{"id":"https://openalex.org/W26989412","doi":null,"title":"Primary hepatic gastrinoma: an unusual case of zollinger-ellison syndrome.","display_name":"Primary hepatic gastrinoma: an unusual case of zollinger-ellison syndrome.","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W26989412","mag":"26989412","pmid":"https://pubmed.ncbi.nlm.nih.gov/20567543","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2886439"},"language":"en","primary_location":{"id":"pmid:20567543","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20567543","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology & hepatology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2886439/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085405229","display_name":"Tetsuhide Ito","orcid":"https://orcid.org/0000-0001-5381-0136","observed_orcids":["https://orcid.org/0000-0001-5381-0136"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tetsuhide Ito","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108777171","display_name":"Robert T. Jensen","orcid":"https://orcid.org/0000-0002-0095-4600","observed_orcids":["https://orcid.org/0000-0002-0095-4600"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert T Jensen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3248,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.61784264,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"6","issue":"1","first_page":"57","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11485","display_name":"Gastrointestinal Tumor Research and Treatment","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11378","display_name":"Gastrointestinal Bleeding Diagnosis and Treatment","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zollinger-ellison-syndrome","display_name":"Zollinger-Ellison syndrome","score":0.9670000076293945},{"id":"https://openalex.org/keywords/gastrinoma","display_name":"gastrinoma","score":0.7609999775886536},{"id":"https://openalex.org/keywords/delayed-diagnosis","display_name":"delayed diagnosis","score":0.6919999718666077},{"id":"https://openalex.org/keywords/proton-pump-inhibitors","display_name":"proton pump inhibitors","score":0.843999981880188},{"id":"https://openalex.org/keywords/hypergastrinemia","display_name":"hypergastrinemia","score":0.8840000033378601},{"id":"https://openalex.org/keywords/peptic-ulcer","display_name":"peptic ulcer","score":0.7350000143051147},{"id":"https://openalex.org/keywords/secretin-stimulation-test","display_name":"secretin test","score":0.7609999775886536},{"id":"https://openalex.org/keywords/multiple-endocrine-neoplasia-type-1","display_name":"multiple endocrine neoplasia type 1","score":0.9259999990463257}],"concepts":[{"id":"https://openalex.org/C2781283050","wikidata":"https://www.wikidata.org/wiki/Q786852","display_name":"Gastrinoma","level":4,"score":0.9687223434448242},{"id":"https://openalex.org/C2777351272","wikidata":"https://www.wikidata.org/wiki/Q218712","display_name":"Zollinger-Ellison syndrome","level":2,"score":0.9427015781402588},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5671952962875366},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4886236786842346},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4153895080089569},{"id":"https://openalex.org/C61434518","wikidata":"https://www.wikidata.org/wiki/Q932510","display_name":"General