{"id":"https://openalex.org/W26965309","doi":"https://doi.org/10.3978/j.issn.2218-6751.2012.09.05","title":"Front-line erlotinib in unselected patient with advanced NSCLC followed by standard chemotherapy with gemcitabine and cisplatin - TORCH study.","display_name":"Front-line erlotinib in unselected patient with advanced NSCLC followed by standard chemotherapy with gemcitabine and cisplatin - TORCH study.","publication_year":2012,"publication_date":"2012-09-01","ids":{"openalex":"https://openalex.org/W26965309","doi":"https://doi.org/10.3978/j.issn.2218-6751.2012.09.05","mag":"26965309","pmid":"https://pubmed.ncbi.nlm.nih.gov/25806186","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4367560"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:3333762","doi":"https://doi.org/10.3978/j.issn.2218-6751.2012.09.05","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4367560","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4367560","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055415475","display_name":"Bin-Chi Liao","orcid":"https://orcid.org/0000-0002-7092-0764","observed_orcids":["https://orcid.org/0000-0002-7092-0764"]},"institutions":[{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Bin-Chi Liao","raw_affiliation_strings":["Department of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan ; ; Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan ; ; Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan ;","institution_ids":["https://openalex.org/I4210131804"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055074037","display_name":"James Chih\u2010Hsin Yang","orcid":"https://orcid.org/0000-0002-5586-5138","observed_orcids":["https://orcid.org/0000-0002-5586-5138"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]},{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"James Chih-Hsin Yang","raw_affiliation_strings":["Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan ; ; Graduate Institute of Oncology and Cancer Research Center, College of Medicine, National Taiwan University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan ; ; Graduate Institute of Oncology and Cancer Research Center, College of Medicine, National Taiwan University, Taipei, Taiwan","institution_ids":["https://openalex.org/I16733864","https://openalex.org/I4210131804"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00344962,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":"3","first_page":"227","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erlotinib","display_name":"erlotinib","score":1.0},{"id":"https://openalex.org/keywords/advanced-non-small-cell-lung-cancer","display_name":"advanced non-small cell lung cancer","score":0.9020000100135803},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.8050000071525574},{"id":"https://openalex.org/keywords/gemcitabine","display_name":"gemcitabine","score":0.8539999723434448},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.6549999713897705},{"id":"https://openalex.org/keywords/egfr-tyrosine-kinase-inhibitors","display_name":"EGFR tyrosine kinase inhibitors","score":0.8489999771118164},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8460000157356262},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.6570000052452087},{"id":"https://openalex.org/keywords/time-to-progression","display_name":"time to progression","score":0.6779999732971191}],"concepts":[{"id":"https://openalex.org/C2778087573","wikidata":"https://www.wikidata.org/wiki/Q418369","display_name":"Erlotinib","level":4,"score":0.9743765592575073},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9019436836242676},{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.7828803062438965},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6779818534851074},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6421890258789062},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6376817226409912},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6108464002609253},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.5165116190910339},{"id":"https://openalex.org/C2909325608","wikidata":"https://www.wikidata.org/wiki/Q418369","display_name":"Erlotinib Hydrochloride","level":5,"score":0.5113139152526855},{"id":"https://openalex.org/C2776283816","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Survival rate","level":2,"score":0.4461739659309387},{"id":"https://openalex.org/C2781190966","wikidata":"https://www.wikidata.org/wiki/Q420436","display_name":"Docetaxel","level":3,"score":0.4139763414859772},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2590083181858063},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.19260075688362122}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:3333762","doi":"https://doi.org/10.3978/j.issn.2218-6751.2012.09.05","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4367560","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4367560","doi":"https://doi.org/10.3978/j.issn.2218-6751.2012.09.05","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4367560","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transl Lung Cancer Res","raw_type":"Text"},{"id":"pmid:25806186","doi":"https://doi.org/10.3978/j.issn.2218-6751.2012.09.05","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25806186","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational lung cancer research","raw_type":"Journal Article"},{"id":"mag:26965309","doi":"https://doi.org/10.3978/j.issn.2218-6751.2012.09.05","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25806186","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3333762","doi":"https://doi.org/10.3978/j.issn.2218-6751.2012.09.05","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4367560","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W2032573089","https://openalex.org/W2100912832","https://openalex.org/W2106585301","https://openalex.org/W2111662961","https://openalex.org/W2128278369","https://openalex.org/W2129360604","https://openalex.org/W2132157071","https://openalex.org/W2138297714","https://openalex.org/W2154662831","https://openalex.org/W2160982674","https://openalex.org/W2166084034","https://openalex.org/W2171981784","https://openalex.org/W2225825236"],"related_works":["https://openalex.org/W2128278369","https://openalex.org/W2175549663","https://openalex.org/W2287408960","https://openalex.org/W2352792612","https://openalex.org/W2135346764","https://openalex.org/W2970400887","https://openalex.org/W2032573089","https://openalex.org/W2185573459","https://openalex.org/W2278057905","https://openalex.org/W2965845866"],"abstract_inverted_index":{"Result":[0],"from":[1],"BR.":[2],"21":[3],"study":[4,52],"demonstrated":[5,62],"that":[6],"in":[7,55],"unselected":[8,43],"patients":[9,44,79],"with":[10,18,45,81],"advanced":[11,46],"non-small":[12],"cell":[13],"lung":[14],"cancer":[15],"(NSCLC)":[16],"pretreated":[17],"standard":[19],"first-line":[20],"or":[21],"second-line":[22],"chemotherapy,":[23],"subsequent":[24],"erlotinib":[25,54],"treatment":[26],"prolonged":[27],"overall":[28,72,95],"survival":[29,73,96],"(OS)":[30,97],"as":[31,39],"compared":[32],"to":[33],"placebo":[34],"(1).":[35],"Erlotinib":[36],"was":[37,87],"evaluated":[38],"front-line":[40],"therapy":[41],"for":[42],"NSCLC.":[47],"In":[48,77],"a":[49,63,70],"phase":[50],"II":[51],"of":[53,67,74],"NSCLC":[56],"patients,":[57],"Giaccone":[58],"et":[59],"al.":[60],"(2)":[61],"tumor":[64],"response":[65,85],"rate":[66,86],"22.7%":[68],"and":[69,89,94,100],"median":[71,90],"391":[75],"days.":[76],"elderly":[78],"treated":[80],"frontline":[82],"erlotinib,":[83],"the":[84],"10%,":[88],"timeto-":[91],"progression":[92],"(TTP)":[93],"were":[98],"3.5":[99],"10.9":[101],"months":[102],"respectively":[103],"(3).":[104]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}