{"id":"https://openalex.org/W26916907","doi":null,"title":"Limiting dilution analysis of CD4 T-cell cytokine production in mice administered native versus polymerized ovalbumin: directed induction of T-helper type-1-like activation.","display_name":"Limiting dilution analysis of CD4 T-cell cytokine production in mice administered native versus polymerized ovalbumin: directed induction of T-helper type-1-like activation.","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W26916907","mag":"26916907","pmid":"https://pubmed.ncbi.nlm.nih.gov/8666423","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1383977"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1383977","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1383977","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1383977","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082896629","display_name":"Randall S. Gieni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"R S Gieni","raw_affiliation_strings":["Department of Immunology, University of Manitoba, Winnipeg, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, University of Manitoba, Winnipeg, Canada","institution_ids":["https://openalex.org/I46247651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100329750","display_name":"Xi Yang","orcid":"https://orcid.org/0000-0002-8831-7488","observed_orcids":["https://orcid.org/0000-0002-8831-7488","https://orcid.org/0009-0002-7272-3841"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"X Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056729267","display_name":"Anne Kelso","orcid":"https://orcid.org/0000-0002-3166-3267","observed_orcids":["https://orcid.org/0000-0002-3166-3267"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Kelso","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5072841776","display_name":"Kent T. HayGlass","orcid":"https://orcid.org/0000-0002-4621-7737","observed_orcids":["https://orcid.org/0000-0002-4621-7737"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K T Hayglass","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3816,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.56053133,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"87","issue":"1","first_page":"119","last_page":"26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.8359000086784363,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.8359000086784363,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.15389999747276306,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovalbumin","display_name":"ovalbumin","score":0.7300000190734863},{"id":"https://openalex.org/keywords/high-molecular-weight-antigens","display_name":"high molecular weight antigen","score":0.5989999771118164},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.8349999785423279},{"id":"https://openalex.org/keywords/th1-th2-polarization","display_name":"Th1/Th2 polarization","score":0.7689999938011169},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9160000085830688},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.8840000033378601},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.9940000176429749},{"id":"https://openalex.org/keywords/t-cell-precursor-frequency","display_name":"T cell precursor frequency","score":0.718999981880188},{"id":"https://openalex.org/keywords/antigen-modification","display_name":"antigen modification","score":0.5199999809265137},{"id":"https://openalex.org/keywords/anti-ifn-gamma-monoclonal-antibody","display_name":"anti-IFN-gamma monoclonal antibody","score":0.8050000071525574},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.4830000102519989}],"concepts":[{"id":"https://openalex.org/C2776946954","wikidata":"https://www.wikidata.org/wiki/Q420291","display_name":"Ovalbumin","level":3,"score":0.8561727404594421},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.6609579920768738},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5934141874313354},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.517969012260437},{"id":"https://openalex.org/C191732599","wikidata":"https://www.wikidata.org/wiki/Q14865947","display_name":"Interleukin 4","level":3,"score":0.5070288181304932},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4857931137084961},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.46174508333206177},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.45208775997161865},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4417233467102051},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.43103331327438354},{"id":"https://openalex.org/C2777371288","wikidata":"https://www.wikidata.org/wiki/Q410130","display_name":"Interleukin 2","level":3,"score":0.42030981183052063},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32726946473121643},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2783820629119873},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2520095705986023},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010047","descriptor_name":"Ovalbumin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010047","descriptor_name":"Ovalbumin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011489","descriptor_name":"Protein Denaturation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018417","descriptor_name":"Th1 