/W2399640568","https://openalex.org/W2743966414","https://openalex.org/W2978170968"],"abstract_inverted_index":{"Pilozytische":[0],"Astrozytome":[1],"der":[2,11,55,59,76,78,99,108,182,235,259,272,317,339],"Sehnerven":[3,195],"(Optikusgliome,":[4],"OPG)":[5],"gehoren":[6],"zu":[7,44,263,269,292,331],"den":[8,97,112,164,187,220,275],"klassischen":[9],"Befunden":[10],"Neurofibromatose":[12],"Typ":[13],"1":[14],"(NF":[15],"1)":[16],"und":[17,57,62,72,107,215,315,328],"treten":[18],"bei":[19,134,170,309],"Kindern":[20,93,121,277],"mit":[21,34,67,94,231],"einer":[22,171,178,232,293,332],"Haufigkeit":[23],"von":[24,65,213,238],"15":[25],"\u2013":[26],"20%":[27],"auf.":[28,301],"Auch":[30],"wenn":[31],"dramatische":[32],"Verlaufe":[33],"schneller":[35],"Tumorprogession":[36],"beschrieben":[37],"sind,":[38],"so":[39],"fuhren":[40],"NF1-assoziierte":[41],"OPG":[42,68,124,138,169,188,203,308],"meist":[43],"keinerlei":[45],"Symptomen.":[46],"Das":[49,132],"Ziel":[50],"unserer":[51,224,352],"Untersuchung":[52],"bestand":[53],"in":[54,111,279,286,316],"Erfassung":[56],"Beschreibung":[58],"Pravalenz,":[60],"Klinik":[61,100],"des":[63,104,137,160,298,334],"Verlaufs":[64],"Patienten":[66,150,311],"aus":[69,96,345],"unseren":[70],"NF1-Ambulanzen":[71],"die":[73,194,226,246],"Evaluation":[74],"Empfehlungen":[77,338],"Optic":[79,340],"Glioma":[80,342],"Task":[81,343],"Force":[82,344],"fur":[83,101,245],"unser":[84],"Patientenkollektiv.\r":[85],"Diese":[87],"retrospektive":[88],"Studie":[89,353],"wurde":[90,167],"an":[91],"356":[92],"NF1":[95,310],"Neurofibromatose-Ambulanzen":[98],"Allgemeine":[102],"Padiatrie":[103],"Universitatsklinikums":[105],"Dusseldorf":[106],"Kinderklinik":[109],"Ludenscheid":[110],"Jahren":[113],"1994":[114],"bis":[115,146],"2008":[116],"durchgefuhrt.\r":[117],"Bei":[119,148,274],"38":[120],"konnte":[122],"ein":[123,155,250],"kernspintomographisch":[125],"nachgewiesen":[126],"werden":[127],"(18":[128],"Madchen,":[129],"20":[130],"Jungen).":[131],"Alter":[133],"Diagnose":[136,159],"betrug":[139],"im":[141,180,350],"Mittel":[142],"4,8":[143],"Jahre":[144],"(1,1":[145],"10).":[147],"11":[149],"fuhrten":[151],"Visusstorungen":[152],"(8/11)":[153],"oder":[154,177,254],"Strabismus":[156],"(6/11)":[157],"zur":[158],"OPG.":[161],"In":[163],"anderen":[165],"Fallen":[166,281,289],"das":[168,207],"Bildgebung":[172],"aufgrund":[173],"anderer":[174],"Fragestellungen":[175],"(11/38)":[176],"\u201eRoutine\u201c-Bildgebung":[179],"Rahmen":[181],"Initialdiagnostik":[183],"entdeckt.":[185],"Von":[186],"betrafen":[189],"57":[190],"%":[191],"(22/38)":[192],"allein":[193],"(16/38":[196],"einseitig,":[197],"6/38":[198],"beidseitig).":[199],"Vier":[200,223],"(10":[201],"%)":[202],"beschrankten":[204],"sich":[205],"auf":[206],"Chiasma,":[208],"9/38":[209],"hatten":[210],"eine":[211,255,282],"Beteiligung":[212],"Chiasma":[214],"Sehnerven,":[216],"wahrend":[217,297],"drei":[218],"auch":[219,268],"Sehtrakt":[221],"involvierten.":[222],"Patienten,":[225],"alle":[227],"symptomatisch":[228],"waren,":[229],"wurden":[230],"Chemotherapie":[233],"nach":[234,241],"HIT-LGG-Studie":[236],"innerhalb":[237],"wenigen":[239],"Wochen":[240],"Diagnosestellung":[242],"behandelt.":[243],"Grund":[244],"Therapie":[247,260],"war":[248],"entweder":[249],"starker":[251],"Visusverlust":[252],"radiologische":[256],"Tumorprogression.":[257],"Unter":[258],"kam":[261,290],"es":[262,291],"keinem":[264],"weiteren":[265,287],"Tumorwachstum,":[266],"allerdings":[267],"keiner":[270],"Verbesserung":[271,333],"Sehkraft.":[273],"nicht-therapierten":[276],"trat":[278],"vier":[280,288],"spontane":[283],"Visusverbesserung":[284],"auf,":[285],"Verschlechterung.":[294],"Todesfalle":[295],"traten":[296],"Beobachtungszeitraums":[299],"nicht":[300,330],"Unsere":[304],"Ergebnisse":[305],"belegen,":[306],"dass":[307],"oft":[312],"symptomlos":[313],"sind":[314],"Regel":[318],"gutartig":[319],"verlaufen.":[320],"Eine":[321],"therapeutische":[322],"Intervention":[323],"ist":[324],"nur":[325],"selten":[326],"notwendig":[327],"fuhrt":[329],"Visus.":[335],"Die":[336],"uberarbeiteten":[337],"Pathway":[341],"dem":[346],"Jahr":[347],"2007":[348],"erscheinen":[349],"Lichte":[351],"sinnvoll.":[354]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}