{"id":"https://openalex.org/W2695686","doi":"https://doi.org/10.1016/0022-2836(92)90554-w","title":"His92Ala mutation in ribonuclease T1 induces segmental flexibility","display_name":"His92Ala mutation in ribonuclease T1 induces segmental flexibility","publication_year":1992,"publication_date":"1992-04-01","ids":{"openalex":"https://openalex.org/W2695686","doi":"https://doi.org/10.1016/0022-2836(92)90554-w","mag":"2695686","pmid":"https://pubmed.ncbi.nlm.nih.gov/1314902"},"language":"en","primary_location":{"id":"doi:10.1016/0022-2836(92)90554-w","doi":"https://doi.org/10.1016/0022-2836(92)90554-w","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0022-2836(92)90554-w","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113701379","display_name":"Gertraud Koellner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gertraud Koellner","raw_affiliation_strings":["Institut f\u00fcr Kristallographie, Freie Universit\u00e4t Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Kristallographie, Freie Universit\u00e4t Berlin, Germany","institution_ids":["https://openalex.org/I75951250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003612798","display_name":"Hui\u2010Woog Choe","orcid":"https://orcid.org/0000-0002-6419-8146","observed_orcids":["https://orcid.org/0000-0002-6419-8146"]},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hui-Woog Choe","raw_affiliation_strings":["Institut f\u00fcr Kristallographie, Freie Universit\u00e4t Berlin Takustra\u03b2e 6, W-1000 Berlin 33, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Kristallographie, Freie Universit\u00e4t Berlin Takustra\u03b2e 6, W-1000 Berlin 33, Germany","institution_ids":["https://openalex.org/I75951250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058504005","display_name":"Udo Heinemann","orcid":"https://orcid.org/0000-0002-8191-3850","observed_orcids":["https://orcid.org/0000-0002-8191-3850"]},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Udo Heinemann","raw_affiliation_strings":["Institut f\u00fcr Kristallographie, Freie Universit\u00e4t Berlin Takustra\u03b2e 6, W-1000 Berlin 33, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Kristallographie, Freie Universit\u00e4t Berlin Takustra\u03b2e 6, W-1000 Berlin 33, Germany","institution_ids":["https://openalex.org/I75951250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111712380","display_name":"Hans\u2010Peter Grunert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hans-Peter Grunert","raw_affiliation_strings":["Institut f\u00fcr Kristallographie, Freie Universit\u00e4t Berlin Takustra\u03b2e 6, W-1000 Berlin 33, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Kristallographie, Freie Universit\u00e4t Berlin Takustra\u03b2e 6, W-1000 Berlin 33, Germany","institution_ids":["https://openalex.org/I75951250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023040689","display_name":"Athina Zouni","orcid":"https://orcid.org/0000-0003-0561-6990","observed_orcids":["https://orcid.org/0000-0003-0561-6990"]},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Athina Zouni","raw_affiliation_strings":["Institut f\u00fcr Kristallographie, Freie Universit\u00e4t Berlin Takustra\u03b2e 6, W-1000 Berlin 33, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Kristallographie, Freie Universit\u00e4t Berlin Takustra\u03b2e 6, W-1000 Berlin 33, Germany","institution_ids":["https://openalex.org/I75951250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027321702","display_name":"Ulrich Hahn","orcid":"https://orcid.org/0000-0002-6526-0693","observed_orcids":["https://orcid.org/0000-0002-6526-0693"]},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ulrich Hahn","raw_affiliation_strings":["Institut f\u00fcr Kristallographie, Freie Universit\u00e4t Berlin Takustra\u03b2e 6, W-1000 Berlin 33, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Kristallographie, Freie Universit\u00e4t Berlin Takustra\u03b2e 6, W-1000 Berlin 33, Germany","institution_ids":["https://openalex.org/I75951250"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044758922","display_name":"Wolfram Saenger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Wolfram Saenger","raw_affiliation_strings":["Institut f\u00fcr Kristallographie, Freie Universit\u00e4t Berlin Takustra\u03b2e 6, W-1000 Berlin 33, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Kristallographie, Freie Universit\u00e4t Berlin Takustra\u03b2e 6, W-1000 Berlin 33, Germany","institution_ids":["https://openalex.org/I75951250"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5044758922"],"corresponding_institution_ids":["https://openalex.org/I75951250"],"apc_list":{"value":4730,"currency":"USD","value_usd":4730},"apc_paid":null,"fwci":1.7624,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.82340168,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"224","issue":"3","first_page":"701","last_page":"713"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.021900000050663948,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10464","display_name":"Crystal structures of chemical compounds","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ribonuclease-t1","display_name":"ribonuclease T1","score":0.9509999752044678},{"id":"https://openalex.org/keywords/segmental-flexibility","display_name":"segmental