surgery","level":1,"score":0.34217560291290283},{"id":"https://openalex.org/C2776986829","wikidata":"https://www.wikidata.org/wiki/Q407181","display_name":"Gastrin","level":3,"score":0.05673074722290039},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmid:20567543","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20567543","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology & hepatology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2886439","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2886439/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterol Hepatol (N Y)","raw_type":"Text"},{"id":"mag:26989412","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20567543","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2886439","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2886439/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterol Hepatol (N Y)","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1579841094","https://openalex.org/W1917620582","https://openalex.org/W1963524034","https://openalex.org/W1964365829","https://openalex.org/W1980010816","https://openalex.org/W1981061325","https://openalex.org/W1990531255","https://openalex.org/W1997342078","https://openalex.org/W1999715445","https://openalex.org/W2006881561","https://openalex.org/W2015654204","https://openalex.org/W2022683286","https://openalex.org/W2042658937","https://openalex.org/W2064295309","https://openalex.org/W2064893457","https://openalex.org/W2069356032","https://openalex.org/W2072325156","https://openalex.org/W2074590150","https://openalex.org/W2079799401","https://openalex.org/W2085968221","https://openalex.org/W2094432811","https://openalex.org/W2095049058","https://openalex.org/W2128743830","https://openalex.org/W2154637459"],"related_works":["https://openalex.org/W2008708144","https://openalex.org/W2913925362","https://openalex.org/W4360616993","https://openalex.org/W3209893704","https://openalex.org/W3199301279","https://openalex.org/W7100679074","https://openalex.org/W4404420268","https://openalex.org/W2408040133","https://openalex.org/W7113898127","https://openalex.org/W2920276583"],"abstract_inverted_index":{"The":[0,681],"case":[1,83,851,954],"of":[2,14,26,42,121,142,165,171,192,195,222,235,238,248,257,265,276,281,294,304,318,386,418,461,468,503,505,512,528,544,585,615,716,722,749,760,788,794,807,836,839,875,943,968,1023,1056,1069,1074,1097,1107,1144,1198,1227,1267],"Zollinger-Ellison":[3],"syndrome":[4,274],"(ZES)":[5],"reported":[6,551,781,802],"by":[7,161,307,333,1082],"Evans":[8,844],"and":[9,29,37,62,124,139,226,244,254,328,358,434,494,608,637,697,713,724,734,824,845,903,1012,1048,1071,1104,1170,1212,1243,1271],"associates1":[10],"contains":[11],"a":[12,64,86,236,305,491,529,533,586,616,619,627,650,661,666,746,854,860,873,878,901,904,936,963,1044,1057,1130,1182,1208,1214,1217],"number":[13,874],"interesting":[15],"points":[16,44],"regarding":[17],"ZES":[18,79,158,262,282,309,351,387,841,1103,1277],"that":[19,30,410,420,428,435,450,705,828,1019,1055,1151,1185,1260,1272],"are":[20,31,412,550,701,763,776,972,1079],"currently":[21,104,413],"important":[22,347,407,515,1006],"in":[23,34,39,48,54,76,81,89,101,340,352,384,400,432,440,479,518,524,532,554,604,618,632,677,765,784,790,805,809,832,849,863,932,952,992,1085,1100,1111,1117,1133,1146,1159,1174,1190,1213,1224,1237,1276],"the":[24,51,98,108,118,143,162,172,184,208,233,246,255,266,279,291,301,316,331,395,414,426,451,459,466,471,480,484,510,522,526,537,541,545,575,583,599,613,678,694,714,735,743,766,791,866,929,950,989,1010,1024,1041,1061,1067,1072,1083,1087,1095,1105,1119,1134,1140,1168,1203,1233,1241,1265],"management":[25],"this":[27,49,77,82,519,687,892,933,953,993,1002,1092,1225],"disease":[28,209,