{"id":"https://openalex.org/W27103444","doi":null,"title":"CMV prophylaxis with foscarnet in allogeneic bone marrow transplant recipients at high risk of developing CMV infections.","display_name":"CMV prophylaxis with foscarnet in allogeneic bone marrow transplant recipients at high risk of developing CMV infections.","publication_year":1994,"publication_date":"1994-06-01","ids":{"openalex":"https://openalex.org/W27103444","mag":"27103444","pmid":"https://pubmed.ncbi.nlm.nih.gov/7920315"},"language":"en","primary_location":{"id":"pmid:7920315","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7920315","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone marrow transplantation","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110503315","display_name":"A Bacigalupo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A Bacigalupo","raw_affiliation_strings":["Divisione Ematologia II, Ospedale San Martino, Genova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisione Ematologia II, Ospedale San Martino, Genova, Italy","institution_ids":["https://openalex.org/I4210146472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010254709","display_name":"Elisabetta Tedone","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Tedone","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110569542","display_name":"Maria Teresa Van Lint","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M T Van Lint","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055603231","display_name":"Graziella Trespi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Trespi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062746125","display_name":"M Lonngren","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Lonngren","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"M A Sanna","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M A Sanna","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"F Moro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Moro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076596928","display_name":"Francesco Frassoni","orcid":"https://orcid.org/0000-0003-1262-0648","observed_orcids":["https://orcid.org/0000-0003-1262-0648"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Frassoni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017966262","display_name":"Domenico Occhini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Occhini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5029072398","display_name":"Francesca Gualandi","orcid":"https://orcid.org/0000-0003-0859-7211","observed_orcids":["https://orcid.org/0000-0003-0859-7211"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Gualandi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.1001,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.84630684,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"13","issue":"6","first_page":"783","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytomegalovirus-infection","display_name":"cytomegalovirus infection","score":0.8169999718666077},{"id":"https://openalex.org/keywords/foscarnet","display_name":"foscarnet","score":0.9459999799728394},{"id":"https://openalex.org/keywords/prophylaxis","display_name":"prophylaxis","score":0.7680000066757202},{"id":"https://openalex.org/keywords/allogeneic-bone-marrow-transplantation","display_name":"allogeneic bone marrow transplantation","score":0.9710000157356262},{"id":"https://openalex.org/keywords/t-cell-depletion","display_name":"T cell depletion","score":0.7929999828338623},{"id":"https://openalex.org/keywords/cmv-antigenemia","display_name":"CMV antigenemia","score":0.8569999933242798},{"id":"https://openalex.org/keywords/acyclovir","display_name":"acyclovir","score":0.8930000066757202},{"id":"https://openalex.org/keywords/treatment-related-mortality","display_name":"non-relapse mortality","score":0.9459999799728394},{"id":"https://openalex.org/keywords/cytomegalovirus-pneumonia","display_name":"cytomegalovirus pneumonia","score":0.8999999761581421},{"id":"https://openalex.org/keywords/total-body-irradiation","display_name":"total body irradiation","score":0.7120000123977661},{"id":"https://openalex.org/keywords/hla-matched-sibling-donor","display_name":"matched sibling donor","score":0.8130000233650208}],"concepts":[{"id":"https://openalex.org/C2776724271","wikidata":"https://www.wikidata.org/wiki/Q420387","display_name":"Foscarnet","level":5,"score":0.9663671255111694},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8906986713409424},{"id":"https://openalex.org/C2777662283","wikidata":"https://www.wikidata.org/wiki/Q747711","display_name":"Betaherpesvirinae","level":5,"score":0.6439793705940247},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5726525187492371},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.571456253528595},{"id":"https://openalex.org/C2777732132","wikidata":"https://www.wikidata.org/wiki/Q6946","display_name":"Cytomegalovirus","level":5,"score":0.5646002292633057},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5151147246360779},{"id":"https://openalex.org/C2779196057","wikidata":"https://www.wikidata.org/wiki/Q835718","display_name":"Opportunistic