{"id":"https://openalex.org/W270098090","doi":null,"title":"Expression of the tumor suppressor gene, p53, during the development of murine malignant mesotheliomas induced by asbestos fibers","display_name":"Expression of the tumor suppressor gene, p53, during the development of murine malignant mesotheliomas induced by asbestos fibers","publication_year":1991,"publication_date":"1991-03-15","ids":{"openalex":"https://openalex.org/W270098090","mag":"270098090"},"language":"en","primary_location":{"id":"mag:270098090","doi":null,"is_oa":false,"landing_page_url":"http://www.osti.gov/scitech/biblio/5172651","pdf_url":null,"source":{"id":"https://openalex.org/S4306510356","display_name":"FASEB Journal (Federation of American Societies for Experimental Biology); (United States)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"FASEB Journal (Federation of American Societies for Experimental Biology); (United States)","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030907877","display_name":"Elsa M. Cora","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elsa M. Cora","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5012413299","display_name":"Agnes B. Kane","orcid":"https://orcid.org/0000-0002-9719-4504","observed_orcids":["https://orcid.org/0000-0002-9719-4504"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Agnes B. Kane","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9719-4504","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.474,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.64940088,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14168","display_name":"Occupational Health and Global Justice","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3306","display_name":"Health"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.871999979019165},{"id":"https://openalex.org/keywords/tumor-suppressor-gene-expression","display_name":"tumor suppressor gene expression","score":0.8270000219345093},{"id":"https://openalex.org/keywords/malignant-mesothelioma","display_name":"malignant mesothelioma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/asbestos-fibers","display_name":"asbestos fibers","score":0.7839999794960022},{"id":"https://openalex.org/keywords/crocidolite","display_name":"crocidolite","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.8349999785423279},{"id":"https://openalex.org/keywords/point-mutations","display_name":"point mutations","score":0.7760000228881836},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.4729999899864197},{"id":"https://openalex.org/keywords/pleural-mesothelioma","display_name":"pleural mesothelioma","score":0.6899999976158142},{"id":"https://openalex.org/keywords/peritoneal-mesothelioma","display_name":"peritoneal mesothelioma","score":0.8740000128746033}],"concepts":[{"id":"https://openalex.org/C177707886","wikidata":"https://www.wikidata.org/wiki/Q48520","display_name":"Northern blot","level":4,"score":0.6229937076568604},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6221455335617065},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.6030470728874207},{"id":"https://openalex.org/C133307689","wikidata":"https://www.wikidata.org/wiki/Q48749","display_name":"Southern blot","level":3,"score":0.4948698878288269},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4798973798751831},{"id":"https://openalex.org/C2909640154","wikidata":"https://www.wikidata.org/wiki/Q35970","display_name":"Mesothelial Cell","level":2,"score":0.47900861501693726},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.47007542848587036},{"id":"https://openalex.org/C510490043","wikidata":"https://www.wikidata.org/wiki/Q104085","display_name":"Asbestos","level":2,"score":0.4565723240375519},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41513362526893616},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4054931104183197},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3957306146621704},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3612380027770996},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30101919174194336},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.2577711045742035},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08112624287605286},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:270098090","doi":null,"is_oa":false,"landing_page_url":"http://www.osti.gov/scitech/biblio/5172651","pdf_url":null,"source":{"id":"https://openalex.org/S4306510356","display_name":"FASEB Journal (Federation of American Societies for Experimental Biology); (United States)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"FASEB Journal (Federation of American Societies for Experimental Biology); (United States)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2037306309","https://openalex.org/W2161865302","https://openalex.org/W2390768106","https://openalex.org/W2161622567","https://openalex.org/W2150696343","https://openalex.org/W1974567990","https://openalex.org/W2048241935","https://openalex.org/W2040333460","https://openalex.org/W2062111206","https://openalex.org/W2291955155"],"abstract_inverted_index":{"Malignant":[0],"mesotheliomas":[1,55],"are":[2,163],"rare":[3],"tumors":[4,116],"arising":[5],"from":[6,112,132],"the":[7,51,143,149,160],"pleural":[8],"or":[9,119],"peritoneal":[10],"lining":[11],"after":[12,44,62,67,72,78,146],"exposure":[13],"to":[14,87,127],"asbestos":[15,36],"fibers.":[16,37],"As":[17],"a":[18],"model":[19,170],"system":[20],"for":[21,95],"human":[22],"occupational":[23],"exposure,":[24],"C57B1/6":[25],"mice":[26,43],"received":[27],"weekly":[28],"intraperitoneal":[29],"injections":[30],"of":[31,34,42,53,89,98,122,142],"200":[32],"{mu}g":[33],"crocidolite":[35],"Tumors":[38],"developed":[39],"in":[40,50,125,159,168],"30-40%":[41],"30-60":[45],"weeks.":[46],"Discrete":[47],"morphologic":[48,91],"stages":[49,92],"development":[52],"malignant":[54],"have":[56,83],"been":[57,84],"identified:":[58],"reactive":[59,133],"mesothelial":[60,134],"cells":[61,66,71,77],"1-6":[63],"wks.,":[64,69,74],"dysplastic":[65],"12-22":[68],"neoplastic":[70,113,166],"30-40":[73],"and":[75,93,100,114],"metastasizing":[76],"40-50":[79],"wks.":[80],"Cell":[81],"lines":[82,110,130],"established":[85],"corresponding":[86],"each":[88],"these":[90],"probed":[94],"altered":[96],"expression":[97,121],"oncogenes":[99],"tumor":[101],"suppressor":[102],"genes.":[103],"Using":[104],"Northern":[105],"blot":[106,137],"analysis,":[107],"four":[108],"cell":[109,129],"derived":[111,131],"invasive":[115],"showed":[117],"absent":[118],"reduced":[120],"p53":[123,144,161],"mRNA":[124],"contrast":[126],"nontumorigenic":[128],"cells.":[135],"Southern":[136],"analysis":[138],"revealed":[139],"no":[140],"rearrangement":[141],"gene":[145,162],"digestion":[147],"with":[148,165],"restriction":[150],"enzyme":[151],"BamHI.":[152],"It":[153],"is":[154],"hypothesized":[155],"that":[156],"point":[157],"mutations":[158],"correlated":[164],"progression":[167],"this":[169],"system.":[171]},"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}