{"id":"https://openalex.org/W269128656","doi":null,"title":"Biomaterials and the Foreign Body Reaction: Surface Chemistry Dependent Macrophage Adhesion, Fusion, Apoptosis, and Cytokine Production","display_name":"Biomaterials and the Foreign Body Reaction: Surface Chemistry Dependent Macrophage Adhesion, Fusion, Apoptosis, and Cytokine Production","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W269128656","mag":"269128656"},"language":"en","primary_location":{"id":"pmh:oai:etd.ohiolink.edu:case1176223290","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=case1176223290","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=case1176223290","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=case1176223290","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://rave.ohiolink.edu/etdc/view?acc_num=case1176223290","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103718781","display_name":"Jacqueline A. Jones","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jacqueline A. Jones","raw_affiliation_strings":["Case Western Reserve University ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve University ,","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5103718781"],"corresponding_institution_ids":["https://openalex.org/I58956616"],"apc_list":null,"apc_paid":null,"fwci":0.4746,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.57780936,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10859","display_name":"Polymer Surface Interaction Studies","score":0.8939999938011169,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10859","display_name":"Polymer Surface Interaction Studies","score":0.8939999938011169,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.05829999968409538,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10512","display_name":"Orthopaedic implants and arthroplasty","score":0.013899999670684338,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/foreign-body-reaction","display_name":"foreign body reaction","score":0.9879999756813049},{"id":"https://openalex.org/keywords/foreign-body-giant-cells","display_name":"foreign body giant cells","score":0.9509999752044678},{"id":"https://openalex.org/keywords/macrophage-adhesion","display_name":"macrophage adhesion","score":0.953000009059906},{"id":"https://openalex.org/keywords/surface-chemistry","display_name":"surface chemistry","score":0.75},{"id":"https://openalex.org/keywords/hydrophilicity","display_name":"hydrophilicity","score":0.593999981880188},{"id":"https://openalex.org/keywords/water-contact-angle","display_name":"water contact angle","score":0.7120000123977661},{"id":"https://openalex.org/keywords/polyethylene-terephthalate","display_name":"polyethylene terephthalate","score":0.8149999976158142},{"id":"https://openalex.org/keywords/polyurethane","display_name":"polyurethane","score":0.5339999794960022},{"id":"https://openalex.org/keywords/poly-2-hydroxyethyl-methacrylate","display_name":"poly(2-hydroxyethyl methacrylate)","score":0.7620000243186951},{"id":"https://openalex.org/keywords/poly-ethylene-oxide","display_name":"poly(ethylene oxide)","score":0.6050000190734863},{"id":"https://openalex.org/keywords/cell-fusion","display_name":"cell fusion","score":0.31700000166893005},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6919999718666077},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.968999981880188},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5590000152587891},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.7649999856948853},{"id":"https://openalex.org/keywords/biomaterials","display_name":"biomaterials","score":0.4090000092983246}],"concepts":[{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.6533673405647278},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6186546683311462},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.6075330972671509},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.5608646273612976},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4967425465583801},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4872378408908844},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.42977407574653625},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2727237045764923},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24115154147148132},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1955341100692749},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.12670019268989563},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:etd.ohiolink.edu:case1176223290","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=case1176223290","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=case1176223290","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=case1176223290","raw_type":"text