326,718,947,1234],"seen":[32,431,975],"frequently":[33,596,973],"some":[35],"cases":[36,808],"infrequently":[38],"others.":[40],"Two":[41],"these":[43,810],"will":[45],"be":[46,211,231,499,590,623,635,859,869,897,908,1122,1156,1172,1221,1250],"discussed":[47],"review:":[50],"long":[52],"delay":[53,88,100,146],"diagnosis,":[55,90],"which":[56,68,91,880,940,1086,1118],"is":[57,69,92,103,112,283,382,394,406,429,446,454,473,486,521,674,691,881,957,995,1033,1127,1138,1205,1235,1244,1253],"not":[58,93,113,653,889,974,996],"uncommon":[59,71,94],"even":[60,95,116,150,438,1026,1124],"today,":[61,96],"whether":[63,699],"primary":[65,530,587,625,664,761,815,855,894,990,1046,1219],"hepatic":[66,816,1031,1045],"gastrinoma,":[67],"an":[70,671,998],"occurrence,":[72],"was":[73,652,888,938],"likely":[74],"present":[75,383,481,679,690],"case.\r\n\r\nThe":[78],"patient":[80,306,354,365,695,744,994,1011,1042,1088,1169],"report":[84],"had":[85],"20-year":[87],"as":[97,263,478,573,643,645,676,918,920,966,1001],"mean":[99],"diagnosis":[102,111,138,280,332,467,511,867],"6":[105,979],"years.2":[106],"Unfortunately,":[107,278,582,629],"time":[109,460],"to":[110,148,220,337,348,408,448,463,552,592,598,659,684,692,711,782,786,803,858,883,913,961,986,1029,1129,1207,1240],"becoming":[114,284],"shorter,":[115],"with":[117,168,241,290,320,356,366,374,402,540,945,1035,1102,1148,1200],"widespread":[119,292],"availability":[120],"gastrin":[122,216,392],"radioimmunoassay2,3":[123],"information":[125,1008],"from":[126,154,189],"more":[127,285,757,977],"than":[128,288,456,476,489,758,813,834,978],"3,500":[129],"articles":[130],"written":[131],"on":[132,137,157,379,507,639],"ZES,":[133,404,469,1149],"including":[134],"excellent":[135],"reviews":[136],"other":[140,169,227,555],"aspects":[141],"disease.":[144],"This":[145,655,1252],"continues":[147],"occur":[149,553,783,804],"though":[151],"comprehensive":[152],"analyses":[153,170],"long-term":[155,1052],"studies":[156,642,922,1016,1258],"patients":[159,198,319,341,401,944,1101,1113,1147,1176,1180,1191,1199],"conducted":[160],"National":[163,792,837],"Institutes":[164,793,838],"Health,":[166],"along":[167,539],"available":[173],"world":[174],"literature,":[175,538],"have":[176,199,779,799,821,826,830,1017],"recently":[177],"provided":[178],"detailed":[179],"guidelines":[180,187,203],"for":[181,206,252,260,315,872,1009,1063],"diagnosis.":[182],"For":[183],"first":[185,930],"time,":[186],"derived":[188],"statistical":[190],"analysis":[191],"large":[193,982],"numbers":[194],"prospectively":[196],"studied":[197],"become":[200],"available.":[201],"These":[202],"include":[204],"recommendations":[205],"when":[207,214,224,669],"should":[210,218,230,498,907,1171,1249],"clinically":[212,349],"suspected2;":[213],"fasting":[215,390],"levels":[217],"lead":[219],"suspicion":[221],"ZES4;":[223],"secretin":[225,442,492,725,736,905,970],"provocative":[228],"tests":[229,1075],"used;":[232],"formation":[234],"definition":[237],"new":[239],"criteria":[240,251],"enhanced":[242],"sensitivity":[243],"specificity5;":[245],"description":[247],"acid":[249,496,1153],"secretory":[250],"diagnosis6;":[253],"reporting":[256],"specific":[258],"features":[259],"recognizing":[261],"part":[264],"multiple":[267],"endocrine":[268],"neoplasia":[269],"type":[270],"1":[271,741,1030],"(MEN":[272],"1)":[273],"(25%":[275],"cases).7":[277],"difficult,":[286],"rather":[287],"easier,":[289],"use":[293],"proton":[295],"pump":[296],"inhibitors":[297],"(PPIs).8":[298],"PPIs":[299,411,508],"mask":[300],"clinical":[302],"presentation