{"id":"https://openalex.org/W2703929","doi":null,"title":"Characterizing the role of the Retinoblastoma protein LXCXE binding cleft in cellular senescence and tumor suppression","display_name":"Characterizing the role of the Retinoblastoma protein LXCXE binding cleft in cellular senescence and tumor suppression","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2703929","mag":"2703929"},"language":"en","primary_location":{"id":"pmh:oai:ir.lib.uwo.ca:etd-2739","doi":null,"is_oa":true,"landing_page_url":"https://ir.lib.uwo.ca/etd/1377","pdf_url":"https://ir.lib.uwo.ca/etd/1377","source":{"id":"https://openalex.org/S4306400648","display_name":"Scholarship@Western (Western University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I125749732","host_organization_name":"Western University","host_organization_lineage":["https://openalex.org/I125749732"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Thesis and Dissertation Repository","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ir.lib.uwo.ca/etd/1377","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112389374","display_name":"Srikanth Talluri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Srikanth Talluri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5112389374"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":5.836e-05,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.6621000170707703,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.6621000170707703,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.32010000944137573,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinoblastoma-protein","display_name":"retinoblastoma protein","score":0.9179999828338623},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.9919999837875366},{"id":"https://openalex.org/keywords/tumor-suppression","display_name":"tumor suppression","score":0.9909999966621399},{"id":"https://openalex.org/keywords/chromatin-regulation","display_name":"chromatin regulation","score":0.7900000214576721},{"id":"https://openalex.org/keywords/heterochromatin","display_name":"heterochromatin","score":0.9139999747276306},{"id":"https://openalex.org/keywords/h3k9me3","display_name":"H3K9me3","score":0.9079999923706055},{"id":"https://openalex.org/keywords/e2f-transcription-factors","display_name":"E2F transcription factors","score":0.847000002861023},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.7749999761581421},{"id":"https://openalex.org/keywords/senescence-escape","display_name":"senescence escape","score":0.7680000066757202},{"id":"https://openalex.org/keywords/oncogenic-stress","display_name":"oncogenic stress","score":0.5379999876022339},{"id":"https://openalex.org/keywords/kras-g12d","display_name":"KRAS G12D","score":0.8529999852180481},{"id":"https://openalex.org/keywords/ras-mutations","display_name":"RAS mutations","score":0.5379999876022339},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.4830000102519989},{"id":"https://openalex.org/keywords/pocket-proteins","display_name":"pocket proteins","score":0.414000004529953}],"concepts":[{"id":"https://openalex.org/C2776062698","wikidata":"https://www.wikidata.org/wiki/Q21111463","display_name":"Retinoblastoma protein","level":4,"score":0.7008092403411865},{"id":"https://openalex.org/C2776577112","wikidata":"https://www.wikidata.org/wiki/Q500695","display_name":"Retinoblastoma","level":3,"score":0.6463468670845032},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.6308619379997253},{"id":"https://openalex.org/C2779523775","wikidata":"https://www.wikidata.org/wiki/Q9075999","display_name":"Cellular senescence","level":4,"score":0.5634368658065796},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43363386392593384},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40544989705085754},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3674702048301697},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3391178846359253},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.22777536511421204},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.21904978156089783},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.16035962104797363},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12084844708442688}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:ir.lib.uwo.ca:etd-2739","doi":null,"is_oa":true,"landing_page_url":"https://ir.lib.uwo.ca/etd/1377","pdf_url":"https://ir.lib.uwo.ca/etd/1377","source":{"id":"https://openalex.org/S4306400648","display_name":"Scholarship@Western (Western University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I125749732","host_organization_name":"Western University","host_organization_lineage":["https://openalex.org/I125749732"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Thesis and Dissertation Repository","raw_type":"text"},{"id":"pmh:oai:uwo.scholaris.ca:20.500.14721/36274","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/20.500.14721/36274","pdf_url":null,"source":{"id":"https://openalex.org/S4306400648","display_name":"Scholarship@Western (Western University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I125749732","host_organization_name":"Western University","host_organization_lineage":["https://openalex.org/I125749732"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"thesis"},{"id":"mag:2703929","doi":null,"is_oa":false,"landing_page_url":"https://ir.lib.uwo.ca/cgi/viewcontent.cgi?article=2739&context=etd","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:ir.lib.uwo.ca:etd-2739","doi":null,"is_oa":true,"landing_page_url":"https://ir.lib.uwo.ca/etd/1377","pdf_url":"https://ir.lib.uwo.ca/etd/1377","source":{"id":"https://openalex.org/S4306400648","display_name":"Scholarship@Western (Western University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I125749732","host_organization_name":"Western University","host_organization_lineage":["https://openalex.org/I125749732"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Thesis and Dissertation Repository","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6922213360","display_name":"HISTOMORPHOMETRIC ANALYSIS OF SPINAL STABILIZATION","funder_award_id":"R29AR038489","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2703929.pdf","grobid_xml":"https://content.openalex.org/works/W2703929.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W12339002","https://openalex.org/W1513463586","https://openalex.org/W1784374550","https://openalex.org/W1965124005","https://openalex.org/W1968813488","https://openalex.org/W1970375657","https://openalex.org/W1973886069","https://openalex.org/W1974794264","https://openalex.org/W1976619282","https://openalex.org/W1985762385","https://openalex.org/W1988715974","https://openalex.org/W1992708996","https://openalex.org/W1998180584","https://openalex.org/W1998492363","https://openalex.org/W2003223749","https://openalex.org/W2015039345","https://openalex.org/W2017235640","https://openalex.org/W2019127724","https://openalex.org/W2019906376","https://openalex.org/W2023033376","https://openalex.org/W2026185344","https://openalex.org/W2027447321","https://openalex.org/W2034962229","https://openalex.org/W2036676765","https://openalex.org/W2041156660","https://openalex.org/W2042300239","https://openalex.org/W2050337904","https://openalex.org/W2058647415","https://openalex.org/W2058689581","https://openalex.org/W2060372356","https://openalex.org/W2067046201","https://openalex.org/W2067200597","https://openalex.org/W2068778750","https://openalex.org/W2069701438","https://openalex.org/W2080769506","https://openalex.org/W2083176422","https://openalex.org/W2086333179","https://openalex.org/W2095370504","https://openalex.org/W2098955488","https://openalex.org/W2104014368","https://openalex.org/W2104106878","https://openalex.org/W2109829350","https://openalex.org/W2109949190","https://openalex.org/W2113239433","https://openalex.org/W2114027014","https://openalex.org/W2120491114","https://openalex.org/W2121126525","https://openalex.org/W2121371748","https://openalex.org/W2121920069","https://openalex.org/W2123546063","https://openalex.org/W2124614845","https://openalex.org/W2128824325","https://openalex.org/W2134524871","https://openalex.org/W2148434747","https://openalex.org/W2150451425","https://openalex.org/W2153643905","https://openalex.org/W2156150950","https://openalex.org/W2158936746","https://openalex.org/W2164026919","https://openalex.org/W2186961771","https://openalex.org/W2315794330","https://openalex.org