{"id":"https://openalex.org/W2698606705","doi":"https://doi.org/10.1200/jco.2014.32.15_suppl.8512","title":"A phase Ib dose escalation trial of SAR650984 (Anti-CD-38 mAb) in combination with lenalidomide and dexamethasone in relapsed/refractory multiple myeloma.","display_name":"A phase Ib dose escalation trial of SAR650984 (Anti-CD-38 mAb) in combination with lenalidomide and dexamethasone in relapsed/refractory multiple myeloma.","publication_year":2014,"publication_date":"2014-05-20","ids":{"openalex":"https://openalex.org/W2698606705","doi":"https://doi.org/10.1200/jco.2014.32.15_suppl.8512","mag":"2698606705"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2014.32.15_suppl.8512","doi":"https://doi.org/10.1200/jco.2014.32.15_suppl.8512","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2014.32.15_suppl.8512","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103703459","display_name":"Thomas G. Martin","orcid":"https://orcid.org/0000-0003-1752-5092","observed_orcids":["https://orcid.org/0000-0003-1752-5092"]},"institutions":[{"id":"https://openalex.org/I76766440","display_name":"University of San Francisco","ror":"https://ror.org/029m7xn54","country_code":"US","type":"education","lineage":["https://openalex.org/I76766440"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas G. Martin","raw_affiliation_strings":["University of San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I76766440"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072906560","display_name":"Karl Hsu","orcid":"https://orcid.org/0000-0003-3137-1202","observed_orcids":["https://orcid.org/0000-0003-3137-1202"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karl Hsu","raw_affiliation_strings":["Sanofi-Aventis, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanofi-Aventis, Cambridge, MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Eric Charpentier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric Charpentier","raw_affiliation_strings":["Sanofi-Aventis, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanofi-Aventis, Cambridge, MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026151069","display_name":"Ravi Vij","orcid":"https://orcid.org/0000-0001-8795-3610","observed_orcids":["https://orcid.org/0000-0001-8795-3610"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ravi Vij","raw_affiliation_strings":["Multiple Myeloma Research Consortium, Norwalk, CT/Washington University School of Medicine, St. Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Multiple Myeloma Research Consortium, Norwalk, CT/Washington University School of Medicine, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077110117","display_name":"Rachid Baz","orcid":"https://orcid.org/0000-0003-4538-4733","observed_orcids":["https://orcid.org/0000-0003-4538-4733"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachid C. Baz","raw_affiliation_strings":["H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112786802","display_name":"Don M. Benson","orcid":"https://orcid.org/0000-0001-8837-0548","observed_orcids":["https://orcid.org/0000-0001-8837-0548"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Don M. Benson","raw_affiliation_strings":["The Ohio State University, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026740596","display_name":"Nikoletta K. Lendvai","orcid":"https://orcid.org/0000-0002-9849-4795","observed_orcids":["https://orcid.org/0000-0002-9849-4795"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nikoletta Lendvai","raw_affiliation_strings":["Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"32","issue":"15_suppl","first_page":"8512","last_page":"8512"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anti-cd38-monoclonal-antibody","display_name":"anti-CD38 monoclonal antibody","score":0.9760000109672546},{"id":"https://openalex.org/keywords/relapsed-refractory-multiple-myeloma","display_name":"relapsed/refractory