{"id":"https://openalex.org/W269186602","doi":null,"title":"Differential binding of fibroblast growth factor-2 and -7 to basement membrane heparan sulfate: comparison of normal and abnormal human tissues.","display_name":"Differential binding of fibroblast growth factor-2 and -7 to basement membrane heparan sulfate: comparison of normal and abnormal human tissues.","publication_year":1997,"publication_date":"1997-04-01","ids":{"openalex":"https://openalex.org/W269186602","mag":"269186602","pmid":"https://pubmed.ncbi.nlm.nih.gov/9094999","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1858159"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:1544297","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1858159","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1858159","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062635660","display_name":"Andreas Friedl","orcid":"https://orcid.org/0000-0001-9027-0167","observed_orcids":["https://orcid.org/0000-0001-9027-0167"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Friedl","raw_affiliation_strings":["Department of Pathology, University of Wisconsin-Madison 53792, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Wisconsin-Madison 53792, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Z Chang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Z Chang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"A Tierney","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Tierney","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5084124992","display_name":"Alan C. Rapraeger","orcid":"https://orcid.org/0000-0003-1719-3286","observed_orcids":["https://orcid.org/0000-0003-1719-3286"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A C Rapraeger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.9845,"has_fulltext":false,"cited_by_count":104,"citation_normalized_percentile":{"value":0.86656649,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"150","issue":"4","first_page":"1443","last_page":"55"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.04170000180602074,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13223","display_name":"Connective Tissue Growth Factor Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fibroblast-growth-factor-2","display_name":"fibroblast growth factor 2","score":0.9900000095367432},{"id":"https://openalex.org/keywords/fibroblast-growth-factor-7","display_name":"fibroblast growth factor 7","score":0.9700000286102295},{"id":"https://openalex.org/keywords/keratinocyte-growth-factor","display_name":"keratinocyte growth factor","score":0.9409999847412109},{"id":"https://openalex.org/keywords/heparan-sulfate","display_name":"heparan sulfate","score":0.9890000224113464},{"id":"https://openalex.org/keywords/basement-membrane","display_name":"basement membrane","score":0.9860000014305115},{"id":"https://openalex.org/keywords/growth-factor-binding","display_name":"growth factor binding","score":0.8970000147819519},{"id":"https://openalex.org/keywords/mast-cells","display_name":"mast cells","score":0.8330000042915344},{"id":"https://openalex.org/keywords/epithelial-cells","display_name":"epithelial cells","score":0.8889999985694885},{"id":"https://openalex.org/keywords/subendothelial-matrix","display_name":"subendothelial matrix","score":0.7450000047683716},{"id":"https://openalex.org/keywords/papillary-renal-cell-carcinoma","display_name":"papillary renal cell carcinoma","score":0.8830000162124634},{"id":"https://openalex.org/keywords/growth-factor-activation","display_name":"growth factor activation","score":0.4659999907016754}],"concepts":[{"id":"https://openalex.org/C2778041096","wikidata":"https://www.wikidata.org/wiki/Q424668","display_name":"Heparan sulfate","level":3,"score":0.925072431564331},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.815589427947998},{"id":"https://openalex.org/C22731427","wikidata":"https://www.wikidata.org/wiki/Q2071346","display_name":"Perlecan","level":4,"score":0.7785855531692505},{"id":"https://openalex.org/C2776193487","wikidata":"https://www.wikidata.org/wiki/Q32846","display_name":"Basement membrane","level":2,"score":0.6905311346054077},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5294387340545654},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4602870047092438},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4013969898223877},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3899693489074707},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.2416309118270874},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.216596782207489}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001485","descriptor_name":"Basement Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001485","descriptor_name":"Basement Membrane","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004817","descriptor_name":"Epidermis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004817","descriptor_name":"Epidermis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006497","descriptor_name":"Heparan Sulfate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007684","descriptor_name":"Kidney Tubules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007684","descriptor_name":"Kidney Tubules","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016475","descriptor_name":"3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051523","descriptor_name":"Fibroblast