flexibility","score":0.7009999752044678},{"id":"https://openalex.org/keywords/loop-conformational-change","display_name":"loop conformational change","score":0.6769999861717224},{"id":"https://openalex.org/keywords/beta-turn","display_name":"beta-turn","score":0.7549999952316284},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.38100001215934753},{"id":"https://openalex.org/keywords/polyethylene-glycol-precipitant","display_name":"polyethylene glycol precipitant","score":0.8159999847412109},{"id":"https://openalex.org/keywords/protein-crystallization","display_name":"protein crystallization","score":0.4259999990463257},{"id":"https://openalex.org/keywords/enzyme-inactivity","display_name":"enzyme inactivity","score":0.5419999957084656}],"concepts":[{"id":"https://openalex.org/C10879258","wikidata":"https://www.wikidata.org/wiki/Q76826611","display_name":"RNase P","level":4,"score":0.7784901857376099},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.5886175632476807},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.56442791223526},{"id":"https://openalex.org/C112887158","wikidata":"https://www.wikidata.org/wiki/Q169324","display_name":"Hydrogen bond","level":3,"score":0.5297825336456299},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5187554359436035},{"id":"https://openalex.org/C207583985","wikidata":"https://www.wikidata.org/wiki/Q128723","display_name":"Wild type","level":4,"score":0.47445258498191833},{"id":"https://openalex.org/C2781285689","wikidata":"https://www.wikidata.org/wiki/Q21921428","display_name":"Crystal (programming language)","level":2,"score":0.47272008657455444},{"id":"https://openalex.org/C2778976237","wikidata":"https://www.wikidata.org/wiki/Q422523","display_name":"Ribonuclease","level":4,"score":0.47015929222106934},{"id":"https://openalex.org/C69766542","wikidata":"https://www.wikidata.org/wiki/Q3430179","display_name":"RNase H","level":5,"score":0.4160839915275574},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.3306676745414734},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.3060768246650696},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.20043832063674927},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15600264072418213},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000249","descriptor_name":"Adenosine Monophosphate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006147","descriptor_name":"Guanine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006157","descriptor_name":"Guanosine Monophosphate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006163","descriptor_name":"Ribonuclease T1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006163","descriptor_name":"Ribonuclease T1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006639","descriptor_name":"Histidine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006639","descriptor_name":"Histidine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014633","descriptor_name":"Valine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014961","descriptor_name":"X-Ray Diffraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/0022-2836(92)90554-w","doi":"https://doi.org/10.1016/0022-2836(92)90554-w","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0022-2836(92)90554-w","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},{"id":"pmid:1314902","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1314902","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of molecular biology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W72107370","https://openalex.org/W172448375","https://openalex.org/W1511229070","https://openalex.org/W1521900320","https://openalex.org/W1553561420","https://openalex.org/W1608052268","https://openalex.org/W1613515614","https://openalex.org/W1709608340","https://openalex.org/W1933901144","https://openalex.org/W1969222787","https://openalex.org/W1985233438","https://openalex.org/W1985418326","https://openalex.org/W1989387701","https://openalex.org/W2011852447","https://openalex.org/W2013917043","https://openalex.org/W2019590135","https://openalex.org/W2019977642","https://openalex.org/W2023925347","https://openalex.org/W2030938300","https://openalex.org/W2034205952","https://openalex.org/W2042987185","https://openalex.org/W2048658736","https://openalex.org/W2049573398","https://openalex.org/W2055035610","https://openalex.org/W2059401704","https://openalex.org/W2065717154","https://openalex.org/W2071770954","https://openalex.org/W2078861058","https://openalex.org/W2094297839","https://openalex.org/W2095453123","https://openalex.org/W2102558845","https://openalex.org/W2104505138","https://openalex.org/W2109750398","https://openalex.org/W2117514600","https://openalex.org/W2117715668","https://openalex.org/W2213968736","https://openalex.org/W2502412871","https://openalex.org/W6724666816"],"related_works":["https://openalex.org/W4390472916","https://openalex.org/W2066713777","https://openalex.org/W2043518876","https://openalex.org/W1882143139","https://openalex.org/W1992902298","https://openalex.org/W4235507962","https://openalex.org/W1994354095","https://openalex.org/W1966454220","https://openalex.org/W2153505843","https://openalex.org/W2033775154"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