multiple myeloma","score":0.9660000205039978},{"id":"https://openalex.org/keywords/lenalidomide","display_name":"lenalidomide","score":0.9929999709129333},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6510000228881836},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.8849999904632568},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.8579999804496765},{"id":"https://openalex.org/keywords/objective-response-rate","display_name":"objective response rate","score":0.7509999871253967},{"id":"https://openalex.org/keywords/hematological-toxicity","display_name":"hematologic toxicity","score":0.5960000157356262},{"id":"https://openalex.org/keywords/infusion-related-reactions","display_name":"infusion reactions","score":0.45899999141693115},{"id":"https://openalex.org/keywords/antibody-dependent-cellular-cytotoxicity","display_name":"antibody-dependent cellular cytotoxicity","score":0.6190000176429749},{"id":"https://openalex.org/keywords/complement-dependent-cytotoxicity","display_name":"complement-dependent cytotoxicity","score":0.9210000038146973}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8803428411483765},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.7412436008453369},{"id":"https://openalex.org/C2776063141","wikidata":"https://www.wikidata.org/wiki/Q425681","display_name":"Lenalidomide","level":3,"score":0.7383055090904236},{"id":"https://openalex.org/C2778524551","wikidata":"https://www.wikidata.org/wiki/Q7227206","display_name":"Pomalidomide","level":4,"score":0.574247419834137},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5297242999076843},{"id":"https://openalex.org/C2780401358","wikidata":"https://www.wikidata.org/wiki/Q422252","display_name":"Dexamethasone","level":2,"score":0.5280645489692688},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.4997289180755615},{"id":"https://openalex.org/C2777478702","wikidata":"https://www.wikidata.org/wiki/Q419319","display_name":"Bortezomib","level":3,"score":0.48325568437576294},{"id":"https://openalex.org/C2780108899","wikidata":"https://www.wikidata.org/wiki/Q15366934","display_name":"Carfilzomib","level":4,"score":0.48116907477378845},{"id":"https://openalex.org/C2778850193","wikidata":"https://www.wikidata.org/wiki/Q3775974","display_name":"Febrile neutropenia","level":4,"score":0.4747234582901001},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.46753689646720886},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.45197367668151855},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.43669945001602173},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.4303801953792572},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35216307640075684},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.21050944924354553}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2014.32.15_suppl.8512","doi":"https://doi.org/10.1200/jco.2014.32.15_suppl.8512","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2014.32.15_suppl.8512","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2533263660","https://openalex.org/W995617888","https://openalex.org/W2552397723","https://openalex.org/W1575172718","https://openalex.org/W2979626733","https://openalex.org/W2504055076","https://openalex.org/W6885071332","https://openalex.org/W2529484267","https://openalex.org/W4405041996","https://openalex.org/W2980220100"],"abstract_inverted_index":{"8512":[0],"Background:":[1],"SAR650984":[2],"(SAR)":[3],"is":[4],"a":[5,14],"humanized":[6],"IgG1":[7],"monoclonal":[8],"antibody":[9],"that":[10],"binds":[11],"selectively":[12],"to":[13,163,234,246],"unique":[15],"epitope":[16],"on":[17,40,47,83,93,107,290,302,362],"human":[18],"CD38":[19,41],"receptor.":[20],"SAR":[21,62,103,165,312,329,342],"kills":[22],"tumor":[23,320],"cells":[24],"via":[25],"antibody