{"id":"https://openalex.org/W2699215617","doi":"https://doi.org/10.4103/2045-9912.208516","title":"Medical gases for stroke therapy: summary of progress 2015\u20132016","display_name":"Medical gases for stroke therapy: summary of progress 2015\u20132016","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2699215617","doi":"https://doi.org/10.4103/2045-9912.208516","mag":"2699215617","pmid":"https://pubmed.ncbi.nlm.nih.gov/28744363","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5510291"},"language":"en","primary_location":{"id":"doi:10.4103/2045-9912.208516","doi":"https://doi.org/10.4103/2045-9912.208516","is_oa":true,"landing_page_url":"https://doi.org/10.4103/2045-9912.208516","pdf_url":"https://www.medgasres.com/article.asp?issn=2045-9912;year=2017;volume=7;issue=2;spage=107;epage=112;aulast=Huang;type=2","source":{"id":"https://openalex.org/S2764726520","display_name":"Medical Gas Research","issn_l":"2045-9912","issn":["2045-9912"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","ki-jl-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Gas Research","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.medgasres.com/article.asp?issn=2045-9912;year=2017;volume=7;issue=2;spage=107;epage=112;aulast=Huang;type=2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028263710","display_name":"Qin Hu","orcid":"https://orcid.org/0000-0002-2270-8822","observed_orcids":["https://orcid.org/0000-0002-2270-8822"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qin Hu","raw_affiliation_strings":["Discipline of Neuroscience, Department of Anatomy, Histology and Embryology, Shanghai Jiao Tong University School of Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discipline of Neuroscience, Department of Anatomy, Histology and Embryology, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110590447","display_name":"Junlong Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun-long Huang","raw_affiliation_strings":["Department of Navy Aeromedicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, China","Discipline of Neuroscience, Department of Anatomy, Histology and Embryology, Shanghai Jiao Tong University School of Medicine, Shanghai, China","Discipline of Neuroscience, Department of Anatomy, Histology and Embryology, Shanghai Jiao Tong University School of Medicine, Shanghai"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Navy Aeromedicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, China","institution_ids":["https://openalex.org/I177933477"]},{"raw_affiliation_string":"Discipline of Neuroscience, Department of Anatomy, Histology and Embryology, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"Discipline of Neuroscience, Department of Anatomy, Histology and Embryology, Shanghai Jiao Tong University School of Medicine, Shanghai","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102268781","display_name":"Bao-lian Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bao-lian Zhao","raw_affiliation_strings":["Department of Navy Aeromedicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Navy Aeromedicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, China","institution_ids":["https://openalex.org/I177933477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061429930","display_name":"Anatol Manaenko","orcid":"https://orcid.org/0000-0002-6153-6226","observed_orcids":["https://orcid.org/0000-0002-6153-6226"]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anatol Manaenko","raw_affiliation_strings":["Departments of Neurology, University of Erlangen-Nuremberg, Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurology, University of Erlangen-Nuremberg, Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100371046","display_name":"Fan Liu","orcid":"https://orcid.org/0000-0002-9481-0797","observed_orcids":["https://orcid.org/0000-0002-9481-0797"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fan Liu","raw_affiliation_strings":["Discipline of Neuroscience, Department of Anatomy, Histology and Embryology, Shanghai Jiao Tong University School of Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discipline of Neuroscience, Department of Anatomy, Histology and Embryology, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100680897","display_name":"Xuejun Sun","orcid":"https://orcid.org/0000-0003-2387-5531","observed_orcids":["https://orcid.org/0000-0003-2387-5531"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xue-jun Sun","raw_affiliation_strings":["Department of Navy Aeromedicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Navy Aeromedicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, China","institution_ids":["https://openalex.org/I177933477"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5028263710"],"corresponding_institution_ids":["https://openalex.org/I183067930"],"apc_list":null,"apc_paid":null,"fwci":0.058,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.11457319,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"7","issue":"2","first_page":"107","last_page":"107"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":0.35010001063346863,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":0.35010001063346863,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neurological Disorders and Treatments","score":0.28130000829696655,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12930","display_name":"Biomedical and Chemical Research","score":0.10279999673366547,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.7379999756813049},{"id":"https://openalex.org/keywords/medical-gases","display_name":"medical gases","score":0.8790000081062317},{"id":"https://openalex.org/keywords/gas-therapy","display_name":"gas therapy","score":0.8399999737739563},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8360000252723694},{"id":"https://openalex.org/keywords/oxygen-therapy","display_name":"oxygen therapy","score":0.75},{"id":"https://openalex.org/keywords/hydrogen-therapy","display_name":"hydrogen