"},{"id":"mag:269128656","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/theses/ETH/4332","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:etd.ohiolink.edu:case1176223290","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=case1176223290","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=case1176223290","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=case1176223290","raw_type":"text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W269128656.pdf","grobid_xml":"https://content.openalex.org/works/W269128656.grobid-xml"},"referenced_works_count":128,"referenced_works":["https://openalex.org/W1211886664","https://openalex.org/W1494386735","https://openalex.org/W1500856190","https://openalex.org/W1512269824","https://openalex.org/W1535223882","https://openalex.org/W1554947160","https://openalex.org/W1563081817","https://openalex.org/W1565411191","https://openalex.org/W1598825449","https://openalex.org/W1929903403","https://openalex.org/W1958425212","https://openalex.org/W1965658210","https://openalex.org/W1966296130","https://openalex.org/W1966993325","https://openalex.org/W1968218735","https://openalex.org/W1968804936","https://openalex.org/W1969681915","https://openalex.org/W1972227130","https://openalex.org/W1972278871","https://openalex.org/W1976230888","https://openalex.org/W1977664815","https://openalex.org/W1978592531","https://openalex.org/W1982144361","https://openalex.org/W1982832450","https://openalex.org/W1986010238","https://openalex.org/W1986031245","https://openalex.org/W1987811647","https://openalex.org/W1988327100","https://openalex.org/W1991923798","https://openalex.org/W1993224545","https://openalex.org/W1993324117","https://openalex.org/W1994705909","https://openalex.org/W1995392909","https://openalex.org/W1997133573","https://openalex.org/W1997137757","https://openalex.org/W1997585819","https://openalex.org/W1997972022","https://openalex.org/W1998309175","https://openalex.org/W1999389062","https://openalex.org/W2001717792","https://openalex.org/W2002771508","https://openalex.org/W2006725349","https://openalex.org/W2010334420","https://openalex.org/W2010922391","https://openalex.org/W2013411867","https://openalex.org/W2016293419","https://openalex.org/W2016639612","https://openalex.org/W2016856932","https://openalex.org/W2018012921","https://openalex.org/W2018860283","https://openalex.org/W2019324625","https://openalex.org/W2019789512","https://openalex.org/W2022071421","https://openalex.org/W2022901882","https://openalex.org/W2023124533","https://openalex.org/W2027323310","https://openalex.org/W2031100089","https://openalex.org/W2032478134","https://openalex.org/W2034795794","https://openalex.org/W2036532945","https://openalex.org/W2038689279","https://openalex.org/W2039059596","https://openalex.org/W2039156036","https://openalex.org/W2040191185","https://openalex.org/W2040345927","https://openalex.org/W2040627030","https://openalex.org/W2041149077","https://openalex.org/W2044099088","https://openalex.org/W2047917567","https://openalex.org/W2049471883","https://openalex.org/W2049929455","https://openalex.org/W2050875490","https://openalex.org/W2056336363","https://openalex.org/W2056804609","https://openalex.org/W2058770369","https://openalex.org/W2059756682","https://openalex.org/W2061609938","https://openalex.org/W2061631515","https://openalex.org/W2062204055","https://openalex.org/W2063638546","https://openalex.org/W2068308185","https://openalex.org/W2068349731","https://openalex.org/W2069060328","https://openalex.org/W2072124073","https://openalex.org/W2074139312","https://openalex.org/W2074277398","https://openalex.org/W2075030807","https://openalex.org/W2077129929","https://openalex.org/W2078610877","https://openalex.org/W2080874749","https://openalex.org/W2084919802","https://openalex.org/W2085900451","https://openalex.org/W2088994503","https://openalex.org/W2089968607","https://openalex.org/W2092664304","https://openalex.org/W2092813888","https://openalex.org/W2093705034","https://openalex.org/W2095105579","https://openalex.org/W2095408585","https://openalex.org/W2098586211","https://openalex.org/W2099302056","https://openalex.org/W2101726477","https://openalex.org/W2103722820","https://openalex.org/W2113952028","https://openalex.org/W2122784431","https://openalex.org/W2123640179","https://openalex.org/W2123804493","https://openalex.org/W2124387185","https://openalex.org/W2128049766","https://openalex.org/W2128920830","https://openalex.org/W2131256178","https://openalex.org/W2132754444","https://openalex.org/W2135045951","https://openalex.org/W2137034111","https://openalex.org/W2142477580","https://openalex.org/W2145865564","https://openalex.org/W2146087209","https://openalex.org/W2150312527","https://openalex.org/W2152487395