":[303],"controlling":[308],"symptoms":[310],"at":[311,458,646,689,728,740,910,923,925],"conventional":[312],"doses":[313],"used":[314],"treatment":[317],"idiopathic":[321],"gastroesophageal":[322],"reflux":[323],"disease/peptic":[324],"ulcer":[325],"(PUD)":[327],"also":[329,800],"complicate":[330],"causing":[334],"hypergastrinemia":[335,462],"secondary":[336],"achlorhydria/":[338],"hypochlorhydria":[339],"without":[342,1114,1177,1181,1192],"ZES.8,9":[343],"It":[344],"is,":[345],"therefore,":[346,612],"suspect":[350],"any":[353,364,1020],"presenting":[355],"PUD":[357],"diarrhea":[359],"or":[360,363,373,547,601,626,769,817,1189],"associated":[361,1034],"endocrinopathies":[362],"familial":[367],"PUD,":[368,372],"severe":[369],"and/or":[370],"refractory":[371],"prominent":[375],"gastric":[376,452,1152],"folds":[377],"found":[378,764,827],"endoscopy":[380],"(which":[381],"92%":[385],"patients).2,10":[388],"Although":[389,772],"serum":[391],"(FSG)":[393],"initial":[396],"study":[397,497],"usually":[398],"performed":[399,909],"suspected":[403],"it":[405,445,657,1126,1273],"remember":[409],"most":[415],"common":[416],"cause":[417,1143],"hypergastrinemia,":[419],"they":[421,436,700,778,829],"often":[422],"elevate":[423],"FSG":[424,472,485,506,708,723,733,902,937],"into":[425],"range":[427],"commonly":[430],"ZES,4,9,10":[433],"can":[437,589,609,622,634,709,1155,1165,1263],"result":[439],"false-positive":[441],"tests.11":[443],"Therefore,":[444],"essential":[447],"determine":[449,698],"pH":[453],"less":[455,488,833],"2":[457],"firmly":[464],"establish":[465,593,962,988],"if":[470,649,1027,1040,1125,1232],"elevated":[474,487],"greater":[475],"10-fold,3,4":[477],"case.":[482,680],"If":[483,731],"10-fold,":[490],"test":[493,726,737,906,971],"basal":[495],"performed.3-5":[500],"No":[501],"level":[502],"elevation":[504],"establishes":[509],"ZES.3-5\r\n\r\nA":[513],"second":[514],"point":[516],"raised":[517],"case1":[520,1093],"difficulty":[523,688],"establishing":[525],"location":[527,543,584,621,895],"gastrinoma":[531,588,617,673,856],"non\u2013duodenal-pancreatic":[534],"site.":[535],"In":[536,1038,1196],"usual":[542],"duodenum":[546,767],"pancreas,":[548],"gastrinomas":[549,595,762,820],"intra-abdominal":[556],"locations":[557],"(ovary,":[558],"mesentery,":[559],"lymph":[560,602,773],"nodes,":[561],"stomach,":[562],"liver,":[563,1025],"biliary":[564,818],"tract,":[565],"gallbladder,":[566],"renal":[567],"capsule,":[568],"pylorus,":[569],"splenic":[570],"hilium),12,13as":[571],"well":[572,644,919],"outside":[574],"abdomen":[576],"(heart,":[577],"nonsmall":[578],"cell":[579],"lung":[580],"cancer).14,15":[581],"difficult":[591,658],"because":[594,1256],"metastasize":[597],"liver":[600,1201,1210,1218,1242,1269],"nodes":[603],"various":[605],"adjacent":[606],"sites":[607],"invade":[610],"them16-19;":[611],"finding":[614,1003],"non\u2013pancreatic-duodenal":[620],"either":[624],"metastasis.":[628],"duodenal":[630,667,886],"primaries,":[631],"particular,":[633],"small":[636,662,885,1215],"missed":[638,663],"all":[640,915,1080,1112,1175],"imaging":[641,921,1099],"surgery,16,20":[647],"particularly":[648,1254],"duodenotomy":[651],"performed.16,20":[654],"makes":[656],"exclude":[660],"(particularly":[665],"primary)":[668],"only":[670,682,935],"extra\u2013pancreatic-duodenal":[672],"found,":[675],"method":[683],"clearly":[685,987],"resolve":[686],"follow":[693],"post-resection":[696],"disease-free.21":[702],"Studies":[703],"show":[704,1259],"post-noncurative":[706],"resection,":[707],"return":[710],"normal":[