/W2324248025","https://openalex.org/W2332271182","https://openalex.org/W2462374023"],"related_works":["https://openalex.org/W1983640288","https://openalex.org/W199456002","https://openalex.org/W2039586210","https://openalex.org/W2008451632","https://openalex.org/W341740200","https://openalex.org/W2158936746","https://openalex.org/W2123546063","https://openalex.org/W7099774862","https://openalex.org/W2117354357","https://openalex.org/W2064241321"],"abstract_inverted_index":{"The":[0,43],"Retinoblastoma":[1],"protein":[2,179],"(pRB)":[3],"is":[4,13,48,147,190],"a":[5,155,205],"key":[6,136],"regulator":[7],"of":[8,45,54,135,145,188,194,200,211,214,292,315,319],"the":[9,51,70,217,232,265,316,322],"cell":[10,40,137,161,207,326,342],"cycle":[11,41,138,162,208,327,343],"and":[12,31,38,82,121,152,197,226,301],"functionally":[14],"inactivated":[15],"in":[16,69,111,133,229,239,264,286,307,325,344],"most":[17],"cancers.":[18],"pRB":[19,55,146,168,189,215,296,320,332],"has":[20,297],"been":[21],"proposed":[22],"to":[23,35,49,86,96,106,113,125,175,181,222,257,274,280,284,339,346],"utilize":[24],"simultaneous":[25],"interactions":[26,56,174,338],"with":[27,57,88,242,261],"E2F":[28,182],"transcription":[29,37],"factors":[30],"chromatin":[32,58,89,293],"regulatory":[33,59,90],"proteins":[34,91,324],"repress":[36],"block":[39,341],"progression.":[42],"goal":[44],"this":[46,143,212,309],"study":[47],"characterize":[50],"physiological":[52],"role":[53,157,318],"proteins.":[60],"I":[61],"used":[62],"gene":[63,73,184],"targeted":[64],"mice":[65,104,247,288],"carrying":[66],"point":[67],"mutations":[68,277],"murine":[71],"Rb1":[72],"(Rb1\u2206L)":[74],"that":[75,290],"specifically":[76],"disrupt":[77],"pRB\u2019s":[78],"LXCXE":[79,170,334],"binding":[80,171,335],"cleft,":[81],"thereby":[83,203],"its":[84,94],"ability":[85,95],"interact":[87],"while":[92],"leaving":[93],"bind":[97],"E2Fs":[98],"intact.":[99],"Embryonic":[100],"fibroblasts":[101],"from":[102,224],"Rb1\u2206L/\u2206L":[103,246,287],"fail":[105,279],"properly":[107],"arrest":[108],"DNA":[109],"synthesis":[110],"response":[112,345],"senescence":[114,225],"inducing":[115],"signals":[116],"such":[117],"as":[118],"oncogene":[119],"expression":[120],"g":[122],"Irradiation.":[123],"Failure":[124],"incorporate":[126],"repressive":[127],"heterochromatin":[128,195],"marks":[129,196],"like":[130],"H3K9me3":[131],"results":[132],"de-repression":[134],"genes":[139,202],"during":[140,149,158,165],"senescence.":[141],"However,":[142,231],"function":[144,187,213],"dispensable":[148],"normal":[150],"differentiation":[151],"development,":[153],"suggesting":[154,289],"specific":[156],"stress":[159,348],"responsive":[160],"arrest.":[163,209],"Furthermore,":[164,271],"cellular":[166],"senescence,":[167],"uses":[169],"cleft":[172,336],"dependent":[173,299],"recruit":[176],"Promyelocytic":[177],"leukemia":[178],"(PML)":[180],"target":[183],"promoters.":[185],"This":[186],"important":[191],"for":[192],"establishment":[193],"stable":[198],"silencing":[199],"these":[201],"creating":[204],"permanent":[206],"Disruption":[210],"by":[216,295,329],"\u2206L":[218],"mutation":[219,234],"confers":[220],"susceptibility":[221,283],"escape":[223],"allows":[227],"transformation":[228],"vitro.":[230],"same":[233],"does":[235,302],"not":[236,303],"enhance":[237,305],"tumorigenesis":[238,306],"tumor":[240,254],"models":[241],"activated":[243],"ras":[244,269,276],"mutations.":[245],"expressing":[248],"oncogenic":[249,347],"KrasG12D":[250],"show":[251],"delayed":[252],"lung":[253],"formation":[255],"compared":[256],"controls,":[258],"which":[259],"correlate":[260],"increased":[262],"apoptosis":[263],"early":[266],"lesions":[267],"following":[268],"activation.":[270],"DMBA":[272],"treatment":[273],"induce":[275],"also":[278],"reveal":[281],"greater":[282],"cancer":[285],"loss":[291],"regulation":[294,328],"context":[298],"outcomes":[300],"universally":[304],"vivo.\\nOverall,":[308],"thesis":[310],"enhances":[311],"our":[312],"current":[313],"understanding":[314],"unique":[317],"among":[321],"pocket":[323],"showing":[330],"how":[331],"utilizes":[333],"mediated":[337],"stably":[340],"signals.":[349]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