Growth Factor 7","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051526","descriptor_name":"Fibroblast Growth Factor 10","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:1544297","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1858159","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1858159","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1858159","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"pmid:9094999","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9094999","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Comparative Study"},{"id":"mag:269186602","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9094999","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1544297","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1858159","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3973601900","display_name":"Role of Heparan Sulfate in FGF Action","funder_award_id":"R01GM048850","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W178745150","https://openalex.org/W190833853","https://openalex.org/W332047183","https://openalex.org/W1245544535","https://openalex.org/W1426257970","https://openalex.org/W1494909024","https://openalex.org/W1513451331","https://openalex.org/W1519091149","https://openalex.org/W1558896136","https://openalex.org/W1578995377","https://openalex.org/W1601446742","https://openalex.org/W1667760140","https://openalex.org/W1745661527","https://openalex.org/W1971359142","https://openalex.org/W1980398407","https://openalex.org/W1984511708","https://openalex.org/W1984821767","https://openalex.org/W1992557354","https://openalex.org/W2003632139","https://openalex.org/W2006641366","https://openalex.org/W2007230427","https://openalex.org/W2008980811","https://openalex.org/W2014678714","https://openalex.org/W2019626689","https://openalex.org/W2033702973","https://openalex.org/W2034534896","https://openalex.org/W2041701283","https://openalex.org/W2045965305","https://openalex.org/W2048381117","https://openalex.org/W2050082215","https://openalex.org/W2050256171","https://openalex.org/W2051701253","https://openalex.org/W2066566675","https://openalex.org/W2083186952","https://openalex.org/W2092852694","https://openalex.org/W2093325301","https://openalex.org/W2109366777","https://openalex.org/W2111363882","https://openalex.org/W2118830070","https://openalex.org/W2131986778","https://openalex.org/W2141790367","https://openalex.org/W2143250882","https://openalex.org/W2166227856","https://openalex.org/W2166578267","https://openalex.org/W2167544720","https://openalex.org/W2262202248","https://openalex.org/W2303379221","https://openalex.org/W2319962899","https://openalex.org/W2410374837","https://openalex.org/W2418607702","https://openalex.org/W2438602659"],"related_works":["https://openalex.org/W2063283462","https://openalex.org/W1601446742","https://openalex.org/W2066566675","https://openalex.org/W2130969923","https://openalex.org/W2056616173","https://openalex.org/W2464383703","https://openalex.org/W7100297802","https://openalex.org/W2159041180","https://openalex.org/W3021246944","https://openalex.org/W2005944250"],"abstract_inverted_index":{"Fibroblast":[0],"growth":[1,17,169,190],"factors":[2,191],"(FGFs)":[3],"play":[4],"multiple":[5],"roles":[6],"during":[7],"development":[8],"and":[9,18,57,69,83,98,111,136,155,172],"in":[10,48,72,109,126,130,133,137],"adult":[11],"tissues":[12],"as":[13,60],"paracrine":[14],"regulators":[15],"of":[16,37,52,141,158,188],"differentiation.":[19],"FGFs":[20,68,163],"signal":[21],"through":[22],"transmembrane":[23],"receptor":[24],"tyrosine":[25],"kinases,":[26],"but":[27],"heparan":[28,43,70,92,107,124,159],"sulfate":[29,44,93,108,125,176],"is":[30,94,150],"also":[31],"required":[32],"for":[33,161],"signaling":[34],"by":[35],"members":[36],"the":[38,138,193],"FGF":[39,76],"family.":[40],"In":[41,152],"addition,":[42],"may":[45,167,177],"be":[46],"involved":[47],"determining":[49],"tissue":[50,80,95,114],"distribution":[51],"FGFs.":[53],"Using":[54],"biotinylated":[55],"FGF-2":[56,101],"FGF-7":[58,117,148],"(KGF)":[59],"probes,":[61],"we":[62],"have":[63,178],"identified":[64,165],"specific":[65,156],"interactions":[66],"between":[67],"sulfates":[71,160],"human":[73],"tissues.":[74],"Both":[75],"species":[77],"bind":[78,120],"to":[79,84,89,104,119,121,182],"mast":[81],"cells":[82],"epithelial":[85],"cell":[86,145],"membranes.":[87],"Binding":[88],"basement":[90,105,122,139,194],"membrane":[91,106,123,140],"source":[96],"dependent":[97],"specific.":[99],"Although":[100],"strongly":[102],"binds":[103],"skin":[110],"most":[112,127],"other":[113],"sites":[115],"examined,":[116],"fails":[118],"locations.":[128],"However,":[129],"subendothelial":[131],"matrix":[132],"blood":[134],"vessels":[135],"a":[142,179],"papillary":[143],"renal":[144],"carcinoma,":[146],"strong":[147],"binding":[149],"seen.":[151],"summary,":[153],"distinct":[154],"affinities":[157],"different":[162],"were":[164],"that":[166],"affect":[168],"factor":[170],"activation":[171],"local":[173],"distribution.":[174],"Heparan":[175],"gatekeeper":[180],"function":[181],"either":[183],"restrict":[184],"or":[185],"permit":[186],"diffusion":[187],"heparin-binding":[189],"across":[192],"membrane.":[195]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}