infection","level":4,"score":0.45747897028923035},{"id":"https://openalex.org/C2780452071","wikidata":"https://www.wikidata.org/wiki/Q418594","display_name":"Valaciclovir","level":5,"score":0.4171209931373596},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4098462164402008},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37776684761047363},{"id":"https://openalex.org/C2779820661","wikidata":"https://www.wikidata.org/wiki/Q6929","display_name":"Human cytomegalovirus","level":3,"score":0.30563783645629883},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.27680718898773193},{"id":"https://openalex.org/C2776409557","wikidata":"https://www.wikidata.org/wiki/Q149348","display_name":"Herpesviridae","level":4,"score":0.26963913440704346},{"id":"https://openalex.org/C2777965375","wikidata":"https://www.wikidata.org/wiki/Q417640","display_name":"Ganciclovir","level":4,"score":0.25982657074928284},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.10753634572029114}],"mesh":[{"descriptor_ui":"D000212","descriptor_name":"Acyclovir","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000212","descriptor_name":"Acyclovir","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014184","descriptor_name":"Transplantation, Homologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016026","descriptor_name":"Bone Marrow Transplantation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D016026","descriptor_name":"Bone Marrow Transplantation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017245","descriptor_name":"Foscarnet","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D017245","descriptor_name":"Foscarnet","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:7920315","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7920315","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone marrow transplantation","raw_type":"Clinical Trial"},{"id":"mag:27103444","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7920315","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1993311197","https://openalex.org/W2075518862","https://openalex.org/W2017025205","https://openalex.org/W29876763","https://openalex.org/W2417854610","https://openalex.org/W1736864826","https://openalex.org/W2050859064","https://openalex.org/W3032577008","https://openalex.org/W2126552350","https://openalex.org/W1984299904"],"abstract_inverted_index":{"Eleven":[0],"patients":[1,42,73,108,180],"underwent":[2],"bone":[3],"marrow":[4],"transplant":[5],"(BMT)":[6],"from":[7,50,92,116],"an":[8],"HLA-identical":[9],"sibling":[10],"following":[11,247],"single":[12],"dose":[13],"total":[14],"body":[15],"irradiation":[16],"(TBI),":[17],"with":[18,33,61],"in":[19,69,176,216,237],"vivo":[20,23],"and":[21,35,58,83,129,148,184,214,244],"ex":[22],"T":[24],"cell":[25],"depletion":[26],"(TCD).":[27],"In":[28],"spite":[29],"of":[30,40,52,118,133,159,164,189,241],"CMV":[31,44,62,81,110,127,135,165,190,242],"prophylaxis":[32,228],"acyclovir":[34,177],"high-dose":[36],"i.v.":[37],"Ig,":[38],"10":[39],"11":[41,70],"developed":[43,109],"antigenemia,":[45],"at":[46,112],"a":[47,113],"median":[48,114,162,186],"interval":[49,115],"BMT":[51,117],"34":[53],"days":[54,93,120],"(range":[55,121,170,174,195,199],"16-72":[56],"days)":[57],"five":[59],"died":[60],"disease.":[63],"Foscarnet":[64,88],"was":[65,89,168,193],"then":[66,99],"given":[67,90],"prophylactically":[68],"additional":[71],"TCD":[72,248],"to":[74,95,126],"test":[75],"whether":[76],"we":[77],"could":[78],"(1)":[79],"prevent":[80],"reactivation,":[82],"(2)":[84],"reduce":[85],"transplant-related":[86,209],"mortality.":[87],"daily":[91],"+10":[94,232],"+15":[96],"(180":[97],"mg/kg/day),":[98],"thrice":[100],"weekly":[101],"(90":[102],"mg/kg/day)":[103],"until":[104],"day":[105,138,231],"+100.":[106],"Five":[107],"antigenemia":[111,136],"42":[119],"16-65":[122],"days);":[123],"one":[124],"progressed":[125],"pneumonitis":[128],"died.":[130],"The":[131,205],"risk":[132,240],"developing":[134],"within":[137],"100":[139],"is":[140,212],"currently":[141],"91%":[142],"for":[143,150],"the":[144,151,161,185,217,239],"historical":[145],"control":[146],"group":[147,153],"45%":[149],"foscarnet":[152,179,227],"(p":[154,181,202,220],"=":[155,182,203,221],"0.005).":[156],"At":[157],"diagnosis":[158],"CMV,":[160],"number":[163,188],"antigen-positive":[166,191],"cells":[167,192],"6.5":[169],"1-13)":[171],"vs":[172,178,197],"1":[173,198,207],"1-5)":[175],"0.02)":[183],"highest":[187],"7":[194],"3-110)":[196],"1-12),":[200],"respectively,":[201],"0.03).":[204],"actuarial":[206],"year":[208],"mortality":[210,246],"(TRM)":[211],"49%":[213],"13%":[215],"two":[218],"groups":[219],"0.08).":[222],"This":[223],"study":[224],"suggests":[225],"that":[226],"starting":[229],"on":[230],"post-BMT":[233],"may":[234],"be":[235],"helpful":[236],"reducing":[238],"disease":[243],"early":[245],"BMT.":[249]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}