-dependent":[26],"cellular-mediated":[27],"cytotoxicity,":[28,30],"complement-dependent":[29],"direct":[31],"apoptosis":[32],"induction":[33],"without":[34],"secondary":[35],"crosslinking":[36],"and":[37,65,75,89,98,110,112,150,203,220,268,298,334,365],"allosteric":[38],"inhibition":[39],"enzymatic":[42],"activity.":[43],"We":[44],"present":[45],"data":[46],"the":[48,53,115,363,366,372],"dose":[49,58,176,310],"escalation":[50],"phase":[51],"of":[52,61,261,328,357],"study":[54],"(NCT01749969).":[55],"Methods:":[56],"Three":[57],"levels":[59,315],"(DL)":[60],"3,":[63],"5":[64,198],"10":[66,269],"mg/kg":[67,270],"were":[68,125,215,316,337],"evaluated":[69],"in":[70,348],"combination":[71,327],"with":[72,123,282,330,350],"lenalidomide":[73],"(LEN)":[74],"dexamethasone":[76],"(Dex).":[77],"LEN":[78,146],"25":[79],"mg":[80,92],"was":[81,104,167,177,253,279,292,332],"given":[82,105],"days":[84],"(d)":[85],"1":[86,109,266,283],"\u2013":[87],"21":[88],"D":[90],"40":[91],"d":[94,108,231],"1,":[95,230],"8,":[96],"15":[97,111],"22":[99],"every":[100],"28":[101],"d\u2019s.":[102],"IV":[106],"escalated":[113],"using":[114],"classic":[116],"3+3":[117],"design.":[118],"Results:":[119],"13":[120],"patients":[121],"(pts)":[122],"RRMM":[124],"treated;":[126],"median":[127,134,159],"age":[128],"61":[129],"yrs":[130,169],"(48":[131],"-":[132,140,171,296],"73);":[133],"prior":[135,145,148,156],"treatment":[136,291],"regimens":[137],"6":[138,190],"(2":[139],"12),":[141],"100%":[142],"had":[143],"received":[144,153],"(23%":[147],"pomalidomide)":[149],"92.3%":[151],"previously":[152],"bortezomib":[154],"(38.5%":[155],"carfilzomib).":[157],"The":[158,173,180,241,326],"time":[160,289],"from":[161,322],"diagnosis":[162],"first":[164],"dosing":[166],"4.5":[168],"(3":[170],"11).":[172],"maximum":[174],"tolerated":[175,333],"not":[178],"reached.":[179],"most":[181],"frequent":[182],"adverse":[183],"events":[184],"included":[185],"nausea,":[186],"cough":[187],"(n":[188,196,205,217,222],"=":[189,197,206,218,223],"each);":[191,199],"fatigue,":[192],"muscle":[193],"spasm,":[194],"infection":[195],"vomiting,":[200],"diarrhea,":[201],"dehydration":[202],"insomnia":[204],"4":[207],"each).":[208],"Grade":[209],"(G)":[210],"\u2265":[211],"3":[212,272,286],"hematologic":[213],"abnormalities":[214],"neutropenia":[216],"4)":[219],"thrombocytopenia":[221],"3).":[224,240],"One":[225],"pt":[226],"discontinued":[227],"therapy":[228],"(cycle":[229],"1)":[232],"due":[233],"an":[235],"infusion":[236],"reaction":[237],"(bronchospasm":[238],"G":[239],"ORR":[242],"(\u2265":[243,277],"PR),":[244],"according":[245],"IMWG":[247],"criteria,":[248],"among":[249],"12":[250],"evaluable":[251],"pts":[252,300,349,359],"58":[254],"%.":[255],"Responses":[256],"occurred":[257],"at":[258,285,308,339,371],"each":[259],"DL":[260],"3mg/kg":[262],"(1PR),":[263],"5mg/kg":[264],"(1PR,":[265,271],"VGPR)":[267],"VGPR).":[273],"Clinical":[274,374],"benefit":[275],"response":[276],"MR)":[278],"67":[280],"%":[281],"MR":[284],"mg/kg.":[287],"Median":[288],"20.6":[293],"weeks":[294],"(0":[295],"35)":[297],"7":[299],"remain":[301],"therapy.":[303],"PK":[304],"showed":[305],"non":[306],"linearity":[307],"select":[309],"levels,":[311],"plasma":[313],"trough":[314],"above":[317],"target":[318],"for":[319],"eradication":[321],"preclinical":[323],"data.":[324],"Conclusions:":[325],"LEN/Dex":[331,344],"no":[335],"DLT\u2019s":[336],"reported":[338,370],"any":[340],"DL.":[341],"+":[343],"demonstrated":[345],"encouraging":[346],"efficacy":[347],"heavily":[351],"pretreated":[352],"RRMM.":[353],"An":[354],"expansion":[355],"cohort":[356],"18":[358],"recently":[360],"enrolled":[361],"trial":[364,375],"results":[367],"will":[368],"be":[369],"meeting.":[373],"information:":[376],"NCT01749969.":[377]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2017-06-30T00:00:00"}