{"id":"https://openalex.org/W27030422","doi":null,"title":"Functional Analysis of Cytosolic Hsp70 Nucleotide Exchange Factor Networks in Yeast","display_name":"Functional Analysis of Cytosolic Hsp70 Nucleotide Exchange Factor Networks in Yeast","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W27030422","mag":"27030422"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1486","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/447","pdf_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/447","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/447","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072661909","display_name":"Jennifer L. Abrams","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jennifer L. Abrams","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5072661909"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hsp70","display_name":"HSP70","score":0.8100000023841858},{"id":"https://openalex.org/keywords/nucleotide-exchange-factor","display_name":"nucleotide exchange factor","score":0.9679999947547913},{"id":"https://openalex.org/keywords/hsp110","display_name":"Hsp110","score":0.8270000219345093},{"id":"https://openalex.org/keywords/bag-1","display_name":"BAG-1","score":0.9399999976158142},{"id":"https://openalex.org/keywords/ssa","display_name":"SSA","score":0.6959999799728394},{"id":"https://openalex.org/keywords/sugar-sweetened-beverages","display_name":"sugar-sweetened beverages","score":0.9990000128746033},{"id":"https://openalex.org/keywords/protein-disaggregation","display_name":"protein disaggregation","score":0.5979999899864197},{"id":"https://openalex.org/keywords/protein-refolding","display_name":"protein refolding","score":0.7940000295639038},{"id":"https://openalex.org/keywords/proteostasis","display_name":"proteostasis","score":0.9309999942779541},{"id":"https://openalex.org/keywords/heat-shock-response","display_name":"heat shock response","score":0.7870000004768372},{"id":"https://openalex.org/keywords/translational-control","display_name":"translational regulation","score":0.9789999723434448},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.8119999766349792},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.6449999809265137}],"concepts":[{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.6521702408790588},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.5599596500396729},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.5395070910453796},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4662213623523712},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.42759978771209717},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36259686946868896},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34971189498901367},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3424736261367798},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1746995449066162},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13492944836616516}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1486","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/447","pdf_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/447","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},{"id":"mag:27030422","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.library.tmc.edu/cgi/viewcontent.cgi?article=1486&context=utgsbs_dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1486","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/447","pdf_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/447","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W27030422.pdf","grobid_xml":"https://content.openalex.org/works/W27030422.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W195389358","https://openalex.org/W1972393612","https://openalex.org/W1975245768","https://openalex.org/W1980505864","https://openalex.org/W1981873223","https://openalex.org/W1995508457","https://openalex.org/W2001610972","https://openalex.org/W2007157911","https://openalex.org/W2013679718","https://openalex.org/W2014294043","https://openalex.org/W2022392367","https://openalex.org/W2034147064","https://openalex.org/W2040359453","https://openalex.org/W2059524588","https://openalex.org/W2069048146","https://openalex.org/W2083114912","https://openalex.org/W2101119637","https://openalex.org/W2107334607","https://openalex.org/W2115988944","https://openalex.org/W2118292263","https://openalex.org/W2132320427","https://openalex.org/W2154290102","https://openalex.org/W2157355956","https://openalex.org/W2158482235","https://openalex.org/W2166752189