{"id":"https://openalex.org/W269424331","doi":null,"title":"Fusidic acid for Beh\u00e7et's colitis: a novel approach to T-cell specific immunosuppressive therapy.","display_name":"Fusidic acid for Beh\u00e7et's colitis: a novel approach to T-cell specific immunosuppressive therapy.","publication_year":1991,"publication_date":"1991-06-01","ids":{"openalex":"https://openalex.org/W269424331","mag":"269424331","pmid":"https://pubmed.ncbi.nlm.nih.gov/1868757"},"language":"en","primary_location":{"id":"pmid:1868757","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1868757","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Danish medical bulletin","raw_type":"Case Reports"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038253678","display_name":"E. Langholz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Langholz","raw_affiliation_strings":["Medicinsk gastroenterologisk afdeling C, K\u00f8benhavns"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinsk gastroenterologisk afdeling C, K\u00f8benhavns","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047967057","display_name":"J\u00f8rn Brynskov","orcid":"https://orcid.org/0000-0002-4946-2172","observed_orcids":["https://orcid.org/0000-0002-4946-2172"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Brynskov","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004120145","display_name":"Leif Gade Freund","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L G Freund","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5105789044","display_name":"Klaus Bendtzen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Bendtzen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.1426,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.91299949,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"38","issue":"3","first_page":"284","last_page":"284"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11571","display_name":"Sarcoidosis and Beryllium Toxicity Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fusidic-acid","display_name":"fusidic acid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/t-cell-suppression","display_name":"T cell suppression","score":0.8579999804496765},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.9340000152587891},{"id":"https://openalex.org/keywords/steroid-sparing-therapy","display_name":"steroid-sparing therapy","score":0.7580000162124634},{"id":"https://openalex.org/keywords/immunomodulatory-therapy","display_name":"immunomodulatory therapy","score":0.5590000152587891},{"id":"https://openalex.org/keywords/prednisolone-dose-reduction","display_name":"prednisolone dose reduction","score":0.7429999709129333}],"concepts":[{"id":"https://openalex.org/C2780483375","wikidata":"https://www.wikidata.org/wiki/Q259930","display_name":"Fusidic acid","level":4,"score":0.9835703372955322},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9284547567367554},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.6692533493041992},{"id":"https://openalex.org/C2776715498","wikidata":"https://www.wikidata.org/wiki/Q11426176","display_name":"Prednisolone","level":2,"score":0.6539673209190369},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.5251343250274658},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.48508989810943604},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4385003447532654},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.09528118371963501},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.06240561604499817},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.05249139666557312},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001528","descriptor_name":"Behcet Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D001528","descriptor_name":"Behcet Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001528","descriptor_name":"Behcet Syndrome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005672","descriptor_name":"Fusidic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:1868757","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1868757","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Danish medical bulletin","raw_type":"Case Reports"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/07cf1f48-b37a-4ebe-8e65-271531e4211f","doi":null,"is_oa":false,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/07cf1f48-b37a-4ebe-8e65-271531e4211f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Langholz, E, Brynskov, J, Freund, L G & Bendtzen, K 1991, 'Fusidic acid for Beh\u00e7et's colitis : a novel approach to T-cell specific immunosuppressive therapy', Danish Medical Bulletin (Print), vol. 38, no. 3, pp. 284.","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:269424331","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1868757","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4205161662","https://openalex.org/W2097597631","https://openalex.org/W1968815613","https://openalex.org/W405799893","https://openalex.org/W2410082838","https://openalex.org/W2432951684","https://openalex.org/W2405254492","https://openalex.org/W2413220932","https://openalex.org/W2396845442","https://openalex.org/W2981394834"],"abstract_inverted_index":{"A":[0],"33-year-old":[1],"patient":[2,16],"suffered":[3],"from":[4,21,50],"recurring":[5],"Beh,cet's":[6],"colitis":[7],"despite":[8],"treatment":[9,30],"with":[10],"corticosteroids":[11],"and":[12,43],"later":[13],"cyclosporin.":[14,75],"The":[15,55],"was":[17],"then":[18],"successfully":[19],"shifted":[20],"cyclosporin,":[22],"a":[23,68],"T-cell":[24,72],"specific":[25],"immunosuppressant,":[26],"to":[27,52],"fusidic":[28,35,65,83],"acid":[29,36,66,84],"(500":[31],"mg":[32],"t.i.d.).":[33],"During":[34],"treatment,":[37],"he":[38],"went":[39],"into":[40],"complete":[41],"remission,":[42],"his":[44],"prednisolone":[45],"dose":[46],"could":[47],"be":[48,91],"reduced":[49],"30":[51],"5":[53],"mg/day.":[54],"case":[56],"report":[57],"substantiates":[58],"recent":[59],"in":[60,85],"vitro":[61],"data":[62],"indicating":[63],"that":[64,79],"has":[67],"similar":[69],"effect":[70,81],"on":[71],"function":[73],"as":[74],"It":[76],"is":[77],"suggested":[78],"the":[80],"of":[82],"other":[86],"chronic":[87],"immunoinflammatory":[88],"diseases":[89],"should":[90],"examined.":[92]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}