{"id":"https://openalex.org/W26954067","doi":null,"title":"Interferon-induced surface alterations in hairy cells. A review.","display_name":"Interferon-induced surface alterations in hairy cells. A review.","publication_year":1988,"publication_date":"1988-03-01","ids":{"openalex":"https://openalex.org/W26954067","mag":"26954067","pmid":"https://pubmed.ncbi.nlm.nih.gov/3368772"},"language":"en","primary_location":{"id":"pmid:3368772","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3368772","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scanning microscopy","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052577613","display_name":"Haim Gamliel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H Gamliel","raw_affiliation_strings":["Department of Medicine, University of Chicago Medical Center, IL 60637"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Chicago Medical Center, IL 60637","institution_ids":["https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085202306","display_name":"Dorit Gurfel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Gurfel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"S H Wu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S H Wu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109876893","display_name":"Harvey M. Golomb","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H M Golomb","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2714,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.52109903,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2","issue":"1","first_page":"485","last_page":"92"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.016699999570846558,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.01269999984651804,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hairy-cell-leukemia","display_name":"hairy cell leukemia","score":0.9229999780654907},{"id":"https://openalex.org/keywords/interferon-alpha","display_name":"interferon-alpha","score":0.8659999966621399},{"id":"https://openalex.org/keywords/hairy-cells","display_name":"hairy cells","score":0.6520000100135803},{"id":"https://openalex.org/keywords/cell-surface-morphology","display_name":"cell surface morphology","score":0.5669999718666077},{"id":"https://openalex.org/keywords/membrane-reorganization","display_name":"membrane reorganization","score":0.7049999833106995},{"id":"https://openalex.org/keywords/microvilli","display_name":"microvilli","score":0.8029999732971191},{"id":"https://openalex.org/keywords/membrane-ruffling","display_name":"ruffles","score":0.7829999923706055},{"id":"https://openalex.org/keywords/hla-dr","display_name":"HLA-DR","score":0.8619999885559082},{"id":"https://openalex.org/keywords/hla-dq","display_name":"HLA-DQ","score":0.9990000128746033},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.8650000095367432}],"concepts":[{"id":"https://openalex.org/C2910537785","wikidata":"https://www.wikidata.org/wiki/Q201299","display_name":"Hairy Cell","level":4,"score":0.8852484822273254},{"id":"https://openalex.org/C2780483514","wikidata":"https://www.wikidata.org/wiki/Q201299","display_name":"Hairy cell leukemia","level":3,"score":0.6788806319236755},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.64045250415802},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.6167115569114685},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5822259187698364},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5298029184341431},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.49469372630119324},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.48956069350242615},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.420899897813797},{"id":"https://openalex.org/C87555872","wikidata":"https://www.wikidata.org/wiki/Q3141316","display_name":"Ultrastructure","level":2,"score":0.41712239384651184},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.412866473197937},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4120522737503052},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3533569574356079},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3066990077495575},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.30599740147590637},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.3042588531970978},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2707885801792145},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14101818203926086},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13136297464370728}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007370","descriptor_name":"Interferon Type I","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007943","descriptor_name":"Leukemia, Hairy