{"id":"https://openalex.org/W27032743","doi":null,"title":"[99mTc-MAA perfusion studies in the treatment of preoperative intra-arterial infusion chemotherapy of malignant bone and soft tissue sarcoma].","display_name":"[99mTc-MAA perfusion studies in the treatment of preoperative intra-arterial infusion chemotherapy of malignant bone and soft tissue sarcoma].","publication_year":1988,"publication_date":"1988-08-01","ids":{"openalex":"https://openalex.org/W27032743","mag":"27032743","pmid":"https://pubmed.ncbi.nlm.nih.gov/3415248"},"language":"ja","primary_location":{"id":"pmid:3415248","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3415248","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gan to kagaku ryoho. Cancer & chemotherapy","raw_type":"Case Reports"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108461742","display_name":"Masaharu Satoh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Satoh","raw_affiliation_strings":["Dept. of Orthopaedic Surgery, Gifu University, School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Orthopaedic Surgery, Gifu University, School of Medicine","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S Takeuchi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Takeuchi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089501623","display_name":"Chiaki Kasai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Kasai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5001116199","display_name":"Y Kushida","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Kushida","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00212174,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"8 Pt 2","first_page":"2359","last_page":"65"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/macroaggregated-albumin","display_name":"macroaggregated albumin","score":0.8859999775886536},{"id":"https://openalex.org/keywords/bone-sarcoma","display_name":"bone sarcoma","score":0.6959999799728394},{"id":"https://openalex.org/keywords/soft-tissue-sarcoma","display_name":"soft tissue sarcoma","score":1.0},{"id":"https://openalex.org/keywords/tumor-perfusion","display_name":"tumor perfusion","score":0.984000027179718},{"id":"https://openalex.org/keywords/arteriovenous-shunt","display_name":"arteriovenous shunt","score":0.8840000033378601},{"id":"https://openalex.org/keywords/lung-scintigraphy","display_name":"lung scintigraphy","score":0.7680000066757202},{"id":"https://openalex.org/keywords/limb-salvage","display_name":"limb salvage","score":0.8029999732971191},{"id":"https://openalex.org/keywords/tumor-response-assessment","display_name":"tumor response assessment","score":0.7099999785423279}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.802672803401947},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.7280423045158386},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.7244539260864258},{"id":"https://openalex.org/C136948725","wikidata":"https://www.wikidata.org/wiki/Q1458306","display_name":"Soft tissue","level":2,"score":0.6243091821670532},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.5056273937225342},{"id":"https://openalex.org/C2778629024","wikidata":"https://www.wikidata.org/wiki/Q720020","display_name":"Soft tissue sarcoma","level":3,"score":0.4920622706413269},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.44393375515937805},{"id":"https://openalex.org/C2908929812","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Arterial perfusion","level":3,"score":0.4302336275577545},{"id":"https://openalex.org/C2781267111","wikidata":"https://www.wikidata.org/wiki/Q652297","display_name":"Catheter","level":2,"score":0.41820377111434937},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.31948888301849365},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.23608100414276123}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007261","descriptor_name":"Infusions, Intra-Arterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011300","descriptor_name":"Preoperative Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011875","descriptor_name":"Radionuclide Angiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D012983","descriptor_name":"Soft Tissue Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D012983","descriptor_name":"Soft Tissue Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012983","descriptor_name":"Soft Tissue Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D013668","descriptor_name":"Technetium Tc 99m Aggregated Albumin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3415248","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3415248","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gan to kagaku ryoho. Cancer & chemotherapy","raw_type":"Case Reports"},{"id":"mag:27032743","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3415248","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W2141998461","https://openalex.org/W2323630565","https://openalex.org/W1973229017","https://openalex.org/W2057169582","https://openalex.org/W2024663422","https://openalex.org/W50824113","https://openalex.org/W2061691229","https://openalex.org/W2093141111","https://openalex.org/W16200308","https://openalex.org/W2021456087","https://openalex.org/W2278347241","https://openalex.org/W2614280718","https://openalex.org/W2007094908","https://openalex.org/W2001757042","https://openalex.org/W2118907329","https://openalex.org/W2096451792","https://openalex.org/W2104985426","https://openalex.org/W1993794693"],"related_works":["https://openalex.org/W2079264758","https://openalex.org/W4255811723","https://openalex.org/W1955945168","https://openalex.org/W4301417438","https://openalex.org/W2426432067","https://openalex.org/W2170560210","https://openalex.org/W7098677274","https://openalex.org/W2598566085","https://openalex.org/W2326636346","https://openalex.org/W2056499099"],"abstract_inverted_index":{"Preoperative":[0],"intra-arterial":[1,116,164,175],"continuous":[2],"chemotherapy":[3,33,117,153],"combined":[4,172],"with":[5,139,173],"surgery":[6],"in":[7,22,34,112,129,182],"the":[8,44,58,67,113,152,157],"treatment":[9,114],"of":[10,40,61,108,115,145,151,159],"malignant":[11,100],"bone":[12,101],"and":[13,57,102,126],"soft":[14,103],"tissue":[15,104,161],"sarcomas":[16],"has":[17],"been":[18],"used":[19],"since":[20],"1968":[21],"our":[23],"clinic.":[24],"This":[25],"approach":[26],"offers":[27,118],"a":[28,76,133,178],"theoretical":[29],"advantage":[30],"over":[31],"systemic":[32,49],"that":[35,169],"it":[36,71],"delivers":[37],"higher":[38],"concentrations":[39],"chemotherapeutic":[41],"agents":[42],"to":[43,66,74,80,122,131,135,163],"tumor":[45,55,68,83,127,137,160],"bed":[46],"without":[47],"increasing":[48],"toxicity.":[50],"Tumor":[51],"response":[52,162],"depends":[53],"on":[54],"sensitivity":[56],"maximum":[59],"amount":[60],"agent":[62],"which":[63],"is":[64,72,177],"deliverable":[65],"tissues,":[69],"so":[70],"important":[73],"maintain":[75],"proper":[77],"catheter":[78,124],"placement":[79,125],"obtain":[81],"good":[82],"response.":[84],"99mTc-Labeled":[85],"macroaggregated":[86],"albumin":[87],"(99mTc-MAA)":[88],"perfusion":[89,110,171],"studies":[90,111],"were":[91],"carried":[92],"out":[93],"19":[94],"patients":[95],"who":[96],"had":[97],"histologically":[98],"proven":[99],"sarcomas.":[105],"The":[106,142],"use":[107],"99mTc-MAA":[109,146,170],"an":[119],"excellent":[120],"way":[121,134],"evaluate":[123,136],"perfusion,":[128],"addition":[130],"providing":[132],"A-Vshunts":[138],"lung":[140],"scanning.":[141],"dynamic":[143],"images":[144],"obtained":[147],"at":[148],"each":[149],"stage":[150],"period":[154],"also":[155],"demonstrate":[156],"degree":[158],"chemotherapy.":[165],"Therefore":[166],"we":[167],"conclude":[168],"preoperative":[174],"infusion":[176],"very":[179],"useful":[180],"method":[181],"cases":[183],"involving":[184],"limb":[185],"salvage":[186],"surgery.":[187]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}