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1383977","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1383977","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},{"id":"pmid:8666423","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8666423","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},{"id":"mag:26916907","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8666423","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1383977","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1383977","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W323722602","https://openalex.org/W1546021870","https://openalex.org/W1555235592","https://openalex.org/W1570219583","https://openalex.org/W1586271020","https://openalex.org/W1594448858","https://openalex.org/W1614077485","https://openalex.org/W1777738032","https://openalex.org/W1891716380","https://openalex.org/W1979514172","https://openalex.org/W1981309200","https://openalex.org/W1998065531","https://openalex.org/W2002726220","https://openalex.org/W2005189283","https://openalex.org/W2018848522","https://openalex.org/W2022363338","https://openalex.org/W2027139443","https://openalex.org/W2029836713","https://openalex.org/W2035339960","https://openalex.org/W2038136978","https://openalex.org/W2051579898","https://openalex.org/W2056859114","https://openalex.org/W2062567403","https://openalex.org/W2067049479","https://openalex.org/W2088582722","https://openalex.org/W2107079403","https://openalex.org/W2114714736","https://openalex.org/W2117480094","https://openalex.org/W2138206033","https://openalex.org/W2139144899","https://openalex.org/W2161362125","https://openalex.org/W2161828600","https://openalex.org/W2162763987","https://openalex.org/W2171760349","https://openalex.org/W2172466148","https://openalex.org/W2175077154","https://openalex.org/W2177385981","https://openalex.org/W2202483530","https://openalex.org/W2285259661","https://openalex.org/W4231581694"],"related_works":["https://openalex.org/W2117480094","https://openalex.org/W7095741799","https://openalex.org/W7097307815","https://openalex.org/W2031675922","https://openalex.org/W352865921","https://openalex.org/W2087035523","https://openalex.org/W7098285724","https://openalex.org/W2127136141","https://openalex.org/W2051005022","https://openalex.org/W1969811846"],"abstract_inverted_index":{"Polarized":[0],"expression":[1],"of":[2,9,25,39,65,95,104,109,118,138,144,153,163,172,178,199,215,228,240,248,259,279,299,310,314,328,333,348,359,369,381],"T-helper":[3],"type-1":[4],"(Th1)-":[5],"or":[6,74],"Th2-like":[7,234],"patterns":[8,358],"cytokine":[10,129,360],"production":[11,36],"frequently":[12],"correlates":[13],"with":[14,307],"disease":[15],"outcome.":[16],"Previously,":[17],"we":[18],"have":[19],"described":[20],"the":[21,101,167,226,229,246,257,277,339,343,370],"long-lived":[22],"reciprocal":[23],"regulation":[24],"ovalbumin":[26],"(OVA)-specific":[27],"IgE":[28,311],"(>":[29],"95%":[30],"inhibition)":[31],"and":[32,49,147,261,274,312,330,363,383],"IgG2a":[33,315],"(300-800-fold":[34],"increased)":[35],"following":[37,76,159,269],"administration":[38,162],"high":[40,168],"MW":[41,169],"OVA":[42,51,77],"polymers":[43],"(OVA-POL),":[44],"in":[45,81,160,189,202,225,296,353,366,376],"both":[46],"de":[47],"novo":[48],"ongoing":[50],"(alum)-induced":[52],"responses.":[53,130],"Here,":[54],"limiting":[55,377],"dilution":[56],"analysis":[57],"(LDA)":[58],"was":[59,157],"used":[60],"to":[61,89,134,175,206,235,250,345,356,387],"compare":[62],"precursor":[63,96,116,264],"frequencies":[64,117,143,265,327,332],"CD4":[66,121,183,281,336,350,385],"T":[67,122,282,301],"cells":[68,195,283,302,386],"producing":[69],"interferon-gamma":[70],"(IFN-gamma),":[71],"interleukin-4":[72],"(IL-4)":[73],"IL-10":[75,191,329],"versus":[78],"OVA-POL":[79,131,249,270],"exposure":[80,271],"vivo.":[82],"Adjuvants":[83],"were":[84,266],"not":[85,285,317],"used,":[86],"so":[87],"as":[88,112],"circumvent":[90],"their":[91],"impact":[92],"on":[93,321],"measurement":[94],"frequencies.":[97],"We":[98],"found":[99],"that":[100,291],"two":[102],"forms":[103],"antigen":[105,173,294],"elicited":[106,126],"T-cell":[107,184,351],"activation":[108,185],"comparable":[110],"intensity,":[111],"indicated":[113],"by":[114,196,212,374],"equivalent":[115],"clonogenic":[119],"antigen-specific":[120],"cells.":[123,337],"However,":[124],"they":[125],"qualitatively":[127],"different":[128],"treatment":[132],"led":[133],"10-fold":[135],"higher":[136],"(mean":[137,272],"six":[139],"independent":[140],"LDA":[141],"experiments)":[142],"IFN-gamma-producing":[145,194,334],"cells,":[146,155],"a":[148,187,197,213,222,304],"mean":[149],"fivefold":[150],"lower":[151],"frequency":[152,278],"IL-10-producing":[154,384],"than":[156],"observed":[158],"vivo":[161,238,297,367],"unmodified":[164],"OVA.":[165],"Thus,":[166],"polymerized":[170],"form":[171],"acted":[174],"steer":[176],"commitment":[177,298,347],"naive":[179,300,354],"(for":[180],"this":[181,292],"antigen)":[182],"from":[186,233],"situation":[188],"which":[190],"producers":[192,210],"outnumbered":[193],"factor":[198,214],"4:1":[200],"(found":[201],"mice":[203,218,355],"administered":[204],"OVA),":[205],"one":[207],"where":[208],"IFN-gamma":[209,375],"dominated":[211],"11:1":[216],"(in":[217],"given":[219],"OVA-POL),":[220],"i.e.":[221],"qualitative":[223],"shift":[224],"nature":[227],"OVA-specific":[230,263,335],"response":[231],"induced":[232],"Th1-like.":[236],"In":[237],"co-administration":[239],"anti-IFN-gamma":[241],"monoclonal":[242],"antibody":[243],"(mAb)":[244],"abolished":[245],"capacity":[247],"preferentially":[251],"elicit":[252],"Th1-like":[253,305],"dominance.":[254],"Interestingly,":[255],"although":[256],"ratios":[258],"IFN-gamma:IL-4":[260],"IFN-gamma:IL-10":[262],"strongly":[267],"increased":[268,331],"18-":[273],"47-fold":[275],"higher),":[276],"IL-4-producing":[280],"did":[284],"differ":[286],"significantly.":[287],"The":[288],"data":[289,340],"suggest":[290],"modified":[293],"promotes":[295],"towards":[303],"response,":[306],"consequent":[308],"inhibition":[309],"enhancement":[313],"responses,":[316],"through":[318],"direct":[319],"effects":[320],"IL-4":[322],"production,":[323],"but":[324],"via":[325],"decreased":[326],"Collectively,":[338],"(1)":[341],"demonstrate":[342],"ability":[344],"manipulate":[346],"antigen-driven":[349],"populations":[352],"specific":[357],"gene":[361],"expression,":[362],"(2)":[364],"provide":[365],"evidence":[368],"regulatory":[371],"role":[372],"played":[373],"induction":[378],"and/or":[379],"expansion":[380],"IL-4-":[382],"protein":[388],"allergens.":[389]},"counts_by_year":[{"year":2017,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