712,1058],"detection":[715],"persistent":[717],"requires":[719],"both":[720,732,900],"assessment":[721],"postoperatively":[727],"regular":[729],"intervals.17,21":[730],"remain":[738],"negative":[739],"year,":[742],"has":[745,1005,1043],"95%":[747],"probability":[748],"being":[750],"cured":[751],"3":[752],"years":[753],"post-resection.21":[754,948],"At":[755,928],"present,":[756],"85%":[759],"(60\u201380%)":[768],"pancreas":[770],"(10\u201340%).10,12,16":[771],"node":[774],"primaries":[775,798],"controversial,":[777],"been":[780,801,822],"up":[785],"10%":[787],"cases17":[789],"Health":[795,840],"studies.":[796,811],"Ovarian":[797],"0.5%":[806],"Fewer":[812],"30":[814],"tract":[819],"reported,":[823],"we":[825],"occurred":[831],"2%":[835],"patients.3,12,16,18,19":[842],"As":[843],"associates":[846],"pointed":[847],"out":[848],"their":[850,864,1051],"discussion,1":[852],"although":[853],"appears":[857],"strong":[861],"possibility":[862,1266],"patient,":[865,934],"cannot":[868,896],"definitively":[870],"established":[871],"reasons.":[876],"First,":[877],"duodenotomy,":[879],"required":[882,1076],"identify":[884],"gastrinomas,16,20,22":[887],"performed1;":[890],"thus,":[891],"possible":[893,964],"excluded.":[898],"Second,":[899],"each":[911],"follow-up":[912,931,951,1078],"detect":[914],"persistent/recurrent":[916,946],"disease,21":[917],"least":[924],"yearly":[926],"intervals.":[927],"performed,":[939],"misses":[941],"45%":[942],"Third,":[949],"(2":[955],"months)1":[956],"much":[958],"too":[959],"short":[960],"cure,":[965],"elevations":[967],"FSG/":[969],"until":[976],"months":[980],"after":[981,1229],"noncurative":[983],"resections.17,21\r\n\r\nThe":[984],"attempt":[985],"site":[991],"merely":[997],"idle":[999],"exercise,":[1000],"possibly":[1004,1166],"prognostic":[1007],"physician.":[1013],"Our":[1014],"prospective":[1015],"shown":[1018],"metastatic":[1021,1194],"involvement":[1022],"limited":[1028,1131,1206,1236],"lobe,":[1032],"decreased":[1036],"survival.23":[1037],"contrast,":[1039],"tumor":[1047,1120,1204],"remains":[1049],"disease-free,":[1050],"survival":[1053,1275],"approaches":[1054],"patient.":[1059],"Furthermore,":[1060],"need":[1062],"additional":[1064],"antitumor":[1065],"treatment,":[1066],"frequency":[1068],"follow-up,":[1070],"extensiveness":[1073],"during":[1077],"influenced":[1081],"category":[1084],"ultimately":[1089],"ends":[1090],"up.\r\n\r\nLastly,":[1091],"demonstrates":[1094],"importance":[1096,1106],"careful":[1098,1230],"considering":[1108],"surgical":[1109,1261],"resection":[1110,1248,1262],"MEN":[1115,1178],"1,":[1116,1179],"may":[1121,1220],"resectable,":[1123,1247],"involved":[1128],"extent":[1132,1239],"liver.3,16,19":[1135],"Tumor":[1136],"progression":[1137],"presently":[1139],"single":[1141,1209],"main":[1142],"death":[1145],"now":[1150],"hypersecretion":[1154],"controlled":[1157],"medically":[1158],"almost":[1160],"every":[1161],"patient.23":[1162],"Only":[1163],"surgery":[1164],"cure":[1167],"considered":[1173],"concurrent":[1183],"illness":[1184],"limits":[1186],"life":[1187],"expectancy,":[1188],"nonresectable":[1193],"disease.16":[1195],"5\u201315%":[1197],"metastases,":[1202],"lobe18":[1211],"percentage,":[1216],"present.":[1222],"Thus,":[1223],"group":[1226],"patients,":[1228],"imaging,":[1231],"its":[1238],"potentially":[1245],"completely":[1246],"considered.18":[1251],"true":[1255],"recent":[1257],"decrease":[1264],"developing":[1268],"metastases":[1270],"increases":[1274],"patients.24,25":[1278]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}