","https://openalex.org/W2898172712","https://openalex.org/W7095379516"],"related_works":["https://openalex.org/W2086750189","https://openalex.org/W2154290102","https://openalex.org/W2618747262","https://openalex.org/W2047477750","https://openalex.org/W3210482","https://openalex.org/W2079685435","https://openalex.org/W2768402286","https://openalex.org/W2308738848","https://openalex.org/W2104058612","https://openalex.org/W2153019640"],"abstract_inverted_index":{"The":[0],"Hsp70":[1,139,296],"class":[2],"of":[3,55,95,101,123,152,203,227,234,258,268,291,314,325],"molecular":[4,326],"chaperones":[5,327],"play":[6],"critical":[7,303],"roles":[8,193,293],"in":[9,19,85,98,120,149,194,224,279,349],"protein":[10,60,81],"homeostasis":[11,61],"via":[12],"an":[13,47,111,336],"ATP-dependent":[14],"folding":[15],"cycle.":[16],"Cytosolic":[17],"Hsp70s":[18,182],"the":[20,51,56,93,99,129,133,153,181,218,225,247,295,311,333,350],"budding":[21],"yeast":[22],"Saccharomyces":[23],"cerevisiae,":[24],"Ssa":[25],"and":[26,44,69,83,141,165,205,254,320,328],"Ssb,":[27],"interact":[28],"with":[29,180],"up":[30],"to":[31,39,49,59,79,118,137,191,229,246,286,304,343],"three":[32],"distinct":[33,178],"nucleotide":[34],"exchange":[35],"factors":[36],"(NEFs)":[37],"homologous":[38],"human":[40,345],"counterparts;":[41],"Sse1/Sse2/HSP110,":[42],"Fes1/HspBP1,":[43],"Snl1/Bag1.":[45],"In":[46],"effort":[48],"understand":[50],"differential":[52,192],"functional":[53],"contributions":[54,162],"cytosolic":[57,154],"NEFs":[58,171],"(\u201cproteostasis\u201d),":[62],"I":[63,76,216,241],"carried":[64],"out":[65],"comparative":[66],"genetic,":[67],"biochemical":[68],"cell":[70],"biological":[71],"analyses.":[72],"For":[73],"these":[74,300],"studies,":[75],"developed":[77],"protocols":[78],"monitor":[80,119],"disaggregation":[82],"reactivation":[84],"a":[86,144,266,272,277,288],"near":[87],"real-time":[88],"coupled":[89,107],"assay":[90],"that":[91,128,170,200,243,255,270,308,340],"revealed":[92],"importance":[94],"aggregate":[96],"dynamics":[97,301],"solubilization":[100],"proteins":[102],"for":[103,147,209,238,252],"their":[104,177,329],"refolding.":[105],"This":[106,125,282],"experimental":[108],"approach,":[109],"represents":[110],"important":[112,208,237],"step":[113],"toward":[114],"developing":[115],"tools":[116],"necessary":[117],"vivo":[121],"mechanisms":[122],"proteostasis.":[124,195],"work":[126],"determined":[127],"Hsp110,":[130],"Sse1,":[131],"is":[132,250,261,302,335],"primary":[134],"NEF":[135,292],"contributing":[136],"most":[138,347],"functions":[140],"also":[142],"uncovered":[143,199],"unique":[145,186,232],"role":[146,278],"Fes1":[148],"Ssa-mediated":[150],"regulation":[151],"heat":[155],"shock":[156],"response,":[157],"while":[158],"revealing":[159],"no":[160],"significant":[161],"from":[163],"Snl1":[164,204,219,235,244,275],"Sse2.":[166],"These":[167,263],"findings":[168],"suggest":[169],"do":[172],"have":[173],"overlapping":[174],"functions,":[175],"but":[176],"associations":[179],"as":[183,185,318,332],"well":[184],"structural":[187],"components":[188],"could":[189],"contribute":[190,342],"Additionally,":[196],"this":[197,214,259],"study":[198],"relative":[201],"levels":[202],"Sse1":[206,228],"are":[207,236],"optimal":[210],"growth.":[211],"To":[212],"probe":[213],"relationship,":[215],"exploited":[217],"overexpression":[220],"toxicity":[221,253],"phenotype":[222,260],"exhibited":[223],"absence":[226],"examine":[230],"which":[231],"characteristics":[233],"its":[239],"function.":[240],"discovered":[242],"localization":[245],"ER":[248],"membrane":[249],"required":[251],"Sse1-mediated":[256],"alleviation":[257],"Ssb-dependent.":[262],"results":[264],"demonstrate":[265],"network":[267],"interactions":[269],"supports":[271],"hypothesis":[273],"where":[274],"plays":[276],"translation":[280],"regulation.":[281],"investigation":[283],"was":[284],"conducted":[285],"gain":[287],"better":[289],"understanding":[290],"within":[294],"chaperone":[297],"network.":[298],"Understanding":[299],"obtain":[305],"successful":[306],"treatments":[307],"can":[309],"reverse":[310],"debilitating":[312],"effects":[313],"neurodegenerative":[315],"disorders":[316],"such":[317,331],"Alzheimer\u2019s":[319],"Parkinson\u2019s":[321],"diseases.":[322],"Pharmacological":[323],"targeting":[324],"co-factors,":[330],"NEFs,":[334],"attractive":[337],"therapeutic":[338],"goal":[339],"may":[341],"improving":[344],"health,":[346],"notably":[348],"aging":[351],"population.":[352]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}