Cell","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007943","descriptor_name":"Leukemia, Hairy Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008855","descriptor_name":"Microscopy, Electron, Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:3368772","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3368772","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scanning microscopy","raw_type":"Journal Article"},{"id":"pmh:oai:digitalcommons.usu.edu:microscopy-1271","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.usu.edu/microscopy/vol2/iss1/46","pdf_url":null,"source":{"id":"https://openalex.org/S4377196327","display_name":"Digital Commons - USU (Utah State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121980950","host_organization_name":"Utah State University","host_organization_lineage":["https://openalex.org/I121980950"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scanning Microscopy","raw_type":"text"},{"id":"mag:26954067","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3368772","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W2048494090","https://openalex.org/W2047540678","https://openalex.org/W2142483035","https://openalex.org/W4240512961","https://openalex.org/W2094759401","https://openalex.org/W2077321817","https://openalex.org/W2044494989","https://openalex.org/W2075332832","https://openalex.org/W2036878667","https://openalex.org/W2070541243","https://openalex.org/W1965410604","https://openalex.org/W2115480752","https://openalex.org/W2059756585","https://openalex.org/W2293877091","https://openalex.org/W1849652248","https://openalex.org/W2144941656","https://openalex.org/W1982832370","https://openalex.org/W2085850337","https://openalex.org/W1993952427","https://openalex.org/W2094788949","https://openalex.org/W2066863490","https://openalex.org/W2069200605","https://openalex.org/W1993347640","https://openalex.org/W1966761529"],"related_works":["https://openalex.org/W2148741607","https://openalex.org/W2420188012","https://openalex.org/W1588836422","https://openalex.org/W1966738174","https://openalex.org/W2417422016","https://openalex.org/W2414457704","https://openalex.org/W2439829481","https://openalex.org/W2398684325","https://openalex.org/W2411918443","https://openalex.org/W2073264791"],"abstract_inverted_index":{"Hairy":[0],"cells":[1,76,110,178],"(HCs),":[2],"derived":[3,47],"from":[4,48,160],"the":[5,73,105,109,124,149,171,191],"peripheral":[6],"blood":[7],"and":[8,20,36,42,59,83,104,112,130,134,154],"spleen":[9],"of":[10,51,72,108,126,170],"hairy":[11,75],"cell":[12],"leukemia":[13],"(HCL)":[14],"patients,":[15],"constantly":[16],"displayed":[17,77],"both":[18],"ruffles":[19],"microvilli.":[21],"HCs":[22,127,159],"which":[23],"were":[24,53,166],"kept":[25],"in":[26,92,123,139,148,158,176,190],"culture":[27],"for":[28,152],"up":[29,69],"to":[30,70],"three":[31],"days":[32],"exhibited":[33],"extremely":[34],"polarized":[35],"active":[37],"surfaces":[38,79],"with":[39,55,80,94,128],"elongated":[40],"microvilli":[41],"exaggerated":[43],"\"spiked\"":[44],"ruffles.":[45],"Cells":[46],"11":[49],"cases":[50,140,161],"HCL":[52],"treated":[54],"alpha-interferon":[56],"(IFN)":[57],"in-vitro":[58],"examined":[60],"by":[61],"immuno-scanning":[62],"electron":[63],"microscopy":[64],"(immuno-SEM).":[65],"In":[66],"8":[67],"cases,":[68],"one-third":[71],"IFN-treated":[74,177],"deformed":[78],"\"bubbling\"":[81],"membrane":[82,142,164,174,188],"markedly":[84],"villous":[85],"bud-like":[86],"formations.":[87],"Monoclonal":[88],"antibodies":[89],"(MoAb),":[90],"used":[91],"conjunction":[93],"immuno-gold":[95],"labeling,":[96],"facilitated":[97],"better":[98],"correlation":[99],"between":[100],"these":[101],"morphological":[102],"changes":[103,122,165,175],"immunological":[106],"profiles":[107],"before":[111,133],"after":[113,135],"interferon":[114],"treatment":[115],"in-vitro.":[116],"Immuno-SEM":[117],"analyses":[118],"revealed":[119],"no":[120],"remarkable":[121],"labeling":[125,150],"Leu-14":[129],"Leu-M5":[131],"MoAbs":[132],"IFN":[136],"treatment,":[137],"even":[138],"showing":[141],"changes.":[143],"However,":[144],"a":[145],"significant":[146],"increase":[147],"intensity":[151],"HLA-DR":[153],"HLA-DQ":[155],"was":[156],"noticed":[157],"where":[162],"IFN-induced":[163],"evident.":[167],"A":[168],"review":[169],"literature":[172],"on":[173],"proposes":[179],"that":[180],"such":[181],"immuno-ultrastructural":[182],"alterations":[183],"might":[184],"reflect":[185],"unique":[186],"interferon-induced":[187],"reorganization":[189],"target":[192],"malignant":[193],"cells.":[194]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