","https://openalex.org/W2154401382","https://openalex.org/W2158847235","https://openalex.org/W2159193014","https://openalex.org/W2160272188","https://openalex.org/W2166987361","https://openalex.org/W2169009185","https://openalex.org/W2169391121","https://openalex.org/W2224483385","https://openalex.org/W2462838772"],"related_works":["https://openalex.org/W2040191185","https://openalex.org/W2016639612","https://openalex.org/W1995063875","https://openalex.org/W1509156154","https://openalex.org/W1976230888","https://openalex.org/W1986031245","https://openalex.org/W7154513193","https://openalex.org/W2030009408","https://openalex.org/W4230999997","https://openalex.org/W7138121596"],"abstract_inverted_index":{"The":[0],"foreign":[1,36],"body":[2,37],"reaction":[3],"has":[4],"proven":[5],"to":[6,10,18,43,303,337],"be":[7],"a":[8],"hindrance":[9],"the":[11,27,44,52,264,270,275,294,313],"functionality":[12],"of":[13,30,46,65,263,308],"implanted":[14],"biomedical":[15,48],"devices.The":[16],"ability":[17],"direct":[19],"this":[20],"reaction,":[21],"inflammation,":[22],"and":[23,35,67,258,266,329],"wound":[24],"healing":[25],"via":[26],"material-dependent":[28],"control":[29],"key":[31],"cellular":[32],"components,":[33],"macrophages":[34],"giant":[38],"cells":[39,292,299],"(FBGCs),":[40],"is":[41],"vital":[42],"development":[45],"future":[47],"devices.This":[49],"dissertation":[50],"addresses":[51],"hypothesis":[53],"that":[54,287,320],"surface":[55,322],"chemistry":[56,323],"directs":[57],"adherent":[58,276,298,336],"macrophage/FBGC":[59],"behavior.Table":[60],"1.2":[61],"Water":[62],"Contact":[63,75],"Angles":[64,76],"Clinically":[66,83],"Experimentally":[68],"Utilized":[69],"Polymers":[70],"11,12":[71],"Material":[72],"Relative":[73,80],"Hydrophobicity":[74],"(":[77],"o":[78],")":[79],"Cell":[81],"Attachment":[82],"Used":[84],"Polymers*":[85],"PFTE":[86],"-Polytetrafluoroethylene":[87],"Very":[88,95,236],"Hydrophobic":[89,96,101,106,111,116,217,227,237],"105-116":[90],"Nonadhesive":[91,98,103,108,113,239],"PDMS":[92],"-Poly(dimethyl":[93],"siloxane)":[94],"100-104":[97],"PE":[99],"-Polyethylene":[100,242],"92-97":[102,107],"PP":[104],"-Polypropylene":[105],"PS":[109],"-Polystyrene":[110],"75-91":[112],"PC":[114],"-Polycarbonates":[115],"95":[117],"Adhesive":[118,124,129,135,142,164,171,202,209,219,229,249],"PMMA":[119],"-Poly(methyl":[120],"methacrylate)":[121,145],"Intermediate":[122,127,133,162,169,200,207,247],"65-80":[123],"PU":[125],"-Polyurethane":[126],"60":[128],"PET":[130,159],"-Poly(ethylene":[131,151,160],"terephthalate)":[132,161,168,174,182,190],"65-81":[134],"TCPS":[136],"-Tissue":[137],"culture":[138],"polystyrene":[139],"Hydrophilic":[140,146,153,175,183,191],"35-68":[141],"p-HEMA":[143],"-Poly(hydroxyethyl":[144],"60-80":[147],"Conditionally":[148,155,177,185,193],"(non)adhesive":[149,156,178,186,194],"PEO":[150],"oxide":[152,243],"20-45":[154],"Photografted":[157],"Polymers^":[158],"71":[163],"BDEDTC":[165],"-Modified":[166,180,188],"poly(ethylene":[167,173,181,189],"68":[170],"PAAm-Modified":[172],"46":[176],"PAANa":[179],"24":[184],"DMAPAAmMeI":[187],"31":[192],"Polyurethanes^":[195],"Elasthane":[196,230,240],"80A":[197,204,212],"-Polyether":[198],"urethane":[199,206,216,226,235,246],"61":[201],"Bionate":[203],"-Polycarbonate":[205],"62":[208,248],"PurSil":[210],"20":[211,221],"-PDMS":[213,223],"modified":[214,224,233,244],"polyether":[215,234,245],"90":[218],"CarboSil":[220],"90A":[222],"polycarbonate":[225],"92":[228],"80A-F":[231],"-Fluorocarbon":[232],"109":[238],"80A-P":[241],"*":[250],"Adapted":[251],"from":[252,333],"references":[253],"[11,12].^":[254],"See":[255],"Chapters":[256],"II":[257],"V":[259],"for":[260],"detailed":[261],"description":[262],"materials":[265],"contact":[267],"angle":[268],"analysis.formation.Normalizing":[269],"ELISA":[271],"data":[272],"based":[273],"on":[274,293],"cell":[277],"population":[278],"provided":[279],"cytokine/chemokine":[280,310,330],"concentrations":[281],"produced":[282],"per":[283],"cell.This":[284],"analysis":[285],"showed":[286],"although":[288],"there":[289],"were":[290,300],"fewer":[291],"hydrophilic/neutral":[295],"surface,":[296],"these":[297],"further":[301],"activated":[302,334],"produce":[304],"significantly":[305],"greater":[306],"amounts":[307],"each":[309],"tested":[311],"than":[312],"other":[314],"surfaces.This":[315],"study":[316],"clearly":[317],"presents":[318],"evidence":[319],"material":[321],"can":[324],"differentially":[325],"affect":[326],"monocyte/macrophage/FBGC":[327],"adhesion":[328],"profiles":[331],"derived":[332],"macrophages/FBGCs":[335],"biomaterial":[338],"surfaces.":[339]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-09-01T08:31:24.195828","created_date":"2016-06-24T00:00:00"}