treatment","score":0.8759999871253967},{"id":"https://openalex.org/keywords/hydrogen-sulfide","display_name":"hydrogen sulfide","score":0.9660000205039978}],"concepts":[{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.7697598934173584},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.68574458360672},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5903122425079346},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.5893353223800659},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4123293161392212},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.12855267524719238},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.12646451592445374},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.4103/2045-9912.208516","doi":"https://doi.org/10.4103/2045-9912.208516","is_oa":true,"landing_page_url":"https://doi.org/10.4103/2045-9912.208516","pdf_url":"https://www.medgasres.com/article.asp?issn=2045-9912;year=2017;volume=7;issue=2;spage=107;epage=112;aulast=Huang;type=2","source":{"id":"https://openalex.org/S2764726520","display_name":"Medical Gas Research","issn_l":"2045-9912","issn":["2045-9912"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","ki-jl-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Gas Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5510291","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5510291","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Med Gas Res","raw_type":"Text"},{"id":"pmid:28744363","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28744363","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical gas research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4103/2045-9912.208516","doi":"https://doi.org/10.4103/2045-9912.208516","is_oa":true,"landing_page_url":"https://doi.org/10.4103/2045-9912.208516","pdf_url":"https://www.medgasres.com/article.asp?issn=2045-9912;year=2017;volume=7;issue=2;spage=107;epage=112;aulast=Huang;type=2","source":{"id":"https://openalex.org/S2764726520","display_name":"Medical Gas Research","issn_l":"2045-9912","issn":["2045-9912"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","ki-jl-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Gas Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2699215617.pdf","grobid_xml":"https://content.openalex.org/works/W2699215617.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W773514957","https://openalex.org/W1518976166","https://openalex.org/W1571754952","https://openalex.org/W1636833482","https://openalex.org/W1775376648","https://openalex.org/W1877655413","https://openalex.org/W1892032706","https://openalex.org/W1919621793","https://openalex.org/W1970453584","https://openalex.org/W1973128362","https://openalex.org/W1973648711","https://openalex.org/W1989569456","https://openalex.org/W1998437958","https://openalex.org/W1999116621","https://openalex.org/W2001163363","https://openalex.org/W2004483297","https://openalex.org/W2008894219","https://openalex.org/W2015123144","https://openalex.org/W2021344817","https://openalex.org/W2029026924","https://openalex.org/W2035140127","https://openalex.org/W2043163117","https://openalex.org/W2044992203","https://openalex.org/W2080251957","https://openalex.org/W2096369120","https://openalex.org/W2099861565","https://openalex.org/W2115130328","https://openalex.org/W2135437261","https://openalex.org/W2142386654","https://openalex.org/W2169657429","https://openalex.org/W2180409130","https://openalex.org/W2195245412","https://openalex.org/W2229999843","https://openalex.org/W2264254915","https://openalex.org/W2270360032","https://openalex.org/W2278345709","https://openalex.org/W2282560043","https://openalex.org/W2297832822","https://openalex.org/W2312109667","https://openalex.org/W2318872620","https://openalex.org/W2331078114","https://openalex.org/W2336822369","https://openalex.org/W2342940718","https://openalex.org/W2391750545","https://openalex.org/W2409707366","https://openalex.org/W2441580746","https://openalex.org/W2444128733","https://openalex.org/W2464676154","https://openalex.org/W2506110046","https://openalex.org/W2523941558","https://openalex.org/W2526533129","https://openalex.org/W2528755216","https://openalex.org/W2565556429","https://openalex.org/W2592804238","https://openalex.org/W2598238228","https://openalex.org/W2615762932"],"related_works":["https://openalex.org/W2997684018","https://openalex.org/W3087645849","https://openalex.org/W4408742056","https://openalex.org/W2097773847","https://openalex.org/W2473858299","https://openalex.org/W4285157968","https://openalex.org/W2565920435","https://openalex.org/W7125370514","https://openalex.org/W2950741708","https://openalex.org/W4307369998"],"abstract_inverted_index":{"Stroke":[0],"is":[1],"a":[2,16],"cerebrovascular":[3],"disease":[4],"with":[5],"high":[6],"mortality":[7],"and":[8,41,71,89,94],"morbidity.":[9],"Despite":[10],"extensive":[11],"research,":[12],"there":[13],"are":[14,44],"only":[15],"very":[17],"limited":[18],"number":[19],"of":[20,26,66,69,91],"therapeutic":[21],"approaches":[22,93],"suitable":[23],"for":[24,97],"treatment":[25],"stroke":[27,70],"patients":[28],"as":[29,38],"yet.":[30],"Mounting":[31],"evidence":[32],"has":[33],"demonstrated":[34],"that":[35],"such":[36],"gases":[37],"oxygen,":[39],"hydrogen":[40,42],"sulfide":[43],"able":[45],"to":[46],"provide":[47,95],"neuroprotection":[48],"after":[49],"stroke.":[50],"In":[51],"this":[52],"paper,":[53],"we":[54],"will":[55,84],"focus":[56],"on":[57],"the":[58,64,74,87],"recent":[59],"two":[60],"years'":[61],"progress":[62],"in":[63,72],"development":[65],"gas":[67],"therapies":[68],"understanding":[73],"molecular":[75],"mechanisms":[76],"underlying":[77],"protection":[78],"induced":[79],"by":[80],"medical":[81],"gases.":[82],"We":[83],"also":[85],"discuss":[86],"advantages":[88],"challenges":[90],"these":[92],"information":[96],"future":[98],"study.":[99]},"counts_by_year":[{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2017-06-30T00:00:00"}