{"id":"https://openalex.org/W270607151","doi":null,"title":"Relationship between Methacholine Challenge Testing and exhaled nitric oxide in adult patients with suspected bronchial asthma.","display_name":"Relationship between Methacholine Challenge Testing and exhaled nitric oxide in adult patients with suspected bronchial asthma.","publication_year":2014,"publication_date":"2014-05-01","ids":{"openalex":"https://openalex.org/W270607151","mag":"270607151","pmid":"https://pubmed.ncbi.nlm.nih.gov/24853569"},"language":"en","primary_location":{"id":"pmid:24853569","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24853569","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European annals of allergy and clinical immunology","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108406283","display_name":"Marcello Giovannini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Giovannini","raw_affiliation_strings":["Pulmonary Diseases Department, Mirandola Hospital, Via Fogazzaro 6, 41100, Modena, Italy, E-mail: m.giovannini@ausl.mo.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary Diseases Department, Mirandola Hospital, Via Fogazzaro 6, 41100, Modena, Italy, E-mail: m.giovannini@ausl.mo.it","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112174702","display_name":"Matteo Valli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Valli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054525240","display_name":"Viviana Ribuffo","orcid":"https://orcid.org/0000-0003-1613-6239","observed_orcids":["https://orcid.org/0000-0003-1613-6239"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Ribuffo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008220656","display_name":"Rosita Melara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Melara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109715076","display_name":"G. Cappiello","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Cappiello","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033992529","display_name":"Elisa Businarolo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Businarolo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"A Andreani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Andreani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3295,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.78955015,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"46","issue":"3","first_page":"109","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12208","display_name":"Occupational exposure and asthma","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methacholine-challenge","display_name":"methacholine challenge","score":0.8180000185966492},{"id":"https://openalex.org/keywords/exhaled-nitric-oxide","display_name":"exhaled nitric oxide","score":0.9810000061988831},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.8399999737739563},{"id":"https://openalex.org/keywords/airway-hyperresponsiveness","display_name":"airway hyperresponsiveness","score":0.9039999842643738},{"id":"https://openalex.org/keywords/airway-inflammation","display_name":"airway inflammation","score":0.878000020980835},{"id":"https://openalex.org/keywords/asthma-diagnosis","display_name":"asthma diagnosis","score":0.9430000185966492},{"id":"https://openalex.org/keywords/asthma-exacerbations","display_name":"asthma exacerbations","score":0.6430000066757202}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9470267295837402},{"id":"https://openalex.org/C2781260171","wikidata":"https://www.wikidata.org/wiki/Q413188","display_name":"Methacholine","level":4,"score":0.9352465867996216},{"id":"https://openalex.org/C2781142857","wikidata":"https://www.wikidata.org/wiki/Q5420174","display_name":"Exhaled nitric oxide","level":4,"score":0.9175878763198853},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.8607270121574402},{"id":"https://openalex.org/C2776238763","wikidata":"https://www.wikidata.org/wiki/Q3801533","display_name":"Bronchial hyperresponsiveness","level":4,"score":0.8182084560394287},{"id":"https://openalex.org/C2777014857","wikidata":"https://www.wikidata.org/wiki/Q1383410","display_name":"Exacerbation","level":2,"score":0.6601312756538391},{"id":"https://openalex.org/C110586980","wikidata":"https://www.wikidata.org/wiki/Q4168588","display_name":"Provocation test","level":3,"score":0.6162161827087402},{"id":"https://openalex.org/C2909082789","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma exacerbations","level":3,"score":0.4678652286529541},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3864113390445709},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37179481983184814},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.2770315408706665},{"id":"https://openalex.org/C2780333948","wikidata":"https://www.wikidata.org/wiki/Q653305","display_name":"Spirometry","level":3,"score":0.17045822739601135},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10559692978858948},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.09379631280899048},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001944","descriptor_name":"Breath Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001985","descriptor_name":"Bronchial Provocation Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016084","descriptor_name":"Bronchoconstriction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016085","descriptor_name":"Bronchoconstrictor Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016210","descriptor_name":"Methacholine Chloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016535","descriptor_name":"Bronchial Hyperreactivity","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D016535","descriptor_name":"Bronchial Hyperreactivity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016535","descriptor_name":"Bronchial Hyperreactivity","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045853","descriptor_name":"Exhalation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:24853569","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24853569","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European annals of allergy and clinical immunology","raw_type":"Journal Article"},{"id":"mag:270607151","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24853569","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W387031605","https://openalex.org/W1998405659","https://openalex.org/W1999545083","https://openalex.org/W2025290348","https://openalex.org/W2064514674","https://openalex.org/W2065814537","https://openalex.org/W2099524026","https://openalex.org/W2099687291","https://openalex.org/W2111666559","https://openalex.org/W2313447230"],"related_works":["https://openalex.org/W4238861684","https://openalex.org/W2777437546","https://openalex.org/W2091783844","https://openalex.org/W4410277311","https://openalex.org/W1908870833","https://openalex.org/W4416634561","https://openalex.org/W2788736697","https://openalex.org/W2978741061","https://openalex.org/W2792553820","https://openalex.org/W2412078158"],"abstract_inverted_index":{"Usually,":[0],"hyperresponsiveness":[1],"to":[2,41,64,96,133],"inhaled":[3],"methacholine":[4,87],"is":[5,26,37,120,129],"considered":[6],"closely":[7],"associated":[8],"with":[9,61,111],"a":[10,28,121],"diagnosis":[11],"of":[12,31,68,76,136,152],"bronchial":[13,23,58,137],"asthma.":[14],"Recently,":[15],"it":[16,128],"has":[17],"been":[18],"clearly":[19],"pointed":[20],"out":[21,151],"that":[22,34,92,118],"hyperreactivity":[24],"(BHR)":[25],"not":[27,38,130],"constant":[29],"feature":[30],"asthma":[32,125,153],"and":[33,54],"this":[35],"condition":[36],"always":[39,131],"related":[40,132],"airways":[42],"inflammation.":[43],"In":[44],"the":[45,62,66,74,90,97,101,134],"present":[46],"study":[47,144],"we":[48],"evaluated":[49,150],"42":[50],"Patients":[51],"(21":[52],"positive":[53,95],"21":[55],"negative":[56],"for":[57,124],"hyperreactivity,":[59],"BHR)":[60],"aim":[63],"determine":[65],"effect":[67],"Methacholine":[69],"Challenge":[70],"Testing":[71],"(MCT)":[72],"on":[73],"levels":[75,83,141],"exhaled":[77],"nitric":[78],"oxide":[79],"(NO).":[80],"Higher":[81],"FeNO":[82,106,140],"were":[84],"found":[85],"before":[86],"provocation":[88],"in":[89,103,108,142],"group":[91],"eventually":[93],"resulted":[94],"challenge,":[98],"while":[99,139],"after":[100],"challenge":[102],"both":[104],"groups":[105],"decreased":[107],"similar":[109],"way,":[110],"no":[112],"statistical":[113],"difference.":[114],"These":[115],"data":[116],"confirm":[117],"MCT":[119],"relevant":[122],"test":[123],"diagnosis,":[126],"but":[127],"severity":[135],"inflammation,":[138],"our":[143],"have":[145],"limited":[146],"clinical":[147],"significance":[148],"when":[149],"exacerbation.":[154]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
